Social security, education retirement and growth

This paper analyzes, firstly, the expected effects of social security reforms that have been implemented in Spain after 2004 (and, secondly, the expected effects of reductions in the minimum pension) on retirement decision and human capital accumulation (and hence on growth and on income inequality). Individuals in our model economy differ in their innate ability and growth is a by-product of the most skilled individuals’ productivity. According to our model, i) increases in the minimum and normal retirement ages are expected to have a strong effect, not only on individuals’ retirement decisions, but also on their education investment; ii) augmented incentives to late retirement are not expected to have any effect; iii) reductions in the minimum pension are not expected to have a significant effect unless it is completely eliminated.Social Security; Pay-as-you-go; Voluntary Retirement; Human Capital; Minimum Pen

Unemployment rates and population changes in Spain

This paper discusses the long run effect of changes in the age distribution of Spanish population on the unemployment rate, disaggregated by sex and age segments in the light of cointegration theory given the non stationarity of the series. Four main results are obtained. First, empirical analysis does not provide a clear scheme concerning the long run relationships between population variables and the specificunemployment rates for different groups. Second, as a first approximation one can detect the existence of, at least, one long run equilibrium relationship in all sex-age groups, except for the ones including the middle aged unemployed female workers and oldest unemployed female workers. Third, a more thorough analysis enables us to justify the existence of such long run relationships for the youngest male workers and middle aged male workers. One cannot argue, however, a joint evolution of population variables and the unemployment rates associated with female workers and to the oldest male workers. Fourth, the short run dynamics of unemployment rates for the youngest (male and female workers) and the middle age male workers is affected by the transitory deviations from these long run relationships. Hence, from an applied economics point of view, the result stresses the likely failure of employment policies which do not take into account the heterogeneous composition of unemployed workers. It stresses the need to design particular policies for specific groups of workers depending on their age and sex characteristics.unemployment rates, population aging, cointegration

hCOA3 stabilizes COX1 and promotes cytochrome c oxidase assembly in human mitochondria

Cytochrome c oxidase (COX) or complex IV of the mitochondrial respiratory chain plays a fundamental role in energy production of aerobic cells. In humans, COX deficiency is the most frequent cause of mitochondrial encephalomyopathies. Human COX is composed of 13 subunits of dual genetic origin, whose assembly requires an increasing number of nuclear-encoded accessory proteins known as assembly factors. Here, we have identified and characterized human CCDC56, an 11.7-kDa mitochondrial transmembrane protein, as a new factor essential for COX biogenesis. CCDC56 shares sequence similarity with the yeast COX assembly factor Coa3 and was termed hCOA3. hCOA3-silenced cells display a severe COX functional alteration owing to a decreased stability of newly synthesized COX1 and an impairment in the holoenzyme assembly process. We show that hCOA3 physically interacts with both the mitochondrial translation machinery and COX structural subunits. We conclude that hCOA3 stabilizes COX1 co-translationally and promotes its assembly with COX partner subunits. Finally, our results identify hCOA3 as a new candidate when screening for genes responsible for mitochondrial diseases associated with COX deficiency

Astroclimate at San Pedro M\'artir I: 2004-2008 Seeing Statistics from the TMT Site Testing Data

We present comprehensive seeing statistics for the San Pedro M\'artir site derived from the Thirty Meter Telescope site selection data. The observations were obtained between 2004 and 2008 with a Differential Image Motion Monitor (DIMM) and a Multi Aperture Scintillation Sensor (MASS) combined instrument (MASS--DIMM). The parameters that are statistically analised here are: whole atmosphere seeing -measured by the DIMM-; free atmosphere seeing --measured by the MASS--; and ground-layer seeing (GL) --difference between the total and free-atmosphere seeing--. We made a careful data coverage study along with statistical distributions of simultaneous MASS--DIMM seeing measurements, in order to investigate the nightly, monthly, seasonal, annual and global behaviour, as well as possible hourly seeing trends. Although this campaign covers five years, the sampling is uneven, being 2006 and 2007 the best sampled years in terms of seasonal coverage. The overall results yield a median seeing of 0.78 (DIMM), 0.37 (MASS) and 0.59 arcsec (GL). The strongest contribution to the whole atmosphere seeing comes, therefore, from a strong ground layer. We find that the best season is summer, while the worst one is winter, in accordance with previous studies. It is worth noting that the best yearly results are correlated with the best sampled years. The hourly analysis shows that there is no statistically significant tendency of seeing degradation towards dawn. The seeing values are slightly larger than those reported before. This may be caused by climate changes.Comment: Accepted for publication (2012 June 14) in MNRAS, 15 pages, 16 Figures, 8 Table

Acceptability and feasibility of a virtual community of practice to primary care professionals regarding patient empowerment: A qualitative pilot study

Background: Virtual communities of practice (vCoPs) facilitate online learning via the exchange of experiences and knowledge between interested participants. Compared to other communities, vCoPs need to overcome technological structures and specific barriers. Our objective was to pilot the acceptability and feasibility of a vCoP aimed at improving the attitudes of primary care professionals to the empowerment of patients with chronic conditions. Methods: We used a qualitative approach based on 2 focus groups: one composed of 6 general practitioners and the other of 6 practice nurses. Discussion guidelines on the topics to be investigated were provided to the moderator. Sessions were audio-recorded and transcribed verbatim. Thematic analysis was performed using the ATLAS-ti software. Results: The available operating systems and browsers and the lack of suitable spaces and time were reported as the main difficulties with the vCoP. The vCoP was perceived to be a flexible learning mode that provided up-to-date resources applicable to routine practice and offered a space for the exchange of experiences and approaches. Conclusions: The results from this pilot study show that the vCoP was considered useful for learning how to empower patients. However, while vCoPs have the potential to facilitate learning and as shown create professional awareness regarding patient empowerment, attention needs to be paid to technological and access issues and the time demands on professionals. We collected relevant inputs to improve the features, content and educational methods to be included in further vCoP implementation. Trial registration: ClinicalTrials.gov, NCT02757781. Registered on 25 April 2016.This study was financed by Instituto de Salud Carlos III and Cofinanced by Fondo Europeo de Desarrollo Regional (FEDER). Ministerio de Economía y Competitividad. Gobierno de España. (PI15/00164, PI15/00586, PI15/00566

Inside the Outbreak of the 2009 Influenza A (H1N1)v Virus in Mexico

Influenza viruses pose a threat to human health because of their potential to cause global disease. Between mid March and mid April a pandemic influenza A virus emerged in Mexico. This report details 202 cases of infection of humans with the 2009 influenza A virus (H1N1)v which occurred in Mexico City as well as the spread of the virus throughout the entire country.From May 1st to May 5th nasopharyngeal swabs, derived from 751 patients, were collected at 220 outpatient clinics and 28 hospitals distributed throughout Mexico City. Analysis of samples using real time RT-PCR revealed that 202 patients out of the 751 subjects (26.9%) were confirmed to be infected with the new virus. All confirmed cases of human infection with the strain influenza (H1N1)v suffered respiratory symptoms. The greatest number of confirmed cases during the outbreak of the 2009 influenza A (H1N1)v were seen in neighbourhoods on the northeast side of Mexico City including Iztapalapa, Gustavo A. Madero, Iztacalco, and Tlahuac which are the most populated areas in Mexico City. Using these data, together with data reported by the Mexican Secretariat of Health (MSH) to date, we plot the course of influenza (H1N1)v activity throughout Mexico.Our data, which is backed up by MSH data, show that the greatest numbers of the 2009 influenza A (H1N1) cases were seen in the most populated areas. We speculate on conditions in Mexico which may have sparked this flu pandemic, the first in 41 years. We accept the hypothesis that high population density and a mass gathering which took in Iztapalapa contributed to the rapid spread of the disease which developed in three peaks of activity throughout the Country

Acceptability and feasibility of a virtual community of practice to primary care professionals regarding patient empowerment : A qualitative pilot study

Background: Virtual communities of practice (vCoPs) facilitate online learning via the exchange of experiences and knowledge between interested participants. Compared to other communities, vCoPs need to overcome technological structures and specific barriers. Our objective was to pilot the acceptability and feasibility of a vCoP aimed at improving the attitudes of primary care professionals to the empowerment of patients with chronic conditions. Methods: We used a qualitative approach based on 2 focus groups: one composed of 6 general practitioners and the other of 6 practice nurses. Discussion guidelines on the topics to be investigated were provided to the moderator. Sessions were audio-recorded and transcribed verbatim. Thematic analysis was performed using the ATLAS-ti software. Results: The available operating systems and browsers and the lack of suitable spaces and time were reported as the main difficulties with the vCoP. The vCoP was perceived to be a flexible learning mode that provided up-to-date resources applicable to routine practice and offered a space for the exchange of experiences and approaches. Conclusions: The results from this pilot study show that the vCoP was considered useful for learning how to empower patients. However, while vCoPs have the potential to facilitate learning and as shown create professional awareness regarding patient empowerment, attention needs to be paid to technological and access issues and the time demands on professionals. We collected relevant inputs to improve the features, content and educational methods to be included in further vCoP implementation. Trial registration: ClinicalTrials.gov, NCT02757781. Registered on 25 April 2016

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality