Millimeter Dust Emission and Planetary Dynamics in the HD 106906 System

Debris disks are dusty, optically thin structures around main sequence stars. HD 106906AB is a short-period stellar binary, host to a wide separation planet, HD 106906b, and a debris disk. Only a few known systems include a debris disk and a directly imaged planet, and HD 106906 is the only one in which the planet is exterior to the disk. The debris disk is edge-on and highly asymmetric in scattered light. Here we resolve the disk structure at a resolution of 0.38" (39 au) with the Atacama Large Millimeter/submillimeter Array (ALMA) at a wavelength of 1.3 mm. We model the disk with both a narrow and broad ring of material, and find that a radially broad, axisymmetric disk between radii of $\sim$50$-$100 au is able to capture the structure of the observations without evidence of any asymmetry or eccentricity, other than a tentative stellocentric offset. We place stringent upper limits on both the gas and dust content of a putative circumplanetary disk. We interpret the ALMA data in concert with scattered light observations of the inner ring and astrometric constraints on the planet's orbit, and find that the observations are consistent with a large-separation, low-eccentricity orbit for the planet. A dynamical analysis indicates that the central binary can efficiently stabilize planetesimal orbits interior to $\sim$100 au, which relaxes the constraints on eccentricity and semimajor axis somewhat. The observational constraints are consistent with in situ formation via gravitational instability, but cannot rule out a scattering event as the origin for HD 106906b's current orbit

In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor

At present no scientific rationale exists for selecting a particular enabling strategy to formulate a poorly water-soluble drug, although this is crucial as it will influence the in vivo performance of the resulting formulation. This study provides an insight into this complicated decision making process for a poorly soluble human immunodeficiency virus (HIV) protease inhibitor based upon in vivo test results. A formulation strategy based on the molecular dispersion of this active pharmaceutical ingredient (API) into a biphasic matrix consisting of water-insoluble poly(lactic-co-glycolic acid) (PLGA) and water-soluble polyvinylpyrrolidone (PVP) was evaluated. The long-term in vivo performance of this strategy was compared to that of other solubility enhancing approaches by evaluating the exposure in male Beagle dogs. Solid dispersions, based on a PLGA/PVP matrix, were compared to solid dispersions in a pure water-insoluble PLGA matrix. Additionally these solid dispersion strategies were compared to the strategy of particle size reduction by means of an API microsuspension. The in vivo performance of the various formulations over a period of 28 days after intramuscular injection was evaluated by the observed initial burst release, plasma concentration-time profiles, time at which maximum plasma levels were reached (tmax,obs) and the estimated bioavailability. Compared to the other formulation strategies assessed, it was concluded that the addition of PVP in a PLGA matrix resulted in vivo in a more sustained release as well as a higher amount of drug released from the polymeric matrix. This was explained based on the structure of these binary PLGA/PVP matrices where the pore network originating from rapidly dissolving PVP plays a crucial role. Moreover, the results suggest that the release of this type of formulations could be delayed by increasing the amount of PLGA in the formulation

First-Year Spectroscopy for the SDSS-II Supernova Survey

This paper presents spectroscopy of supernovae discovered in the first season of the Sloan Digital Sky Survey-II Supernova Survey. This program searches for and measures multi-band light curves of supernovae in the redshift range z = 0.05 - 0.4, complementing existing surveys at lower and higher redshifts. Our goal is to better characterize the supernova population, with a particular focus on SNe Ia, improving their utility as cosmological distance indicators and as probes of dark energy. Our supernova spectroscopy program features rapid-response observations using telescopes of a range of apertures, and provides confirmation of the supernova and host-galaxy types as well as precise redshifts. We describe here the target identification and prioritization, data reduction, redshift measurement, and classification of 129 SNe Ia, 16 spectroscopically probable SNe Ia, 7 SNe Ib/c, and 11 SNe II from the first season. We also describe our efforts to measure and remove the substantial host galaxy contamination existing in the majority of our SN spectra.Comment: Accepted for publication in The Astronomical Journal(47pages, 9 figures

A Multiwavelength Study of the Highly Asymmetrical Debris Disk around HD 111520

International audienceWe observed the nearly edge-on debris disk system HD 111520 at the HJ and K1 near-infrared (NIR) bands using both the spectral and polarization modes of the Gemini Planet Imager. With these new observations, we have performed an empirical analysis in order to better understand the disk morphology and its highly asymmetrical nature. We find that the disk features a large brightness and radial asymmetry, most prominent at shorter wavelengths. We also find that the radial location of the peak polarized intensity differs on either side of the star by 11 au, suggesting that the disk may be eccentric, although, such an eccentricity does not fully explain the large brightness and radial asymmetry observed. Observations of the disk halo with the Hubble Space Telescope also show the disk to be warped at larger separations, with a bifurcation feature in the northwest, further suggesting that there may be a planet in this system creating an asymmetrical disk structure. Measuring the disk color shows that the brighter extension is bluer compared to the dimmer extension, suggesting that the two sides have different dust grain properties. This finding, along with the large brightness asymmetry, are consistent with the hypothesis that a giant impact occurred between two large bodies in the northern extension of the disk, although confirming this based on NIR observations alone is not feasible. Follow-up imaging with the Atacama Large Millimeter/submillimeter Array to resolve the asymmetry in the dust mass distribution is essential in order to confirm this scenario

Octofitter: Fast, Flexible, and Accurate Orbit Modeling to Detect Exoplanets

As next-generation imaging instruments and interferometers search for planets closer to their stars, they must contend with increasing orbital motion and longer integration times. These compounding effects make it difficult to detect faint planets but also present an opportunity. Increased orbital motion makes it possible to move the search for planets into the orbital domain, where direct images can be freely combined with the radial velocity and proper motion anomaly, even without a confirmed detection in any single epoch. In this paper, we present a fast and differentiable multimethod orbit-modeling and planet detection code called Octofitter. This code is designed to be highly modular and allows users to easily adjust priors, change parameterizations, and specify arbitrary function relations between the parameters of one or more planets. Octofitter further supplies tools for examining model outputs including prior and posterior predictive checks and simulation-based calibration. We demonstrate the capabilities of Octofitter on real and simulated data from different instruments and methods, including HD 91312, simulated JWST/NIRISS aperture masking interferometry observations, radial velocity curves, and grids of images from the Gemini Planet Imager. We show that Octofitter can reliably recover faint planets in long sequences of images with arbitrary orbital motion. This publicly available tool will enable the broad application of multiepoch and multimethod exoplanet detection, which could improve how future targeted ground- and space-based surveys are performed. Finally, its rapid convergence makes it a useful addition to the existing ecosystem of tools for modeling the orbits of directly imaged planets

A Deep Polarimetric Study of the Asymmetrical Debris Disk HD 106906

19 pages, 10 figures, 4 tables, accepted for publication in ApJInternational audienceHD 106906 is a young, binary stellar system, located in the Lower Centaurus Crux (LCC) group. This system is unique among discovered systems in that it contains an asymmetrical debris disk, as well as an 11 M$_{Jup}$ planet companion, at a separation of $\sim$735 AU. Only a handful of other systems are known to contain both a disk and directly imaged planet, where HD 106906 is the only one in which the planet has apparently been scattered. The debris disk is nearly edge on, and extends roughly to $>$500 AU, where previous studies with HST have shown the outer regions to have high asymmetry. To better understand the structure and composition of the disk, we have performed a deep polarimetric study of HD 106906's asymmetrical debris disk using newly obtained $H$-, $J$-, and $K1$-band polarimetric data from the Gemini Planet Imager (GPI). An empirical analysis of our data supports a disk that is asymmetrical in surface brightness and structure, where fitting an inclined ring model to the disk spine suggests that the disk may be highly eccentric ($e\gtrsim0.16$). A comparison of the disk flux with the stellar flux in each band suggests a blue color that also does not significantly vary across the disk. We discuss these results in terms of possible sources of asymmetry, where we find that dynamical interaction with the planet companion, HD 106906b, is a likely candidate