New Power Law Signature of Media Exposure in Human Response Waiting Time Distributions

We study the humanitarian response to the destruction brought by the tsunami generated by the Sumatra earthquake of December 26, 2004, as measured by donations, and find that it decays in time as a power law ~ 1/t^(alpha) with alpha=2.5 +/- 0.1. This behavior is suggested to be the rare outcome of a priority queuing process in which individuals execute tasks at a rate slightly faster than the rate at which new tasks arise. We believe this to be the first empirical evidence documenting this recently predicted regime, and provide additional independent evidence that suggests it arises as a result of the intense focus placed on this donation "task" by the media.Comment: 4 pages, 3 figures, submitted for publicatio

Time Critical Social Mobilization: The DARPA Network Challenge Winning Strategy

It is now commonplace to see the Web as a platform that can harness the collective abilities of large numbers of people to accomplish tasks with unprecedented speed, accuracy and scale. To push this idea to its limit, DARPA launched its Network Challenge, which aimed to "explore the roles the Internet and social networking play in the timely communication, wide-area team-building, and urgent mobilization required to solve broad-scope, time-critical problems." The challenge required teams to provide coordinates of ten red weather balloons placed at different locations in the continental United States. This large-scale mobilization required the ability to spread information about the tasks widely and quickly, and to incentivize individuals to act. We report on the winning team's strategy, which utilized a novel recursive incentive mechanism to find all balloons in under nine hours. We analyze the theoretical properties of the mechanism, and present data about its performance in the challenge.Comment: 25 pages, 6 figure

A GIS-Based Prioritisation of Coastal Legacy Mine Spoil Deposits in England and Wales for Effective Future Management

Increases in coastal flooding and erosion due to climate change threaten many coastal mine waste deposits in the UK. As such, a robust approach to prioritising sites for management is required. A spatial dataset of 9094 mine spoil deposits in England and Wales was analysed against coastal erosion and flood projections to identify deposits most at-risk. Of these, 58 were at risk of tidal flooding and 33 of coastal erosion over the coming century. Within the 10 highest-priority deposits, 426,283 m3 of spoil was at risk of release by erosion, with Blackhall Colliery (County Durham) being the largest predicted contributor

Excessive Activation of TGFβ by Spinal Instability Causes Vertebral Endplate Sclerosis

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SharePoint as enabler for collaboration and efficient project knowledge sharing

Abstract: Background: Cutting-edge web technology applications have improved the manner in which business is conducted, allowing organisations to deliver business projects effectively. There is an untapped potential to power up SharePoint as a business application platform for content management, knowledge sharing and collaboration within organisations

Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis

Intervertebral disc (IVD) degeneration is the leading cause of disability with no disease-modifying treatment. IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal (NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin αv β6-mediated activation of transforming growth factor beta (TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease (DDD). Knockout of TGFβ type II receptor (TβRII) or integrin α v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading. Administration of RGD peptide, TGFβ, and α v β 6-neutralizing antibodies attenuated IVD degeneration. Thus, integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD

Multifunctional Skin-Like Electronics for Quantitative, Clinical Monitoring of Cutaneous Wound Healing

Non-invasive, biomedical devices have the potential to provide important, quantitative data for the assessment of skin diseases and wound healing. Traditional methods either rely on qualitative visual and tactile judgments of a professional and/or data obtained using instrumentation with forms that do not readily allow intimate integration with sensitive skin near a wound site. Here, an electronic sensor platform that can softly and reversibly laminate perilesionally at wounds to provide highly accurate, quantitative data of relevance to the management of surgical wound healing is reported. Clinical studies on patients using thermal sensors and actuators in fractal layouts provide precise time-dependent mapping of temperature and thermal conductivity of the skin near the wounds. Analytical and simulation results establish the fundamentals of the sensing modalities, the mechanics of the system, and strategies for optimized design. The use of this type of “epidermal” electronics system in a realistic clinical setting with human subjects establishes a set of practical procedures in disinfection, reuse, and protocols for quantitative measurement. The results have the potential to address important unmet needs in chronic wound management

Ciliary parathyroid hormone signaling activates transforming growth factor-β to maintain intervertebral disc homeostasis during aging

© 2018 The Author(s). Degenerative disc disease (DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus (NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor (PTH1R) to the cilia and enhances parathyroid hormone (PTH) signaling in NP cells. PTH induces transcription of integrin αvβ6 to activate the transforming growth factor (TGF)-β-connective tissue growth factor (CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH (iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1R is expressed in both mouse and human NP cells. Importantly, knockout PTH1R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD

Incorporating conceptual site models into national-scale environmental risk assessments for legacy waste in the coastal zone

Solid wastes deposited in the coastal zone that date from an era of lax environmental regulations continue to pose significant challenges for regulators and coastal managers worldwide. The increasing risk of contaminant release from these legacy disposal sites, due to a range of factors including rising sea levels, associated saline intrusion, and greater hydrological extremes, have been highlighted by many researchers. Given this widespread challenge, and the often-limited remedial funds available, there is a pressing need for the development of new advanced site prioritization protocols to limit potential pollution risks to sensitive ecological or human receptors. This paper presents a multi-criteria decision analysis that integrates the principles of Conceptual Site Models (Source-Pathway-Receptor) at a national scale in England and Wales to identify legacy waste sites where occurrence of pollutant linkages are most likely. A suite of spatial data has been integrated in order to score potential risks associated with waste type (Source), likelihood of pollutant release relating to current and future flood and erosion climate projections, alongside current management infrastructure (Pathway), and proximity to sensitive ecological features or proxies of human use in coastal areas (Receptors). Of the 30,281 legacy waste deposits identified in England and Wales, 3,219 were located within the coastal zone, with coastal areas containing a density of legacy wastes (by area) 10.5 times higher than inland areas. Of these, 669 were identified as priority sites in locations without existing coastal defences or flood management infrastructure, with 2550 sites identified in protected areas where contaminant transfer risks could still be apparent. The majority (63%) of the priority sites have either undefined source terms, or are classified as mixed wastes. Mining and industrial wastes were also notable waste categories, and displayed strong regional distributions in the former mining areas of north-east and south-west of England, south Wales, and post-industrial estuaries. The large-scale screening process presented here could be used by environmental managers as a foundation to direct more high-resolution site assessment and remedial work at priority sites, and can be used as a tool by governments for directing funding to problematic sites