Pharmacological and neurophysiological aspects of space/motion sickness

A motorized motion testing device modeled after a Ferris wheel was constructed to perform motion sickness tests on cats. Details of the testing are presented, and some of the topics covered include the following: xylazine-induced emesis; analysis of the constituents of the cerebrospinal fluid (CSF) during motion sickness; evaluation of serotonin-1A (5-HT sub 1A) agonists; other 5HT receptors; antimuscarinic mechanisms; and antihistaminergic mechanisms. The ability of the following drugs to reduce motion sickness in the cats was examined: amphetamines, adenosinergic drugs, opioid antagonists, peptides, cannabinoids, cognitive enhancers (nootropics), dextromethorphan/sigma ligands, scopolamine, and diphenhydramine

A VLT/FORS2 Multi-Slit Search for Lyman-alpha Emitting Galaxies at z~6.5

We present results from a deep spectroscopic search in the 9150A atmospheric window for z~6.5 Lyman-alpha emitting galaxies using the VLT/FORS2. Our multi-slit+narrow-band filter survey covers a total spatial area of 17.6 sq. arcmin in four different fields and reaches fluxes down to 5x10^(-18) erg/s/cm^2 (7 sigma detection). Our detection limit is significantly fainter than narrow-band searches at this redshift and fainter also than the unlensed brightness of Hu et al.'s HCM6A at z=6.56, and thus provides better overlap with surveys at much lower redshifts. Eighty secure emission line galaxies are detected. However, based on their clear continuum emission shortward of the line or the presence of multiple lines, none of these can be Ly-alpha emission at z~6.5. Our null result of finding no z~6.5 Ly-alpha emitters suggests that the number density of Ly-alpha emitters with L>2x10^(42) erg/s declines by ~2 between z~3 and z~6.5.Comment: accepted by ApJ Letters (originally submitted June 11, 2004

Stimulation of serotonin-1A receptors in mammals to alleviate motion sickness and emesis induced by chemical agents

A method for the alleviation of both motion sickness and chemically-induced emesis is provided which includes the administration of a nontoxic, therapeutically effective amount of a composition which stimulates serotonin-1A receptors in a mammal in need of such treatment. The preferred compounds for use are buspirone and 8-hydroxy-2(di-n-propylamino)-tetralin (8-OH-DPAT)

Remarks on the Basic Plan of the Terminal Abdominal Structures of the Males of Winged Insects

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Evaluation of putative neurochemical intermediaries in space/motion sickness

The topics covered include the following: the emetic stimuli used on the cats in the study; analysis of the constituents of the cerebral spinal fluid (CSF) during motion sickness; evaluation of serotonin-1A agonists; other 5-HT receptors; and additional studies and activities

Bulk de novo mitogenome assembly from pooled total DNA elucidates the phylogeny of weevils (Coleoptera: Curculionoidea)

Complete mitochondrial genomes have been shown to be reliable markers for phylogeny reconstruction among diverse animal groups. However, the relative difficulty and high cost associated with obtaining de novo full mitogenomes have frequently led to conspicuously low taxon sampling in ensuing studies. Here, we report the successful use of an economical and accessible method for assembling complete or near-complete mitogenomes through shot-gun next-generation sequencing of a single library made from pooled total DNA extracts of numerous target species. To avoid the use of separate indexed libraries for each specimen, and an associated increase in cost, we incorporate standard polymerase chain reaction-based “bait” sequences to identify the assembled mitogenomes. The method was applied to study the higher level phylogenetic relationships in the weevils (Coleoptera: Curculionoidea), producing 92 newly assembled mitogenomes obtained in a single Illumina MiSeq run. The analysis supported a separate origin of wood-boring behavior by the subfamilies Scolytinae, Platypodinae, and Cossoninae. This finding contradicts morphological hypotheses proposing a close relationship between the first two of these but is congruent with previous molecular studies, reinforcing the utility of mitogenomes in phylogeny reconstruction. Our methodology provides a technically simple procedure for generating densely sampled trees from whole mitogenomes and is widely applicable to groups of animals for which bait sequences are the only required prior genome knowledge

Deep Galaxy survey at 6.75 micron with the ISO satellite

Deep 6.75um mid-IR ISOCAM observations were obtained of the Canada-France Redshift Survey (CFRS) 1415+52 field with the Infrared Space Observatory. The identification of the sources with optical counterparts is described in detail, and a classification scheme is devised which depends on the S/N of the detection and the inverse probability of chance coincidence. 83% of the 54 ISOCAM sources are identified with Iab<23.5 counterparts. The (I-K)ab colors, radio properties, spectrophotometric properties and frequency of nuclear activity of these counterparts differ on average from those of typical CFRS galaxies. CFRS spectra are available for 21 of the sources which have Iab <= 22.5 (including 7 stars). Most of the strongest sources are stars or AGN. Among the non--stellar counterparts with spectra, 40% are AGNs, and 53% are galaxies that display star formation activity and/or significant contributions of A stars. The ISOCAM sources also display an IR excess, even when compared with heavily-reddened local starburst galaxies. An upper limit of 30% of extragalactic ISO sources could be at z>1 of the 44 S6.75um > 150uJy sources which are non-stellar (7 "spectroscopic" and 3 "photometric" stars excluded)Comment: 13 pages, 12 figures. Accepted for publication in A

Determination of the Quadrupole Coupling Constant in the N^{14} Atomic Ground State

The zero-field hyperfine frequencies in the ground state of atomic N14 have been measured in a hydrogen maser with sufficient accuracy to resolve the quadrupole coupling constant B. The result is B=+1.32±0.20 Hz.Molecular and Cellular Biolog

Magellanic Cloud X-ray Sources: III. Completion of a ROSAT Survey

This paper concludes a series of three papers presenting ROSAT High-Resolution Imager (HRI) observations of unidentified Einstein and serendipitous ROSAT X-ray sources in the direction of the Magellanic Clouds. Accurate positions and fluxes have been measured for these sources. Optical photometry and spectroscopy were obtained to search for identifications in order to determine the physical nature of these sources. The present paper includes new data for 24 objects; identifications are given or confirmed for 30 sources. For six sources optical finding charts showing the X-ray positions are provided. The results from this program are summarized, showing the populations of luminous X-ray sources in the Magellanic Clouds are quite different from those in the Galaxy.Comment: 28 pages, 2 figures; to appear in Astronomical Journa