Conjunto de viviendas para seniors en el Parque del Agua (Zaragoza)

La propuesta se basa en 24 unidades de vivienda de gran superficie, buscando la racionalidad económica. El interés que mueve a este grupo de personas está basado en la idea del envejecimiento activo, y en valores como el cooperativismo, la solidaridad, la participación, la auto-gestión y el respeto al medio ambiente. Se diseña una propuesta que dialogue con el entorno y se desarrollan unas unidades de vivienda que perpetúan la autonomía del usuario en la mayor medida posible a lo largo del tiempo sin tener que abandonar el entorno en el que han vivido

Barley-ß-glucans reduce systemic inflammation, renal injury and aortic calcification through ADAM17 and neutral-sphingomyelinase2 inhibition

In chronic kidney disease (CKD), hyperphosphatemia-induced inflammation aggravates vascular calcification (VC) by increasing vascular smooth muscle cell (VSMC) osteogenic differentiation, ADAM17-induced renal and vascular injury, and TNFα-induction of neutral-sphingomyelinase2 (nSMase2) to release pro-calcifying exosomes. This study examined anti-inflammatory β-glucans efficacy at attenuating systemic inflammation in health, and renal and vascular injury favoring VC in hyperphosphatemic CKD. In healthy adults, dietary barley β-glucans (Bβglucans) reduced leukocyte superoxide production, inflammatory ADAM17, TNFα, nSMase2, and pro-aging/pro-inflammatory STING (Stimulator of interferon genes) gene expression without decreasing circulating inflammatory cytokines, except for γ-interferon. In hyperphosphatemic rat CKD, dietary Bβglucans reduced renal and aortic ADAM17-driven inflammation attenuating CKD-progression (higher GFR and lower serum creatinine, proteinuria, kidney inflammatory infiltration and nSMase2), and TNFα-driven increases in aortic nSMase2 and calcium deposition without improving mineral homeostasis. In VSMC, Bβglucans prevented LPS- or uremic serum-induced rapid increases in ADAM17, TNFα and nSMase2, and reduced the 13-fold higher calcium deposition induced by prolonged calcifying conditions by inhibiting osteogenic differentiation and increases in nSMase2 through Dectin1-independent actions involving Bβglucans internalization. Thus, dietary Bβglucans inhibit leukocyte superoxide production and leukocyte, renal and aortic ADAM17- and nSMase2 gene expression attenuating systemic inflammation in health, and renal injury and aortic calcification despite hyperphosphatemia in CKD.A grant to A.S.D. and M.J.M. from IRBLleida and Agrotecnio Research collaborative projects from the Consell Social at Lleida University supported initial work, Instituto de Salud Carlos III and co-funded by European Union (ERDF/FEDER) (FIS PI11/00259, PI14/01452, PI17/02181), Plan de Ciencia, Tecnología e Innovación 2013–2017 y 2018–2022 del Principado de Asturias (GRUPIN14-028, IDI-2018-000152), RedInRen from ISCIII (ISCIII-RETIC REDINREN RD16/0009). Investigator support included: NC-L by GRUPIN14-028 and IDI-2018-000152, LM-A by GRUPIN14-028, SP by FICYT; MVA and PV by Educational Grant 2 A/2015 from ERA-EDTA CKD-MBD Working Group; PV and AC by ERA-EDTA fellowships 2011 and 2012; JR-C by MINECO (“Juan de la Cierva” program, FJCI-2015-23849); A.S.D. by Asociación Investigación de Fisiología Aplicada. A.S.D. and M.J.M. are members of the Campus Iberus (Ebro Valley Campus of International Excellence)

Seroprevalencia y conocimiento de vacunación en nuevos residentes

Artículos originales[ES] Objetivo: Valorar el conocimiento de los nuevos residentes sobre su calendario vacunal, su estado serológico frente enfermedades vacunoprevenibles y la validez de la historia clínico-laboral como indicador de protección frente éstas. Método: Mediante cuestionario específico obtenemos datos sobre el conocimiento del estado e historia vacunal, y mediante serología comprobamos el estado de protección actual de 130 nuevos residentes hospitalarios. Resultados: La edad media es de 26,7 años, siendo 62% mujeres. Son españoles 82%, de Centro y Sur América 17% y un 1% europeos. El 42% desconocen su calendario vacunal. Están protegidos frente varicela 93,1% y frente a sarampión 90.8%, pero frente parotiditis y rubéola sólo presentan anticuerpos positivos el 69.2% y 61.5% respectivamente. Refieren vacunación frente hepatitis B 81.5% y están protegidos 80,8%. Refieren vacunación de hepatitis A 35% y están protegidos 52.3%. 65% nunca se vacunó de gripe. Conclusiones: Se ha objetivado un gran desconocimiento sobre vacunaciones. La protección frente parotiditis y rubéola ha resultado escasa. La cobertura vacunal frente a VHB, VHA y gripe es baja contando con que se trata ya de personal de riesgo antes de realizar este estudio. La historia clínico laboral no es congruente con los resultados serológicos en muchos casos. [EN] Objective: To evaluate knowledge about vaccines, protection against vaccine-preventable diseases and labour medical history value. Methods: We obtained data on immunization status and serum antibodies against these diseases from 130 newcomers residents to our hospital that were enrolled from May to June 2008. Results: Their mean age was 26.7 years (62% women). They are Spanish 82%, from Centre and South America 17% and 1% European. 42% of subjects don’t know their immunization schedule. 93.1% are immune against varicella and 90.8% against measles, but only 69,2% are immune against rubella and 61,5% against mumps. 81% have been vaccinated against hepatitis B and 80,8% are protected. 35% related to be vaccinated against hepatitis A, but 52.3% are protected. 65% of them never have been flu vaccinated. Conclusion: A lack of knowledge about vaccine has been found. Protection against mumps and rubella is not enough. Immunization coverage against VHB, VHA and flu is low for this biological risk population. Lot of the subjects doesn’t have a labour medical history consistent with serological results.N

Medidas de desigualdad: Un estudio analítico

Este documento es el primero de una serie de trabajos en los que abordamos la cuantificación de la desigualdad de renta de una población. En el trabajo de discusión que ahora presentamos se hace un planteamiento general de las medidas de desigualdad desde una óptica puramente analítica. Comenzaremos considerando los índices usualmente utilizados para cuantificar la desigualdad haciendo explícitos los inconvenientes que plantea el empleo de los mismos. A continuación se hace referencia a las propiedades que intuitivamente parece lógico exigir a las medidas de desigualdad. En la sección siguiente estudiaremos de modo exhaustivo el Índice de orden - 1, poniendo de manifiesto las ventajas que esta medida presenta frente a otros indicadores. A modo de apéndice se recogen otros tipos de medidas de desigualdad además de las ya estudiadas y se evalúa la bondad de todas ellas a partir de un conjunto de propiedades consideradas deseables

Vaccination adjuvated against hepatitis B in Spanish National Healthcare System (SNS) workers typed as non-responders to conventional vaccines

[EN] Trial Design: An interventional, phase 4, single group assignment, without masking (open label), preventive clinical trial was carried out in health workers with biological risk in their tasks, who have been filed as non-responders to conventional vaccination against Hepatitis B. Methods: 67 health workers with biological risk in their tasks, who have been filed as non-responders to conventional vaccination against Hepatitis B, were enrolled in the Clinical Trial. All participants were from 18 years up to 64 years old. Inclusion Criteria: NHS workers -including university students doing their internships in health centres dependent on the National Health System (inclusion of students is regulated and limited by specific instructions on labour prevention in each autonomous community)- classified as non-responders. The criteria defining them as non-responders to the conventional hepatitis B vaccine is anti HBsAb titers < 10 mUI/ml following the application of six doses of conventional vaccine at 20 lg doses (two complete guidelines). The objective of this study was to provide Health workersstaff with an additional protection tool against hepatitis B infection, and to evaluate the efficacy of the adjuvanted vaccine in healthy non-responders to conventional hepatitis B vaccine. The primary outcome was the measurement of antibody antiHBs before the first Fendrix dose and a month after the administration of each dose. Other outcome was collection of adverse effects during administration and all those that could be related to the vaccine and that occur within 30 days after each dose. In this study, only one group was assigned. There was no randomization or masking. Results: The participants were recruited between April 13, 2018 and October 31, 2019. 67 participants were enrolled in the Clinical Trial and included the analyses. The primary immunisation consists of 4 separate 0.5 ml doses of Fendrix , administered at the following schedule: 1 month, 2 months and 6 months from the date of the first dose. Once the positivity was reached in any of the doses, the participant finished the study and was not given the following doses. 68.66% (46 out 67) had a positive response to first dose of Fendrix. 57.14% (12 out 21) had a positive response to second dose of Fendrix . 22.22% (2 out 9) had a positive response to third dose of Fendrix and 42.96% (3 out 7) had a positive response to last dose of Fendrix. Overall, 94.02% (64 out 67) of participants had a positive response to Fendrix . No serious adverse event occurred. Conclusions: The use of Fendrix , is a viable vaccine alternative for NHS workers classified as ‘‘nonresponders”. Revaccination of healthy non-responders with Fendrix, resulted in very high proportions of responders without adverse events. Trial registration: The trial was registered in the Spanish National Trial Register (REEC), ClinicalTrials.gov and inclusion has been stopped (identifier NCT03410953; EudraCT-number 2016-004991-23). Funding: GRS 1360/A/16: Call for aid for the financing of research projects in biomedicine, health management and socio-health care to be developed in the centres of the Regional Health Management of Autonomous Community of Castile-Leon. In addition, this work has been supported by the Spanish Platform for Clinical Research and Clinical Trials, SCReN (Spanish Clinical Research Network), funded by the Subdirectorate General for Research Evaluation and Promotion of the Carlos III Health Institute (ISCIII), through the project PT13/0002/0039 and project PT17/0017/0023 integrated in the State Plan for R&D&I 2013–2016 and co-financed by and the European Regional Development Fund (ERDF)

Superior antigen-specific CD4+ T-cell response with AS03-adjuvantation of a trivalent influenza vaccine in a randomised trial of adults aged 65 and older

BACKGROUND: The effectiveness of trivalent influenza vaccines may be reduced in older versus younger adults because of age-related immunosenescence. The use of an adjuvant in such a vaccine is one strategy that may combat immunosenescence, potentially by bolstering T-cell mediated responses. METHODS: This observer-blind study, conducted in the United States (US) and Spain during the 2008-2009 influenza season, evaluated the effect of Adjuvant System AS03 on specific T-cell responses to a seasonal trivalent influenza vaccine (TIV) in >/=65 year-old adults.Medically-stable adults aged >/=65 years were randomly allocated to receive a single dose of AS03-adjuvanted TIV (TIV/AS03) or TIV. Healthy adults aged 18-40 years received only TIV. Blood samples were collected on Day 0, Day 21, Day 42 and Day 180. Influenza-specific CD4+ T cells, defined by the induction of the immune markers CD40L, IL-2, IFN-gamma, or TNF-alpha, were measured in ex vivo cultures of antigen-stimulated peripheral blood mononuclear cells. RESULTS: A total of 192 adults were vaccinated: sixty nine and seventy three >/=65 year olds received TIV/AS03 and TIV, respectively; and fifty 18 - 40 year olds received TIV. In the >/=65 year-old group on Day 21, the frequency of CD4+ T cells specific to the three vaccine strains was superior in the TIV/AS03 recipients to the frequency in TIV (p /=65 year-old recipients of TIV/AS03 than in the 18 - 40 year old recipients of TIV on Days 21 (p = 0.006) and 42 (p = 0.011). CONCLUSION: This positive effect of AS03 Adjuvant System on the CD4+ T-cell response to influenza vaccine strains in older adults could confer benefit in protection against clinical influenza disease in this population. TRIAL REGISTRATION: (Clinicaltrials.gov.). NCT00765076

La estructura de los planes de estudio de Economía y ADE en España antes del Espacio Europeo de Educación Superior

The aim of this article is describing the main features of the degrees on Economics and Business in Spain prior to the European Higher Education Area (EHEA). The description is based on the syllabi of the public universities. The structure of the article is as follows: after the introduction, section two is dedicated to the methodology, the sources and the description of the main features of the syllabi. Section three and four are devoted to the analysis of the compulsory courses established by the National Guidelines in the degrees of Economics and Business, respectively. Section five is focused on the compulsory courses that are common to several universities. Finally, the article concludes with the main results. The main conclusions are, on the one hand, the implicit equilibrium between subjects and, on the other hand, that the universities have profited from the changes in the National Guidelines in order to adjust the compulsory courses. Therefore, it is foreseeable that the share of the syllabus that is compulsory will be adjusted again with the new National Guidelines associated to the EHEA.El objetivo de este artículo es describir las principales características de las licenciaturas en Administración y Dirección de Empresas (ADE) y Economía en España antes del Espacio Europeo de Educación Superior (EEES). La descripción se realiza sobre la base de los planes de estudio de las universidades públicas. El orden de exposición es el siguiente: tras la introducción, en el segundo apartado se expone la metodología y las fuentes y se señalan las principales características de los planes de estudio. En los apartados tercero y cuarto se analizan los campos troncales de la licenciatura en Economía y de la licenciatura en ADE, respectivamente. En el quinto apartado se analizan los campos obligatorios. Finalmente, el artículo se cierra con las conclusiones. Las principales conclusiones son, por una parte, la existencia de equilibrios tácitos entre campos y, por otra, que las universidades aprovechan las oportunidades que les dan los cambios en las Directrices para ajustar las materias troncales y obligatorias. Consecuentemente, es previsible que dicho peso se ajuste de nuevo como consecuencia de las Directrices asociadas al EEES