Role Of Suspension Media For Electrophoretic Deposition: The Case Of Functional Oxides

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High Frequency Characterization and Nonlinear Analysis of BST Thick Films Produced by Electrophoretic Deposition

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Phytochemical Approach and Evaluation of the Osmotic Fragility and Cytotoxic Activity of Piptadenia stipulacea (Benth) Ducke / Abordagem Fitoquímica e Avaliação da Fragilidade Osmótica e Atividade Citotóxica de Piptadenia stipulacea (Benth) Ducke

Piptadenia stipulacea (Benth.) Ducke, Fabaceae, is a medicinal plant that can be found in the Caatinga is the only exclusively Brazilian biome. Various biological activities, such as antimicrobial, anti-inflammatory, antifungal and antioxidant activities are reported for this plant. This work investigated the chemical compounds present in the ethanolic extract of the leaves of P. stipulacea (EELPs), being used in the test of osmotic fragility in the blood of sheep and cytotoxic and genotoxic effect in the Allium cepa test with onion roots. Phytochemical analysis were performed by thin-layer chromatography.  Results revealed the presence of tannin, alkaloids, saponins, cumarins, flavonoids and terpenes. The erythrocyte osmotic fragility test showed low hemolysis levels, in the qualitative evaluation of the supernatant and in the result of the hemolytic percentage. Cytological examination with Allium cepa with different concentration EELPs (50 µg.mL-1, 500 µg.mL-1 e 1000 µg.mL-1) no chromosomal abnormality were identified in the cell division process  (Interphase, prophase, metaphase, anaphase, telophase) in relation to the  control group. However, the EELPs at the concentration of 50 µg.mL-1 presented a root development when compared to 500 µg.mL-1 and 1000 µg.mL-1. This demonstrates a pharmacological importance of this plant and low hemolysis index, cell membrane integrity and low toxicity absence of chromosomal abnormality. The results suggest that P. stipulacea may present antigenotoxic

Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis

Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.info:eu-repo/semantics/publishedVersio

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe