O consumo de alimentos orgânicos sob o enfoque das atitudes de sustentabilidade e alimentação saudável

Crescimento demográfico e aumento da expectativa de vida dos brasileiros ensejaram destaque à alimentação. A visão do alimento como eixo da saúde e preservação do meio ambiente despontaram e alimentos orgânicos evidenciaram-se perante o consumidor. Essa conjuntura embasou o estudo de como as atitudes em relação à sustentabilidade e alimentação saudável impactam no comportamento de consumo de alimentos orgânicos. Resultado: consumidores com consciência ecológica buscam manter uma alimentação saudável através de alimentos orgânicos, assim infere-se, dentre outros: a visão diferenciada do consumidor consciente; a relevância do estudo para empresários desse setor e para gestores públicos que administram os incentivos e propiciam agregar valor aos produtos brasileiros

MAMGEST : uma proposta de modelo para a avaliação da maturidade em gestão da pós-graduação lato sensu na UFRGS

Este trabalho propôs o desenvolvimento de um modelo de maturidade em gestão voltado à Pós-Graduação Lato Sensu (PGLS) para o escopo do setor público. A PGLS como parte do processo finalístico das Instituições de Ensino Superior Públicas (IESP) objetiva a complementação da formação profissional de graduados, capacitando-os nas áreas específicas relacionadas às respectivas áreas de formação. Assim, o estudo se justifica pela necessidade de a IESP qualificar a gestão da PGLS a fim de retornar à comunidade acadêmica e à sociedade serviços otimizados, ainda atender às exigências dos órgãos reguladores, além de colaborar com mais uma ferramenta para gerir a área da educação superior pública. Para executar o estudo, utilizou-se a metodologia Design Science Research (DSR) com as seguintes técnicas de pesquisa: observação participante, pesquisa documental e pesquisa de literatura. Dentro das etapas desenvolvidas na DSR evoluiu-se com a criação do artefato: I) conscientização: estabelecimento do problema de pesquisa e de uma de uma proposta para solução; II) Sugestão: criação do projeto temporário do artefato; III) Desenvolvimento: criação do artefato final; IV) Avaliação: verificação do potencial de aplicabilidade do artefato VI) Conclusão: consolidação dos resultados. Na etapa de desenvolvimento o artefato foi submetido à análise e avaliação de especialistas da área da PGLS, gestão universitária e modelos de maturidade por meio de entrevista semiestruturada a fim de refinamento. A pesquisa resultou no Modelo de Avaliação da Maturidade em Gestão para a PGLS (MAMGEST), composto por 15 dimensões, 38 elementos e 5 níveis de maturidade. Na etapa de avaliação, foi verificada a aplicabilidade do modelo por meio de sua implementação na instituição selecionada, a Universidade Federal do Rio Grande do Sul (UFRGS), concluindose que o MAMGEST tem aderência ao caso concreto, sendo potencialmente profícuo para a avaliar a maturidade de gestão da PGLS.This work proposed the development of a management maturity model aimed at the Lato Sensu Graduate Program (PGLS) for the scope of the public sector. PGLS as part of the finalistic process of Public Higher Education Institutions (IESP) aims to complement the professional training of graduates, training them in specific areas related to the respective training areas. Thus, the study is justified by the need for IESP to qualify the management of PGLS to return optimized services to the academic community and society, still meet the requirements of regulatory bodies, in addition to collaborating with another tool to manage the area of education public superior. To guide the study, the Design Science Research (DSR) methodology was used using the following research tools: participant observation, documentary research and literature research. Within the stages developed in the DSR, the creation of the artifact evolved: I) awareness: establishment of the research problem and one of a proposal for a solution; II) Suggestion: creation of the temporary artifact project; III) Development: creation of the final artifact; IV) Evaluation: verification of the applicability of the artifact VI) Conclusion: consolidation of the results. The research resulted in the Management Maturity Assessment Model for PGLS (MAMGEST), composed of 15 dimensions, 38 elements and 5 levels of maturity. It is important to note that in the development stage, the artifact was subjected to analysis and evaluation by specialists in the PGLS area, university management and maturity models through semi-structured interviews to improve it. Furthermore, in the evaluation stage, the applicability of the model was verified through its implementation in the selected institution, the Federal University of Rio Grande do Sul (UFRGS), concluding that MAMGEST has adherence to the specific case, being useful to evaluate the management maturity of PGLS

Repurposing plant-derived substances as antivirals against sars-cov-2 / Redirecionando substâncias derivadas de plantas como antivirais contra Sars-cov-2

The urgent need for effective treatments for COVID-19 has developed, encouraging pharmaceutical companies to develop or redirect substances against SARS-CoV-2. Among them, substances used against worms, malaria, or bacteria were targeted to combat the virus. Such substances have been used in clinical trials and evaluated in vitro and in silico regarding the action on viral proteins, pharmacodynamics and toxicity of drugs. In this study, we conducted a systematic review of peer-reviewed articles involving molecules of plant origin with potential antiviral action on SARS-CoV-2. Reports containing the combinations of key words herbal, medicinal plants, natural products, and SARS-CoV-2 available from 01-01-2019 to 28-08-2020 in the Pubmed Central and World Wide Science sites were selected. A total of 677 items were retrieved. Of these, 170 were excluded because they were not complete, peer reviewed, freely, or related to vegetable products. Of the remaining, 345 were review articles, 23 were discussions, 4 were clinical trials, 14 showed in vitro experiments, and 121 were in silico studies. The proteins of SARS-CoV-2 considered as the therapeutic targets for the molecular docking were the structural spike glycoprotein (S protein), membrane protein Mpro, papain-like protease (PLpro), and RNA-dependent RNA polymerase (RdRp). Also, some studies have addressed the cell receptor ACE2 and natural products interaction. From in silico tests, therefore, 149 isolated plant molecules were identified with binding affinity to SARS-CoV-2 Mpro. Also, pharmacokinetic properties and bioavailability of some products were investigated highlighting the products nimbolide, withaferin-A, caffeic acid derivatives, rhamnetin, delta d-Viniferin, myri-citrin, chrysanthemin, myritilin, taiwanhomoflavone A, lactucopicrin 15-oxalate, nympholide A, afzelin, biorobin, herperidin and phyllaemblicin B, glycyrrhizic acid, and rutin. As reported, rutin may influence viral functional protein assembly and host inflammatory suppression. Its affinity for Mpro and toll like receptors (TLRs) besides in vivo results render rutin a potential novel therapeutic anti-coronavirus strategy. This study highlights the in silico diversity of plant metabolites with high potential of antiviral activity against SARS-CoV-2 as alternatives in the repurposing course against COVID-19 as well as other viral pandemics that may arise.The urgent need for effective treatments for COVID-19 has developed, encouraging pharmaceutical companies to develop or redirect substances against SARS-CoV-2. Among them, substances used against worms, malaria, or bacteria were targeted to combat the virus. Such substances have been used in clinical trials and evaluated in vitro and in silico regarding the action on viral proteins, pharmacodynamics and toxicity of drugs. In this study, we conducted a systematic review of peer-reviewed articles involving molecules of plant origin with potential antiviral action on SARS-CoV-2. Reports containing the combinations of key words herbal, medicinal plants, natural products, and SARS-CoV-2 available from 01-01-2019 to 28-08-2020 in the Pubmed Central and World Wide Science sites were selected. A total of 677 items were retrieved. Of these, 170 were excluded because they were not complete, peer reviewed, freely, or related to vegetable products. Of the remaining, 345 were review articles, 23 were discussions, 4 were clinical trials, 14 showed in vitro experiments, and 121 were in silico studies. The proteins of SARS-CoV-2 considered as the therapeutic targets for the molecular docking were the structural spike glycoprotein (S protein), membrane protein Mpro, papain-like protease (PLpro), and RNA-dependent RNA polymerase (RdRp). Also, some studies have addressed the cell receptor ACE2 and natural products interaction. From in silico tests, therefore, 149 isolated plant molecules were identified with binding affinity to SARS-CoV-2 Mpro. Also, pharmacokinetic properties and bioavailability of some products were investigated highlighting the products nimbolide, withaferin-A, caffeic acid derivatives, rhamnetin, delta d-Viniferin, myri-citrin, chrysanthemin, myritilin, taiwanhomoflavone A, lactucopicrin 15-oxalate, nympholide A, afzelin, biorobin, herperidin and phyllaemblicin B, glycyrrhizic acid, and rutin. As reported, rutin may influence viral functional protein assembly and host inflammatory suppression. Its affinity for Mpro and toll like receptors (TLRs) besides in vivo results render rutin a potential novel therapeutic anti-coronavirus strategy. This study highlights the in silico diversity of plant metabolites with high potential of antiviral activity against SARS-CoV-2 as alternatives in the repurposing course against COVID-19 as well as other viral pandemics that may arise

Metodologia do censo com play-back: teste de acuracidade do equipamento nos macacos-prego (Cebus nigritus) do Museu de História Natural e Jardim Botânico (MHNJB) da UFMG

O censo com play-back associado ao transecto de ponto vem mostrando bons resultados em levantamentos de primatas. Porém, existem variáveis que podem prejudicar a acuracidade dos dados como: distância do som emitido, freqüência e distância de relevância do som para os indivíduos. Assim, este estudo objetivou avaliar a eficácia do equipamento de play-back minimizando os efeitos dessas variáveis não consideradas anteriormente. Com a construção de um espectograma verificou-se que não houve variação significativa da freqüência não sendo necessário considera-la para diferenciar o tipo de resposta e/ou distância durante o censo com play-back. O som apresentou-se com propagação circular o que corrobora com o método transecto de ponto. Para quantificar o alcance do som, as vocalizações foram medidas pelo decibelímetro, mas a partir de 100m ele não foi capaz de detectar a vocalização o que infere que o mais importante para atrair os animais é a percepção do som. Para testar a percepção dos indivíduos, realizou-se um teste para sugerir a distância na qual os animais fossem atraídos pelo play-back. A resposta positiva (vocalização e aproximação) ocorre a partir de distâncias inferiores a 200m sendo este o melhor raio de alcance para se calcular a densidade de primatas do gênero Cebus

Nursing care postpartum women seropositive for hiv before the inability to natural breastfeeding

Objectives: to know the expertise of nurses in caring for postpartum women seropositive for HIV on breastfeeding; identify the interaction of nurses with women with HIV about the impossibility of breastfeeding. Method: this was a descriptive, exploratory and qualitative in nature, with twenty-three women in the rooming Antônio Pedro University Hospital (HUAP) through structured interviews and analyzed with the precepts of content analysis in thematic, after approval by the Ethics Committee of the HUAP, under nº 254.060/13. Results: the following categories emerged: disparities in the guidelines at the rooming set: natural breastfeeding; interaction of nurses rooming with HIV-positive mothers for HIV on the impossibility of breastfeeding. Conclusion: the need for guidance and awareness of women about their reasons and issues related to the inability to breastfeed

Carotenoid analysis of Cassava genotypes roots (Manihot Esculenta Crantz) cultivated in Southern Brazil using chemometric tools

Manihot esculenta roots rich in -carotene are an important staple food for populations with risk of vitamin A deficiency. Cassava genotypes with high pro-vitamin A activity have been identified as a strategy to reduce the prevalence of deficiency of this vitamin, In this study, the metabolomics characterization focusing on the carotenoid composition of ten cassava genotypes cultivated in southern Brazil by UV-visible scanning spectrophotometry and reverse phase-high performance liquid chromatography was performed. The data set was used for the construction of a descriptive model by chemometric analysis. The genotypes of yellow roots were clustered by the higher concentrations of cis--carotene and lutein. Inversely, cream roots genotypes were grouped precisely due to their lower concentrations of these pigments, as samples rich in lycopene differed among the studied genotypes. The analytical approach (UV-Vis, HPLC, and chemometrics) used showed to be efficient for understanding the chemodiversity of cassava genotypes, allowing to classify them according to important features for human health and nutrition.(undefined

Atypical Gianotti-Crosti syndrome

We report the case of a male 22-month-old child, with atypical presentation of Gianotti-Crosti syndrome after infection with Epstein-Barr virus.Univ Fed Sao Paulo, Unifesp, EPM, Outpatient Clin Pediat Dermatol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Unifesp, EPM, Outpatient Clin Pediat Dermatol, Sao Paulo, SP, BrazilWeb of Scienc

Effectiveness of clinical, surgical and percutaneous treatment to prevent cardiovascular events in patients referred for elective coronary angiography: an observational study

Purpose: To ascertain the most appropriate treatment for chronic, stable, coronary artery disease (CAD) in patients submitted to elective coronary angiography. Patients and Methods: A total of 814 patients included in the prospective cohort study were referred for elective coronary angiography and were followed up on average for 6±1.9 years. Main outcomes were all-cause death, cardiovascular death, non-fatal myocardial infarction (MI) and stroke and late revascularization and their combinations as major adverse cardiac and cerebral events (MACCE): MACCE-1 included cardiovascular death, nonfatal MI, and stroke; MACCE-2 was MACCE-1 plus late revascularization. Survival curves and adjusted Cox proportional hazard models were used to explore the association between the type of treatment and outcomes. Results: All-cause death was lower in participants submitted to percutaneous coronary intervention (PCI) (0.41, 0.16–1.03, P=0.057) compared to medical treatment (MT). Coronary-artery bypass grafting (CABG) had an overall trend for poorer outcomes: cardiovascular death 2.53 (0.42–15.10), combined cardiovascular death, nonfatal MI, and stroke 2.15 (0.73–6.31) and these events plus late revascularization (2.17, 0.86–5.49). The corresponding numbers for PCI were 0.27 (0.05–1.43) for cardiovascular death, 0.77 (0.32–1.84) for combined cardiovascular death, nonfatal MI, and stroke and 2.35 (1.16–4.77) with the addition of late revascularization. These trends were not influenced by baseline blood pressure, left ventricular ejection fraction and previous MI. Patients with diabetes mellitus had a significantly higher risk of recurrent revascularization when submitted to PCI than CABG. Conclusion: Patients with confirmed CAD in elective coronary angiography do not have a better prognosis when submitted to CABG comparatively to medical treatment. Patients treated with PCI had a trend for the lower incidence of combined cardiovascular events, at the expense of additional revascularization procedures. Patients without significant CAD had a similar prognosis than CAD patients treated with medical therapy

Acesso à informação – promovendo competitividade em p&d com o uso de tecnologia de informação

O presente trabalho visa a mostrar o uso e o diferencial de competitividade que a Tecnologia de Informação (TI) vem trazendo à área de pesquisa e desenvolvimento no Estado de Santa Catarina. A questão fundamental nesta era de domínio da TI está em padronizar sistemas incompatíveis transformando o fluxo da informação em um processo “sem costuras” e transparente. Este estudo, de caráter exploratório, teve como foco identificar usos estratégicos da TI e o diferencial competitivo decorrente destes usos em algumas organizações que desenvolvem pesquisa e desenvolvimento. Procedeu-se ao levantamento de informações por meio de entrevista semi-estruturada junto a cinco grupos de pesquisa e desenvolvimento da Embraco, Epagri e UFSC. Os resultados da pesquisa, em linhas gerais, constataram a obtenção de diferencial competitivo com o uso da tecnologia da informação. Contribui também com estes resultados a forma como se articulam nestas organizações o planejamento, a capacitação contínua de seus funcionários. O diferencial competitivo obtido com o uso de TI nas organizações pesquisadas reflete, de maneira geral, uma nova forma de conectar pessoas e processos, pelo redesenho de funções e ambientes dentro e fora das organizações. Marcadas por uma visão estratégica e por uma estrutura organizacional adequada a esta visão, estas organizações, com o uso da TI, estão contribuindo para o novo cenário mundial da pesquisa e dos negócios