Factores socioeconómicos en la estimación de la huella hídrica personal: el caso de la Pontificia Universidad Católica del Ecuador (Tema Central)

The present study aims to determine the existence of correlations between the personal water footprint (HH) estimated in a volumetric way (cubic meters / person), with certain socio-economic variables such as sex, age, family income, level of education, the type and age of the dwelling and the number of people with whom they share the dwelling. With a descriptive and exploratory research methodology, a virtual survey was conducted at the end of 2019 to the entire university community of the Pontificia Universidad Católica del Ecuador (teachers, administrators and students) at the main headquarters of Quito. It was also left open the possibility that people from outside the university could fill out the survey and in this way be able to assess whether the consumption of people from the university community who had received information on sustainable water use presented any difference with those who they had not received it. It was found that there is a significant correlation between HH and some of the socioeconomic variables analysed, such as family income, sex and educational level. It is also clear from the research that HH can be used as a good aggregate indicator of water consumption that helps to become aware of unsustainable patterns of consumption, and not being used as an instrument for hydrological management and planning due to concentration and simplicity of information it presents.El presente estudio tiene como objetivo determinar la existencia de correlaciones entre la huella hídrica personal (HH) estimada de manera volumétrica (metros cúbicos/persona), con determinadas variables socioeconómicas como el sexo, la edad, el ingreso familiar, el nivel de educación, el tipo y los años de la vivienda y el número de personas con las que comparten la vivienda. Con una metodología de investigación descriptiva y exploratoria, se realizó una encuesta virtual a finales de 2019 a toda la comunidad universitaria de la Pontificia Universidad Católica del Ecuador (docentes, administrativos y alumnos) en la sede principal de la ciudad de Quito. También se dejó abierta la posibilidad de que personas fuera de la universidad pudieran llenar la encuesta y de esta manera poder evaluar si el consumo de los miembros de la comunidad universitaria que habían recibido información sobre uso sustentable del agua, presentaba alguna diferencia con las personas que no la habían recibido. Se encontró que existe una correlación significativa entre la HH y algunas de las variables socioeconómicas analizadas como el ingreso familiar, el sexo y el nivel educativo. Se desprende también de la investigación que la HH puede ser utilizada como un buen indicador agregado de consumo de agua que ayude a tomar conciencia sobre patrones insostenibles de consumo, mas no es recomendable su utilización como instrumento para la gestión y planificación hidrológica por la concentración y sencillez de la información que presenta

New spinocerebellar ataxia subtype caused by SAMD9L mutation triggering mitochondrial dysregulation (SCA49)

Spinocerebellar ataxias consist of a highly heterogeneous group of inherited movement disorders clinically characterized by progressive cerebellar ataxia variably associated with additional distinctive clinical signs. The genetic heterogeneity is evidenced by the myriad of associated genes and underlying genetic defects identified. In this study, we describe a new spinocerebellar ataxia subtype in nine members of a Spanish five-generation family from Menorca with affected individuals variably presenting with ataxia, nystagmus, dysarthria, polyneuropathy, pyramidal signs, cerebellar atrophy and distinctive cerebral demyelination. Affected individuals presented with horizontal and vertical gaze-evoked nystagmus and hyperreflexia as initial clinical signs, and a variable age of onset ranging from 12 to 60 years. Neurophysiological studies showed moderate axonal sensory polyneuropathy with altered sympathetic skin response predominantly in the lower limbs. We identified the c.1877C > T (p.Ser626Leu) pathogenic variant within the SAMD9L gene as the disease causative genetic defect with a significant log-odds score (Z(max) = 3.43; theta = 0.00; P < 3.53 x 10(-5)). We demonstrate the mitochondrial location of human SAMD9L protein, and its decreased levels in patients' fibroblasts in addition to mitochondrial perturbations. Furthermore, mutant SAMD9L in zebrafish impaired mobility and vestibular/sensory functions. This study describes a novel spinocerebellar ataxia subtype caused by SAMD9L mutation, SCA49, which triggers mitochondrial alterations pointing to a role of SAMD9L in neurological motor and sensory functions. Corral-Juan et al. describe a novel dominantly inherited spinocerebellar ataxia subtype, SCA49, caused by SAMD9L mutation characterized by polyneuropathy, distinctive cerebral demyelination with gaze-evoked nystagmus and hyperreflexia as initial clinical signs. The study demonstrates the mitochondrial location of human SAMD9L protein triggering mitochondrial and lysosomal alterations

Wind and turbulence relationship with NO2 in an urban environment: a fine-scale observational analysis

It is well known that meteorology plays an important role in the diurnal evolution of pollutants, especially those variables related to atmospheric dispersion. Most studies typically relate the concentration of some pollutants with wind speed from conventional anemometers; however, the use of turbulence variables is less common, in part because the needed instruments are not so typical in standard air-quality stations. In this work, we compare the wind-NO2 relationship with the turbulence-NO2 one using observational data from two field campaigns developed in Madrid (winter and summer). The turbulence data comes from two sonic anemometers deployed at different locations: one close to the street and the other at the top of a nearby tall building. The results indicate that the turbulent variables correlate better with the pollutant concentration than the wind speed when using data from the street sonic, while the contrary is found when using the terrace sonic. These data are also used to perform a fine-scale analysis of the turbulent diffusion-NO2 behaviour during a very-stable period in winter, when the turbulence typically shows a decrease in the evening transition, causing the highestNO2 concentrations. Conversely, under these conditions, the formation of thermally-driven winds is also favoured later in the night, which favours the pollutant dispersion and cleaning of the air. The important role of these dynamical processes on the NO2 evolution highlights the importance of the correct understanding of small-scale atmospheric processes to understand their relationship with the concentration of pollutants

CyberKnife Robotic-Assisted Stereotactic Radiosurgery for Advanced Stages of Ciliochoroidal Uveal Melanoma. Preliminary Results in Mexico

Objective: The objective of this study was to report the early results of CyberKnife® (CK®) stereotactic radiosurgery in advanced stages of ciliochoroidal (CBCh) melanoma in Mexican patients. Methods: A retrospective review of charts was performed to analyze the outcomes of patients who underwent CK® (Accuray Inc, Sunnyvale, CA, United States). Results: Four patients with CBCh melanoma were treated under this protocol. The mean age was 53.2 ± 5.3 years (range, 47-60). Median of follow-up was 9.5 ± 3.1 months (range, 5-12). Mean tumor diameter was 13.49 mm, mean thickness, 11.74 mm, and mean gross tumor volume was 1251.97 mm3. Tumors were dome- (50%) and mushroom-shaped (50%) in medium-to-large sizes. Three patients had T3b tumors, and one had a T4d tumor at the early tumor staging according to the American Joint Committee on Cancer. A mean dose of 2763 ± 181.3 cGy was prescribed to the 90% isodose line. All patients achieved local tumor control after single-session radiosurgery at the latest follow-up. One patient presented with acute toxicity (extensive serous retinal detachment associated with radiation induced tumor vasculopathy) that was promptly managed. None of the patients required secondary enucleation. Conclusions: CK® appears to be an effective therapy for medium to large-sized CBCh melanoma. A prospective comparative study with longer follow-up is needed to confirm these findings and to evaluate long-term morbidity

Ética Profesional y Responsabilidad Social Universitaria

este libro compila reflexiones y experiencias en responsabilidad social y ética profesional desde instituciones de Educación Superior. La responsabilidad social universitaria, como ámbito de investigación y de desarrollo conceptual y metodológico es transversal a las universidades, tanto desde el punto de vista organizacional, como desde el misional e investigativo. Quienes impulsen la responsabilidad social, requieren de ética profesional, que debe ser la clave para la construcción de principios que guíen a empresarios, políticos, gestores sociales, investigadores, entre otros, para lograr consensuar el a veces difícil equilibrio entre el bien común y el desarrollo personal

El reto de la inclusión de los Objetivos de Desarrollo Sostenible en la formación inicial de profesores de secundaria: creación del MOOC curso cero sobre educación y ODS, inclusión en asignaturas y en trabajos fin de máster

Memoria ID-041. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2021-2022

Efecto geográfico de la cubierta del suelo y el mes calendario, en la meteorología superficial e insolación de bosques de coníferas en México

Abstract: In order to demonstrate the influence of geographic location of a sampling site, land cover and calendar month on the expression of thirteen indirect indicators of surface meteorology and solar radiation, the technique of information re-scaling was applied based on latitude in order to calculate the zenith angle in coordinated pairs, in coniferous forests in Mexico. This historical series of information covers a period of 22 years of daily records. Ten sampling sites were defined in five geographical localities with two absolute land covers (natural forest and deforested) with a common spatial border; this neighboring condition was mandatory for the study. Statistical analysis revealed significant differences (p < 0.05), for land cover, sampling site and calendar month. In the expression of the indices, an apparent latitudinal effect was observed of proximity to the coastline, which seems to suggest its influence on the evaluated indexes. The results suggest the extension of the database to include direct information pertaining to meteorology (wind speed and direction) and solar radiation. These data are necessary in order to characterize the response of the land cover for spectral invariance according to variations in the radiant flow, for the ratio of reflectance, absorbance and transmittance.Resumen: Para evidenciar cómo influyen la localización geográfica del sitio de muestreo, la cubierta del suelo y el mes calendario en la expresión de trece indicadores indirectos de meteorología superficial y de insolación, se aplicó la técnica de re-escalamiento de datos basado en latitud para calcular el ángulo cenital en pares coordenados, en bosques de coníferas de México. Esta serie histórica de datos cubre un periodo de 22 años de registros diarios. Se definieron diez sitios de muestreo en cinco localidades geográficas con dos coberturas absolutas del suelo (bosque natural y deforestado) con frontera espacial común; esta condición de vecindad compartida fue obligada para el estudio. El análisis estadístico arrojó diferencias significativas (p < 0.05), para cobertura del suelo, sitio de muestreo y mes calendario. En la expresión de los índices, se observó un aparente efecto latitudinal de cercanía a la línea de costa lo cual parece sugerir su influencia en los índices evaluados. Los resultados obtenidos sugieren la ampliación de la base de datos para incluir datos directos de meteorología (velocidad y dirección del viento) e insolación, necesarios para caracterizar la respuesta de la cubierta del suelo para invarianza espectral según las variaciones en el flujo radiante, para las razones de reflectancia, absorbancia y transmitancia

Estudio del correlato paraparesia espástica del pacifico y el virus humano linfotrópico de células T adultas (HTLV-1) en Colombia

IP 1106-05-070-87ARTICULO(S) EN REVISTA: Linfocitos y monolitos anormales en lasangre periferica como factores predictivos;de paraparesia espastica tropical asociada con el virus linfotropico humano tipo I en Tumaco, Colombia / Cesar;Arango Jaramillo. ... [et. al]. -- En: Colombia Medica. --Vol.22, no 3 (1991); p. 88-93. -- CAPITULO(S) EN;LIBRO: Tropical spastic paraparesis-associated risk factors inTumaco, Colombia / Cesar Arango. ... [et. al].; p. 377-383. -- En: Human Retrovirology: HTLV / editor WilliamA. Blattner. -- New York : 28 cm. ISBN;0881676616

Clinical, genetic and neuropathological characterization of spinocerebellar ataxia type 37.

The autosomal dominant spinocerebellar ataxias (SCAs) consist of a highly heterogeneous group of rare movement disorders characterized by progressive cerebellar ataxia variably associated with ophthalmoplegia, pyramidal and extrapyramidal signs, dementia, pigmentary retinopathy, seizures, lower motor neuron signs, or peripheral neuropathy. Over 41 different SCA subtypes have been described evidencing the high clinical and genetic heterogeneity. We previously reported a novel spinocerebellar ataxia type subtype, SCA37, linked to an 11-Mb genomic region on 1p32, in a large Spanish ataxia pedigree characterized by ataxia and a pure cerebellar syndrome distinctively presenting with early-altered vertical eye movements. Here we demonstrate the segregation of an unstable intronic ATTTC pentanucleotide repeat mutation within the 1p32 5' non-coding regulatory region of the gene encoding the reelin adaptor protein DAB1, implicated in neuronal migration, as the causative genetic defect of the disease in four Spanish SCA37 families. We describe the clinical-genetic correlation and the first SCA37 neuropathological findings caused by dysregulation of cerebellar DAB1 expression. Post-mortem neuropathology of two patients with SCA37 revealed severe loss of Purkinje cells with abundant astrogliosis, empty baskets, occasional axonal spheroids, and hypertrophic fibres by phosphorylated neurofilament immunostaining in the cerebellar cortex. The remaining cerebellar Purkinje neurons showed loss of calbindin immunoreactivity, aberrant dendrite arborization, nuclear pathology including lobulation, irregularity, and hyperchromatism, and multiple ubiquitinated perisomatic granules immunostained for DAB1. A subpopulation of Purkinje cells was found ectopically mispositioned within the cerebellar cortex. No significant neuropathological alterations were identified in other brain regions in agreement with a pure cerebellar syndrome. Importantly, we found that the ATTTC repeat mutation dysregulated DAB1 expression and induced an RNA switch resulting in the upregulation of reelin-DAB1 and PI3K/AKT signalling in the SCA37 cerebellum. This study reveals the unstable ATTTC repeat mutation within the DAB1 gene as the underlying genetic cause and provides evidence of reelin-DAB1 signalling dysregulation in the spinocerebellar ataxia type 37