76 research outputs found
Environmental Influences on Children's Physical Activity: Quantitative Estimates Using a Twin Design
Twin studies offer a 'natural experiment' that can estimate the magnitude of environmental and genetic effects on a target phenotype. We hypothesised that fidgetiness and enjoyment of activity would be heritable but that objectively-measured daily activity would show a strong shared environmental effect.In a sample of 9-12 year-old same-sex twin pairs (234 individuals; 57 MZ, 60 DZ pairs) we assessed three dimensions of physical activity: i) objectively-measured physical activity using accelerometry, ii) 'fidgetiness' using a standard psychometric scale, and iii) enjoyment of physical activity from both parent ratings and children's self-reports. Shared environment effects explained the majority (73%) of the variance in objectively-measured total physical activity (95% confidence intervals (CI): 0.63-0.81) with a smaller unshared environmental effect (27%; CI: 0.19-0.37) and no significant genetic effect. In contrast, fidgetiness was primarily under genetic control, with additive genetic effects explaining 75% (CI: 62-84%) of the variance, as was parent's report of children's enjoyment of low 74% (CI: 61-82%), medium 80% (CI: 71-86%), and high impact activity (85%; CI: 78-90%), and children's expressed activity preferences (60%, CI: 42-72%).Consistent with our hypothesis, the shared environment was the dominant influence on children's day-to-day activity levels. This finding gives a strong impetus to research into the specific environmental characteristics influencing children's activity, and supports the value of interventions focused on home or school environments
Sleep and nighttime energy consumption in early childhood:A population-based cohort study
BACKGROUND: Shorter sleep is a risk factor for weight gain in young children. Experimental studies show that sleep deprivation is associated with higher nighttime energy intake, but no studies have examined the patterning of energy intake in relation to nighttime sleep duration in young children. OBJECTIVES: The objectives of the study were to test the hypothesis that shorterâsleeping children would show higher nighttime energy intake and to examine whether the additional calories were from drinks, snacks or meals. METHODS: Participants were 1278 families from the Gemini twin cohort, using data from one child per family selected at random to avoid clustering effects. Nighttime sleep duration was measured at 16 months of age using the Brief Infant Sleep Questionnaire. Energy intake by time of day and eating episode (meal, snack, drink) were derived from 3âday diet diaries completed when children were 21 months. RESULTS: Consistent with our hypothesis, shorterâsleeping children consumed more calories at night only (linear trend Pâ<â0.001), with those sleeping <10âh consuming on average 120 calories (15.2% of daily intake) more at night than those sleeping â„13âh. The majority of nighttime intake was from milk drinks. Associations remained after adjusting for age, sex, birth weight, gestational age, maternal education, weight and daytime sleep. CONCLUSIONS: Shorterâsleeping, young children consume more calories, predominantly at night, and from milk drinks. Parents should be aware that providing milk drinks at night may contribute to excess intake. This provides a clear target for intervention that may help address associations between sleep and weight observed in later childhood
How are habits formed : Modelling habit formation in the real world
To investigate the process of habit formation in everyday life, 96 volunteers chose an eating, drinking or activity behaviour
to carry out daily in the same context (for example âafter breakfastâ) for 12 weeks. They completed the self-report habit
index (SRHI) each day and recorded whether they carried out the behaviour. The majority (82) of participants provided
sufficient data for analysis, and increases in automaticity (calculated with a sub-set of SRHI items) were examined over the
study period. Nonlinear regressions fitted an asymptotic curve to each individualâs automaticity scores over the 84 days.
The model fitted for 62 individuals, of whom 39 showed a good fit. Performing the behaviour more consistently was
associated with better model fit. The time it took participants to reach 95% of their asymptote of automaticity ranged from
18 to 254 days; indicating considerable variation in how long it takes people to reach their limit of automaticity and
highlighting that it can take a very long time. Missing one opportunity to perform the behaviour did not materially affect
the habit formation process. With repetition of a behaviour in a consistent context, automaticity increases following an
asymptotic curve which can be modelled at the individual level
Parental Reports of Infant and Child Eating Behaviors are not Affected by Their Beliefs About Their Twinsâ Zygosity
Parental perception of zygosity might bias heritability estimates derived from parent rated twin data. This is the first study to examine if similarities in parental reports of their young twinsâ behavior were biased by beliefs about their zygosity. Data were from Gemini, a British birth cohort of 2402 twins born in 2007. Zygosity was assessed twice, using both DNA and a validated parent report questionnaire at 8 (SD = 2.1) and 29 months (SD = 3.3). 220/731 (8 months) and 119/453 (29 months) monozygotic (MZ) pairs were misclassified as dizygotic (DZ) by parents; whereas only 6/797 (8 months) and 2/445 (29 months) DZ pairs were misclassified as MZ. Intraclass correlations for parent reported eating behaviors (four measured at 8 months; five at 16 months) were of the same magnitude for correctly classified and misclassified MZ pairs, suggesting that parental zygosity perception does not influence reporting on eating behaviors of their young twins
Gender-specific risk factors for mortality associated with incident coronary heart disease - A prospective community-based study
Background. Risk factors for mortality in community-residing persons developing congestive heart failure (CHF) and acute myocardial infarction (AMI) may differ for males and females. Method. Persons from the Groningen Longitudinal Aging Study with incident CHF (N=274) or AMI (N=198) were identified between 1993 and 1998 and their survival status was collected in 2001. Risk factors are assessed prior to the cardiac diagnosis. Results. The 1-, 5-, 7-year survival rates were 65, 53, 50% for AMI and 74, 45, 32% for CHF. Multivariate analyses showed that male gender, high age, smoking, diabetes and low physical function were risk factors for mortality among persons with CHE For AMI, 1 month mortality was related to high age and baseline low body mass index, while longer term mortality was related to male gender and high age. In addition, diabetes increased longer term mortality among females but not among males with AMI. Depression was not a risk factor for mortality for either condition in either gender. Conclusion. Males with CHF or AMI have worse survival rates compared to females. Risk factors for mortality are predominantly similar for males and females, except for diabetes which is a risk factor among females, but not males with AMI. (c) 2006 Elsevier Inc. All rights reserved
Common genetic architecture underlying young children's food fussiness and liking for vegetables and fruit
Background: Food fussiness (FF) is common in early childhood and is often associated with the rejection of nutrient-dense foods such as vegetables and fruit. FF and liking for vegetables and fruit are likely all heritable phenotypes; the genetic influence underlying FF may explain the observed genetic influence on liking for vegetables and fruit. Twin analyses make it possible to get a broad-based estimate of the extent of the shared genetic influence that underlies these traits. Objective: We quantified the extent of the shared genetic influence that underlies FF and liking for vegetables and fruit in early childhood with the use of a twin design. Design: Data were from the Gemini cohort, which is a populationbased sample of twins born in England and Wales in 2007. Parents of 3-y-old twins (n = 1330 pairs) completed questionnaire measures of their children's food preferences (liking for vegetables and fruit) and the FF scale from the Children's Eating Behavior Questionnaire. Multivariate quantitative genetic modeling was used to estimate common genetic influences that underlie FF and liking for vegetables and fruit. Results: Genetic correlations were significant and moderate to large in size between FF and liking for both vegetables (20.65) and fruit (20.43), which indicated that a substantial proportion of the genes that influence FF also influence liking. Common genes that underlie FF and liking for vegetables and fruit largely explained the observed phenotypic correlations between them (68-70%). Conclusions: FF and liking for fruit and vegetables in young children share a large proportion of common genetic factors. The genetic influence on FF may determine why fussy children typically reject fruit and vegetables
Dietary Energy Density Affects Fat Mass in Early Adolescence and Is Not Modified by FTO Variants
BACKGROUND: Dietary energy density (DED) does not have a simple linear relationship to fat mass in children, which suggests that some children are more susceptible than others to the effects of DED. Children with the FTO (rs9939609) variant that increases the risk of obesity may have a higher susceptibility to the effects of DED because their internal appetite control system is compromised. We tested the relationship between DED and fat mass in early adolescence and its interaction with FTO variants. METHODS AND FINDINGS: We carried out a prospective analysis on 2,275 children enrolled in the Avon Longitudinal Study of Parents and Children (ALSPAC). Diet was assessed at age 10 y using 3-day diet diaries. DED (kJ/g) was calculated excluding drinks. Children were genotyped for the FTO (rs9939609) variant. Fat mass was estimated at age 13 y using the Lunar Prodigy Dual-energy X-ray Absorptiometry scanner. There was no evidence of interaction between DED at age 10 y and the high risk A allele of the FTO gene in relation to fat mass at age 13 y (beta = 0.005, p = 0.51), suggesting that the FTO gene has no effect on the relation between DED at 10 y and fat mass at 13 y. When DED at 10 y and the A allele of FTO were in the same model they were independently related to fat mass at 13 y. Each A allele of FTO was associated with 0.35+/-0.13 kg more fat mass at 13 y and each 1 kJ/g DED at 10 y was associated with 0.16+/-0.06 kg more fat mass at age 13 y, after controlling for misreporting of energy intake, gender, puberty, overweight status at 10 y, maternal education, TV watching, and physical activity. CONCLUSIONS: This study reveals the multi-factorial origin of obesity and indicates that although FTO may put some children at greater risk of obesity, encouraging a low dietary energy density may be an effective strategy to help all children avoid excessive fat gain
Epidemiology of heart failure in a community-based study of subjects aged >= 57 years:Incidence and long-term survival
Background: Survival data from hospital-based or clinical trial studies of patients with chronic heart failure (CHF) do not represent survival in community-based settings. Aims: To determine the incidence of CHF and the associated long-term Survival in a community-based sample aged >= 57 years and to assess the mortality risk associated with sex and age. Methods: This study was part of the Groningen Longitudinal Aging Study. Results: Annual incidence of CHF per 1000 ranged from 2.5 in middle aged adults (57-60 years) up to 22.4 in older females (>= 80 years) and 28.2 in older males (>= 80 years). The 1, 2, 5 and 7-year survival rates were 74%, 65%, 45%, 32% for patients with CHF, compared to 97%, 94%, 80% and 70% in a matched reference group without CHF. Higher age (>= 76 years) was a risk factor for mortality (OR=2.1) and male sex was a risk Factor in those aged Conclusion: Long-term survival rates for patients with CHF in the community were worse than the known survival rates front clinical trials. There is a need for Studies describing the care of patients with CHF in the community, including the type of care, the provider, the quality of care and the outcome. (c) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved
Parents' underestimation of their child's weight status. Moderating factors and change over time: A cross-sectional study
BACKGROUND: Parents' underestimation of their child's weight status can hinder active participation in overweight prevention programs. We examined the level of agreement between the parents' perception of their child's weight status and the child's actual weight status, moderating factors, and change over time. METHODS: This cross-sectional study used data collected in 2009 (n = 8105), 2013 (n = 8844) and 2017 (n = 11,022) from a community-based survey conducted among parents of children age 2-12 years in the Netherlands. Parents classified their perception of their child's weight status on a 5-point Likert scale. In 2009 and 2013, the child's BMI was calculated from self-reported data by parents. The level of agreement between the parent's perception of the weight status and the actual weight status was examined using Cohen's kappa. The role of demographic factors on parents' perception were examined using logistic regression. RESULTS: In 2009, 2013 and 2017, 6%, 6% and 5% of the parents, respectively, classified their child as heavy/extremely heavy. In 2009 and 2013, 64.7% and 61.0% of parents, respectively, underestimated the weight status of their overweight child. This was even higher among parents of obese children. Overall, the agreement between the parents' perception and the actual weight status improved from 2009 (kappa = 0.38) to 2013 (kappa = 0.43) (p<0.05), but remained unsatisfactory. The parents' underestimation of their child's overweight/obesity status was associated with the child's age in 2009 and 2013 (2-7 years; OR: 0.18), the child's gender in 2009 (male; OR: 0.55), and the parents' education level in 2009 (middle and high education; OR: 0.56 and 0.44 respectively). CONCLUSIONS: Parents' underestimation of their child's weight status remains alarmingly high, particularly among parents of young, obese children. This underestimation is a barrier to preventing childhood overweight/obesity. Healthcare professionals should take this underestimation into consideration and should actively encourage parents to take steps to prevent overweight/obesity in their children
The relationship between appetite and food preferences in British and Australian children
Background: Appetitive traits and food preferences are key determinants of childrenâs eating patterns but it is unclear how these behaviours relate to one another. This study explores relationships between appetitive traits and preferences for fruits and vegetables, and energy dense, nutrient poor (noncore) foods in two distinct samples of Australian and British preschool children. Methods: This study reports secondary analyses of data from families participating in the British GEMINI cohort study (n = 1044) and the control arm of the Australian NOURISH RCT (n = 167). Food preferences were assessed by parent-completed questionnaire when children were aged 3â4 years and grouped into three categories; vegetables, fruits and noncore foods. Appetitive traits; enjoyment of food, food responsiveness, satiety responsiveness, slowness in eating, and food fussiness were measured using the Childrenâs Eating Behaviour Questionnaire when children were 16 months (GEMINI) or 3â4 years (NOURISH). Relationships between appetitive traits and food preferences were explored using adjusted linear regression analyses that controlled for demographic and anthropometric covariates. Results: Vegetable liking was positively associated with enjoyment of food (GEMINI; ÎČ = 0.20 ± 0.03, p < 0.001, NOURISH; ÎČ = 0.43 ± 0.07, p < 0.001) and negatively related to satiety responsiveness (GEMINI; ÎČ = -0.19 ± 0.03, p < 0.001, NOURISH; ÎČ = -0.34 ± 0.08, p < 0.001), slowness in eating (GEMINI; ÎČ = -0.10 ± 0.03, p = 0.002, NOURISH; ÎČ = -0.30 ± 0.08, p < 0.001) and food fussiness (GEMINI; ÎČ = â0.30 ± 0.03, p < 0.001, NOURISH; ÎČ = -0.60 ± 0.06, p < 0.001). Fruit liking was positively associated with enjoyment of food (GEMINI; ÎČ = 0.18 ± 0.03, p < 0.001, NOURISH; ÎČ = 0.36 ± 0.08, p < 0.001), and negatively associated with satiety responsiveness (GEMINI; ÎČ = â0.13 ± 0.03, p < 0.001, NOURISH; ÎČ = â0.24 ± 0.08, p = 0.003), food fussiness (GEMINI; ÎČ = -0.26 ± 0.03, p < 0.001, NOURISH; ÎČ = â0.51 ± 0.07, p < 0.001) and slowness in eating (GEMINI only; ÎČ = -0.09 ± 0.03, p = 0.005). Food responsiveness was unrelated to liking for fruits or vegetables in either sample but was positively associated with noncore food preference (GEMINI; ÎČ = 0.10 ± 0.03, p = 0.001, NOURISH; ÎČ = 0.21 ± 0.08, p = 0.010). Conclusion: Appetitive traits linked with lower obesity risk were related to lower liking for fruits and vegetables, while food responsiveness, a trait linked with greater risk of overweight, was uniquely associated with higher liking for noncore foods
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