Sangre y sexo en el cine de terror español

En un contexto sociopolítico donde nada escapaba a los ojos del censor, se desarrolló un tipo de cine que hoy en día sorprende por su crudeza sanguinolenta, así como por sus excesos sexuales. El desdén de la censura por el cine de terror español producido en las décadas de los sesenta y setenta permitió que se convirtiera en el espacio idóneo donde los espectadores de laépoca encontraron la válvula de escape a la represión a la que estaban sometidos. La muerte del general Francisco Franco y el aperturismo provocaron que las ansiedades eróticas de un buennúmero de espectadores se centraran en otro tipo de cine. Sin embargo, ese corto pero intenso periodo de tiempo, caracterizado por una altísima producción de género terrorífico, ha legado imágenes con una gran carga erótica, sexual y violenta, muy desconocidas, que merecen ser rescatadas. Para ello, haremos un repaso histórico por el género en España para, finalmente, centrarnos en el análisis de cuatro filmes representativos de los setenta.Abstract:A rawness and crudity cinema was developed in Spain, in a socio-political context where everything was always subject to censorship, through the sixties and seventies. Still today, thisbloody and erotic cinema may cause surprise to the audience. Censorship showed a scornful attitude to this cinema, and spectators considered it as a release-valve, due to the repressionthey were suffered. This fact permitted an intense production of this kind of movies in a really short time. The death of Francisco Franco and the brand new openness caused that all this audiencefocused their attention in another kind of cinema. Nevertheless, that brief but extremely intense period allowed us to enjoy those erotical and violent images, that today remains almost unknown,and, withouth a doubt, it deserves to be rescued. For that, we will make a skim though this genre in Spain and, eventually, we will analyze four emblematic films of the seventies

Exotic smooth structures and symplectic forms on closed manifolds

We give a short proof of the (known) result that there are no Kaehler structures on exotic tori. This yields a negative solution to a problem posed by Benson and Gordon. W discuss the symplectic version of the problem and analyze results which yield an evidence for the conjecture that there are no symplectic structures on exotic tori.Comment: AMSLaTeX, 16 pages, a new version. A survey of the symplectic version of the problem is adde

Contexto arqueológico y cultural

UIDB/00749/2020 UIDP/00749/2020En el ámbito del proyecto de investigación IGAEDIS (Da civitas Igaeditanorum à Egitânia. A construção e evolução da cidade e a definição dos seus territórios da Época Romana até à doação dos Templários - séculos I a XII) se han realizado diferentes actuaciones arqueológicas en la actual aldea histórica de Idanha-a-Velha (Portugal). Además, la revisión de anteriores intervenciones, complementadas con la realización de dataciones absolutas, han permitido atribuir una cronología más temprana de la asignada hasta ahora a los dos “baptisterios” documentados en el yacimiento. Esta nueva lectura nos lleva a plantear un renovado marco de reflexión y crítica histórica, tanto de estas construcciones - piscinas bautismales - como del contexto en el que se insertan. Un ejercicio presentado en este trabajo de manera diacrónica, con el objetivo de mejorar el conocimiento sobre la evolución histórica de este sitio arqueológico entre los siglos IV-VIII.publishersversionpublishe

Efficacy of β-lactam/β-lactamase inhibitors to treat extended-spectrum beta-lactamase-producing Enterobacterales bacteremia secondary to urinary tract infection in kidney transplant recipients

Background Whether active therapy with β-lactam/β-lactamase inhibitors (BLBLI) is as affective as carbapenems for extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) bloodstream infection (BSI) secondary to urinary tract infection (UTI) in kidney transplant recipients (KTRs) remains unclear. Methods We retrospectively evaluated 306 KTR admitted to 30 centers from January 2014 to October 2016. Therapeutic failure (lack of cure or clinical improvement and/or death from any cause) at days 7 and 30 from ESBL-E BSI onset was the primary and secondary study outcomes, respectively. Results Therapeutic failure at days 7 and 30 occurred in 8.2% (25/306) and 13.4% (41/306) of patients. Hospital-acquired BSI (adjusted OR [aOR]: 4.10; 95% confidence interval [CI]: 1.50-11.20) and Pitt score (aOR: 1.47; 95% CI: 1.21-1.77) were independently associated with therapeutic failure at day 7. Age-adjusted Charlson Index (aOR: 1.25; 95% CI: 1.05-1.48), Pitt score (aOR: 1.72; 95% CI: 1.35-2.17), and lymphocyte count ≤500 cells/μL at presentation (aOR: 3.16; 95% CI: 1.42-7.06) predicted therapeutic failure at day 30. Carbapenem monotherapy (68.6%, primarily meropenem) was the most frequent active therapy, followed by BLBLI monotherapy (10.8%, mostly piperacillin-tazobactam). Propensity score (PS)-adjusted models revealed no significant impact of the choice of active therapy (carbapenem-containing vs any other regimen, BLBLI- vs carbapenem-based monotherapy) within the first 72 hours on any of the study outcomes. Conclusions Our data suggest that active therapy based on BLBLI may be as effective as carbapenem-containing regimens for ESBL-E BSI secondary to UTI in the specific population of KTR. Potential residual confounding and unpowered sample size cannot be exclude

Phylogenetic Analysis of West Nile Virus, Nuevo Leon State, Mexico

West Nile virus RNA was detected in brain tissue from a horse that died in June 2003 in Nuevo Leon State, Mexico. Nucleotide sequencing and phylogenetic analysis of the premembrane and envelope genes showed that the virus was most closely related to West Nile virus isolates collected in Texas in 2002

Development of an activity disease score in patients with uveitis (UVEDAI)

To develop a disease activity index for patients with uveitis (UVEDAI) encompassing the relevant domains of disease activity considered important among experts in this field. The steps for designing UVEDAI were: (a) Defining the construct and establishing the domains through a formal judgment of experts, (b) A two-round Delphi study with a panel of 15 experts to determine the relevant items, (c) Selection of items: A logistic regression model was developed that set ocular inflammatory activity as the dependent variable. The construct "uveitis inflammatory activity" was defined as any intraocular inflammation that included external structures (cornea) in addition to uvea. Seven domains and 15 items were identified: best-corrected visual acuity, inflammation of the anterior chamber (anterior chamber cells, hypopyon, the presence of fibrin, active posterior keratic precipitates and iris nodules), intraocular pressure, inflammation of the vitreous cavity (vitreous haze, snowballs and snowbanks), central macular edema, inflammation of the posterior pole (the presence and number of choroidal/retinal lesions, vascular inflammation and papillitis), and global assessment from both (patient and physician). From all the variables studied in the multivariate model, anterior chamber cell grade, vitreous haze, central macular edema, inflammatory vessel sheathing, papillitis, choroidal/retinal lesions and patient evaluation were included in UVEDAI. UVEDAI is an index designed to assess the global ocular inflammatory activity in patients with uveitis. It might prove worthwhile to motorize the activity of this extraarticular manifestation of some rheumatic diseases

RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

RAS-like (RAL) GTPases function in Wnt signalling-dependent intestinal stem cell proliferation and regeneration. Whether RAL proteins work as canonical RAS effectors in the intestine, and the mechanisms of how they contribute to tumourigenesis remain unclear. Here, we show that RAL GTPases are necessary and sufficient to activate EGFR/MAPK signalling in the intestine, via induction of EGFR internalisation. Knocking down Drosophila RalA from intestinal stem and progenitor cells leads to increased levels of plasma membrane-associated EGFR and decreased MAPK pathway activation. Importantly, in addition to impacting stem cell proliferation during damage-induced intestinal regeneration, this role of RAL GTPases impacts on EGFR-dependent tumorigenic growth in the intestine and in human mammary epithelium. However, the effect of oncogenic RAS in the intestine is independent from RAL function. Altogether, our results reveal previously unrecognised cellular and molecular contexts where RAL GTPases become essential mediators of adult tissue homeostasis and malignant transformation

The induction of natural competence adapts staphylococcal metabolism to infection

A central question concerning natural competence is why orthologs of competence genes are conserved in non-competent bacterial species, suggesting they have a role other than in transformation. Here we show that competence induction in the human pathogen Staphylococcus aureus occurs in response to ROS and host defenses that compromise bacterial respiration during infection. Bacteria cope with reduced respiration by obtaining energy through fermentation instead. Since fermentation is energetically less efficient than respiration, the energy supply must be assured by increasing the glycolytic flux. The induction of natural competence increases the rate of glycolysis in bacteria that are unable to respire via upregulation of DNA- and glucose-uptake systems. A competent-defective mutant showed no such increase in glycolysis, which negatively affects its survival in both mouse and Galleria infection models. Natural competence foster genetic variability and provides S. aureus with additional nutritional and metabolic possibilities, allowing it to proliferate during infection