Divulgação da informação contabilística na campanha eleitoral autárquica: estudo exploratório

O presente estudo tem como objetivo analisar a divulgação da informação contabilística por parte dos políticos locaisna campanha eleitoral autárquica das últimas eleições (2013) e identificar os fatores que potencialmente explicam essa divulgação, tomando como referência o caso específico dos municípios de Trás os Montes e Alto Douro. Os resultados mostram que os políticos locais tendem a divulgar a informação contabilística para fins de campanha eleitoral autárquica. O valor dos investimentos realizados e das dívidas por pagar revelam ser os tipos de informação divulgados em maior número. Os resultados permitiram ainda concluir que a divulgação da informação contabilística na campanha eleitoral autárquica é influenciada pela dimensão do município, pelo tipo de governação (maioria ou minoria) do partido político do executivo e pelo montante das dívidas a pagar

The AIDS epidemic in the Amazon region: a spatial case-control study in Rondonia, Brazil

OBJETIVO Analisar mudanças espaciais no risco de Aids e a relação entre incidência da doença e variáveis socioeconômicas. MÉTODOS Estudo caso-controle espacial, de base populacional, realizado em Rondônia, Brasil, com 1.780 casos notificados pelo Sistema de Vigilância Epidemiológica e os controles a partir de dados demográficos de 1987 a 2006. Os casos foram agrupados em cinco períodos de cinco anos consecutivos. Um modelo aditivo generalizado foi ajustado aos dados. O status dos indivíduos (caso ou controle) foi considerado como a variável dependente e independente: um alisamento ( spline ) bidimensional das coordenadas geográficas e variáveis socioeconômicas municipais. Os valores observados para o teste Moran I foram comparados com a distribuição de referência dos valores obtidos em condições de aleatoriedade espacial. RESULTADOS O risco de Aids apresentou padrão espacial e temporal marcado. A incidência associou-se a indicadores socioeconômicos municipais, como urbanização e capital humano. As maiores taxas de incidência de Aids ocorreram em municípios ao longo da rodovia BR-364; os resultados do teste Moran I mostram correlação espacial positiva associada à contiguidade dos municípios com a rodovia, no terceiro e quarto períodos (p = 0,05). CONCLUSÕES A incidência da doença foi maior em municípios de maior riqueza econômica e urbanização e naqueles cortados pelas estradas principais de Rondônia. O rápido desenvolvimento associado à ocupação de regiões remotas pode ser acompanhado por aumento de riscos à saúde.OBJETIVO Analizar cambios espaciales en el riesgo de Sida y la relación entre incidencia de la enfermedad y variables socioeconómicas. MÉTODOS Estudio caso-control espacial, de base poblacional, realizado en Rondonia, Brasil con 1.780 casos notificados por el Sistema de Vigilancia Epidemiológica y los controles a partir de datos demográficos de 1987 a 2006. Los casos fueron agrupados en cinco períodos de cinco años consecutivos. Un modelo aditivo generalizado fue ajustado a los datos. El estatus de los individuos (caso o control) fue considerado como la variable dependiente e independiente: un alisamiento (spline) bidimensional de las coordenadas geográficas y variables socioeconómicas municipales. Los valores observados para la prueba Moran I fueron comparados con la distribución de referencia de los valores obtenidos en condiciones de aleatoriedad espacial. RESULTADOS El riesgo de Sida presentó patrón espacial y temporal marcado. La incidencia se asoció a indicadores socioeconómicos municipales, como urbanización y capital humano. Las mayores tasas de incidencia de Sida ocurrieron en municipios a lo largo de la carretera BR-364; los resultados de la prueba Moran I muestran correlación espacial positiva asociada a la cercanía de los municipios a la carretera, en el tercero y cuarto periodos (p=0,05). CONCLUSIONES La incidencia de la enfermedad fue mayor en municipios de mayor riqueza económica y urbanización y en aquellos atravesados por las carreteras principales de Rondonia. El rápido desarrollo asociado a la ocupación de regiones remotas puede ser acompañado por aumento de riesgos para la salud.OBJECTIVE To analyze spatial changes in the risk of AIDS and the relationship between AIDS incidence and socioeconomic variables in the state of Rondonia, Amazon region. METHODS A spatial, population case-control study in Rondonia, Brazil, based on 1,780 cases reported to the Epidemiological Surveillance System and controls based on demographic data from 1987 to 2006. The cases were grouped into five consecutive four-year periods. A generalized additive model was adjusted to the data; the dependent variable was the status of the individuals (case or control), and the independent variables were a bi-dimensional spline of the geographic coordinates and some municipality-level socioeconomic variables. The observed values of the Moran’s I test were compared to a reference distribution of values generated under conditions of spatial randomness. RESULTS AIDS risk shows a marked spatial and temporal pattern. The disease incidence is related to socioeconomic variables at the municipal level in Rondônia, such as urbanization and human capital. The highest incidence rates of AIDS are in municipalities along the BR-364 highway and calculations of the Moran’s I test show positive spatial correlation associated with proximity of the municipality to the highway in the third and fourth periods (p = 0.05). CONCLUSIONS Incidence of the disease is higher in municipalities of greater economic wealth and urbanization, and in those municipalities bisected by Rondônia’s main roads. The rapid development associated with the opening up of once remote regions may be accompanied by an increase in these risks to health

Ocorrência de eflorescências sulfatadas na mina de São Domingos

The intense exploration of sulphide ore deposit in São Domingos mine, produced considerable amount of sulphide material that when are exposed to weathering generates acid mine drainage (AMD). The main goal of this paper is to study a specific occurrence regarding composition and morphology of the salts that arise at the end of the dry season. Soluble salts appear at the banks of the drainage channels and over the waste materials, exhibiting different colours and aspects. The obtained results showed by X-Ray diffraction and scanning electronic microscopy, that the mineralogy of salt efflorescences is dominated by sulphates, displaying different occurrence modes. Melanterite and copiapite are the main iron sulphates while minerals from the series of pickeringite-halotrichite dominate the aluminium sulphates. In addition, dehydration and dissolution laboratory experiments were carried out in order to simulate the transformations suffered by soluble salts and evaluate the environmental effect in aquatic system.Patrícia Gomes wishes to acknowledge FCT (Science and Technology Foundation, Portugal) by the research fellowship under the POCH (Programa Operacional Capital Humano) supported by the European Social Fund and National Funds of MCTES with reference SFRH/BD/108887/2015. This work was co-funded by the European Union through the European Regional Development Fund, based on COMPETE 2020 (Programa Operacional da Competitividade e Internacionalização), project ICT (UID/GEO/04683/2013) with reference POCI-01-0145-FEDER-007690 and national funds provided by FCT (Science and Technology Foundation, Portugal)

Prevalence of four urogenital sexually transmitted infections in a dedicated clinic from Lisbon

Background/Objectives: To determine the prevalence of urogenital Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Trichomonas vaginalis (TV), and Mycoplasma genitalium (MG) among attendees of an open and freely available sexually transmitted infections (STI) dedicated clinic in Lisbon, at Centro de Saúde da Lapa, during 1-year. Methods: Molecular testing for CT, NG, MG, and TV was performed on 1,062 urogenital specimens (one specimen per person). A descriptive, cross- sectional, observational study was conducted to evaluate the characteristics of infected persons. Statistical analysis was performed. Results: Around 237 infections were detected in 214 patients. CT was the most prevalent (11.6%), with a similar infection rate between men and women. NG was the second most frequently detected (7.3%), followed by MG and TV (2.9 and 0.5%, respectively). Statistically significant associations were found: 1) between younger age and CT and NG prevalence, where being < 25 years old constituted an increased risk factor; 2) between CT and NG prevalence and sexual orientation, where heterosexuals presented an increased risk for CT infections while men who have sex with men (MSM) had a higher risk for NG infections; and 3) between “having symptoms” and gonococcal infection. Conclusions: This study highlights the rising of CT and NG in contrast to a low rate of MG and to the scarceness of TV.info:eu-repo/semantics/publishedVersio

Novel hydroxyamides and amides containing D-glucopyranose or D-fructose units: biological assays in MCF-7 and MDST8 cell lines

A novel library of 15 compounds, hydroxyamides and amides containing a β-d-glucopyranose (d-Gluc) or a β-d-fructose (d-Fruc) units was designed and synthesized for antiproliferative assays in breast (MCF-7) and colon (MDST8) cancer cell lines. Twelve of them were hydroxyamides and were successfully synthesized from β-d-glucuronic acid (d-GluA). Six of these hydroxyamides which were acetylated hydroxy-β-d-glucopyranuronamide 2a–2f (1st Family) and the other six were their respective isomers, that is, hydroxy-β-d-fructuronamide 3a–3f (2nd Family), obtained by acid–base catalyzed isomerization. These compounds have the general structure, d-Glucsingle bondCdouble bond; length as m-dashONHsingle bondCHRsingle bond(CH2)nsingle bondOH and d-Frucsingle bondCdouble bond; length as m-dashONHsingle bondCHRsingle bond(CH2)nsingle bondOH, where R = an aromatic, alkyl or a hydrogen substituent, with n = 0 or 1. Eight of these contained a chiral aminoalcohol group. Three compounds were amides containing a d-glucopyranose unit (3rd Family). SAR studies were conducted with these compounds. Antiproliferative studies showed that compound 4a, the bromo-amide containing the β-d-glucopyranose ring, potently inhibits the proliferation of the MDST8 cells. Five compounds (2e, 2f, 3d, 3e, and 3f) were shown to potently selectively inhibit the proliferation of the MCF-7 cells. Compound 4b was the only one showing inhibition in both cell lines. In general, the more active compounds were the amides and hydroxyamides containing the β-d-fructose moiety, and containing an alkyl group or hydrogen. Half-inhibitory concentrations (IC50) of between 0.01 and 10 μM, were observed

IMEP-32: Determination of Inorganic Arsenic in Animal Feed of Marine Origin: A Collaborative Trial Report

A collaborative study, IMEP-32, was conducted in accordance with international protocols to determine the performance characteristics of an analytical method for the determination of inorganic arsenic in animal feed of marine origin. The method will support the implementation of Directive No 2002/32/EC of the European Parliament and the Council on undesirable substances in animal feed where it is indicated that "Upon request of the competent authorities, the responsible operator must perform an analysis to demonstrate that the content of inorganic arsenic is lower than 2 ppm". The method is based on solid phase extraction (SPE) separation of inorganic arsenic from organoarsenic compounds followed by detection with hydride generation atomic absorption spectrometry (HG-AAS). The collaborative study investigated different types of samples of marine origin, including complete feed (unspiked and spiked), fish meal (unspiked and spiked), fish fillet (spiked) and a lobster hepatopancreas (unspiked). In total seven samples were investigated within the concentration range of 0.07 – 2.6 mg kg-1. The test samples were dispatched to 23 laboratories in 12 different countries. Nineteen participants reported results. The performance characteristics are presented in this report. All method performance characteristics obtained in the frame of this collaborative trial indicates that the proposed SPE-HG-AAS standard method is fit for the intended analytical purpose.JRC.D.6-Food Safety and Qualit

Germline genetic variants of the renin-angiotensin system, hypoxia and angiogenesis in non-small cell lung cancer progression : discovery and validation studies

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Introduction: The renin–angiotensin system (RAS) is involved in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. Our aim was to study the association of putatively functional genetic polymorphisms in genes coding for proteins involved in RAS, hypoxia and angiogenesis with non-small cell lung cancer (NSCLC) prognosis. Methods: Genotyping of 52 germline variants from genes of the RAS and hypoxic/angiogenic factors/receptors was performed using MassARRAY iPLEX Gold in a retrospective cohort (n = 167) of advanced NSCLC patients. Validation of the resulting genetic markers was conducted in an independent group (n = 190), matched by clinicopathological characteristics. Results: Multivariate analysis on the discovery set revealed that MME rs701109 C carriers were protected from disease progression in comparison with homozygous T (hazard ratio (HR) = 0.5, 95% confidence interval (CI) = 0.2–0.8, p = 0.010). Homozygous A and T genotypes for KDR rs1870377 were at increased risk for disease progression and death compared to heterozygous (HR = 1.7, 95% CI = 1.2–2.5, p = 0.005 and HR = 2.1, 95% CI = 1.2–3.4, p = 0.006, respectively). Carriers of homozygous genotypes for ACE2 rs908004 presented increased risk for disease progression, only in the subgroup of patients without tumour actionable driver mutations (HR = 2.9, 95% CI = 1.3–6.3, p = 0.010). Importantly, the association of homozygous genotypes in MME rs701109 with risk for disease progression was confirmed after multivariate analysis in the validation set. Conclusion: This study provides evidence that MME polymorphism, which encodes neprilysin, may modulate progression-free survival in advanced NSCLC. Present genetic variation findings will foster basic, translational, and clinical research on their role in NSCLC.M.J.C. was supported by the Associação de Estudos Respiratórios and the Portuguese Pulmonology Society.info:eu-repo/semantics/publishedVersio

Fast and low-cost synthesis of MoS2 nanostructures on paper substrates for near-infrared photodetectors

Recent advances in the production and development of two-dimensional transition metal dichalcogenides (2D TMDs) allow applications of these materials, with a structure similar to that of graphene, in a series of devices as promising technologies for optoelectronic applications. In this work, molybdenum disulfide (MoS2) nanostructures were grown directly on paper substrates through a microwave-assisted hydrothermal synthesis. The synthesized samples were subjected to morphological, structural, and optical analysis, using techniques such as scanning electron microscopy (SEM), X-ray diffraction (XRD), and Raman. The variation of synthesis parameters, as temperature and synthesis time, allowed the manipulation of these nanostructures during the growth process, with alteration of the metallic (1T) and semiconductor (2H) phases. By using this synthesis method, two-dimensional MoS2 nanostructures were directly grown on paper substrates. The MoS2 nanostructures were used as the active layer, to produce low-cost near-infrared photodetectors. The set of results indicates that the interdigital MoS2 photodetector with the best characteristics (responsivity of 290 mA/W, detectivity of 1.8 × 109 Jones and external quantum efficiency of 37%) was obtained using photoactive MoS2 nanosheets synthesized at 200◦C for 120 min.publishersversionpublishe

New insights on the ultramafic intrusions surrounding the Kunene Anorthosite Complex (SW Angola) from gravity, magnetic and radiometric data [Abstract]

ABSTRACT: The Kunene Anorthosite Complex (KAC), located in SW Angola, is one of the largest anorthosite structures in the world. Dating from the Mesoproterozoic, its installation process is still not clear. Several mafic and ultramafic outcrops can be found surrounding the KAC. Once considered related with its emplacement, the study of these bodies may help us understand the history of this unique geological feature. While geochronological data show that they are synchronous, or possibly a bit younger, than the embedding granites and migmatites of Paleoproterozoic age, the question arises of whether they are intrusions installed in the host rock or if they are instead recycled remains of older Arch crust. The development of these outcrops in depth provides relevant clues regarding the origin of these bodies and their relationship with the Eburnean (~1.93-2.04 Ga) and Epupa-Namibe (~1.83-1.74 Ga) events. One of these mafic outcrops, designated the Hamutenha outcrop (Huíla Province) exhibits an elongated shape and a NW-SE orientation and is characterized by an internal zonation. Generally, the innermost part is composed of ultramafic rocks of (mostly harzburgites and dunites), with diorites outcropping in its NW and SE borders. The Hamutenha outcrop was previously identified for potentially bearing Cr, Ni and PGE mineralization.N/

Enterococcus faecium as potential probiotic for ornamental neotropical cichlid fish, Pterophyllum scalare (Schultze, 1823).

Made available in DSpace on 2020-01-09T18:09:31Z (GMT). No. of bitstreams: 1 EnterococcusFaeciumAsPotential1.pdf: 524292 bytes, checksum: 59313afe5c660d0447f94a73bfa2f2c9 (MD5) Previous issue date: 2019bitstream/item/203264/1/EnterococcusFaeciumAsPotential-1.pd