Probing the IGM/Galaxy Connection IV: The LCO/WFCCD Galaxy Survey of 20 Fields Surrounding UV Bright Quasars

We publish the survey for galaxies in 20 fields containing ultraviolet bright quasars (with z_em 0.1 to 0.5) that can be used to study the association between galaxies and absorption systems from the low-z intergalactic medium (IGM). The survey is magnitude limited (R~19.5 mag) and highly complete out to 10' from the quasar in each field. It was designed to detect dwarf galaxies (L ~ 0.1 L*) at an impact parameter rho 1Mpc (z=0.1) from a quasar. The complete sample (all 20 fields) includes R-band photometry for 84718 sources and confirmed redshifts for 2800 sources. This includes 1198 galaxies with 0.005 < z < (z_em - 0.01) at a median redshift of 0.18, which may associated with IGM absorption lines. All of the imaging was acquired with cameras on the Swope 40" telescope and the spectra were obtained via slitmask observations using the WFCCD spectrograph on the Dupont 100" telescope at Las Campanas Observatory (LCO). This paper describes the data reduction, imaging analysis, photometry, and spectral analysis of the survey. We tabulate the principal measurements for all sources in each field and provide the spectroscopic dataset online.Comment: Accepted to the Astrophysical Journal Supplements; 20 pages, only 6 figures shown in this version. See http://www.ucolick.org/~xavier/WFCCDOVI/index.html for a full-length manuscript and other supportive materia

Danish Balance of Payments Support

Summaries This study is an analysis of Danish Balance of Payments Support (BOP) covering the period 1988–94. This aid instrument was not as significant in Denmark as in other like minded donor countries. Danish BOP was mainly used in a residual manner to keep up disbursement rates and promote procurement from Danish suppliers. Commodity Import Support (CIS) was by far the dominant modality used, although fundamental changes have been on the way since 1991. Nonetheless, despite the macroeconomic nature of BOP assistance existing evaluation studies and reviews have focused on microeconomic and administrative issues. Very little can therefore at this stage be concluded about the macroeconomic impact of Danish BOP aid

Probing the IGM/Galaxy Connection V: On the Origin of Lya and OVI Absorption at z<0.2

We analyze the association of galaxies to Lya and OVI absorption, the most commonly detected transitions in the low-z intergalactic medium (IGM), in the fields of 14 quasars with z_em = 0.06-0.57. Confirming previous studies, we observe a high covering fraction for Lya absorption to impact parameter rho = 300kpc: 33/37 of our L>0.01L* galaxies show Lya equivalent width W_Lya>50mA. Galaxies of all luminosity L>0.01L* and spectral type are surrounded by a diffuse and ionized circumgalactic medium (CGM), whose baryonic mass is estimated at ~10^(10.5 +/- 0.3) Msun for a constant N_H. The virialized halos and extended CGM of present-day galaxies are responsible for most strong Lya absorbers (W_Lya > 300mA) but cannot reproduce the majority of observed lines in the Lya forest. We conclude that the majority of Lya absorption with W_Lya=30-300mA occurs in the cosmic web predicted by cosmological simulations and estimate a characteristic width for these filaments of ~400kpc. Regarding OVI, we observe a near unity covering fraction to rho=200kpc for L>0.1L* galaxies and to rho = 300kpc for sub-L* (0.1 L*<L<L*) galaxies. Similar to our Lya results, stronger OVI systems (W_OVI > 70mA) arise in the virialized halos of L>0.1L* galaxies. Unlike Lya, the weaker OVI systems (W_OVI~30mA) arise in the extended CGM of sub-L* galaxies. The majority of OVI gas observed in the low-z IGM is associated with a diffuse medium surrounding individual galaxies with L~0.3L*, and rarely originates in the so-called warm-hot IGM (WHIM) predicted by cosmological simulations.Comment: Submitted to the Astrophysical Journal; 26 pages, 9 figures. See http://www.ucolick.org/~xavier/WFCCDOVI/index.html for mor

Rapid measurement of antituberculosis drug activity in vitro and in macrophages using bioluminescence

OBJECTIVES: Tuberculosis drug development is hampered by the slow growth of Mycobacterium tuberculosis. Bioluminescence, light produced by an enzymatic reaction, constitutes a rapid and highly sensitive measurement of cell metabolic function that can be used as an indirect marker of cell viability in drug screening assays. The aim of this work was to validate and standardize the use of luminescent M. tuberculosis strains to test the activity of antibacterial drugs in vitro and inside macrophages in a 96-well format. METHODS: We have used strains that express the bacterial lux operon and therefore do not require exogenous substrate to produce light, as well as strains expressing the firefly luciferase that need luciferin substrate. Results were compared with those obtained using the resazurin reduction assay and cfu plating. RESULTS: Using bioluminescence we were able to reduce the time required to measure the MIC and bactericidal concentrations of antimicrobials to just 3 and 6 days, respectively. Furthermore, antibacterial activity against intracellular mycobacteria was detected within 2 days post-infection. Results were comparable to those obtained by conventional methods. CONCLUSIONS: We have developed a simple and rapid method for screening antimycobacterial drugs in culture and in macrophages. The use of autoluminescent bacteria also facilitates the determination of growth and inhibition kinetics. The method is cost-effective, can easily be adapted to a larger scale and is amenable to automation. Current efforts are directed towards applying this technology to drug screening in vivo

Frequency and characteristics of disease flares in ankylosing spondylitis

Objective. To examine the characteristics and frequency of disease flares in a cohort of people with AS

Fundamental Properties of the Highly Ionized Plasmas in the Milky Way

The cooling transition temperature gas in the interstellar medium (ISM), traced by the high ions, Si IV, C IV, N V, and O VI, helps to constrain the flow of energy from the hot ISM with T >10^6 K to the warm ISM with T< 2x10^4 K. We investigate the properties of this gas along the lines of sight to 38 stars in the Milky Way disk using 1.5-2.7 km/s resolution spectra of Si IV, C IV, and N V absorption from the Space Telescope Imaging Spectrograph (STIS), and 15 km/s resolution spectra of O VI absorption from the Far Ultraviolet Spectroscopic Explorer (FUSE). The absorption by Si IV and C IV exhibits broad and narrow components while only broad components are seen in N V and O VI. The narrow components imply gas with T<7x10^4 K and trace two distinct types of gas. The strong, saturated, and narrow Si IV and C IV components trace the gas associated with the vicinities of O-type stars and their supershells. The weaker narrow Si IV and C IV components trace gas in the general ISM that is photoionized by the EUV radiation from cooling hot gas or has radiatively cooled in a non-equilibrium manner from the transition temperature phase, but rarely the warm ionized medium (WIM) probed by Al III. The broad Si IV, C IV, N V, and O VI components trace collisionally ionized gas that is very likely undergoing a cooling transition from the hot ISM to the warm ISM. The cooling process possibly provides the regulation mechanism that produces N(C IV)/N(Si IV) = 3.9 +/- 1.9. The cooling process also produces absorption lines where the median and mean values of the line widths increase with the energy required to create the ion.Comment: Accepted for publication in the ApJ. Only this PDF file contains all the figures and tables in a single fil

Educating novice practitioners to detect elder financial abuse: A randomised controlled trial

© 2014 Harries et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.This article has been made available through the Brunel Open Access Publishing Fund.Background - Health and social care professionals are well positioned to identify and intervene in cases of elder financial abuse. An evidence-based educational intervention was developed to advance practitioners’ decision-making in this domain. The objective was to test the effectiveness of a decision-training educational intervention on novices’ ability to detect elder financial abuse. The research was funded by an E.S.R.C. grant reference RES-189-25-0334. Methods - A parallel-group, randomised controlled trial was conducted using a judgement analysis approach. Each participant used the World Wide Web to judge case sets at pre-test and post-test. The intervention group was provided with training after pre-test testing, whereas the control group were purely given instructions to continue with the task. 154 pre-registration health and social care practitioners were randomly allocated to intervention (n78) or control (n76). The intervention comprised of written and graphical descriptions of an expert consensus standard explaining how case information should be used to identify elder financial abuse. Participants’ ratings of certainty of abuse occurring (detection) were correlated with the experts’ ratings of the same cases at both stages of testing. Results - At pre-test, no differences were found between control and intervention on rating capacity. Comparison of mean scores for the control and intervention group at pre-test compared to immediate post-test, showed a statistically significant result. The intervention was shown to have had a positive moderate effect; at immediate post-test, the intervention group’s ratings had become more similar to those of the experts, whereas the control’s capacity did not improve. The results of this study indicate that the decision-training intervention had a positive effect on detection ability. Conclusions - This freely available, web-based decision-training aid is an effective evidence-based educational resource. Health and social care professionals can use the resource to enhance their ability to detect elder financial abuse. It has been embedded in a web resource at http://www.elderfinancialabuse.co.uk.ESR

Parental factors associated with walking to school and participation in organised activities at age 5: Analysis of the Millennium Cohort Study

BACKGROUND: Physical activity is associated with better health. Two sources of activity for children are walking to school and taking part in organised sports and activities. This study uses a large national cohort to examine factors associated with participation in these activities. METHODS: The Millennium Cohort study contains 5 year follow-up of 17,561 singleton children recruited between 2000-2002 in the UK. All participants were interviewed in their own homes at 9 months, 3 years and 5 years follow-up and all measures were self reports. Logistic regression and likelihood ratio tests were used. RESULTS: Children are less likely to walk to school as income and parental education increase [Adjusted odds: 0.7 (95%CI: 0.6-0.8) for higher income/education compared to low income/no qualifications]. However, if the parent plays with the child in high income families the child is more likely to walk to school [Adjusted odds: 1.67 (95%CI: 1.3-2.1)]. Children taking part in organised activities are from higher income, higher education families, with a car, in a "good" area with non-working mothers. However, in low socio-economic families where the parent plays with the child the child is more likely to take part in organised activities [Adjusted odds: 2.0 (95% CI: 1.5-2.7)]. CONCLUSIONS: Income is an important determinant of the type of activity available to children. Families that report good health behaviours (non-smoking, low TV viewing) and play with their children show higher levels of physical activity. Thus, parenting practice appears to have a strong impact on their child's physical activity