The Haymakers

Working in the hayfields during summer.https://egrove.olemiss.edu/kgbsides_uk/1543/thumbnail.jp

I\u27m Afloat! I\u27m Afloat!

I\u27m afloat! I\u27m afloat! on the fierce rolling tide,The ocean\u27s my home, and my bark is my bride!Up! up! with my flag! let it wave o\u27er the sea,I\u27m afloat! I\u27m afloat! and the rover is free!I fear not the monarch, I heed not the law;I\u27ve a compass to steer by, a dagger to draw;And ne\u27er as a coward! or slave will I kneel,While my guns carry shot, or my belt bears a steel!Quick! quick! trim her sails, let her sheets kiss the windAnd I warrant we\u27ll soon leave the seagulls behind;Up! up! with my flag! let it wave o\u27er the sea!I\u27m afloat! I\u27m afloat! and the rover is free!I\u27m afloat! I\u27m afloat! and the rover is free! The night gathers o\u27er us, the thunder is heard;What matter, our vessel skins on like a birdlWhat to her is the dash of the storm ridden main?She has brav\u27d it before, and will brave it again!The fire gleaming flashes around us may fall;They may strike, they may cleave, but they cannot appal;With lightnings above us, and darkness below,Through the wild waste of waters right onward we go;Hurrah! my brave boys, ye may drink, ye may sleepThe stars fiend is hush\u27d, we\u27re a lone on the deepOur flag of defiance still waves o\u27er the sea,Hurrah! boys hurrah! the rover is free! Hurrah! boys hurrah! the rover is free

Stakeholders' views on the use of psychotropic medication in older people: a systematic review

BACKGROUND: psychotropic medication use has been shown to increase with age and has been associated with increased risk of falls, strokes and mortality. Various guidelines, regulations and tools have been developed to reduce inappropriate prescribing, but this remains high. In order to understand the reasons for this, we aimed to systematically review healthcare professionals', patients' and family caregivers' attitudes towards the use of psychotropic medication in older people. METHODS: a systematic literature search was carried out from inception to September 2020 using PUBMED, EMBASE, PsycINFO and CINAHL and hand-searching of reference lists. Included studies investigated stakeholder views on psychotropic in adults over the age of 65. Findings were thematically synthesised. RESULTS: overall, there was an acceptance of long-term psychotropic medication for older people both living in the community and in residential care. While healthcare professionals were aware of guidelines for the use of benzodiazepines and psychotropic medicines, they identified barriers to following them on individual, team and organisational levels. Alternative non-pharmacological approaches were not always available or accepted by patients. CONCLUSION: psychotropic medicine use in older adults remains a complex issue, which needs to be addressed on a broad level. Attitudes of older people and healthcare professionals encourage long-term use. Meanwhile, various internal and external factors act as barriers to the use of non-drug alternatives in this population. In order to reduce overprescribing of psychotropics, there is a need to increase the acceptability and accessibility of alternative interventions in both care homes and the community

Volcanism and the Greenland ice cores: A new tephrochronological framework for the last glacial-interglacial transition (LGIT) based on cryptotephra deposits in three ice cores

Chemical profiles from Greenland ice cores show that the frequency of volcanism was higher during the last glacial-interglacial transition (LGIT) and early Holocene, (17–9 ka b2k) than in any other period during the last 110 kyr. This increased frequency has partly been linked to climate-driven melting of the Icelandic ice sheet during the last deglaciation, with regional isostatic changes thought to alter mantle viscosity and lead to more eruptions. Our study is the first to construct a comprehensive tephrochronological framework from Greenland ice cores over the LGIT to aid in the reconstruction of volcanic activity over this period. The framework is based on extensive high-resolution sampling of three Greenland ice cores between 17.4 and 11.6 ka b2k and comprises a total of 64 cryptotephra deposits from the NGRIP, GRIP and NEEM ice cores. We show that many of these tephras are preserved within the core without an associated chemical signature in the ice, which implies that reconstructions of volcanism based solely on glacio-chemical indicators might underestimate the number of events. Single glass shards from each deposit were geochemically characterised to trace the volcanic source and many of these deposits could be correlated between cores. We show that the 64 deposits represent tephra deposits from 42 separate volcanic events, and of these, 39 are from Iceland, two from the north Pacific region (Japan and USA) and one has an unknown source. Six deposits can be correlated to terrestrial and/or marine tephra deposits in the Northern Hemisphere and the remaining 36 are unreported in other archives. We did not locate tephra from the compositionally distinctive Laacher See eruption (∼13 ka b2k) in our records. Combining our new discoveries with the previously published tephra framework, raises the number of individual tephra horizons found in Greenland ice over this interval to 50. This significantly improves the regional tephrochronological framework, our knowledge of the eruptive history of Iceland during the LGIT and provides new tephra constraints over key LGIT climate events. Consequentially, this framework can guide sampling strategies of future tephra studies in the terrestrial and marine realms aiming to link these records to the Greenland ice cores to assess regional climate synchroneity

Time Course of Changes in Peripheral Blood Gene Expression During Medication Treatment for Major Depressive Disorder.

Changes in gene expression (GE) during antidepressant treatment may increase understanding of the action of antidepressant medications and serve as biomarkers of efficacy. GE changes in peripheral blood are desirable because they can be assessed easily on multiple occasions during treatment. We report here on GE changes in 68 individuals who were treated for 8 weeks with either escitalopram alone, or escitalopram followed by bupropion. GE changes were assessed after 1, 2, and 8 weeks of treatment, with significant changes observed in 156, 121, and 585 peripheral blood gene transcripts, respectively. Thirty-one transcript changes were shared between the 1- and 8-week time points (seven upregulated, 24 downregulated). Differences were detected between the escitalopram- and bupropion-treated subjects, although there was no significant association between GE changes and clinical outcome. A subset of 18 genes overlapped with those previously identified as differentially expressed in subjects with MDD compared with healthy control subjects. There was statistically significant overlap between genes differentially expressed in the current and previous studies, with 10 genes overlapping in at least two previous studies. There was no enrichment for genes overexpressed in nervous system cell types, but there was a trend toward enrichment for genes in the WNT/β-catenin pathway in the anterior thalamus; three genes in this pathway showed differential expression in the present and in three previous studies. Our dataset and other similar studies will provide an important source of information about potential biomarkers of recovery and for potential dysregulation of GE in MDD

Old Arm Chair

I love it, I love it, and who shall dare, To chide me for loving that old arm chair, I’ve treasured it long as a holy prize, I’ve bedew’d it with tears, and embalmed it with sighs; ‘Tis bound by a thousand bands to my heart; Not a tie will break, not a link will start. Would ye learn the spell, a mother sat there, And a sacred thing is that old arm chair. I sat and watch’d her many a day, When her eye grew dim, and her locks were grey And I almost worshipp’d her when she smil’d, And turn’d from her bible to bless her child. Years rolled on, but the last on sped, My idol was shatter’d, my earth star fled: I learnt how much the heart can bear, When I saw her die in the old arm chair. ‘Tis past! ‘tis past! But I gaze on it now With quivering breath and throbbing brow; ‘Twas there she nursed me, ‘twas there she died; And mem’ry flows with lava tide. Say it is folly, and deem me weak, While the scalding drops start down my cheek; But I love it, I love it, and cannot tear My soul from a mother’s old arm chair

Independent tephrochronological evidence for rapid and synchronous oceanic and atmospheric temperature rises over the Greenland stadial-interstadial transitions between ca. 32 and 40 ka b2k

Understanding the dynamics that drove past abrupt climate changes, such as the Dansgaard-Oeschger (DO) events, depends on combined proxy evidence from disparate archives. To identify leads, lags and synchronicity between different climate system components, independent and robust chronologies are required. Cryptotephrochronology is a key geochronological tool as cryptotephra horizons can act as isochrons linking disparate and/or distant records. Here, we investigated marine sediment core MD99-2284 from the Norwegian Sea to look for previously identified Greenland ice core cryptotephra horizons and define time-parallel markers between the archives. We explored potential secondary transport and depositional mechanisms that could hamper the isochronous integrity of such horizons. We identified six cryptotephra layers of which four correlate to previously known Greenland ice core horizons. None of those were identified in other marine cores and thus, this study contributes greatly to the North Atlantic tephra framework tripling the original amount of existing isochrons between ca. 25 and 60 ka b2k. The latter allow a synchronization between MD99-2284 and the Greenland ice cores between ca. 32 e40 ka b2k, which is, in the North Atlantic, the shortest time-interval during the Last Glacial Period to be constrained by four independent tephra isochrons. These findings provide essential tephra-based evidence for synchronous and rapid oceanic and atmospheric temperature rises during the Greenland Stadial-Interstadial transitions. Furthermore, it enables us to estimate the average peak-duration of interstadial temperature overshoots at approximately 136 years. As such, this well-targeted high-resolution investigation successfully demonstrates the use of cryptotephra for geochronological purposes in the marine realm.publishedVersio

Mid-to Late Holocene East Antarctic ice-core tephrochronology : implications for reconstructing volcanic eruptions and assessing their climatic impacts over the last 5,500 years

PA and MS received funding from the European Research Council under the European Union's Horizon 2020 research and innovation programme (grant agreement no. 820047). WH is funded by a UKRI Future Leaders Fellowship (MR/S033505/1). Continuous analysis of the B53 and B54 cores for sulphur and insoluble particles was supported by internal funding from the Desert Research Institute, with partial support for interpretation provided by National Science Foundation grant 1925417 to JRM.Ice cores are powerful archives for reconstructing volcanism as they contain both soluble (i.e. aerosols) and insoluble (i.e. tephra) products of volcanic eruptions and for more recent periods have high-precision annually resolved chronologies. The identification and geochemical analysis of cryptotephra in these cores can provide their volcanic source and latitude of injection, complementing records of sulphur injections from volcanic eruptions developed using continuous flow ice-core analysis. Here, we aim to improve the volcanic record for the Southern Hemisphere using a sampling strategy for cryptotephra identification based on coeval deposition of sulphate and microparticles in ice cores from the interior of East Antarctica covering the Mid-to Late Holocene. In total, 15 cryptotephras and one visible horizon were identified and geochemically characterised. Through comparisons to proximal deposits a range of possible sources were isolated for these horizons including the South Sandwich Islands, South Shetland Islands, Victoria Land (Antarctica) and South America. This new tephra framework contributes to the volcanic history of the region by extending the known geographical range of tephra deposition for previously identified events and providing a potential indication of phases of eruptive activity from key sources. Using the tephra-based source attributions and comparison of the timing of the events to a database of sulphur injections from Holocene volcanic eruptions it is possible to refine injection latitudes for some events, which can lead to improved estimates of their radiative forcing potential. The relatively low magnitude of the volcanic stratospheric sulphur injections related to the events in the tephra framework indicates they would have had a limited impact on Southern Hemisphere climate. Further work is required to improve source attributions for some events and/or to determine the magnitude of sulphur injections for individual events during years when coeval eruptions occurred. One limitation of the framework is the dominance of cryptotephra from regional volcanic sources and a lack of tephra from tropical sources, which hampers the refinement of eruption parameters for these large magnitude and often climate-impacting eruptions. This issue could be explored further through increased sampling of these events and/or development of additional analytical techniques for the identification and robust geochemical analysis of glass tephra shards less than 5 μm in diameter. Such investigations could be coupled with model experiments to determine the likelihood that past tropical eruptions deposited glass tephra shards over Antarctica and the potential size range and geographical spread of deposition.Peer reviewe

Volcanism and the Greenland ice cores: A new tephrochronological framework for the last glacial-interglacial transition (LGIT) based on cryptotephra deposits in three ice cores

Chemical profiles from Greenland ice cores show that the frequency of volcanism was higher during the last glacial-interglacial transition (LGIT) and early Holocene, (17–9 ka b2k) than in any other period during the last 110 kyr. This increased frequency has partly been linked to climate-driven melting of the Icelandic ice sheet during the last deglaciation, with regional isostatic changes thought to alter mantle viscosity and lead to more eruptions. Our study is the first to construct a comprehensive tephrochronological framework from Greenland ice cores over the LGIT to aid in the reconstruction of volcanic activity over this period. The framework is based on extensive high-resolution sampling of three Greenland ice cores between 17.4 and 11.6 ka b2k and comprises a total of 64 cryptotephra deposits from the NGRIP, GRIP and NEEM ice cores. We show that many of these tephras are preserved within the core without an associated chemical signature in the ice, which implies that reconstructions of volcanism based solely on glacio-chemical indicators might underestimate the number of events. Single glass shards from each deposit were geochemically characterised to trace the volcanic source and many of these deposits could be correlated between cores. We show that the 64 deposits represent tephra deposits from 42 separate volcanic events, and of these, 39 are from Iceland, two from the north Pacific region (Japan and USA) and one has an unknown source. Six deposits can be correlated to terrestrial and/or marine tephra deposits in the Northern Hemisphere and the remaining 36 are unreported in other archives. We did not locate tephra from the compositionally distinctive Laacher See eruption (∼13 ka b2k) in our records. Combining our new discoveries with the previously published tephra framework, raises the number of individual tephra horizons found in Greenland ice over this interval to 50. This significantly improves the regional tephrochronological framework, our knowledge of the eruptive history of Iceland during the LGIT and provides new tephra constraints over key LGIT climate events. Consequentially, this framework can guide sampling strategies of future tephra studies in the terrestrial and marine realms aiming to link these records to the Greenland ice cores to assess regional climate synchroneity