112 research outputs found
A Fatal Case of Gu 蠱 Poisoning in Fourth-Century BC China?
This essay reexamines the fourth century BC divination records found in the tomb of Shao Tuo 邵佗 in Baoshan 包山, Jingzhou 荊州, Hubei. Using charts, rules, and examples for divination from a newly discoveredtrigram divination text, called by modern scholars, the Shifa 筮法 (Stalk Method), and preserved in the Tsinghua University collection of Warring States period bamboo manuscripts, the author suggests a radical new way to interpret stalk divination results and speculates upon a possible diagnosis. Essentially, the author unpacks the Baoshan results according to the rules of trigram divination given in the Shifa and not of hexagram divination as in the Zhouyi 周易 (Changes of Zhou)
2002 Wild Blueberry Project Reports
The 2002 edition of the Wild Blueberry Project Reports was prepared for the Wild Blueberry Commission of Maine and the Wild Blueberry Advisory Committee by researchers at the University of Maine, Orono. Projects in this report include:
1. Factors Affecting Microbial and Pesticide Residue Levels on Wild Blueberries
2. Effect of Blueberry Products on Oxidation in Meat Based Food
3. Determination of Pesticide Residue Levels in Freshly Harvested and Processed Wild Blueberries
4. Detection of Infested Wild Blueberries using Near-Infrared Spectroscopy
5. Investigation Of The Mechanism By Which Blueberry Fractions Maintain Arterial Integrity
6. Antioxidant Assessment in the Elderly
7. Water Use of Wild Blueberries and the Impact of Plant Water Stress on Yield
8. Control Tactics for Wild blueberry Pest Insects
9. IPM Strategies
10. Pest Biology
11. Wild Blueberry Pollination Research
12. Survey and Determination of Effective Control of Stem Blight and Leaf Spot Diseases in Wild Blueberry Fields
13. Effect of Foliar-applied Iron Chelate Concentration on Leaf Iron Concentration, Wild Blueberry Growth and Yield
14. Effect of Boron Application Methods on Boron Uptake in Wild Blueberries
15. Effect of Foliar N spray on Leaf N Concentration, Growth and Yield of Wild Blueberries
16. Effect of Foliar Spray (4-13-15) on Leaf Nutrient Concentration, Growth and Yield of Wild Blueberries
17. Effect of Foliar Copper Application on Growth and Yield of Wild Blueberries
18. Effect of Foliar Copper and/or Iron Application on Growth and Yield of Wild Blueberries
19. Effect of Soil pH on Nutrient Uptake
20. Assessment of Hexazinone Alternatives for Weed Control in Wild Blueberries and Weed Control
21. Evaluation of Fall Applications of Sulfonylurea Herbicides for Bunchberry Control in Wild Blueberries
22. Evaluation and Demonstration of Techniques for Filling in Bare Spots in Wild Blueberry Fields
23. Blueberry Extension Education Program Base
24. 2002 Pesticide Groundwater Survey
25. Cultural Weed Management using sulfur to lower the p
The deglacial history of surface and intermediate water of the Bering Sea
Author Posting. © The Authors, 2005. This is the author's version of the work. It is posted here by permission of Elsevier B. V. for personal use, not for redistribution. The definitive version was published in Deep Sea Research Part II: Topical Studies in Oceanography 52 (2005): 2163-2173, doi:10.1016/j.dsr2.2005.07.004.The lithology of deglacial sediments from the Bering Sea includes intervals of laminated
or dysaerobic sediments. These intervals are contemporaneous with the occurrence
of laminated sediments from the California margin and Gulf of California,
which suggests widespread low-oxygen conditions at intermediate depths in the
North Pacific Ocean. The cause could be reduced intermediate water ventilation,
increased organic carbon
flux, or a combination of the two. We infer abrupt decreases
of planktonic foraminifer δ18O at 14,400 y BP and 11,650 y BP, which may
be a combination of both freshening and warming. On the Shirshov Ridge, the abundance
of sea-ice diatoms of the genus Nitzschia reach local maxima twice during the
deglaciation, the latter of which may be an expression of the Younger Dryas. These
findings expand the extent of the expression of deglacial millennial-scale climate
events to include the northernmost Pacific.The Oak Foundation of Boston, Massachusetts,
and the WHOI Academic Programs Office provided support for Mea Cook.
This project was funded by NSF grant OPP-9912122
Disclosing Harmful Mammography Errors to Patients
To assess radiologists’ attitudes about disclosing errors to patients by using a survey with a vignette involving an error interpreting a patient's mammogram, leading to a delayed cancer diagnosis
Female Chromosome X Mosaicism is Age-Related and Preferentially Affects the Inactivated X Chromosome
To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events 4 2 Mb in 97 (0.25%) women. Here we show rates for X-chromosome mosaicism are four times higher than mean autosomal rates; X mosaic events more often include the entire chromosome and participants with X events more likely harbour autosomal mosaic events. X mosaicism frequency increases with age (0.11% in 50-year olds; 0.45% in 75-year olds), as reported for Y and autosomes. Methylation array analyses of 33 women with X mosaicism indicate events preferentially involve the inactive X chromosome. Our results provide further evidence that the sex chromosomes undergo mosaic events more frequently than autosomes, which could have implications for understanding the underlying mechanisms of mosaic events and their possible contribution to risk for chronic diseases
How can students-as-partners work address challenges to student, faculty, and staff mental health and well-being?
Unintended consequences of cigarette price changes for alcohol drinking behaviors across age groups: evidence from pooled cross sections
Genome-wide association study of endometrial cancer in E2C2
Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women. Women with a family history of EC have an increased risk for the disease, suggesting that inherited genetic factors play a role. We conducted a two-stage genome-wide association study of Type I EC. Stage 1 included 5,472 women (2,695 cases and 2,777 controls) of European ancestry from seven studies. We selected independent single-nucleotide polymorphisms (SNPs) that displayed the most significant associations with EC in Stage 1 for replication among 17,948 women (4,382 cases and 13,566 controls) in a multiethnic population (African America, Asian, Latina, Hawaiian and European ancestry), from nine studies. Although no novel variants reached genome-wide significance, we replicated previously identified associations with genetic markers near the HNF1B locus. Our findings suggest that larger studies with specific tumor classification are necessary to identify novel genetic polymorphisms associated with EC susceptibility. Electronic supplementary material The online version of this article (doi:10.1007/s00439-013-1369-1) contains supplementary material, which is available to authorized users
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling. © 2018 The Author(s).Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling. © 2018 The Author(s).Peer reviewe
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