Me diz, com o quê que cê sonha?

Qual a importância do sonho na criação e transformação da realidade? Ailton Krenak diz que em muitas culturas a experiência do sonho não se limita ao dormir e sonhar, mas é percebida como um exercício de buscar no sonho respostas e orientações para nossos dilemas e decisões do cotidiano “acordado”. O sonho traz uma abertura de sentidos e perspectivas para pensar um amanhã diferente do ontem, para imaginar uma vida outra. Ele fala sobre o sonho como uma “suspensão do céu”, um exercício de ampliação do nosso horizonte existencial quando a sensação de que céu e terra estão próximos demais for sufocante. Uns tem tempo para sonhar, outros só vivem acordados, e mais tantos têm a vida interrompida no meio do sonho. O mecanismo que nos quer rodando nessa dança sem graça e violenta quer acabar com os sonhos: “Pregam o fim do mundo como uma possibilidade de fazer a gente desistir dos nossos próprios sonhos. E a minha provocação sobre adiar o fim do mundo é exatamente poder contar mais uma história.” (KRENAK, 2019. p. 14) Essa obra surge com a motivação de se fazer viver os sonhos, de resgatar esses contos. Me diz, com o quê que cê sonha

Structure and Nanomechanics of Model Membranes by Atomic Force Microscopy and Spectroscopy: Insights into the Role of Cholesterol and Sphingolipids

Biological membranes mediate several biological processes that are directly associated with their physical properties but sometimes difficult to evaluate. Supported lipid bilayers (SLBs) are model systems widely used to characterize the structure of biological membranes. Cholesterol (Chol) plays an essential role in the modulation of membrane physical properties. It directly influences the order and mechanical stability of the lipid bilayers, and it is known to laterally segregate in rafts in the outer leaflet of the membrane together with sphingolipids (SLs). Atomic force microscope (AFM) is a powerful tool as it is capable to sense and apply forces with high accuracy, with distance and force resolution at the nanoscale, and in a controlled environment. AFM-based force spectroscopy (AFM-FS) has become a crucial technique to study the nanomechanical stability of SLBs by controlling the liquid media and the temperature variations. In this contribution, we review recent AFM and AFM-FS studies on the effect of Chol on the morphology and mechanical properties of model SLBs, including complex bilayers containing SLs. We also introduce a promising combination of AFM and X-ray (XR) techniques that allows for in situ characterization of dynamic processes, providing structural, morphological, and nanomechanical information

Synthesis, Antiproliferative Activity And Molecular Properties Predictions Of Galloyl Derivatives.

The present study was designed to investigate the in vitro antiproliferative activity against ten human cancer cell lines of a series of galloyl derivatives bearing substituted-1,3,4-oxadiazole and carbohydrazide moieties. The compounds were also assessed in an in silico study of the absorption, distribution, metabolism and excretion (ADME) in the human body using Lipinski's parameters, the topological polar surface area (TPSA) and percentage of absorption (%ABS). In general, the introduction of N'-(substituted)-arylidene galloyl hydrazides 4-8 showed a moderate antitumor activity, while the 2-methylthio- and 2-thioxo-1,3,4-oxadiazol-5-yl derivatives 9 and 10 led to increased inhibition of cancer cell proliferation. The precursor compound methyl gallate 2 and the intermediary galloyl hydrazide 3 showed greater antiproliferative activity with GI50 values < 5.54 µM against all human tumor cell lines tested. A higher inhibition effect against ovarian cancer (OVCAR-3) (GI50 = 0.05-5.98 µM) was also shown, with compounds 2, 3, 9 and 10 with GI50 ≤ 0.89 µM standing out in this respect. The in silico study revealed that the compounds showed good intestinal absorption.205360-537

Lei de Informática e seus Resultados no Polo de Informática de Ilhéus, BA

This article discusses the effectiveness of public policies on science, technology and innovation based on the survey and analysis of the Information Technology Law in an industrial area related to a priority sector. The work carried out an exploratory research as a form of bibliographical research enabling an approach of innovation from the perspective of regulation and government financing, assessing the role of the government in this process and analyzing the result of the Information Technology Law in the companies installed in the Information Technology Center of Ilhéus - BA. It is concluded that public incentive policies, if not allied to other actions, are not enough. There is no regional development without coordinated actions by the various spheres of government that can ensure that companies have all the conditions for their growth.O presente artigo aborda a efetividade de políticas públicas de ciência, tecnologia e inovação a partir de levantamento e análise da Lei de Informática em um polo industrial relacionado a um setor considerado prioritário. Neste trabalho realizou-se uma pesquisa exploratória como forma de pesquisa bibliográfica que possibilitou uma abordagem da inovação sob a perspectiva da regulamentação e do financiamento governamental, aferindo-se o papel do governo nesse processo e analisando-se o resultado da Lei de Informática nas empresas instaladas no Polo de Informática de Ilhéus – BA. Conclui-se que políticas públicas de incentivos, se não aliadas a outras ações, não são suficientes. Não há desenvolvimento regional sem ações coordenadas pelas diversas esferas do poder público que possam garantir que as empresas tenham todas as condições para o seu crescimento

Structure and Nanomechanics of Model Membranes by Atomic Force Microscopy and Spectroscopy: Insights into the Role of Cholesterol and Sphingolipids

Biological membranes mediate several biological processes that are directly associated with their physical properties but sometimes difficult to evaluate. Supported lipid bilayers (SLBs) are model systems widely used to characterize the structure of biological membranes. Cholesterol (Chol) plays an essential role in the modulation of membrane physical properties. It directly influences the order and mechanical stability of the lipid bilayers, and it is known to laterally segregate in rafts in the outer leaflet of the membrane together with sphingolipids (SLs). Atomic force microscope (AFM) is a powerful tool as it is capable to sense and apply forces with high accuracy, with distance and force resolution at the nanoscale, and in a controlled environment. AFM-based force spectroscopy (AFM-FS) has become a crucial technique to study the nanomechanical stability of SLBs by controlling the liquid media and the temperature variations. In this contribution, we review recent AFM and AFM-FS studies on the effect of Chol on the morphology and mechanical properties of model SLBs, including complex bilayers containing SLs. We also introduce a promising combination of AFM and X-ray (XR) techniques that allows for in situ characterization of dynamic processes, providing structural, morphological, and nanomechanical information

Percepção de pacientes oncológicos sobre terminalidade de vida

Resumo Objetivou-se analisar, por meio de pesquisa descritiva, a percepção de pacientes oncológicos diante da terminalidade da vida. Aplicou-se questionário para 100 pacientes oncológicos, dos quais 85% desconheciam testamento vital/diretivas antecipadas de vontade, 81% desconheciam cuidados paliativos e 70% desconheciam ordem de não reanimar. Após esclarecimento sobre os termos empregados, 62% concordariam em elaborar testamento vital/diretivas antecipadas de vontade, 82% concordariam em receber cuidados paliativos no domicílio e 64% em ser reanimados em qualquer situação, mas a maioria (73%) discordou da prática de distanásia. Apenas 11% referiram inadequação na forma de comunicação de seu diagnóstico pelo médico. A presença de metástases suscitou reflexão mais ampla sobre terminalidade da vida. Os resultados permitem inferir que é necessário incentivar a discussão sobre terminalidade da vida na população durante a assistência aos pacientes, bem como estimular o debate sobre o assunto durante a formação de profissionais de saúde

Structure and Nanomechanics of Model Membranes by Atomic Force Microscopy and Spectroscopy: Insights into the Role of Cholesterol and Sphingolipids

Biological membranes mediate several biological processes that are directly associated with their physical properties but sometimes difficult to evaluate. Supported lipid bilayers (SLBs) are model systems widely used to characterize the structure of biological membranes. Cholesterol (Chol) plays an essential role in the modulation of membrane physical properties. It directly influences the order and mechanical stability of the lipid bilayers, and it is known to laterally segregate in rafts in the outer leaflet of the membrane together with sphingolipids (SLs). Atomic force microscope (AFM) is a powerful tool as it is capable to sense and apply forces with high accuracy, with distance and force resolution at the nanoscale, and in a controlled environment. AFM-based force spectroscopy (AFM-FS) has become a crucial technique to study the nanomechanical stability of SLBs by controlling the liquid media and the temperature variations. In this contribution, we review recent AFM and AFM-FS studies on the effect of Chol on the morphology and mechanical properties of model SLBs, including complex bilayers containing SLs. We also introduce a promising combination of AFM and X-ray (XR) techniques that allows for in situ characterization of dynamic processes, providing structural, morphological, and nanomechanical information

Structure and Nanomechanics of Model Membranes by Atomic Force Microscopy and Spectroscopy: Insights into the Role of Cholesterol and Sphingolipids

Biological membranes mediate several biological processes that are directly associated with their physical properties but sometimes difficult to evaluate. Supported lipid bilayers (SLBs) are model systems widely used to characterize the structure of biological membranes. Cholesterol (Chol) plays an essential role in the modulation of membrane physical properties. It directly influences the order and mechanical stability of the lipid bilayers, and it is known to laterally segregate in rafts in the outer leaflet of the membrane together with sphingolipids (SLs). Atomic force microscope (AFM) is a powerful tool as it is capable to sense and apply forces with high accuracy, with distance and force resolution at the nanoscale, and in a controlled environment. AFM-based force spectroscopy (AFM-FS) has become a crucial technique to study the nanomechanical stability of SLBs by controlling the liquid media and the temperature variations. In this contribution, we review recent AFM and AFM-FS studies on the effect of Chol on the morphology and mechanical properties of model SLBs, including complex bilayers containing SLs. We also introduce a promising combination of AFM and X-ray (XR) techniques that allows for in situ characterization of dynamic processes, providing structural, morphological, and nanomechanical information

Volatility, financial constraints, and trade

We construct a dynamic monopolistic competition model with heterogeneous firms to study the links between firms’ earnings volatility, their degree of financial constraints, their survival probabilities, and their export market participation decisions. Our model predicts that more volatile firms are more likely to face financial constraints and to go bankrupt, need to be more productive to stay in the market, and have more incentives to enter export markets. A further implication is that through market diversification, exports tend to stabilize firms’ total sales. We test these predictions, using a panel of 23,674 UK manufacturing firms over the period 1993-2006