6 research outputs found
Primary renal mucosa-associated lymphoid tissue lymphoma, the result of chronic pyelonephritis?
The impacts of some sedative drugs on α -glycosidase, acetylcholinesterase and butyrylcholinesterase enzymes-potential drugs for some metabolic diseases
Background: The present paper focuses on the in vitro inhibition of some sedative drugs such as Midazolam, Propofol, Hipnodex, Ketamine, and Pental sodium on acetylcholinesterase (AChE), Butyrylcholinesterase (BChE), and α-glycosidase (α-Gly) enzymes. Methods: These drugs were tested in diverse concentrations, which showed positive effects in vitro AChE, BChE, and α-Gly activities. Ki values were 20.14, 94.93, 636.78, 416.42, and 953.75 μM for AChE, 17.52, 32.03, 88.02, 93.48, and 91.84 μM for BChE, and 10.87, 156.68, 48.21, 37.88, 151.01 μM for α-glycosidase, respectively. Results: An enhancing number of experiential observations show potentially harmful effects of sedative drugs on the extension of brain Conclusion: Midazolam exhibited effective inhibitory activity compared with the other drugs for these enzymes. © 2019 Bentham Science Publishers
Global sport governing bodies and human rights: Fédération Internationale de l’Automobile
Ecotoxicological assessment of the anticancer drug cisplatin in the the polychaete Nereis diversicolor
Anticancer drugs are designed to inhibit tumor cell proliferation by interacting with DNA and altering cellular
growth factors. When released into the waterbodies of municipal and hospital effluents these pharmaceutical
compounds may pose a risk to non-target aquatic organisms, due to their mode of action (cytotoxic, genotoxic,
mutagenic and teratogenic). The present study aimed to assess the ecotoxicological potential of the alkylating
agent cisplatin (CisPt) to the polychaete Nereis diversicolor, at a range of relevant environmental concentrations
(i.e. 0.1, 10 and 100 ng Pt L−1
). Behavioural impairment (burrowing kinetic impairment), ion pump effects (SR
Ca2+-ATPase), neurotoxicity (AChE activity), oxidative stress (SOD, CAT and GPXs activities), metal exposure
(metallothionein-like proteins - MTLP), biotransformation (GST), oxidative damage (LPO) and genotoxicity
(DNA damage), were selected as endpoints to evaluate the sublethal responses of the ragworms after 14-days
of exposure in a water-sediment system. Significant burrowing impairment occurred in worms exposed to the
highest CisPt concentration (100 ng Pt L−1
) along with neurotoxic effects. The activity of antioxidant enzymes
(SOD, CAT) and second phase biotransformation enzyme (GST) was inhibited but such effects were compensated
by MTLP induction. Furthermore, LPO levels also increased. Results showed that the mode of action of cisplatin
may pose a risk to this aquatic species even at the range of ng L−1info:eu-repo/semantics/publishedVersio