PIETRO KANDLER E LA GENESI DEL SAGGIO DI BIBLIOGRAFIA ISTRIANA

Nazocnost primjerka Saggio di bibliografia istriana (Ogleda istarske bibliografije) Carla Combija u Diplomatskom arhivu Gradske biblioteke u Trstu, s bilje5kama Pietra Kandlera, polemikama glede autora i Bibliografije uopée, potakla je istrazivanje o nastanku toga djela . Od dokumenata su predstavljeni prijepis Kandlerova komentara dopisana u gore navedenu primjerku i niz ulomaka iz pisama kljucnih osoba oko toga djela, koje nas izvjeséuju o vaznosti koju im Kandler, sastavljanjem svoga <<Plana za istarske tiskotine>>, pridaje u organiziranju rada na Bibliografiji. Od najzanimljivijih je kritika, u komentaru trséanskoga povjesnika o Bibliografiji, ona koja se odnosi na nedostatak u njoj naziva izdanja na slavenskom jeziku. Clanak zavrsava razmatranjima svrsishodnosti ponovne izrade, nakon 120 godina, nove Bibliografije, ustrojene uz pomoé kompjutora kao banka podataka, sto bi mogio otvoriti novo poglavlje u istrazivanju istarske povijesti

A pharmacoeconomic analysis of the use of single MMC instillation in low risk NMIBC in Italy

BACKGROUND: Bladder cancer accounts for 5-10% of all cancers in Europe and up to 85% patients presents a noninvasive tumor, whose treatment of choice is the transurethral bladder resection (TURB) paired with adjuvant intravesical chemotherapy or immunotherapy. Despite several clinical trials showed that this treatment is safe and decreases recurrences by 17% to 44% this practice is limited for many reasons. The study objective is to analyze the economical advantages of the single immediate post operative Mitomycin C instillation in Non Muscle-invasive Bladder Cancer (NMIBC) low-risk patients.METHODS: A cost-benefit analysis was performed evaluating the economical gain that would raised from a scenario with a single immediate post operative mitomycin C instillation in each low-risk NMIBC patient who underwent to TURB. Net present value and cost-benefit ratio were calculated and sensitivity analyses were performed. Base case analysis was performed considering tumor recurrence rate reduction of 11.7% and a TURB costs of 2,167.0 €, while sensitivity analyses were performed using a recurrence rate reduction of 19.2% and 15.0% and a TURB cost of 2,472.93 €. The discount rate was 2%.RESULTS: The single immediate post operative instillation of mitomycin C resulted to be cost-beneficial with a cost-benefit ratio that goes from 0.48 to 0.79 when compared to TURB alone raising a Net Present Value that goes from 660,284.39 € to 2,650,530.79 €.CONCLUSION: This study demonstrates that even assuming conservative parameters for recurrence rates reduction, a single immediate post operative mitomycin C instillation in low risk NMIBC patients would lower not only the recurrence rate but also the caring cost for bladder cancer

Effect of allogeneic intraoperative blood transfusion on survival in patients treated with radical cystectomy for nonmetastatic bladder cancer: Results from a single high-volume institution

Transfusion has been related to poor survival after surgery in several cancers. Recently, timing of transfusion has been proposed as crucial in the determination of poor survival expectanies after surgery, in fact, intra- operative but not postoperative transfusion were found to be related. We confirmed these findings in patients who underwent radical cystectomy because of bladder cancer; physicians should avoid use of transfusion intraoperatively. Background: Previous studies have demonstrated that perioperative blood transfusion (BT) is associated with a significantly increased risk of cancer recurrence and mortality after radical cystectomy (RC). Recently, it was shown for the first time that intraoperative transfusion has a detrimental effect on cancer survival. The aim of the current study was to validate this finding in a single European institution. Patients and Methods: The study focused on 1490 consecutive nonmetastatic bladder cancer patients treated with RC at a single tertiary care referral center between January 1990 and August 2013. KaplaneMeier analyses and Cox regression analyses were used to assess the effect of timing of BT administration (no transfusion vs. intraoperative transfusion vs. postoperative transfusion vs. intra- operative and postoperative transfusion) on cancer-specific mortality (CSM), overall mortality (OM), and disease recurrence. Results: Mean age at the time of RC was 67 years. Overall, 322 (21.6%) patients received intraoperative BT and 97 (6.5%) received postoperative BT. At a mean follow-up time of 125 months (median, 110 months), the 5- and 10-year CSM rate was 846 (58%) and 715 (48%), respectively. In multivariable analyses patients who received intraoperative BT had greater risk of disease recurrence (hazard ratio [HR], 1.24; P .2). Conclusion: Our study confirms that intraoperative, but not postoperative BT, are related to a detrimental effect on survival after RC. These results should be take into account by physicians to administer BT using the correct timing

A physiologically-oriented mathematical model for the description of in vivo drug release and absorption

This paper focuses on a physiologically-oriented mathematical model aimed at studying the in vivo drug release, absorption, distribution, metabolism and elimination (ADME). To this purpose, the model accounts for drug delivery from an ensemble of non-eroding poly-disperse polymeric particles and the subsequent ADME processes. The model outcomes are studied with reference to three widely used drugs: theophylline, temazepam and nimesulide. One of the most important results of this study is the quantitative evaluation of the interplay between the release kinetics and the subsequent ADME processes. Indeed, it is usually assumed that in vivo drug release coincides with in vitro so that the effect exerted by the ADME processes is neglected. In addition, the proposed model may be an important tool for the design of delivery systems since, through proper changes, it could also account for different oral delivery systems

Translation and cultural adaptation of the Computer Vision Syndrome Questionnaire (CVS-Q©) into Italian

Background: The original Spanish version of the Computer Vision Syndrome Questionnaire (CVS-Q©) is a validated instrument with good psychometric properties to measure the Computer Visual Syndrome (CVS) in workers exposed to video display terminals (VDT). The Italian version would facilitate research and its use in clinical practice the prevention of occupational hazards. Objective: To culturally translate and adapt the CVS-Q© into Italian. Methods: Study with 5 consecutive stages: Direct translation, Synthesis of translations, Retro-translation, Consolidation by a committee of experts and Pre-test. During the Pre-test, a cross-sectional pilot study was conducted on users of VDT (n=40) who completed the Italian version of the questionnaire. Socio-demographic information and exposure assessment to VDT was also collected, as well as on the difficulty to fill in the CVS-Q©. Results: The final version into Italian of the CVS-Q© was obtained. The totality of the sample considered that it didn’t present difficulty in its completion and 90% confirmed that no improvement was needed; so that the 15% required to make changes was not reached. The mean age of participants was of 35.80±16.28 (20-65 years), 57.5% were women and 67.5% used VDT at work. A prevalence of CVS of 62.5% was observed. Conclusion: The CVS-Q© can be considered a tool easy to understand and manage for measuring the CVS in the population exposed to VDT in Italy.Introduzione: La versione originale in lingua spagnola del Questionario per lo studio della Sindrome da Visione al Computer (CVS-Q©) è uno strumento validato e con buone proprietà psicometriche per valutare tale Sindrome (CVS) in lavoratori esposti a videoterminali (VDT). La versione del questionario in italiano potrà fornire un utile strumento sia per la ricerca che per la pratica clinica nella prevenzione dei rischi professionali da VDT. Obiettivo: Tradurre e adattare culturalmente il CVS-Q© in italiano. Metodi: Studio condotto in 5 fasi consecutive: Traduzione diretta, Sintesi delle traduzioni, Retro-traduzione, Approvazione da parte di un comitato di esperti e Pre-test. Durante il pre-test è stato condotto uno studio pilota trasversale in utilizzatori di VDT (n=40) che hanno compilato la versione del questionario in lingua italiana. Si è inoltre proceduto alla raccolta di informazioni socio-demografiche, sull’esposizione a VDT e sulla difficoltà di compilazione. Risultati: È stata ottenuta la versione definitiva del CVSQ© in italiano. La totalità del campione ha ritenuto che il questionario non presentasse difficoltà di compilazione ed il 90% del campione che non fosse necessario apportare miglioramenti; per cui, il 15% richiesto per apportare modifiche non è stato raggiunto. L’età media dei partecipanti era di 35.80±16.28 (20-65 anni), il 57.5% erano donne e il 67.5% ha utilizzato il VDT sul lavoro. La prevalenza della CVS osservata è stata del 62.5%. Conclusione: Il CVSQ© può essere considerato uno strumento di facile comprensione e gestione per misurare la CVS nella popolazione esposta a VDT in Italia

AVALIAÇÃO DA INCORPORAÇÃO DE RESÍDUO DE CORTE DE MÁRMORE E GRANITO EM CONCRETO PARA PRODUÇÃO DE PISOS INTERTRAVADOS PARA PAVIMENTAÇÃO

A indústria da construção civil é uma atividade que consome elevado volume de recursos naturais e no cenário atual é imprescindível se preocupar com o desenvolvimento sustentável e encontrar alternativas de reaproveitamento de resíduos sólidos. Nesse contexto, a reinserção do resíduo de corte de mármore e granito (RCMG) na cadeia produtiva é uma alternativa para amenizar um sério problema ambiental, pois o consumo de rochas ornamentais vem crescendo e elevando a quantidade de resíduo produzido. Devido ao grande volume de resíduos de corte de granito produzido e não reutilizado, este artigo técnico avalia a viabilidade técnica da sua utilização como adição em concretos e produção de blocos intertravados com resistência à compressão mínima de 35 MPa e a absorção d'água de 6% no máximo. As matérias primas foram caracterizadas quanto à massa específica, massa unitária, distribuição do tamanho de partículas, materiais pulverulentos e composição química (FRX). Em seguida, os corpos de prova foram moldados de acordo com as prescrições da norma técnica NBR 9781:2013 e foram realizadas análises de desempenho mecânico (resistência à compressão) e absorção d'água. Em suma, a partir dos resultados obtidos no programa experimental, o uso do resíduo de corte de mármore e granito como adição em concretos para produção de pisos de pavimentação é viável tecnicamente para tráfego de pedestres, veículos leves e veículos comerciais de linha

Multicentre International Study for the Prevention with iAluRil of Radio-induced Cystitis (MISTIC) : A Randomised Controlled Study

Radiation-induced cystitis is a common side effect of radiotherapy (RT) to the pelvic area. Hyaluronic acid (HA) and chondroitin sulfate (CS) are components of the urothelial mucosa and positive results have been obtained for intravesical HA/CS instillations for the treatment of urinary tract infections and bladder pain syndrome. HA/CS may also have a protective effect against RT bladder toxicity. To investigate whether HA and CS protect the urothelium during RT, alleviate lower urinary tract symptoms, and improve quality of life. This multicentre randomised controlled trial was conducted across seven centres in four countries. Male patients aged ≥18 yr scheduled to undergo primary intensity-modulated radiotherapy for localised prostate cancer were enrolled. Patients were randomised to intravesical HA/CS plus an oral formulation of curcumin, quercetin, HA, and CS (group A) or no treatment (group B). The primary endpoint was absolute changes from baseline to follow-up in urinary domain scores for the Expanded Prostate Cancer Index Composite (EPIC), the International Consultation on Incontinence Questionnaire-Male Lower Urinary Tract Symptoms (ICIQ-MLUTS), and the EuroQol Group EQ-5D-5L questionnaire. Data analysis for efficacy and safety outcomes was performed using an intention-to-treat (ITT) approach; the ITT population was defined as all randomised patients. Of 57 patients screened, 49 were enrolled and randomly assigned to either active treatment (group A, n = 25) or the control (group B, n = 24). Three patients in the control group withdrew after randomisation. Changes from baseline to 12 mo were worse in the control group for subtotal scores for urinary symptoms and impact of symptoms on quality of life and for the total score (p = 0.05, p = 0.003, and p = 0.008, respectively). There was a significant time × group interaction in favour of active treatment for the incontinence symptom score (p = 0.011) and bother score (p = 0.017). The absence of a sham procedure and/or placebo is the main limitation. Our results suggest that intravesical HA/CS in combination with an oral formulation may reduce urinary symptoms and improve QoL at short-term (1 yr) follow-up. We investigated whether hyaluronic acid (HA) and chondroitin sulfate (CS) have a protective effect against the bladder toxicity of radiotherapy for prostate cancer. HA/CS used for weekly bladder irrigation for 6 wk and given orally with curcumin and quercetin for 12 wk reduced urinary incontinence symptoms and bother measured at 1-year follow-up. This may hold promise as a preventive treatment if the results are confirmed in further trials. Our findings show a beneficial effect of intravesical hyaluronic acid (HA)/chondroitin sulfate (SC) plus the oral combination of curcumin, quercetin, HA, and CS for prevention of acute and late (1 yr) radiation-induced cystitis and improvement in quality of life. The current strategy may have a place among treatment options for the prevention of radiation-induced bladder complications, which until now have been limited to symptom-relieving and temporary modalities