Bistable molecular conductors with a field-switchable dipole group

A class of bistable "stator-rotor" molecules is proposed, where a stationary bridge (stator) connects the two electrodes and facilitates electron transport between them. The rotor part, which has a large dipole moment, is attached to an atom of the stator via a single sigma bond. Hydrogen bonds formed between the rotor and stator make the symmetric orientation of the dipole unstable. The rotor has two potential minima with equal energy for rotation about the sigma bond. The dipole orientation, which determines the conduction state of the molecule, can be switched by an external electric field that changes the relative energy of the two potential minima. Both orientation of the rotor correspond to asymmetric current-voltage characteristics that are the reverse of each other, so they are distinguishable electrically. Such bistable stator-rotor molecules could potentially be used as parts of molecular electronic devices.Comment: 8 pages, 7 figure

Computing the divisional cost of capital using the pure play method

The Cost of Capital Model is used to calculate the net present value of projects within a multi-unit corporation but may provide incorrect answers for projects that have a level of risk that differs from the overall average risk level for the corporation. We demonstrate the use of the Pure Play Method for calculating the required rate of return for a division of a corporation that has risk characteristics that differ from the risk characteristics of the overall corporation. We apply this methodology to the Integrated Electronic Systems Segment of the Motorola Corporation. We find that the IESS division cost of capital of is 9.3% rather than the 12.3% cost of capital for the corporation as a whole

AGN behind the SMC selected from radio and X-ray surveys

The XMM-Newton survey of the Small Magellanic Cloud (SMC) revealed 3053 X-ray sources with the majority expected to be active galactic nuclei (AGN) behind the SMC. However, the high stellar density in this field often does not allow assigning unique optical counterparts and hinders source classification. On the other hand, the association of X-ray point sources with radio emission can be used to select background AGN with high confidence, and to constrain other object classes like pulsar wind nebula. To classify X-ray and radio sources, we use clear correlations of X-ray sources found in the XMM-Newton survey with radio-continuum sources detected with ATCA and MOST. Deep radio-continuum images were searched for correlations with X-ray sources of the XMM-Newton SMC-survey point-source catalogue as well as galaxy clusters seen with extended X-ray emission. Eighty eight discrete radio sources were found in common with the X-ray point-source catalogue in addition to six correlations with extended X-ray sources. One source is identified as a Galactic star and eight as galaxies. Eight radio sources likely originate in AGN that are associated with clusters of galaxies seen in X-rays. One source is a PWN candidate. We obtain 43 new candidates for background sources located behind the SMC. A total of 24 X-ray sources show jet-like radio structures.Comment: 9 pages, 6 figures, accepted for publication in A&

Investigation of the filamin A-Dependent mechanisms of tissue factor incorporation into microvesicles

We have previously shown that phosphorylation of tissue factor (TF) at Ser253 increases the incorporation of TF into microvesicles (MVs) following protease-activated receptor 2 (PAR2) activation through a process involving filamin-A, whereas Ser258 phosphorylation suppresses this process. Here we examined the contribution of the individual phosphorylation of these serine residues to the interaction between filamin-A and TF, and further examined how filamin-A regulates the incorporation of TF into MVs. In vitro binding assays using recombinant filamin-A C-terminal repeats 22-24 with biotinylated phospho-TF cytoplasmic domain peptides as bait, showed that filamin-A had the highest binding affinities for phospho-Ser253 and double-phosphorylated TF peptides, whilst the phospho-Ser258 TF peptide had the lowest affinity. Analysis of MDA-MB-231 cells using an in situ proximity ligation assay revealed increased proximity between the C-terminus of filamin-A and TF following PAR2 activation, which was concurrent with Ser253 phosphorylation and TF-positive MV release from these cells. Knock-down of filamin-A expression suppressed PAR2-mediated increases in cell surface TF procoagulant activity without reducing cell surface TF antigen expression. Disrupting lipid rafts by pre-incubation with methyl-beta cyclodextrin (MβCD) prior to PAR2 activation reduced TF-positive MV release and cell surface TF procoagulant activity to the same extent as filamin-A knock-down. In conclusion, this study shows that the interaction between TF and filamin-A is dependent on the differential phosphorylation of Ser253 and Ser258. Furthermore the interaction of TF with filamin-A may translocate cell surface TF to cholesterol-rich lipid rafts, increasing cell surface TF activity as well as TF incorporation and release into MVs

The first magnetic maps of a pre-main sequence binary star system - HD 155555

We present the first maps of the surface magnetic fields of a pre-main sequence binary system. Spectropolarimetric observations of the young, 18 Myr, HD 155555 (V824 Ara, G5IV + K0IV) system were obtained at the Anglo-Australian Telescope in 2004 and 2007. Both datasets are analysed using a new binary Zeeman Doppler imaging (ZDI) code. This allows us to simultaneously model the contribution of each component to the observed circularly polarised spectra. Stellar brightness maps are also produced for HD 155555 and compared to previous Doppler images. Our radial magnetic maps reveal a complex surface magnetic topology with mixed polarities at all latitudes. We find rings of azimuthal field on both stars, most of which are found to be non-axisymmetric with the stellar rotational axis. We also examine the field strength and the relative fraction of magnetic energy stored in the radial and azimuthal field components at both epochs. A marked weakening of the field strength of the secondary star is observed between the 2004 and 2007 epochs. This is accompanied by an apparent shift in the location of magnetic energy from the azimuthal to radial field. We suggest that this could be indicative of a magnetic activity cycle. We use the radial magnetic maps to extrapolate the coronal field (by assuming a potential field) for each star individually - at present ignoring any possible interaction. The secondary star is found to exhibit an extreme tilt (~75 deg) of its large scale magnetic field to that of its rotation axis for both epochs. The field complexity that is apparent in the surface maps persists out to a significant fraction of the binary separation. Any interaction between the fields of the two stars is therefore likely to be complex also. Modelling this would require a full binary field extrapolation.Comment: 17 pages, 12 figures, accepted for publication in MNRA

Rotational modulation of X-ray emission in Orion Nebula young stars

We investigate the spatial distribution of X-ray emitting plasma in a sample of young Orion Nebula Cluster stars by modulation of their X-ray light-curves due to stellar rotation. The study, part of the Chandra Orion Ultradeep Project (COUP), is made possible by the exceptional length of the observation: 10 days of ACIS integration during a time span of 13 days, yielding a total of 1616 detected sources in the 17x17 arcmin field of view. We here focus on a subsample of 233 X-ray-bright stars with known rotational periods. We search for X-ray modulation using the Lomb Normalized Periodogram method. X-ray modulation related to the rotation period is detected in at least 23 stars with periods between 2 and 12 days and relative amplitudes ranging from 20% to 70%. In 16 cases, the X-ray modulation period is similar to the stellar rotation period while in seven cases it is about half that value, possibly due to the presence of X-ray emitting structures at opposite stellar longitudes. These results constitute the largest sample of low mass stars in which X-ray rotational modulation has been observed. The detection of rotational modulation indicates that the X-ray emitting regions are distributed inhomogeneneously in longitude and do not extend to distances significantly larger than the stellar radius. Modulation is observed in stars with saturated activity levels (L_X/L_bol ~ 10^(-3)) showing that saturation is not due to the filling of the stellar surface with X-ray emitting regions.Comment: 41 pages, 15 figures, ApJS in press. Figure 15 (34 panels) is an on-line only figure and is not included. A pdf file which includes figure 15 as well as full resolution versions of figure 10 and 11 is available at: http://www.astropa.unipa.it/~ettoref/COUP_RotMod.pd

The genotype-phenotype relationship in multicellular pattern-generating models - the neglected role of pattern descriptors

Background: A deep understanding of what causes the phenotypic variation arising from biological patterning processes, cannot be claimed before we are able to recreate this variation by mathematical models capable of generating genotype-phenotype maps in a causally cohesive way. However, the concept of pattern in a multicellular context implies that what matters is not the state of every single cell, but certain emergent qualities of the total cell aggregate. Thus, in order to set up a genotype-phenotype map in such a spatiotemporal pattern setting one is actually forced to establish new pattern descriptors and derive their relations to parameters of the original model. A pattern descriptor is a variable that describes and quantifies a certain qualitative feature of the pattern, for example the degree to which certain macroscopic structures are present. There is today no general procedure for how to relate a set of patterns and their characteristic features to the functional relationships, parameter values and initial values of an original pattern-generating model. Here we present a new, generic approach for explorative analysis of complex patterning models which focuses on the essential pattern features and their relations to the model parameters. The approach is illustrated on an existing model for Delta-Notch lateral inhibition over a two-dimensional lattice. Results: By combining computer simulations according to a succession of statistical experimental designs, computer graphics, automatic image analysis, human sensory descriptive analysis and multivariate data modelling, we derive a pattern descriptor model of those macroscopic, emergent aspects of the patterns that we consider of interest. The pattern descriptor model relates the values of the new, dedicated pattern descriptors to the parameter values of the original model, for example by predicting the parameter values leading to particular patterns, and provides insights that would have been hard to obtain by traditional methods. Conclusion: The results suggest that our approach may qualify as a general procedure for how to discover and relate relevant features and characteristics of emergent patterns to the functional relationships, parameter values and initial values of an underlying pattern-generating mathematical model

Analysis of the potential of cancer cell lines to release tissue factor-containing microvesicles: correlation with tissue factor and PAR2 expression

BackgroundDespite the association of cancer-derived circulating tissue factor (TF)-containing microvesicles and hypercoagulable state, correlations with the incidence of thrombosis remain unclear.MethodsIn this study the upregulation of TF release upon activation of various cancer cell lines, and the correlation with TF and PAR2 expression and/or activity was examined. Microvesicle release was induced by PAR2 activation in seventeen cell lines and released microvesicle density, microvesicle-associated TF activity, and phoshpatidylserine-mediated activity were measured. The time-course for TF release was monitored over 90 min in each cell line. In addition, TF mRNA expression, cellular TF protein and cell-surface TF activities were quantified. Moreover, the relative expression of PAR2 mRNA and cellular protein were analysed. Any correlations between the above parameters were examined by determining the Pearson’s correlation coefficients.ResultsTF release as microvesicles peaked between 30–60 min post-activation in the majority of cell lines tested. The magnitude of the maximal TF release positively correlated with TF mRNA (c = 0.717; p

Current-Driven Conformational Changes, Charging and Negative Differential Resistance in Molecular Wires

We introduce a theoretical approach based on scattering theory and total energy methods that treats transport non-linearities, conformational changes and charging effects in molecular wires in a unified way. We apply this approach to molecular wires consisting of chain molecules with different electronic and structural properties bonded to metal contacts. We show that non-linear transport in all of these systems can be understood in terms of a single physical mechanism and predict that negative differential resistance at high bias should be a generic property of such molecular wires.Comment: 9 pages, 4 figure

Reddening, Emission-Line, and Intrinsic Absorption Properties in the Narrow-Line Seyfert 1 Galaxy Akn 564

We use Hubble Space Telescope UV and optical spectra of the narrow-line Seyfert 1 (NLS1) galaxy Akn 564 to investigate its internal reddening and properties of its emission-line and intrinsic UV absorption gas. We find that the extinction curve of Akn 564, derived from a comparison of its UV/optical continuum to that of an unreddened NLS1, lacks a 2200 A bump and turns up towards the UV at a longer wavelength (4000 A) than the standard Galactic, LMC, and SMC curves. However, it does not show the extremely steep rise to 1200 A that characterizes the extinction curve of the Seyfert 1 galaxy NGC 3227. The emission-lines and continuum experience the same amount of reddening, indicating the presence of a dust screen that is external to the narrow-line region (NLR). Echelle spectra from the Space Telescope Imaging Spectrograph show intrinsic UV absorption lines due to Ly-alpha, N V, C IV, Si IV, and Si III, centered at a radial velocity of -190 km/s (relative to the host galaxy). Photoionization models of the UV absorber indicate that it has a sufficient columnand is at a sufficient distance from the nucleus (D > 95 pc) to be the source of the dust screen. Thus, Akn 564 contains a dusty ``lukewarm absorber'' similar to that seen in NGC 3227.Comment: 25 pages, 4 figures. LaTeX with encapsulated postscript figures. Accepted for publication in the Astrophysical Journa