Evaluation of the biodiversity in Bryophytes and Pteridophytes in Nueva’s river basin (Llanes, Asturias, North Iberian Peninsula): scientific grounds for its protection and conservation

El valle del río de Nueva, orientado al este, se encuentra muy próximo al mar Cantábrico. Su cuenca alta y media, con una superficie de 5,5 Km2, presenta una elevada biodiversidad de briófitos al haberse identificado 145 taxones (85 musgos, 59 hepáticas y 1 antocerota), lo que representa el 23% de la flora briofítica de Asturias. El muestreo realizado, por cuadrículas UTM de 0,5 Km de lado, nos revela también la riqueza en briófitos de este territorio, ya que se han contabilizado hasta 70 taxones distintos en cada unidad de cuadrícula. Del catálogo elaborado resultan ser novedad para la Península Ibérica Dicranodontium asperulum y, además, para el Principado de Asturias, los musgos: Dicranum scottianum y Plagiothecium platyphyllum, y las hepáticas: Bazzania trilobata var. depauperata, Cephalozia crassifolia, Cephalozia loitlesbergeri, Kurzia sylvatica, Lepidozia cupressina, Nowellia curvifolia y Jungermannia paroica, taxa, la mayoría, de reducida distribución. Se amplía el área de distribución, a escala regional, de otras especies (15 hepáticas y 5 musgos) raras o amenazadas, incluidas en la «Red List of Bryophytes of the Iberian Peninsula» (Sérgio & al. 1994). Se ha realizado un estudio fitosociológico de las comunidades briopteridofíticas, en especial las presididas por helechos de carácter «subtropical» presentes en el área de estudio: Woodwardia radicans, Hymenophyllum tunbrigense, Culcita macrocarpa, Stegnogramma pozoi, Vandenboschia speciosa, etc. En su mayoría, estas comunidades pertenecen a la alianza Hymenophyllion tunbrigensis (Orden Anomodonto-Polypodietalia, Clase Anomodonto-Polypodietea), que agrupa fitocenosis constituidas, fundamentalmente, por briófitos y pteridófitos, que colonizan repisas de peñascos, muros y taludes terrosos compactos sobre una delgada capa de tierra (exocomófitos), desarrolladas en ambientes saturados de humedad ambiental, bajo el dosel de formaciones forestales. Mediante el cálculo de los índices de rareza específica, coeficiente de diversidad fitocenótica y calidad botánica, entre otros, se ha evaluado el territorio con el fin de sentar las bases científicas para su protección y conservación.Nueva’s River Valley lies close to the Cantabrico sea, facing towards the east. The upper and middle part of its basin, with a surface of 5.5 Km2, shows a high diversity of bryophytes, as we have identified 145 taxa (85 mosses, 59 liverworts and 1 hornworts), which represent 23% of the Asturias bryophytic flora. The use as sampling unit UTM squares of 0.5 Km side, shows also the richness in bryophytes of this place, as we have found up to 70 different taxa in each square unit. From the catalogue made, Dicranodontium asperulum turns out to be new for the Iberian Peninsula, as in the same way for Principado de Asturias are the mosses Dicranum scottianum and Plagiothecium platyphyllum, and the liverworts Bazzania trilobata var. depauperata, Cephalozia crassifolia, Cephalozia loitlesbergeri, Kurzia sylvatica, Lepidozia cupressina, Nowellia curvifolia and Jungermannia paroica. Most of these taxa have very reduced distribution area. At the regional level, our data represent to enlarge the area of some other rare or threatened species (15 liverworts and 5 mosses), included in the «Red List of Bryophytes of the Iberian Peninsula» (Sérgio & al. 1994). A phytosociologic study of the bryo-pteridophytic communities has been made, especially on those dominated by ferns bearing «subtropical» character: Woodwardia radicans, Hymenophyllum tunbrigense, Culcita macrocarpa, Stegnogramma pozoi, Vandenboschia speciosa, etc. Most of these communities belong to the alliance Hymenophyllion tunbrigensis (Order Anomodonto-Polypodietalia, Class Anomodonto- Polypodietea). This alliance gathers phytocoenoses mainly made by bryophytes and pteridophytes, that inhabit sides of large rocks, walls and compact earth slopes, rootin in a thin layer of soil (exocomophytes), and developed in a really wet environment, under the canopy of forest formations. Through calculation of the «Rare specific index», coefficient of diversity phytocenotics and of botanic quality, among others, we have evaluated the zone with the aim to lay the scientific grounds for its protection and conservation

IgA vasculitis: influence of CD40, BLK and BANK1 gene polymorphisms

CD40, BLK and BANK1 genes involved in the development and signaling of B-cells are identified as susceptibility loci for numerous inflammatory diseases. Accordingly, we assessed the potential influence of CD40, BLK and BANK1 on the pathogenesis of immunoglobulin-A vasculitis (IgAV), predominantly a B-lymphocyte inflammatory condition. Three genetic variants within CD40 (rs1883832, rs1535045, rs4813003) and BLK (rs2254546, rs2736340, rs2618476) as well as two BANK1 polymorphisms (rs10516487, rs3733197), previously associated with inflammatory diseases, were genotyped in 382 Caucasian patients with IgAV and 955 sex- and ethnically matched healthy controls. No statistically significant differences were observed in the genotype and allele frequencies of CD40, BLK and BANK1 when IgAV patients and healthy controls were compared. Similar results were found when CD40, BLK and BANK1 genotypes or alleles frequencies were compared between patients with IgAV stratified according to the age at disease onset or to the presence/absence of gastrointestinal or renal manifestations. Moreover, no CD40, BLK and BANK1 haplotype differences were disclosed between patients with IgAV and healthy controls and between patients with IgAV stratified according to the clinical characteristics mentioned above. Our findings indicate that CD40, BLK and BANK1 do not contribute to the genetic background of IgAV.Funding: This study was supported by European Union FEDER funds and “Fondo de Investigaciones Sanitarias” (grants PI18/00042 and PI21/00042) from “Instituto de Salud Carlos III” (ISCIII, Health Ministry, Spain). D.P.-P. is a recipient of a Río Hortega program fellowship from the ISCIII, co-funded by the European Social Fund (ESF, “Investing in your future”) (grant number CM20/00006). F.G. is supported by funds of the RICORS Program from ISCIII, co-funded by the European Union (grant number RD21/0002/0025). V.P.-C. is supported by funds of PI18/00042. S.R.-M. is supported by funds of the RETICS Program (RD16/0012/0009) (ISCIII, co-funded by the European Regional Development Fund (ERDF)). O.G. is a staff member of Xunta de Galicia (Servizo Galego de Saude (SERGAS)) through a research-staff stabilization contract (ISCIII/SERGAS) and his work is funded by ISCIII and the European Union FEDER fund (grant numbers RD16/0012/0014 (RIER) and PI17/00409). He is a beneficiary of project funds from the Research Executive Agency (REA) of the European Union in the framework of MSCA-RISE Action of the H2020 Program, project 734899—Olive-Net. R.L.-M. is a recipient of a Miguel Servet type II program fellowship from the ISCIII, co-funded by ESF (“Investing in your future”) (grant number CPII21/00004). Acknowledgments: We are indebted to the patients and healthy controls for their essential collaboration on this study. We also thank the National DNA Bank Repository (Salamanca) for supplying part of the control samples

Time to Switch to Second-line Antiretroviral Therapy in Children With Human Immunodeficiency Virus in Europe and Thailand.

Background: Data on durability of first-line antiretroviral therapy (ART) in children with human immunodeficiency virus (HIV) are limited. We assessed time to switch to second-line therapy in 16 European countries and Thailand. Methods: Children aged <18 years initiating combination ART (≥2 nucleoside reverse transcriptase inhibitors [NRTIs] plus nonnucleoside reverse transcriptase inhibitor [NNRTI] or boosted protease inhibitor [PI]) were included. Switch to second-line was defined as (i) change across drug class (PI to NNRTI or vice versa) or within PI class plus change of ≥1 NRTI; (ii) change from single to dual PI; or (iii) addition of a new drug class. Cumulative incidence of switch was calculated with death and loss to follow-up as competing risks. Results: Of 3668 children included, median age at ART initiation was 6.1 (interquartile range (IQR), 1.7-10.5) years. Initial regimens were 32% PI based, 34% nevirapine (NVP) based, and 33% efavirenz based. Median duration of follow-up was 5.4 (IQR, 2.9-8.3) years. Cumulative incidence of switch at 5 years was 21% (95% confidence interval, 20%-23%), with significant regional variations. Median time to switch was 30 (IQR, 16-58) months; two-thirds of switches were related to treatment failure. In multivariable analysis, older age, severe immunosuppression and higher viral load (VL) at ART start, and NVP-based initial regimens were associated with increased risk of switch. Conclusions: One in 5 children switched to a second-line regimen by 5 years of ART, with two-thirds failure related. Advanced HIV, older age, and NVP-based regimens were associated with increased risk of switch

Portafolios Grado en Enfermería 2013-2014. Practicum I,II,III,IV,V,VI,VII

Documento de registro personal de prácticas clínicas para los estudiantes de Grado en Enfermería de la Universidad de Cádiz.Documento de registro de prácticas clínicas para los estudiantes de Grado en Enfermería. Basado en el aprendizaje reflexivo. El documento es único para todo el practicum, de manera que el estudiante va cumplimentándolo y realizando las actividades solicitadas en cada curso. Incluye un apartado de requisitos, recomendaciones y normas y el listado de actividades y tareas a realizar por cada curso académico. Además introduce en cada bloque de actividades, un apartado para la reflexión personal del estudiante.Documento de 36 páginas, en formato word

Aprendo a desplazarme con total seguridad

Se desarrolla un proyecto de innovación educativa que pretende sensibilizar al alumnado hacia comportamientos correctos en los espacios comunes: en la calle, en los parques, o en las carreteras. Pretende desarrollar hábitos de comportamiento correcto en relación con los desplazamientos a pie, en los desplazamientos en vehículos y en los desplazamientos colectivos. Se trata de aprender a valorar el riesgo que supone para uno mismo y para los demás el uso inadecuado de los espacios comunes y el incumplimiento de las normas en los desplazamientos. El proyecto trata de conocer las señalizaciones relacionadas con el tráfico y la circulación en general y valorar la importancia de respetar esas normas de seguridad y señales. Se trata de tomar conciencia de las dificultades de desplazamiento que se presentan a personas con discapacidad, transitoria o permanente, y de las barreras que creamos para esas mismas personas, contribuyendo a una sensibilización hacia comportamientos correctos en el seno de la familia. La experiencia se ha llevado a cabo en todos los niveles de Infantil y Primaria. El proyecto ha incidido en muchas familias, a pesar de su escasa asistencia a la charla organizada para ellas y ha tenido repercusión también en el barrio, al participar la Policía de Barrio en el desarrollo de algunas actividades. En la etapa de Educación Infantil se ha desarrollado programación de dos unidades didácticas que han servido para realizar actividades de grupo e individuales, y para Educación Primaria se ha creado un cuaderno de trabajo adaptado a cada nivel. El proyecto de innovación ha destacado con resultados favorables: la verbalización de conductas positivas y negativas en los comportamientos propios y en el seno de la familia relacionadas con los desplazamientos en la calle, en el coche familiar; la reflexión sobre algunos aspectos que habitualmente mantenemos inconscientes, tales como las consecuencias de los accidentes y las dificultades que sufren las personas con alguna discapacidad; la estimulación de actitudes de respeto a las normas de tráfico, tratando de desarraigar hábitos peligrosos en los desplazamientos.Castilla y LeónConsejería de Educación. Dirección General de Universidades e Investigación; Monasterio de Nuestra Señora de Prado, Autovía Puente Colgante s. n.; 47071 Valladolid; +34983411881; +34983411939ES

Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P <0.01) and previous renal failure (57.9%, P <0.01). Patients treated with cloxacillin presented higher rates of septic shock (25%, P = 0.033) and new-onset or worsening renal failure (47.3%, P = 0.024) with significantly higher rates of in-hospital mortality (38.5%, P = 0.017). One-year IE-related mortality and rate of relapses were similar between treatment groups. None of the treatments were identified as risk or protective factors. Conclusion: Our results suggest that cefazolin is a valuable option for the treatment of MSSA IE, without differences in 1-year mortality or relapses compared with cloxacillin, and might be considered equally effective

Prevalence and Clinical Outcomes of Poor Immune Response Despite Virologically Suppressive Antiretroviral Therapy Among Children and Adolescents With Human Immunodeficiency Virus in Europe and Thailand: Cohort Study

International audienceIn human immunodeficiency virus (HIV)-positive adults, low CD4 cell counts despite fully suppressed HIV-1 RNA on antiretroviral therapy (ART) have been associated with increased risk of morbidity and mortality. We assessed the prevalence and outcomes of poor immune response (PIR) in children receiving suppressive ART

Prevalence and Clinical Outcomes of Poor Immune Response Despite Virologically Suppressive Antiretroviral Therapy Among Children and Adolescents With Human Immunodeficiency Virus in Europe and Thailand: Cohort Study

BACKGROUND: In human immunodeficiency virus (HIV)-positive adults, low CD4 cell counts despite fully suppressed HIV-1 RNA on antiretroviral therapy (ART) have been associated with increased risk of morbidity and mortality. We assessed the prevalence and outcomes of poor immune response (PIR) in children receiving suppressive ART. METHODS: Sixteen cohorts from the European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) contributed data. Children &lt;18 years at ART initiation, with sustained viral suppression (VS) (≤400 copies/mL) for ≥1 year were included. The prevalence of PIR (defined as World Health Organization advanced/severe immunosuppression for age) at 1 year of VS was described. Factors associated with PIR were assessed using logistic regression. Rates of acquired immunodeficiency syndrome (AIDS) or death on suppressive ART were calculated by PIR status. RESULTS: Of 2318 children included, median age was 6.4 years and 68% had advanced/severe immunosuppression at ART initiation. At 1 year of VS, 12% had PIR. In multivariable analysis, PIR was associated with older age and worse immunological stage at ART start, hepatitis B coinfection, and residing in Thailand (all P ≤ .03). Rates of AIDS/death (95% confidence interval) per 100 000 person-years were 1052 (547, 2022) among PIR versus 261 (166, 409) among immune responders; rate ratio of 4.04 (1.83, 8.92; P &lt; .001). CONCLUSIONS: One in eight children in our cohort experienced PIR despite sustained VS. While the overall rate of AIDS/death was low, children with PIR had a 4-fold increase in risk of event as compared with immune responders