453 research outputs found
Understanding walking and cycling:summary of key findings and recommendations
It is widely recognized that there is a need to increase levels of active and sustainable travel in British urban areas. The Understanding Walking and Cycling (UWAC) project, funded by the EPSRC, has examined the factors influencing everyday travel decisions and proposes a series of policy measures to increase levels of walking and cycling for short trips in urban areas. A wide range of both quantitative and qualitative data were collected in four English towns (Lancaster, Leeds, Leicester and Worcester), including a questionnaire survey, spatial analysis of the built environment, interviews (static and whilst mobile) and detailed ethnographies. Key findings of the research are that whilst attitudes to walking and cycling are mostly positive or neutral, many people who would like to engage in more active travel fail to do so due to a combination of factors. These can be summarised as:
Concerns about the physical environment, especially with regard to safety when walking or cycling;
The difficulty of fitting walking and cycling into complex household routines
(especially with young children);
The perception that walking and cycling are in some ways abnormal things to do. It is suggested that policies to increase levels of walking and cycling should focus not only on improving infrastructure (for instance through fully segregated cycle routes along main roads and restriction on vehicle speeds), but also must tackle broader social, economic, cultural and legal factors that currently inhibit walking and cycling. Together, such changes can create an environment in which driving for short trips in urban areas is seen as abnormal and walking or cycling seem the obvious choices. A joint project by by Lancaster University, Oxford Brookes University and the University of Leeds
F21RS SGB No. 3 (Constitutional amendment)
A Bill
To amend the Constitution of the Student Government of Louisiana State Universit
F21RS SGR No. 5 (Memorial Day)
A Resolution
To Urge and Request LSU Faculty to not hold University classes on Memorial Da
The role of apoptosis in the development of AGM hematopoietic stem cells revealed by Bcl-2 overexpression
Apoptosis is an essential process in embryonic tissue remodeling and adult
tissue homeostasis. Within the adult hematopoietic system, it allows for
tight regulation of hematopoietic cell subsets. Previously, it was shown
that B-cell leukemia 2 (Bcl-2) overexpression in the adult increases the
viability and activity of hematopoietic cells under normal and/or
stressful conditions. However, a role for apoptosis in the embryonic
hematopoietic system has not yet been established. Since the first
hematopoietic stem cells (HSCs) are generated within the
aortagonad-mesonephros (AGM; an actively remodeling tissue) region
beginning at embryonic day 10.5, we examined this tissue for expression of
apoptosis-related genes and ongoing apoptosis. Here, we show expression of
several proapoptotic and antiapoptotic genes in the AGM. We also generated
transgenic mice overexpressing Bcl-2 under the control of the
transcriptional regulatory elements of the HSC marker stem cell antigen-1
(Sca-1), to test for the role of cell survival in the regulation of AGM
HSCs. We provide evidence for increased numbers and viability of Sca-1(+)
cells in the AGM and subdissected midgestation aortas, the site where HSCs
are localized. Most important, our in vivo transplantation data show that
Bcl-2 overexpression increases AGM and fetal liver HSC activity, strongly
suggesting that apoptosis plays a role in HSC development
Cerberus : a human powered vehicle
A recumbent trike was designed and built for the ASME Human Powered Vehicle Challenge held at San Jose State University in April of 2013. The vehicle was designed to be low cost for use by commuters and as primary transportation in developing countries. The vehicle placed 11th overall in the competition out of 29 teams, and scored 8th in the innovation event, which was its best ranking out of the 5 individual events
Variational water-wave model with accurate dispersion and vertical vorticity
A new water-wave model has been derived which is based on variational techniques and combines a depth-averaged vertical (component of) vorticity with depth-dependent potential flow. The model facilitates the further restriction of the vertical profile of the velocity potential to n-th order polynomials or a finite-element profile with a small number of elements (say), leading to a framework for efficient modeling of the interaction of steepening and breaking waves near the shore with a large-scale horizontal flow. The equations are derived from a constrained variational formulation which leads to conservation laws for energy, mass, momentum and vertical vorticity. It is shown that the potential-flow water-wave equations and the shallow-water equations are recovered in the relevant limits. Approximate shock relations are provided, which can be used in numerical schemes to model breaking waves
Why business angels reject investment opportunities: Is it personal?
A major focus of research on business angels has examined their decision-making processes and investment criteria. As business angels reject most of the opportunities that they receive, this article explores the reasons informing such decisions. In view of angel heterogeneity, investment opportunities might be expected to be rejected for differing reasons. Two sources of data are used to examine this issue. Face-to-face interviews with 30 business angels in Scotland and Northern Ireland provided information on typical ‘deal killers’. This was complemented by an Internet survey of United Kingdom that attracted responses from 238 UK business angels. The findings confirm that the main reason for rejection relates to the entrepreneur/management team. However, angel characteristics do not explain the number of reasons given for opportunity rejection nor do they predict the reasons for rejecting investment opportunities. This could be related to the increasing trend for business angels to join organised groups which, in turn, leads to the development of a shared repertoire of investment approaches. We suggest the concept of ‘communities-of-practice’ as an explanation for this finding
Minimum Information about a Neuroscience Investigation (MINI) Electrophysiology
This module represents the formalized opinion of the authors and the CARMEN consortium, which identifies the minimum information required to report the use of electrophysiology in a neuroscience study, for submission to the CARMEN system (www.carmen.org.uk).

ARL3 mutations cause Joubert syndrome by disrupting ciliary protein composition
Joubert syndrome (JBTS) is a genetically heterogeneous autosomal recessive neurodevelopmental
ciliopathy. We investigated further the underlying genetic etiology of Joubert syndrome by studying
two unrelated families in whom JBTS was not associated with pathogenic variants in known JBTSrelated
genes. Combined autozygosity mapping of both families highlighted a candidate locus on
chromosome 10 (chr10: 101569997-109106128 (hg 19)), and exome sequencing revealed two
missense variants in ARL3 within the candidate locus. The encoded protein, ADP Ribosylation
Factor-Like GTPase 3, ARL3, is a small GTP-binding protein that is involved in directing lipid-modified
proteins into the cilium in a GTP-dependent manner. Both missense variants replace the highly
conserved Arg149 residue, which we show to be necessary for the interaction with its guanine
nucleotide exchange factor ARL13B, such that the mutant protein is associated with reduced INPP5E
and NPHP3 localisation in cilia. We propose that ARL3 provides a potential hub in the network of
encoded ciliopathy genes, whereby perturbation of ARL3 results in the mislocalisation of multiple
ciliary proteins due to abnormal displacement of lipidated protein cargo
- …