19 research outputs found
Imaging the Circumnuclear Region of NGC 1365 with Chandra
- Author
- Arnaud
- Baldi
- Baldi
- Colbert
- Colina
- Condon
- Croston
- Dahlem
- Dahlem
- Engelbracht
- Evans
- Evans
- Fabbiano
- Fabbiano
- Fabbiano
- Fabbiano
- Fazio
- Ferruit
- Figer
- Freeman
- G. Fabbiano
- G. Risaliti
- Gibson
- González Delgado
- Heckman
- Hjelm
- Hopkins
- Iyomoto
- J. H. Howell
- J. M. Mazzarella
- Jones
- Junfeng Wang
- Kallman
- Komossa
- Kraemer
- Kraft
- Kristen
- Lindblad
- M. Elvis
- Madore
- McDowell
- Mengel
- Muno
- Nagataki
- Ogle
- Osterbrock
- Phillips
- Read
- Risaliti
- Risaliti
- Risaliti
- Roy
- Ryter
- S. Lord
- Sakamoto
- Sakamoto
- Sandage
- Sanders
- Sandqvist
- Sandqvist
- Schmitt
- Schulz
- Scoville
- Silbermann
- Silk
- Smith
- Storchi-Bergmann
- Strateva
- Strickland
- Strickland
- Strickland
- Swartz
- Tucker
- Tyler
- Veilleux
- Veilleux
- Veron
- Wang
- Weaver
- Werner
- Wilms
- Wilson
- Yang
- Young
- Zacharias
- Publication venue
- 'IOP Publishing'
- Publication date
- 02/01/2009
- Field of study
We present the first Chandra/ACIS imaging study of the circumnuclear region
of the nearby Seyfert galaxy NGC 1365. The X-ray emission is resolved into
point-like sources and complex, extended emission. The X-ray morphology of the
extended emission shows a biconical soft X-ray emission region extending ~5 kpc
in projection from the nucleus, coincident with the high excitation outflow
cones seen in optical emission lines particularly to the northwest. Harder
X-ray emission is detected from a kpc-diameter circumnuclear ring, coincident
with the star-forming ring prominent in the Spitzer mid-infrared images; this
X-ray emission is partially obscured by the central dust lane of NGC 1365.
Spectral fitting of spatially separated components indicates a thermal plasma
origin for the soft extended X-ray emission (kT=0.57 keV). Only a small amount
of this emission can be due to photoionization by the nuclear source. Detailed
comparison with [OIII]5007 observations shows the hot interstellar medium (ISM)
is spatially anticorrelated with the [OIII] emitting clouds and has thermal
pressures comparable to those of the [OIII] medium, suggesting that the hot ISM
acts as a confining medium for the cooler photoionized clouds. The abundance
ratios of the hot ISM are fully consistent with the theoretical values for
enrichment from Type II supernovae, suggesting that the hot ISM is a wind from
the starburst circumnuclear ring. X-ray emission from a ~450 pc long nuclear
radio jet is also detected to the southeast.Comment: Accepted for publication in The Astrophysical Journal (April 2009).
50 pages, 13 figures, 6 table
The Lyman Continuum Escape Fraction of Star-forming Galaxies at 2.4≲z≲3.7 from UVCANDELS
- Author
- Alavi Anahita
- Ashcraft Teresa
- Bagley Micaela
- Baronchelli Ivano
- Barro Guillermo
- Blanche Alex
- Brammer Gabriel
- Broussard Adam
- Carleton Timothy
- Chartab Nima
- Cheng Yingjie
- Codoreanu Alex
- Cohen Seth
- Colbert James
- Conselice Christopher
- Dai Y. Sophia
- Darvish Behnam
- Dave Romeel
- De Mello Duilia
- DeGroot Laura
- Dickinson Mark
- Emami Najmeh
- Ferguson Henry
- Ferreira Leonardo
- Finkelstein Keely
- Finkelstein Steven
- Gardner Jonathan P.
- Gawiser Eric
- Gburek Timothy
- Giavalisco Mauro
- Grazian Andrea
- Grogin Norman
- Gronwall Caryl
- Guo Yicheng
- Haro Pablo Arrabal
- Hathi Nimish P.
- Hayes Matthew
- Hemmati Shoubaneh
- Howell Justin
- Iyer Kartheik
- Jansen Rolf A.
- Ji Zhiyuan
- Kaviraj Sugata
- Koekemoer Anton M.
- Kurczynski Peter
- Lazar Ilin
- Lucas Ray A.
- MacKenty John
- Mantha Kameswara Bharadwaj
- Martin Alec
- Martin Garreth
- McCabe Tyler
- Mehta Vihang
- Mobasher Bahram
- Nedkova Kalina
- O'Connell Robert
- Olsen Charlotte
- Otteson Lillian
- Prichard Laura
- Rafelski Marc
- Ravindranath Swara
- Redshaw Caleb
- Robertson Brant
- Rutkowski Michael
- Sattari Zahra
- Scarlata Claudia
- Siana Brian
- Smith Brent M.
- Soto Emmaris
- Sunnquist Ben
- team the UVCANDELS
- Teplitz Harry I.
- Vanzella Eros
- Wang Xin
- Windhorst Rogier A.
- Yung L. Y. Aaron
- Zabelle Bonnabelle
- Publication venue
- Publication date
- 17/08/2023
- Field of study
The UltraViolet Imaging of the Cosmic Assembly Near-infrared Deep
Extragalactic Legacy Survey Fields (UVCANDELS) survey is a Hubble Space
Telescope (HST) Cycle-26 Treasury Program, allocated in total 164 orbits of
primary Wide-Field Camera 3 Ultraviolet and Visible light F275W imaging with
coordinated parallel Advanced Camera for Surveys F435W imaging, on four of the
five premier extragalactic survey fields: GOODS-N, GOODS-S, EGS, and COSMOS. We
introduce this survey by presenting a thorough search for galaxies at
z≳2.4 that leak significant Lyman continuum (LyC) radiation, as well as
a stringent constraint on the LyC escape fraction (fesc) from stacking
the UV images of a population of star-forming galaxies with secure redshifts.
Our extensive search for LyC emission and stacking analysis benefit from the
catalogs of high-quality spectroscopic redshifts compiled from archival
ground-based data and HST slitless spectroscopy, carefully vetted by dedicated
visual inspection efforts. We report a sample of five galaxies as individual
LyC leaker candidates, showing fescrel≳60% estimated
using detailed Monte Carlo analysis of intergalactic medium attenuation. We
develop a robust stacking method to apply to five samples of in total 85
non-detection galaxies in the redshift range of z∈[2.4,3.7]. Most stacks
give tight 2-σ upper limits below fescrel<6%. A stack
for a subset of 32 emission-line galaxies shows tentative LyC leakage detected
at 2.9-σ, indicating fescrel=5.7% at z∼2.65,
supporting the key role of such galaxies in contributing to the cosmic
reionization and maintaining the UV ionization background. These new F275W and
F435W imaging mosaics from UVCANDELS have been made publicly available on the
Barbara A. Mikulski Archive for Space Telescopes.Comment: 33 pages, 21 figures, and 5 tables. Resubmitted after addressing the
referee repor
Coastal Upwelling Supplies Oxygen-Depleted Water to the Columbia River Estuary
- Author
- A Huyer
- A Paulmier
- António M. Baptista
- B Grantham
- B Hales
- BA Ryan
- BA Sullivan
- BM Hickey
- BM Hickey
- BM Kennedy
- Breitburg
- C Deutsch
- C Hauri
- CA Brown
- CE Warren
- CM Whitmore
- CS Price
- CW Sigleo AC Mordy
- D Colbert
- DA Armstrong
- DA Jay
- DD Dauble
- DD Roby
- Diaz
- DL Breitburg
- DL Curtis
- DL Kramer
- DM Kaplan
- E Di Lorenzo
- EA Pearson
- EL Hazen
- F Chan
- G. Curtis Roegner
- GC Roegner
- GC Roegner
- GC Roegner
- GC Roegner
- GC Roegner
- GE Davis
- HJ Freeland
- IJ McGaw
- IK Birtwell
- IK Birtwell
- JC Davis
- JJ Helly
- JL Bernatis
- Joseph A. Needoba
- JS Alabaster
- Juan A. Añel
- JW Beeman
- K Collis
- KW Bruland
- L Haertel
- L Herfort
- L Stramma
- MA de Angelis
- MC Lohan
- MG Mesa
- ML Dahlberg
- NN Rabalais
- NP Nezlin
- NS Banas
- PA Wheeler
- PC Sugerman
- Prahl
- R Vaquer-Sunyer
- RA Feely
- RD Seitz
- RF Keeling
- RJ Diaz
- RM Tyler
- RP Stone
- S Bricker
- SA Ludsin
- SB Bricker
- SJ Bograd
- SJ Webster
- SL Vargo
- T Järvi
- T Takahashi
- Whitney
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Low dissolved oxygen (DO) is a common feature of many estuarine and shallow-water
environments, and is often attributed to anthropogenic nutrient enrichment from
terrestrial-fluvial pathways. However, recent events in the U.S. Pacific
Northwest have highlighted that wind-forced upwelling can cause naturally
occurring low DO water to move onto the continental shelf, leading to
mortalities of benthic fish and invertebrates. Coastal estuaries in the Pacific
Northwest are strongly linked to ocean forcings, and here we report observations
on the spatial and temporal patterns of oxygen concentration in the Columbia
River estuary. Hydrographic measurements were made from transect (spatial
survey) or anchor station (temporal survey) deployments over a variety of wind
stresses and tidal states during the upwelling seasons of 2006 through 2008.
During this period, biologically stressful levels of dissolved oxygen were
observed to enter the Columbia River estuary from oceanic sources, with minimum
values close to the hypoxic threshold of 2.0 mg L−1. Riverine
water was consistently normoxic. Upwelling wind stress controlled the timing and
magnitude of low DO events, while tidal-modulated estuarine circulation patterns
influenced the spatial extent and duration of exposure to low DO water. Strong
upwelling during neap tides produced the largest impact on the estuary. The
observed oxygen concentrations likely had deleterious behavioral and
physiological consequences for migrating juvenile salmon and benthic crabs.
Based on a wind-forced supply mechanism, low DO events are probably common to
the Columbia River and other regional estuaries and if conditions on the shelf
deteriorate further, as observations and models predict, Pacific Northwest
estuarine habitats could experience a decrease in environmental quality
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
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- A. -G. Wu
- A. C. Ma
- A. K. Au
- Abdel-Aziz A. K.
- Abdelfatah S.
- Abdellatif M.
- Abdoli A.
- Abel S.
- Abeliovich H.
- Abildgaard M. H.
- Abudu Y. P.
- Acevedo-Arozena A.
- Adamopoulos I. E.
- Adeli K.
- Adolph T. E.
- Adornetto A.
- Aflaki E.
- Agam G.
- Agarwal A.
- Aggarwal B. B.
- Agnello M.
- Agostinis P.
- Agrewala J. N.
- Agrotis A.
- Aguilar P. V.
- Ahmad S. T.
- Ahmed Z. M.
- Ahumada-Castro U.
- Aits S.
- Aizawa S.
- Akkoc Y.
- Akoumianaki T.
- Akpinar H. A.
- Al-Abd A. M.
- Al-Akra L.
- Al-Gharaibeh A.
- Alaoui-Jamali M. A.
- Alberti S.
- Alcocer-Gomez E.
- Alessandri C.
- Ali M.
- Alim Al-Bari M. A.
- Aliwaini S.
- Alizadeh J.
- Almacellas E.
- Almasan A.
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-Gómez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
- Alves da Costa C
- Alves S
- Alzaharna MM
- Amadio M
- Amantini C
- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
- Andrabi SA
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- Angelini S
- Ann D
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- Arévalo M-A
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- Aschner M
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- Atanasov AG
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- Zhuang H
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- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
HIV-Nef Protein Transfer to Endothelial Cells Requires Rac1 Activation and Leads to Endothelial Dysfunction Implications for Statin Treatment in HIV Patients
- Author
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 27/08/2019
- Field of study
Rationale
Even in antiretroviral therapy (ART) treated patients, HIV continues to play a pathogenic role in cardiovascular diseases. A possible cofactor may be persistence of the early HIV response gene Nef, which we have demonstrated recently to persist in the lungs of HIV+ patients on ART. Previously, we have reported that HIV strains with Nef, but not Nef-deleted HIV strains, cause endothelial proinflammatory activation and apoptosis.
Objective
To characterize mechanisms through which HIV-Nef leads to the development of cardiovascular diseases using ex vivo tissue culture approaches as well as interventional experiments in transgenic murine models.
Methods and Results
EV (extracellular vesicles) derived from both peripheral blood mononuclear cells (PBMC) and plasma from HIV+ patient blood samples induced human coronary artery endothelial cells dysfunction. Plasma derived EV from ART+ patients that were HIV-Nef+ induced significantly greater endothelial apoptosis compared to HIV-Nef- plasma EV. Both HIV-Nef expressing T cells and HIV-Nef-induced EV increased transfer of cytosol and Nef protein to endothelial monolayers in a Rac1-dependent manner, consequently leading to endothelial adhesion protein upregulation and apoptosis. HIV-Nef induced Rac1 activation also led to dsDNA breaks in endothelial colony forming cells (ECFC), thereby resulting in ECFC premature senescence and eNOS downregulation. These Rac1 dependent activities were characterized by NOX2-mediated ROS production. Statin treatment equally inhibited Rac1 inhibition in preventing or reversing all HIV-Nef-induction abnormalities assessed. This was likely due to the ability of statins to block Rac1 prenylation as geranylgeranyl transferase inhibitors were effective in inhibiting HIV-Nef-induced ROS formation. Finally, transgenic expression of HIV-Nef in endothelial cells in a murine model impaired endothelium-mediated aortic ring dilation, which was then reversed by 3-week treatment with 5mg/kg atorvastatin.
Conclusion
These studies establish a mechanism by which HIV-Nef persistence despite ART could contribute to ongoing HIV related vascular dysfunction which may then be ameliorated by statin treatment
Short notes
- Author
- Publication venue
- 'Edinburgh University Press'
- Publication date
- Field of study
Business impact of procedural justice leadership: organizational commitment mediated
- Author
- Adams J. S.
- Alexander S.
- Allen N. J.
- Baron G. A.
- Becker B.
- Clegg C. W.
- Colbert B. A.
- De Cremer D.
- Delaney J. T.
- Fiske S. T.
- Folger R.
- Fryxell G. E.
- Greenberg J.
- Konovsky M. A.
- Korsgaard M. A.
- Lado A. A.
- Large M.
- Meyer J. P.
- Meyer J. P.
- Mowday R. T.
- Niehoff B. P.
- O'Reilly C. III.
- Sweeney P.
- Tyler T. R.
- 고수일
- 김호정
- 나순복
- 서재현
- 서재현
- 윤대혁
- 이철우
- 임준철
- Publication venue
- 'Korea International Trade Research Institute'
- Publication date
- Field of study
VESTIBULAR PROCESSING DYSFUNCTION IN CHILDREN WITH SEVERE EMOTIONAL AND BEHAVIOR DISORDERS:
- Author
- Ayres A
- Ayres A
- Ayres A J
- Ayres A J
- Ayres A J
- Ayres A J.
- Bender L A
- Bender L A
- Bender L A Freedman A M
- Bender LA
- Bergman P
- Colbert E
- Colbert E
- Fish B
- Gemandt BE
- Halpike C S
- Kenneth Ottenbacher
- Levy D
- Magnus R
- Maurer R G Damasio A R
- Montgomery P
- Omitz E
- Omitz E
- Omitz E M Brown M B, Mason A, Putnam N H
- Omitz E M Guthrie P.
- Omitz EM
- Omitz EM
- Omitz EM
- Omtz E
- Orlovsky G N
- Ornitz E
- Pollack M
- Pompeiano
- Ritvo ER
- Schilder P
- Schilder P
- Sherrington C S
- Tyler D P Bard P
- Wilson V
- Young L R Dichgans J, Murphy R, Brandt T
- Yule W
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Lifetime physical activity and pelvic organ prolapse in middle-aged women
- Author
- Ainsworth
- Ali-Ross
- Besson
- Braekken
- Brand
- Bump
- Chan
- Chasan-Taber
- Chasan-Taber
- Chiaffarino
- Colbert
- Cook
- DeLancey
- Donders
- Egger
- Elkadry
- Friedenreich
- Hall
- Handa
- Hankinson
- Hendrix
- Ingrid E. Nygaard
- Janet M. Shaw
- Jorgensen
- Kobak
- Larsen
- Larsen
- Lewicky-Gaupp
- Lissner
- Lukacz
- Lukacz
- Marlene J. Egger
- Miedel
- Nygaard
- Nygaard
- Nygaard
- Pearce
- Sandvik
- Sandvik
- Slieker-ten Hove
- Smith
- Spernol
- Sung
- Textor
- Tosteson
- Troiano
- Tyler Bardsley
- van Buuren
- Wagner
- Waller
- Woodman
- Yuan
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study