5 research outputs found
Overcoming Clinical Barriers to Exclusive Breastfeeding
- Author
- Ahluwalia
- Akuse
- Bain
- Bartick
- Batan
- Bolton
- Bramson
- Braun
- Brazelton
- Bunik
- Bunik
- Bunik
- Chapman
- Chapman
- Chapman
- Chezem
- Cloherty
- Czank
- Dabritz
- Daly
- Daly
- Damota
- Declercq
- Dewey
- Dewey
- DiGirolamo
- Dusdieker
- Dyson
- Eidelman
- Engle
- Erkkola
- Fein
- Fein
- Feinstein
- Feldman-Winter
- Feldman-Winter
- Fewtrell
- Gagnon
- Gatti
- Green
- Grummer-Strawn
- Guendelman
- Harder
- Hartmann
- Heinig
- Hill
- Holmes
- Holmes
- Hornell
- Ip
- Kramer
- Kramer
- Kristiansen
- Labarere
- Lauzon-Guillain
- Lawrence
- Li
- Mandal
- Marianne Neifert
- Mattox
- Maya Bunik
- McQueen
- Meier
- Merewood
- Merewood
- Mohrbacher
- Moore
- Morrison
- Murray
- Neifert
- Neifert
- Neville
- Neville
- Nommsen-Rivers
- Nommsen-Rivers
- Ogbuanu
- Olds
- Olson
- Perrine
- Philipp
- Pisacane
- Pollard
- Prime
- Profit
- Reiff
- Rempel
- Renfrew
- Rosenberg
- Sadacharan
- Scott
- Shealy
- Snell
- Suitor
- Surgeon General's report: US Department of Health and Human Services
- Taveras
- Taveras
- Taveras
- Tender
- Tohotoa
- Wilhelm
- Wright
- Yun
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
- Author
- Aantaa Riku
- Abdel-Hafiz Mostafa
- Abdelaal Amr
- Abou-Samra Mark
- Absalom Anthony
- Acevedo Bambaren Ismael
- Adam Christian
- Adriaens Veronique
- Afshari Arash
- Ahmed Samira
- Alanoglu Zekeriyya
- Albarello Raffaella
- Albokrinov Andrew
- Alders David
- Alderson Peter
- Alexandri Bogdan
- Ali Eissa Eid Mohamed
- Alkis Neslihan
- Allen Claire
- Allison Celia
- Almenrader Nicole
- Amaral Rosa
- Amory Catherine
- Ancupans Agris
- Anders Kroken Bjørn
- Anders Nicola
- Angadi Pradeep
- Angeles Sanz M.
- Anselmi Irene
- Anselmi Luciano
- Antonio Idone Francesco
- Anuncia Escontrela RodrĂguez Blanca
- Armoniene Inesa
- Artes David
- Aslami Hamid
- Astuto Marinella
- Audren Noémie
- Aurilio Caterina
- Ayyash Reema
- Babici Remus
- Badarau Victoria
- Badeti Rodica
- Baethge Sabine
- Bakken Boerke Wenche
- Balamat Stefania
- Bandrabur Daniela
- Banerjee Indrani
- Banus Ester
- Bapat Smita
- Baraggia Paolo
- Barak Yuri
- Baranowski Artur
- Barber Nicola
- Barbera Cinzia
- Barbunc Danut
- Bari Francoise
- Baris Sibel
- Barlow Victoria
- Barr Katharine
- Bartholomew Karen
- Bartkowska-Sniatkowska Alicja
- Barzdina Arta
- Basiewicz Ewa
- Basov Mikhail
- Bassett Mike
- Batoz Hélène
- Bauer Annette
- Bauer Martin
- Bauer Michael
- Baujard Catherine
- Bauwman Arthur
- Beate Solas Anne
- Becke Karin
- Becke Karin
- Begec Zekine
- Bekavac Ivan
- Bell Graham
- Bell Sarah J
- Benito Pilar
- Berger Jelena
- Berghmans Johan
- Bergland Unni
- Bergsma Margot
- Bermede Onat
- Bernhard Eich Christoph
- Bernotiene Aurelija
- Berton Jerome
- Bevilacqua Michela
- Bew Stephanie
- Bird Victoria
- Birliba Mihaela-Petronela
- Biskupova Vera
- Bloomfield Tom
- Blythe Elizabeth
- Boda Krisztina
- Boda Krisztina B
- Boegli Yann
- Bollinger Matthias
- Book Malte
- Bordes Maryline
- Bortone Luciano
- Boryshkevych Ivanna
- Bourdaud Nathalie
- Boyd Matthew
- Boyle David
- Bracci Paolo
- Brackhahn Michael
- Bradbury Carol L.
- Breschan Christian
- Brezac Gilles
- Briggs Sandra
- Brotatsch Philipp
- Browning Mike
- Budic Ivana
- Buhre Wolfgang
- Busche René
- Busi Ilaria
- Bussolin Leonardo
- Butkovic Diana
- Butler Patrick
- Byers Gordon
- Börjesson Glenda
- Bøttger Morten
- Cabanova Barbora
- Cagney Brid
- Cakar Turhan K. Sanem
- Calderini Edoardo
- Calvao Santos Carolina
- Camporesi Anna
- Camus Blandine
- Capusan Alin
- Carachi Peter
- Carre Anne-Charlotte
- Cartal Marielle
- Casaer Sari
- Castellheim Albert
- Casutt Mattias
- Catalina Ionescu Gabriela
- Cavalier Alison
- Cecini Mariateresa
- Cento Valeria
- Cerati Giorgia
- Cerne Uros
- Cerutti Elisabetta
- Cettler Maciej
- Ceuca Daniela
- Ceyda Meco Basak
- Chapotte Catherine
- Chazelet Chantal
- Checinska Magdalena
- Checuti Sarah
- Chee Lew-Chin
- Childs Sophie
- Chirichiello Luca
- Chizhov Dmitri
- Chlopin Mikhail
- Chloropoulou Pelagia
- Christian Nilsson Jens
- Chrysi Mpratzou
- Cigdem TĂĽtĂĽncĂĽ Ayse
- Cillis Annagrazia
- Cimpeanu Luminita
- Cindea Iulia
- Ciobanu Tudor
- Clausen Nicola G.
- Cloherty Marianne
- Cnudde Steven
- Cohen Marc
- Colbus Laurent
- Coppens Marc
- Corouge Julien
- Cortegiani Andrea
- Coucke Patricia
- Crawford Michael
- Cristina Mondardini Maria
- Cuciuc Veaceslav
- Cucui-Cozma Cosmina
- Cullen Julia
- Cullen Pauline
- Cumming Craig
- D'Alessandro Sandra
- Dadure Christophe
- Dahmani Souhayl
- Dalton Andrew
- Dalton Mark
- Damps Maria
- Darwin Leanne
- Daugelavicius Vidunas
- Davidescu Irina
- Davidson Sarah
- Davies Jack
- Davies Kay
- Davin Isabelle
- Davison Rachel
- Day Alexandra
- De Abreu Leidy
- de Graaff Jurgen C.
- De Groote Françoise
- De Hert Stefan
- De Josemaria Belen
- de la Brière Francois
- De La Cruz Benito Fausto
- De Lorenzo Brita
- De Melo Eric
- De Pooter Françoise
- De Smet Karen
- De Villé Andrée
- Debrabant Lise
- Dei Giudici Luigi
- Dekens Jacky
- Dekker Elsa
- del RĂo Cristina
- Delcuze Axelle
- Desjeux Luc
- Diacono Jacques
- Dickinson Matthew
- Didier Anne
- Diers Anja
- Dirckx Maaike
- Disma Nicola
- Disma Nicola
- Divák Jan
- Diwan Rishi
- Dix Philippa
- Djapic Dajana
- Dockiene Ilona
- Dogger Jaap
- Dolci Mirko
- Dolinaj Vladimir
- Domingas Patuleia M.
- DomĂnguez Fernando
- Dons-Sinke Ilse
- Dorman Teresa
- Draskovic Biljana
- Druot Emilie
- Duflo Frédéric
- Dumitru Rusu Florin
- Dupont Hervé
- Eberl Susanne
- Ecoffey Claude
- Ehm Birgit
- Eisner Christoph
- Eissa Ayman
- Elena Malos Anca
- Elizabeth Biercamp Claire
- Ellekvist Marguerite B.
- Ellerkmann Richard
- Ellwood James
- Engel Nicole
- Engelhardt Thomas
- Eniko Kovacs
- Ephraim Erik
- Erb Christian
- Erb Thomas
- Errass Loreen
- Fairgrieve Ross
- Faliszewski Isabella
- Farinelli Ivano
- Farquharson Pamela
- Feliu Montserrat
- Fiedler Fritz
- Fischer Thomas
- Fisher Haran
- Flewin Lisa
- Foster Brian
- Franco Teresa
- Fredrik Lund Ole
- Frelich Michal
- Frey Denise
- Fritzsche Katrin
- Funk Wolfgang
- Gabilondo Garcia Gustavo
- Gabriella Elena Clement Maria
- Gaebler Ralf
- Gagey Anne-Charlotte
- Gaidelyte Lina
- Galinescu Irena
- Galvin Deborah
- Gande Richard
- Gandhi Monica
- Garces Antonio
- GarcĂa Irene
- Garrigue Delphine
- Garrioch Sweyn
- Gatt David
- Gaynor James
- Geary Tim
- Geil Dfominik
- Genco Daniele
- Gerin Marc
- Gerling Volker
- Germann Reinhard
- Gernoth Christian
- Gestautaite Dalia
- Ghent Robert
- Gillberg Lars
- Gillet Patricia
- Giuseppe Picardo Sergio
- Glasgow Russell
- Glazunov Anton
- Godsiff Leisha
- Goebel Ulrich
- Gomes Cristina
- Goncharenko Galyna
- Gonçalves Marta
- Gooch Ingrid
- Gordeeva Elena
- Grau Catharina
- Grazzini Maurizia
- Grein Elodie
- Grindheim Guro
- Grundmann Ulrich
- Grynyuk Andry
- Guarracino Fabio
- Guddo Annamaria
- Guedes Isabel
- Guericke Holger
- Guerin Christilynn
- Guido Locatelli Bruno
- Guillier Marion
- Gurita Adriana
- Gurita Adriana
- Guskov Igor
- Gutierrez Valcarcel Andrea
- Gutierrez Ignacio
- Gutmann Anton
- Guzman Ines
- Gymoese Berthelsen Kasper
- Habre Walid
- Habre Walid
- Hammerschlag Jacinda
- Hamonic Yann
- Hannie J.
- Hansen Tom G
- Hansen Tom G.
- Hanula Miloslav
- Happo Johanna
- Harden Alison
- Hare Alison
- Harlet Pierre
- Harmen Herrema Idse
- Harris Sarah
- Harrison Richard
- Hasani Antigona
- Hashimi Medita
- Hatipoglu Zehra
- Hawksworth Chris
- Hayem Catherine
- Hearn Robert
- Hedlund Lars
- Hein Maximilian
- Helena Gaitan M.
- Heli Litvic Dubravka
- Helm Emma
- Heyse Björn
- Himpe Dirk
- Hinz José
- Hivey Sarah
- Hizal Ayse
- Hobbs Amy
- Hochhold Christoph
- Hodgetts Vanessa
- Hoeft Andreas
- Hoehne Claudia
- Hofmann Ulrich
- Hogea Cristiana
- Holy Rolf
- Homer Rachel
- Hopman Geranne A. J.
- Horhota Lucian
- Huber Matthias
- Hullatt Laurence
- Hunter Catherine
- Hurni Thomas
- Hussain Nageena
- Hussey Joseph
- Hutchinson Adel
- Huygens Christel
- Hölzle Martin
- Ilie Luminita
- Ilksen Toprak Huseyin
- Ilmoja Mari-Liis
- Ingeborg Madsen Birgitte
- Ioannou Ioannis
- Iordanidou Despoina
- Ireland Nicholas
- Irwin Janice
- Isohanni Mika
- Isselhorst Carsten
- Ivani Giorgio
- Ivanov Alexander
- Ivascu Constantin
- Izzo Francesca
- Jack Ewan
- Jacomet Alfred
- Jacqmarcq Olivier
- Jamil Yosry
- jan Scheffer Gert
- Janjevic Dusanka
- Jeng Min Law Savio
- Jerome Kevin
- Jetzek-Zader Martin
- Jiménez Anabel
- Joao Susano Maria
- Johanne Lynch
- Johansen Mathias
- John Robert
- Johnston Graham
- Jokinen Johanna
- Jones Gareth
- Joukes Ellen
- Julien-Marsollier Florence
- Jureckova Lucie
- Juzwa Magdalena
- Jöhr Martin
- Jöhr Martin
- Kachko Ludmyla
- Kahn David
- Kalagac Fabris Lada
- Kalliardou Evagelia
- Kappen Teus H.
- Karadeniz Meltem Savran
- Karjagin Juri
- Katz Jacob
- Kaufmann Nils
- Kazak Bengisun Zuleyha
- Keilhauer Julia
- Kelgeri Nivedita
- Kemal Arslantas Mustafa
- Kendigelen Pinar
- Kerovec Soric Ivana
- Kesic-Valpotic Gordana
- Khaffaf Ranj
- Khotcholava Magda
- Khrapak Maksym
- Kienbaum Peter
- Kikas Reet
- Kindermann Petra
- King Stephanie
- Kirilov Dmitry
- Kirton Christine
- Kiviluoma Kai
- Klimscha Walter
- Kloessing Jan
- Klymenko Tetyana
- Knauss Kristina
- Knezevic Mirjana
- Kochkin Vladimir
- Koessler Herbert
- Konecny Regina
- Kopycinska Renata
- Kortgen Andreas
- Kotecha Ami
- Kotzeva Svetlana
- Kranke Peter
- Krikstaponiene Jolita
- Kroess Ruth
- Kuehhirt Thomas
- Kuppers Beate
- Kusnirikova Zuzana
- Kyselova Iryna
- Ladak Nadia
- Laffargue Anne
- Lagarde Sylvaine
- Lako Sandra
- Lalot Michaël
- Lambelin Veronique
- Lambotte Patricia
- Lang Colin
- Lapi Maria
- Larcher Claire
- Laschat Michael
- Lauweryns Julie
- Lazarev Vladimir
- Lazaro Juan J
- Le Freche Hélène
- Leal Teresa
- Lechat Jean-Paul
- Leclercq Mickeal
- Lee Clover-Ann
- Lee Corina
- Lee Juliette
- Legrand Aurélien
- Lehousse Thierry
- Lejus Corinne
- Lesmes Carlos
- Leva Brigitte
- Leva Brigitte
- Levinzon Michael
- Levitchi Roxana
- Levy David
- LeĂłn Carsi Irene
- Lhubat Elizabeth
- Lindenskov Pal H H
- Lipczynski Dariusz
- Liyanage Ganga
- Locke Christie
- Lofino Giuseppe
- Lomas Bernadette
- Longobardo Annalisa
- Lonsdale Hannah
- Love David
- Loveniers Birgit
- Lucia Pinciroli Rosa
- Ludot Hugues
- Lugovoy Alexander
- Lukosiene Laura
- Luntzer Robert
- Lyly Anniina
- LĂłpez Galera SĂlvia
- Machado Elvira
- Machotta Andreas
- Mackiewicz Tomasz
- Mackova Iveta
- Maddalena Schellino Maria
- Mader Thomas
- Magasich Natalia
- Magner Claire
- Mahadewsing Ravin
- Majid Saleem Mohammed
- Makin Andrew
- Malarkkan Nalini
- Malisiova Anna
- Mameli Leila
- Mandras Ana
- Manen Berga Ferran
- Manevich Yair
- Maniora Maud
- Manner Tuula
- Marchesini Laura
- Marchetti Giuliano
- Marco Valls Joan
- Marcucci Carine
- Marcus Ritchie
- Maretic Hrvoje
- Maria Gago Martinez Andrea
- Maria Nistor Alina
- Marie Drage Inger
- Marie Anais
- Marjanovic Vesna
- Marthe Ballovarre Kari
- Martikainen Kati
- Martinez Maldonado Ever
- MartĂnez Ruiz Alberto
- Mascarenhas Catia
- Masip Nuria
- Mauch Jacqueline
- Maupain Olivier
- Maurizio Raineri Santi
- Mausser Gerlinde
- Mawer Rebecca
- Mayell Antonia
- McClintock Joanna
- McKee Lesley
- Megens A. M.
- Meijer Patrick
- Melero Alicia
- Meneghini Luisa
- Merella Federica
- Mesbah Ahmed
- Messerer Brigitte
- Metrangolo Salvatore
- Meybohm Patrick
- Meyer-Treschan Tanja
- Michelon Stefania
- Micici Slobodan
- Mielke Golo
- Mierzewska-Schmidt Magdalena
- Mifsud Mark
- Mifsud Stephanie
- Migeon Anne
- Mihaela Gheorghe Ligia
- Mihaela Dubau
- Milde Alexander
- Milojevic Irina
- Minardi Carmelo
- Mircetic Maja
- Mitchell John
- Miulescu Magdalena
- Mixa Vladimir
- Mocioiu Gabriel
- Molies Dolors
- Monclus Enric
- Moncreiff Michael
- Moniz Antonio
- Monrigal Jean
- Montague James
- Montferrer NĂşria
- Montobbio Giovanni
- Moors Xavier
- Moraru-Draghici Lucia
- Morawk-Wintersperger Ulrike
- Morgan Judith
- Morton Neil
- Morton Neil S
- Moscaliuc Melania
- Moscatello Djurdjica
- Mossetti Valeria
- Muir Vimty
- Munar Francisca
- Munteanu Valentin
- Muro Cristina
- Najafi Nadia
- Nakhjavani Solmaz
- Nasser Leila
- Nastran Andraz
- Navaro Montserrat
- Nechaev Vladislav
- Neckebroek Martine
- Neiger Franz
- Nekrasov Konstantin
- Neri Simona
- Neumann Claudia
- Nicoleta Daraban
- Nolte Claire
- Noriega Bryant
- Nouette-Gaulain Karine
- Ntavlis Merkourios
- Numan Sandra C.
- Nuño Rosario
- O'Donahue Lizanne
- O'Hare Brendan
- Oberhauser Markus
- Ochsenreiter Miriam
- Oeding Joachim
- Olaru Valentin
- Oller Duque Lara
- Olmos Mendez Alberto
- Olteanu Dana
- Oppenrieder Karin
- Orliaguet Gilles
- Oshan Vimmi
- Ostreikov Ivan
- Ottolina Davide
- Ovezov Alexey
- Ozcengiz Dilek
- Ozer Yetkin
- Paal Peter
- Paiu Corneliu
- Paliokaite Evelina
- Pamies Carmen
- Pandurov Marina
- Parashchanka Aliaksandra
- Parasuraman Tamaraichelvi
- Pasini Lorena
- Passariello Leandro
- Patel Pradip
- Patel Shivali
- Pattar Alexander
- Paul Mission Jean
- Pauling Mark
- Pavlenko Vitaliy
- Pavlickova Jana
- Pearson Karen
- Pedro Pina AntĂłnio
- Pedrotti Dino
- Pegg Rachel
- Peiris Kawshala
- Peled Elia
- Pellegrini Michel
- Pereira Ricardo
- PerellĂł Marina
- Perera Remel
- Peresbota Daliana
- Perez Garcia Anibal
- Perez- Ferrer Antonio
- Perova-Sharonova Valentina
- Perry Nicole
- Peter Laura
- Petrescu Luxita
- Petrovic Sladjana
- Phaff Steen Nick
- Phillips Trudie
- Pick Darina
- Picker Olaf
- Pilla Clotaire
- Pino Gema
- Pirat Philippe
- Pirc Dejan
- Pirotte Thierry
- Pistidda Laura
- Pitino Sofia
- Plant Nina
- Platzer Manuela
- Plichon Benoit
- Plumb James
- Poduskov Evgeny
- Podvin Alexandre
- Poelaert Jan
- Popescu Barbura
- Popic Rok
- Popov Alexander
- Popovic Ljiljana
- Powell Alex
- Prat Mar
- Pratt Thomas
- Pregardien Caroline
- Preussler Niels-Peter
- Pribul Vicky
- Prysiazhniuk Dmytro
- Pryzmont Miroslaw
- Punt Kees
- Punzo Cinzia
- Puric Selena
- PĂ© d'Arca Sandra
- Quintel Michael
- Qureshi Arif
- Raber Manfred
- Rad Mandana
- Raffoflandreur Celine
- Raistrick Christopher
- Rajamani Balaji
- Ramminger Axel
- Ravi Radha
- Rawlinson Ellen
- Razlevice Ilona
- Reali Simone
- Rebac Vlatka
- Reikvam Tore
- Reindl Doris
- Reinert Jennifer
- Reinoso Barbero Francisco
- Retka Wlodzimierz
- Ribo Laura
- Richart Pierre
- Riche Jean-Claude
- Ricol Lainez Laura
- Riggenbach Christine
- Rizzo Giuliana
- Robert Philippe
- Roberts Steve
- Rodrigues Sara
- Rogerson David
- Roofthooft Eva
- Roos Torbjörn
- Rosada-Kurasinska Jowita
- Ross Mark
- Rossetti Francesca
- Rosu Lilica
- Roth Benjamin
- Roth Jens
- Roth Winfried
- Roulleau Philippe
- Roxo Helena
- Rubio Paloma
- Rudewicz Iwona
- Rudio Olga
- Rushman Sarah
- Russell Susan
- Russell William
- Russo Sebastian G.
- Rustemeyer Lydia
- Rutherford John
- Rutherford William
- RĂ©mond Charlotte
- Sa Angela
- Sabau Lucie
- Sabourdin Nada
- Sage Frederic
- Saha Rita
- Salgado Helena
- Salici Fabiana
- Salota Vishal
- Salvo Ida
- Samani Amee
- Sammartino Maria
- Sanchez Torres Cristel
- Sandström Kerstin
- Sanko Elena
- Sanna Andrea
- Sansone Pasquale
- Santos Maria
- Saour Anne-Charlotte
- Saviciene Nijole
- Savu Anca
- Sawicki Piotr
- Sbaraglia Fabio
- Scalisi Rita
- Schaefer Maximilian S.
- Schierlinger Bettina
- Schindler Ehrenfried
- Schink Cornel
- Schmain Dmitri
- Schmucker Erika
- Schoeler Michael
- Scholten Harm
- Schorer Clemens
- Schousboe Birgitte MB
- Schouten Anton N. J.
- Schramm Michael
- Schwarzkopf Konrad
- Sciascia Angela
- Scordo Lucia
- Scott-Warren Victoria
- Seabra Manuel
- Seidel-Ahyai Natascha
- Semjen François
- Serrano Silvia
- Seyhan Ozkan Tulay
- Sharman Sarah-Jane
- Shaw Neil
- Sheinkin Olga
- Shepherd Elizabeth
- Short Judith
- Sidlovskaite-Baltake Dominika
- Sieben Anne
- Siemek-Mitela Jadzia
- Sileo Rosanna
- Simhi Eliahu
- Simic Dusica
- Simic Irena
- Simin Jovana
- Simitzes Helena
- Simon Dominique
- Simpson Joanna
- Simurina Tatjana
- Sinclair John
- Singh Piyush
- Sinner Barbara
- Sirghie Rodica
- Sivrikoz Nuket
- Skaaden Lene
- Skacel Monika
- Sketcher Jonathan
- Sklyar Vitaliy
- Skordou Natalia
- Slater Patricia
- Slavkovic Bojana
- Smith Carolyn
- Smith Fiona
- Smith Natalie
- Smitz Carine
- Snoek Aarjan
- Sobczyk Jaek
- Sodhi Puja
- Sola Ruiz Eva
- Sola Chrystelle
- Sonzogni Valter
- Soskova Tereza
- Spahr-Schopfer Isabelle
- Spanjer Vera
- Spanjersberg Rob
- Sponheim Sjur
- Staals Lonneke
- Stack Charles
- Staiti Giuseppe
- Standl Thomas
- Starita Giusi
- Stasevski Vladyslav
- Steel Simon
- Stefan Violeta
- Steiner Maria
- Steinmann Johannes
- Stevanovic Vesna
- Stevens France
- Stevens Markus F
- Stevic Marija
- Steward Heather
- StoegermĂĽller Birgit
- Stoia Paolo
- Strachan Dominic
- Stranjanac Vladimir
- Straume Zane
- Stuck Tus Ivana
- Stupnik Spela
- Sulen Nina
- Supthut Hauke
- Surkov Denis
- Sutherland Paul
- Suvejan Mirela
- Svircevic Vesna
- Sweeney Lorraine
- Tabacaru Radu
- Takala Annika
- Takil Arzu
- Talalaj Mariola
- Talbot Laura
- Tarabikin Alex
- Taright Hanna
- Taylor Christopher
- Taylor Matthew
- Taylor Matthew
- Teodora Nastase Alina
- Teresa Rocha Maria
- Tesoro Simonetta
- Thadsad Muthu
- Thil Elke
- Thomas Alun
- Thomas Deborah
- Thomson Wendy
- Tielens Luc
- Tognon Costanza
- Tolasov Konstantin
- Toller Wolfgang
- Tomlinson William
- Tonise Virge
- Tore Altun GĂĽlbin
- Trabkin Evelina
- Trante Irinel
- Trieschmann Uwe
- Trifan Oana
- Trikash Nikolay
- Tsiotou Adelais
- Turner Nigel M.
- Uhrig Lynn
- Ullensvang Kyrre
- Ulrici Johanna
- Umuroglu Tumay
- Underhill Helen
- Urbanec René
- Vaidyanath Chandra
- Vail Hannah
- Vaitoskaite Agne
- Vallejo Tarrat Andrea
- Valzan Silvia
- van de Riet Yvette
- Van de Velde Anne
- Van Deenen Denise
- Van Den Eynde Nancy
- van der Knijff - van Dortmont Anouk
- van der Marel Caroline
- van der Schatte Olivier Roelof
- Van Der Werff Désirée B. M.
- van der Zwan Tim
- van Doorn Thea
- Van Hecke Rachel
- Van Limmen Jurgen
- Van Mossevelde Veerle
- van Osch Rob
- Van Reeth Veronique
- van Stijn Mireille F M
- Vanpeteghem Caroline
- Varyvoda Mykhailo
- Vason Milo
- Velcev Ana
- Veldhuizen Marianne
- Verchere-Montmayeur Juliette
- Vermeulen Petronella M
- Vermeulen Petronella M
- Veyckemans Francis
- Veyckemans Francis
- Viacava Rosanna
- Viken Oddbjorn
- Vilo Sanna
- Virag Katalin
- Vittinghoff Maria
- Vittori Alessandro
- Vodianytskyi Sergii
- Voet Marieke
- Volger Hauke
- Volkers Martin
- Volpe Claudia
- Vons Mark Hendriks Kristy
- Vossen Carine
- Wai Carolynn
- Wappler Frank
- Wasiluk Malgorzata
- Watson Karen
- Weber Stefan
- Weinlichova Stanislava
- Weiss Katja
- Wellesley Hugo
- Wensing Renee T. M.
- Weyland Andreas
- Whiteside Jeanette
- Whiteside Jonathan
- Whyte Emma
- Wieczorek Pawel
- WiefelspĂĽtz Christina
- Wilkins Andrew
- Wilson Catharine
- Wilson Graham
- Wilson-Smith Elaine
- Wodey Eric
- Wojciechowski Dariusz
- Wolfe Barry Juliet
- Wolfler Andrea
- Woodward Tom
- Wossner Stephanie
- Wright Dave
- Wyffels Piet
- Yagudaev Irena
- Yamamoto Tomohiro
- Yildirim Guclu Cigdem
- Zadra Nicola
- Zaghet Brigitte
- Zalewska Dorota
- Zammit Simone
- Zanaboni Clelia
- Zang Aurélien
- Zangl Gregor
- Zani Gianluca
- Zederer Nicole
- Zeitlin Deborah
- Zeitlin Yelena
- Zettl Angelika
- Ziegler Bernhard
- Zielinska Marzena
- Zielinska Marzena
- Zoppellari Roberto
- Zundane Anda
- Zunser Igor
- Zurawska Magdalena
- Ĺ˝urek JirĂ
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31â127 anaesthetic procedures in 30â874 children with a mean age of 6·35 years (SD 4·50) were included. The incidence of perioperative severe critical events was 5·2% (95% CI 5·0â5·5) with an incidence of respiratory critical events of 3·1% (2·9â3·3). Cardiovascular instability occurred in 1·9% (1·7â2·1), with an immediate poor outcome in 5·4% (3·7â7·5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10â000. This was independent of type of anaesthesia. Age (relative risk 0·88, 95% CI 0·86â0·90; p<0·0001), medical history, and physical condition (1·60, 1·40â1·82; p<0·0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0·99, 0·981â0·997; p<0·0048 for respiratory critical events, and 0·98, 0·97â0·99; p=0·0039 for cardiovascular critical events), rather than the type of health institution or providers. Interpretation This study highlights a relatively high rate of severe critical events during the anaesthesia management of children for surgical or diagnostic procedures in Europe, and a large variability in the practice of paediatric anaesthesia. These findings are substantial enough to warrant attention from national, regional, and specialist societies to target education of anaesthesiologists and their teams and implement strategies for quality improvement in paediatric anaesthesia. Funding European Society of Anaesthesiology
Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
- Author
- Aantaa Riku
- Abdel-Hafiz Mostafa
- Abdelaal Amr
- Abou-Samra Mark
- Absalom Anthony
- Acevedo Bambaren Ismael
- Adam Christian
- Adriaens Veronique
- Afshari Arash
- Ahmed Samira
- Alanoglu Zekeriyya
- Albarello Raffaella
- Albokrinov Andrew
- Alders David
- Alderson Peter
- Alexandri Bogdan
- Ali Eissa Eid Mohamed
- Alkis Neslihan
- Allen Claire
- Allison Celia
- Almenrader Nicole
- Amaral Rosa
- Amory Catherine
- Ancupans Agris
- Anders Kroken Bjørn
- Anders Nicola
- Angadi Pradeep
- Angeles Sanz M.
- Anselmi Irene
- Anselmi Luciano
- Antonio Idone Francesco
- Anuncia Escontrela RodrĂguez Blanca
- Armoniene Inesa
- Artes David
- Aslami Hamid
- Astuto Marinella
- Audren Noémie
- Aurilio Caterina
- Ayyash Reema
- Babici Remus
- Badarau Victoria
- Badeti Rodica
- Baethge Sabine
- Bakken Boerke Wenche
- Balamat Stefania
- Bandrabur Daniela
- Banerjee Indrani
- Banus Ester
- Bapat Smita
- Baraggia Paolo
- Barak Yuri
- Baranowski Artur
- Barber Nicola
- Barbera Cinzia
- Barbunc Danut
- Bari Francoise
- Baris Sibel
- Barlow Victoria
- Barr Katharine
- Bartholomew Karen
- Bartkowska-Sniatkowska Alicja
- Barzdina Arta
- Basiewicz Ewa
- Basov Mikhail
- Bassett Mike
- Batoz Hélène
- Bauer Annette
- Bauer Martin
- Bauer Michael
- Baujard Catherine
- Bauwman Arthur
- Beate Solas Anne
- Becke Karin
- Becke Karin
- Begec Zekine
- Bekavac Ivan
- Bell Graham
- Bell Sarah J.
- Benito Pilar
- Berger Jelena
- Berghmans Johan
- Bergland Unni
- Bergsma Margot
- Bermede Onat
- Bernotiene Aurelija
- Berton Jerome
- Bevilacqua Michela
- Bew Stephanie
- Bird Victoria
- Birliba Mihaela-Petronela
- Biskupova Vera
- Bloomfield Tom
- Blythe Elizabeth
- Boda Krisztina
- Boda Krisztina B.
- Boegli Yann
- Bollinger Matthias
- Book Malte
- Bordes Maryline
- Bortone Luciano
- Boryshkevych Ivanna
- Bourdaud Nathalie
- Boyd Matthew
- Boyle David
- Bracci Paolo
- Brackhahn Michael
- Bradbury Carol L.
- Breschan Christian
- Brezac Gilles
- Briggs Sandra
- Brotatsch Philipp
- Browning Mike
- Budic Ivana
- Buhre Wolfgang
- Busche René
- Busi Ilaria
- Bussolin Leonardo
- Butkovic Diana
- Butler Patrick
- Byers Gordon
- Börjesson Glenda
- Bøttger Morten
- Cabanova Barbora
- Cagney Brid
- Cakar Turhan K. Sanem
- Calderini Edoardo
- Calvao Santos Carolina
- Camporesi Anna
- Camus Blandine
- Capusan Alin
- Carachi Peter
- Carre Anne-Charlotte
- Cartal Marielle
- Casaer Sari
- Castellheim Albert
- Casutt Mattias
- Catalina Ionescu Gabriela
- Cavalier Alison
- Cecini Mariateresa
- Cento Valeria
- Cerati Giorgia
- Cerne Uros
- Cerutti Elisabetta
- Cettler Maciej
- Ceuca Daniela
- Ceyda Meco Basak
- Chapotte Catherine
- Chazelet Chantal
- Checinska Magdalena
- Checuti Sarah
- Chee Lew-Chin
- Childs Sophie
- Chirichiello Luca
- Chizhov Dmitri
- Chlopin Mikhail
- Chloropoulou Pelagia
- Christian Nilsson Jens
- Chrysi Mpratzou
- Cigdem TĂĽtĂĽncĂĽ Ayse
- Cillis Annagrazia
- Cimpeanu Luminita
- Cindea Iulia
- Ciobanu Tudor
- Clausen Nicola G.
- Clement Maria Gabriella Elena
- Cloherty Marianne
- Cnudde Steven
- Cohen Marc
- Colbus Laurent
- Coppens Marc
- Corouge Julien
- Cortegiani Andrea
- Coucke Patricia
- Crawford Michael
- Cristina Mondardini Maria
- Cuciuc Veaceslav
- Cucui-Cozma Cosmina
- Cullen Julia
- Cullen Pauline
- Cumming Craig
- D'Alessandro Sandra
- Dadure Christophe
- Dahmani Souhayl
- Dalton Andrew
- Dalton Mark
- Damps Maria
- Darwin Leanne
- Daugelavicius Vidunas
- Davidescu Irina
- Davidson Sarah
- Davies Jack
- Davies Kay
- Davin Isabelle
- Davison Rachel
- Day Alexandra
- De Abreu Leidy
- de Graaff Jurgen C.
- De Groote Françoise
- De Hert Stefan
- De Josemaria Belen
- de la Brière Francois
- De La Cruz Benito Fausto
- De Lorenzo Brita
- De Melo Eric
- De Pooter Françoise
- De Smet Karen
- De Villé Andrée
- Debrabant Lise
- Dei Giudici Luigi
- Dekens Jacky
- Dekker Elsa
- del RĂo Cristina
- Delcuze Axelle
- Desjeux Luc
- Diacono Jacques
- Dickinson Matthew
- Didier Anne
- Diers Anja
- Dirckx Maaike
- Disma Nicola
- Disma Nicola
- Divák Jan
- Diwan Rishi
- Dix Philippa
- Djapic Dajana
- Dockiene Ilona
- Dogger Jaap
- Dolci Mirko
- Dolinaj Vladimir
- Domingas Patuleia M.
- DomĂnguez Fernando
- Dons-Sinke Ilse
- Dorman Teresa
- Draskovic Biljana
- Druot Emilie
- Duflo Frédéric
- Dumitru Rusu Florin
- Dupont Hervé
- Eberl Susanne
- Ecoffey Claude
- Ehm Birgit
- Eich Christoph Bernhard
- Eisner Christoph
- Eissa Ayman
- Elena Malos Anca
- Elizabeth Biercamp Claire
- Ellekvist Marguerite B.
- Ellerkmann Richard
- Ellwood James
- Engel Nicole
- Engelhardt Thomas
- Eniko Kovacs
- Ephraim Erik
- Erb Christian
- Erb Thomas
- Errass Loreen
- Fairgrieve Ross
- Faliszewski Isabella
- Farinelli Ivano
- Farquharson Pamela
- Feliu Montserrat
- Fiedler Fritz
- Fischer Thomas
- Fisher Haran
- Flewin Lisa
- Foster Brian
- Franco Teresa
- Fredrik Lund Ole
- Frelich Michal
- Frey Denise
- Fritzsche Katrin
- Funk Wolfgang
- Gabilondo Garcia Gustavo
- Gaebler Ralf
- Gagey Anne-Charlotte
- Gaidelyte Lina
- Galinescu Irena
- Galvin Deborah
- Gande Richard
- Gandhi Monica
- Garces Antonio
- GarcĂa Irene
- Garrigue Delphine
- Garrioch Sweyn
- Gatt David
- Gaynor James
- Geary Tim
- Geil Dominik
- Genco Daniele
- Gerin Marc
- Gerling Volker
- Germann Reinhard
- Gernoth Christian
- Gestautaite Dalia
- Ghent Robert
- Gillberg Lars
- Gillet Patricia
- Giuseppe Picardo Sergio
- Glasgow Russell
- Glazunov Anton
- Godsiff Leisha
- Goebel Ulrich
- Gomes Cristina
- Goncharenko Galyna
- Gonçalves Marta
- Gooch Ingrid
- Gordeeva Elena
- Grau Catharina
- Grazzini Maurizia
- Grein Elodie
- Grindheim Guro
- Grundmann Ulrich
- Grynyuk Andry
- Guarracino Fabio
- Guddo Annamaria
- Guedes Isabel
- Guericke Holger
- Guerin Christilynn
- Guido Locatelli Bruno
- Guillier Marion
- Gurita Adriana
- Gurita Adriana
- Guskov Igor
- Gutierrez Valcarcel Andrea
- Gutierrez Ignacio
- Gutmann Anton
- Guzman Ines
- Gymoese Berthelsen Kasper
- Habre Walid
- Habre Walid
- Hammerschlag Jacinda
- Hamonic Yann
- Hannie J.
- Hansen Tom G.
- Hansen Tom G.
- Hanula Miloslav
- Happo Johanna
- Harden Alison
- Hare Alison
- Harlet Pierre
- Harmen Herrema Idse
- Harris Sarah
- Harrison Richard
- Hasani Antigona
- Hashimi Medita
- Hatipoglu Zehra
- Hawksworth Chris
- Hayem Catherine
- Hearn Robert
- Hedlund Lars
- Hein Maximilian
- Helena Gaitan M.
- Heli Litvic Dubravka
- Helm Emma
- Heyse Björn
- Himpe Dirk
- Hinz José
- Hivey Sarah
- Hizal Ayse
- Hobbs Amy
- Hochhold Christoph
- Hodgetts Vanessa
- Hoeft Andreas
- Hoehne Claudia
- Hofmann Ulrich
- Hogea Cristiana
- Holy Rolf
- Homer Rachel
- Hopman Geranne A. J.
- Horhota Lucian
- Huber Matthias
- Hullatt Laurence
- Hunter Catherine
- Hurni Thomas
- Hussain Nageena
- Hussey Joseph
- Hutchinson Adel
- Huygens Christel
- Hölzle Martin
- Ilie Luminita
- Ilksen Toprak Huseyin
- Ilmoja Mari-Liis
- Ingeborg Madsen Birgitte
- Ioannou Ioannis
- Iordanidou Despoina
- Ireland Nicholas
- Irwin Janice
- Isohanni Mika
- Isselhorst Carsten
- Ivani Giorgio
- Ivanov Alexander
- Ivascu Constantin
- Izzo Francesca
- Jack Ewan
- Jacomet Alfred
- Jacqmarcq Olivier
- Jamil Yosry
- jan Scheffer Gert
- Janjevic Dusanka
- Jeng Min Law Savio
- Jerome Kevin
- Jetzek-Zader Martin
- Jiménez Anabel
- Joao Susano Maria
- Johansen Mathias
- John Robert
- Johnston Graham
- Jokinen Johanna
- Jones Gareth
- Joukes Ellen
- Julien-Marsollier Florence
- Jureckova Lucie
- Juzwa Magdalena
- Jöhr Martin
- Jöhr Martin
- Kachko Ludmyla
- Kahn David
- Kalagac Fabris Lada
- Kalliardou Evagelia
- Kappen Teus H.
- Karadeniz Meltem Savran
- Karjagin Juri
- Katz Jacob
- Kaufmann Nils
- Kazak Bengisun Zuleyha
- Keilhauer Julia
- Kelgeri Nivedita
- Kemal Arslantas Mustafa
- Kendigelen Pinar
- Kerovec Soric Ivana
- Kesic-Valpotic Gordana
- Khaffaf Ranj
- Khotcholava Magda
- Khrapak Maksym
- Kienbaum Peter
- Kikas Reet
- Kindermann Petra
- King Stephanie
- Kirilov Dmitry
- Kirton Christine
- Kiviluoma Kai
- Klimscha Walter
- Kloessing Jan
- Klymenko Tetyana
- Knauss Kristina
- Knezevic Mirjana
- Kochkin Vladimir
- Koessler Herbert
- Konecny Regina
- Kopycinska Renata
- Kortgen Andreas
- Kotecha Ami
- Kotzeva Svetlana
- Kranke Peter
- Krikstaponiene Jolita
- Kroess Ruth
- Kuehhirt Thomas
- Kuppers Beate
- Kusnirikova Zuzana
- Kyselova Iryna
- Ladak Nadia
- Laffargue Anne
- Lagarde Sylvaine
- Lako Sandra
- Lalot Michaël
- Lambelin Veronique
- Lambotte Patricia
- Lang Colin
- Lapi Maria
- Larcher Claire
- Laschat Michael
- Lauweryns Julie
- Lazarev Vladimir
- Lazaro Juan J.
- Le Freche Hélène
- Leal Teresa
- Lechat Jean-Paul
- Leclercq Mickeal
- Lee Clover-Ann
- Lee Corina
- Lee Juliette
- Legrand Aurélien
- Lehousse Thierry
- Lejus Corinne
- Lesmes Carlos
- Leva Brigitte
- Leva Brigitte
- Levinzon Michael
- Levitchi Roxana
- Levy David
- LeĂłn Carsi Irene
- Lhubat Elizabeth
- Lindenskov Pal H. H.
- Lipczynski Dariusz
- Liyanage Ganga
- Locke Christie
- Lofino Giuseppe
- Lomas Bernadette
- Longobardo Annalisa
- Lonsdale Hannah
- Love David
- Loveniers Birgit
- Lucia Pinciroli Rosa
- Ludot Hugues
- Lugovoy Alexander
- Lukosiene Laura
- Luntzer Robert
- Lyly Anniina
- Lynch Johanne
- LĂłpez Galera SĂlvia
- Machado Elvira
- Machotta Andreas
- Mackiewicz Tomasz
- Mackova Iveta
- Mader Thomas
- Magasich Natalia
- Magner Claire
- Mahadewsing Ravin
- Majid Saleem Mohammed
- Makin Andrew
- Malarkkan Nalini
- Malisiova Anna
- Mameli Leila
- Mandras Ana
- Manen Berga Ferran
- Manevich Yair
- Maniora Maud
- Manner Tuula
- Marchesini Laura
- Marchetti Giuliano
- Marco Valls Joan
- Marcucci Carine
- Marcus Ritchie
- Maretic Hrvoje
- Maria Gago Martinez Andrea
- Maria Nistor Alina
- Marie Drage Inger
- Marie Anais
- Marjanovic Vesna
- Marthe Ballovarre Kari
- Martikainen Kati
- Martinez Maldonado Ever
- MartĂnez Ruiz Alberto
- Mascarenhas Catia
- Masip Nuria
- Mauch Jacqueline
- Maupain Olivier
- Maurizio Raineri Santi
- Mausser Gerlinde
- Mawer Rebecca
- Mayell Antonia
- McClintock Joanna
- McKee Lesley
- Megens A. M.
- Meijer Patrick
- Melero Alicia
- Meneghini Luisa
- Merella Federica
- Mesbah Ahmed
- Messerer Brigitte
- Metrangolo Salvatore
- Meybohm Patrick
- Meyer-Treschan Tanja
- Michelon Stefania
- Micici Slobodan
- Mielke Golo
- Mierzewska-Schmidt Magdalena
- Mifsud Mark
- Mifsud Stephanie
- Migeon Anne
- Mihaela Gheorghe Ligia
- Mihaela Dubau
- Milde Alexander
- Milojevic Irina
- Minardi Carmelo
- Mircetic Maja
- Mitchell John
- Miulescu Magdalena
- Mixa Vladimir
- Mocioiu Gabriel
- Molies Dolors
- Monclus Enric
- Moncreiff Michael
- Moniz Antonio
- Monrigal Jean
- Montague James
- Montferrer NĂşria
- Montobbio Giovanni
- Moors Xavier
- Moraru-Draghici Lucia
- Morawk-Wintersperger Ulrike
- Morgan Judith
- Morton Neil
- Morton Neil S.
- Moscaliuc Melania
- Moscatello Djurdjica
- Mossetti Valeria
- Muir Vimty
- Munar Francisca
- Munteanu Valentin
- Muro Cristina
- Najafi Nadia
- Nakhjavani Solmaz
- Nasser Leila
- Nastran Andraz
- Navaro Montserrat
- Nechaev Vladislav
- Neckebroek Martine
- Neiger Franz
- Nekrasov Konstantin
- Neri Simona
- Neumann Claudia
- Nicoleta Daraban
- Nolte Claire
- Noriega Bryant
- Nouette-Gaulain Karine
- Ntavlis Merkourios
- Numan Sandra C.
- Nuño Rosario
- O'Donahue Lizanne
- O'Hare Brendan
- Oberhauser Markus
- Ochsenreiter Miriam
- Oeding Joachim
- Olaru Valentin
- Oller Duque Lara
- Olmos Mendez Alberto
- Olteanu Dana
- Oppenrieder Karin
- Orliaguet Gilles
- Oshan Vimmi
- Ostreikov Ivan
- Ottolina Davide
- Ovezov Alexey
- Ozcengiz Dilek
- Ozer Yetkin
- Paal Peter
- Paiu Corneliu
- Paliokaite Evelina
- Pamies Carmen
- Pandurov Marina
- Parashchanka Aliaksandra
- Parasuraman Tamaraichelvi
- Pasini Lorena
- Passariello Leandro
- Patel Pradip
- Patel Shivali
- Pattar Alexander
- Paul Mission Jean
- Pauling Mark
- Pavlenko Vitaliy
- Pavlickova Jana
- Pearson Karen
- Pedro Pina AntĂłnio
- Pedrotti Dino
- Pegg Rachel
- Peiris Kawshala
- Peled Elia
- Pellegrini Michel
- Pereira Ricardo
- PerellĂł Marina
- Perera Remel
- Peresbota Daliana
- Perez Garcia Anibal
- Perez- Ferrer Antonio
- Perova-Sharonova Valentina
- Perry Nicole
- Peter Laura
- Petrescu Luxita
- Petrovic Sladjana
- Phaff Steen Nick
- Phillips Trudie
- Pick Darina
- Picker Olaf
- Pilla Clotaire
- Pino Gema
- Pirat Philippe
- Pirc Dejan
- Pirotte Thierry
- Pistidda Laura
- Pitino Sofia
- Plant Nina
- Platzer Manuela
- Plichon Benoit
- Plumb James
- Poduskov Evgeny
- Podvin Alexandre
- Poelaert Jan
- Popescu Barbura
- Popic Rok
- Popov Alexander
- Popovic Ljiljana
- Powell Alex
- Prat Mar
- Pratt Thomas
- Pregardien Caroline
- Preussler Niels-Peter
- Pribul Vicky
- Prysiazhniuk Dmytro
- Pryzmont Miroslaw
- Punt Kees
- Punzo Cinzia
- Puric Selena
- PĂ© d'Arca Sandra
- Quintel Michael
- Qureshi Arif
- Raber Manfred
- Rad Mandana
- Raffoflandreur Celine
- Raistrick Christopher
- Rajamani Balaji
- Ramminger Axel
- Ravi Radha
- Rawlinson Ellen
- Razlevice Ilona
- Reali Simone
- Rebac Vlatka
- Reikvam Tore
- Reindl Doris
- Reinert Jennifer
- Reinoso Barbero Francisco
- Retka Wlodzimierz
- Ribo Laura
- Richart Pierre
- Riche Jean-Claude
- Ricol Lainez Laura
- Riggenbach Christine
- Rizzo Giuliana
- Robert Philippe
- Roberts Steve
- Rodrigues Sara
- Rogerson David
- Roofthooft Eva
- Roos Torbjörn
- Rosada-Kurasinska Jowita
- Ross Mark
- Rossetti Francesca
- Rosu Lilica
- Roth Benjamin
- Roth Jens
- Roth Winfried
- Roulleau Philippe
- Roxo Helena
- Rubio Paloma
- Rudewicz Iwona
- Rudio Olga
- Rushman Sarah
- Russell Susan
- Russell William
- Russo Sebastian G.
- Rustemeyer Lydia
- Rutherford John
- Rutherford William
- RĂ©mond Charlotte
- Sa Angela
- Sabau Lucie
- Sabourdin Nada
- Sage Frederic
- Saha Rita
- Salgado Helena
- Salici Fabiana
- Salota Vishal
- Salvo Ida
- Samani Amee
- Sammartino Maria
- Sanchez Torres Cristel
- Sandström Kerstin
- Sanko Elena
- Sanna Andrea
- Sansone Pasquale
- Santos Maria
- Saour Anne-Charlotte
- Saviciene Nijole
- Savu Anca
- Sawicki Piotr
- Sbaraglia Fabio
- Scalisi Rita
- Schaefer Maximilian S.
- Schellino Maria Maddalena
- Schierlinger Bettina
- Schindler Ehrenfried
- Schink Cornel
- Schmain Dmitri
- Schmucker Erika
- Schoeler Michael
- Scholten Harm
- Schorer Clemens
- Schousboe Birgitte M. B.
- Schouten Anton N. J.
- Schramm Michael
- Schwarzkopf Konrad
- Sciascia Angela
- Scordo Lucia
- Scott-Warren Victoria
- Seabra Manuel
- Seidel-Ahyai Natascha
- Semjen François
- Serrano Silvia
- Seyhan Ozkan Tulay
- Sharman Sarah-Jane
- Shaw Neil
- Sheinkin Olga
- Shepherd Elizabeth
- Short Judith
- Sidlovskaite-Baltake Dominika
- Sieben Anne
- Siemek-Mitela Jadzia
- Sileo Rosanna
- Simhi Eliahu
- Simic Dusica
- Simic Irena
- Simin Jovana
- Simitzes Helena
- Simon Dominique
- Simpson Joanna
- Simurina Tatjana
- Sinclair John
- Singh Piyush
- Sinner Barbara
- Sirghie Rodica
- Sivrikoz Nuket
- Skaaden Lene
- Skacel Monika
- Sketcher Jonathan
- Sklyar Vitaliy
- Skordou Natalia
- Slater Patricia
- Slavkovic Bojana
- Smith Carolyn
- Smith Fiona
- Smith Natalie
- Smitz Carine
- Snoek Aarjan
- Sobczyk Jaek
- Sodhi Puja
- Sola Ruiz Eva
- Sola Chrystelle
- Sonzogni Valter
- Soskova Tereza
- Spahr-Schopfer Isabelle
- Spanjer Vera
- Spanjersberg Rob
- Sponheim Sjur
- Staals Lonneke
- Stack Charles
- Staiti Giuseppe
- Standl Thomas
- Starita Giusi
- Stasevski Vladyslav
- Steel Simon
- Stefan Violeta
- Steiner Maria
- Steinmann Johannes
- Stevanovic Vesna
- Stevens France
- Stevens Markus F.
- Stevic Marija
- Steward Heather
- StoegermĂĽller Birgit
- Stoia Paolo
- Strachan Dominic
- Stranjanac Vladimir
- Straume Zane
- Stuck Tus Ivana
- Stupnik Spela
- Sulen Nina
- Supthut Hauke
- Surkov Denis
- Sutherland Paul
- Suvejan Mirela
- Svircevic Vesna
- Sweeney Lorraine
- Tabacaru Radu
- Takala Annika
- Takil Arzu
- Talalaj Mariola
- Talbot Laura
- Tarabikin Alex
- Taright Hanna
- Taylor Christopher
- Taylor Matthew
- Taylor Matthew
- Teodora Nastase Alina
- Teresa Rocha Maria
- Tesoro Simonetta
- Thadsad Muthu
- Thil Elke
- Thomas Alun
- Thomas Deborah
- Thomson Wendy
- Tielens Luc
- Tognon Costanza
- Tolasov Konstantin
- Toller Wolfgang
- Tomlinson William
- Tonise Virge
- Tore Altun GĂĽlbin
- Trabkin Evelina
- Trante Irinel
- Trieschmann Uwe
- Trifan Oana
- Trikash Nikolay
- Tsiotou Adelais
- Turner Nigel M.
- Uhrig Lynn
- Ullensvang Kyrre
- Ulrici Johanna
- Umuroglu Tumay
- Underhill Helen
- Urbanec René
- Vaidyanath Chandra
- Vail Hannah
- Vaitoskaite Agne
- Vallejo Tarrat Andrea
- Valzan Silvia
- van de Riet Yvette
- Van de Velde Anne
- Van Deenen Denise
- Van Den Eynde Nancy
- van der Knijff - van Dortmont Anouk
- van der Marel Caroline
- van der Schatte Olivier Roelof
- Van Der Werff Désirée B. M.
- van der Zwan Tim
- van Doorn Thea
- Van Hecke Rachel
- Van Limmen Jurgen
- Van Mossevelde Veerle
- van Osch Rob
- Van Reeth Veronique
- van Stijn Mireille F. M.
- Vanpeteghem Caroline
- Varyvoda Mykhailo
- Vason Milo
- Velcev Ana
- Veldhuizen Marianne
- Verchere-Montmayeur Juliette
- Vermeulen Petronella M.
- Vermeulen Petronella M.
- Veyckemans Francis
- Veyckemans Francis
- Viacava Rosanna
- Viken Oddbjorn
- Vilo Sanna
- Virag Katalin
- Vittinghoff Maria
- Vittori Alessandro
- Vodianytskyi Sergii
- Voet Marieke
- Volger Hauke
- Volkers Martin
- Volpe Claudia
- Vons Mark Hendriks Kristy
- Vossen Carine
- Wai Carolynn
- Wappler Frank
- Wasiluk Malgorzata
- Watson Karen
- Weber Stefan
- Weinlichova Stanislava
- Weiss Katja
- Wellesley Hugo
- Wensing Renee T. M.
- Weyland Andreas
- Whiteside Jeanette
- Whiteside Jonathan
- Whyte Emma
- Wieczorek Pawel
- WiefelspĂĽtz Christina
- Wilkins Andrew
- Wilson Catharine
- Wilson Graham
- Wilson-Smith Elaine
- Wodey Eric
- Wojciechowski Dariusz
- Wolfe Barry Juliet
- Wolfler Andrea
- Woodward Tom
- Wossner Stephanie
- Wright Dave
- Wyffels Piet
- Yagudaev Irena
- Yamamoto Tomohiro
- Yildirim Guclu Cigdem
- Zadra Nicola
- Zaghet Brigitte
- Zalewska Dorota
- Zammit Simone
- Zanaboni Clelia
- Zang Aurélien
- Zangl Gregor
- Zani Gianluca
- Zederer Nicole
- Zeitlin Deborah
- Zeitlin Yelena
- Zettl Angelika
- Ziegler Bernhard
- Zielinska Marzena
- Zielinska Marzena
- Zoppellari Roberto
- Zundane Anda
- Zunser Igor
- Zurawska Magdalena
- Ĺ˝urek JirĂ
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31 127 anaesthetic procedures in 30 874 children with a mean age of 6.35 years (SD 4.50) were included. The incidence of perioperative severe critical events was 5.2% (95% CI 5.0-5.5) with an incidence of respiratory critical events of 3.1% (2.9-3.3). Cardiovascular instability occurred in 1.9% (1.7-2.1), with an immediate poor outcome in 5.4% (3.7-7.5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10 000. This was independent of type of anaesthesia. Age (relative risk 0.88, 95% CI 0.86-0.90; p<0.0001), medical history, and physical condition (1.60, 1.40-1.82; p<0.0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0.99, 0.981-0.997; p<0.0048 for respiratory critical events, and 0.98, 0.97-0.99; p=0.0039 for cardiovascular critical events), rather than the type of health institution or providers. Interpretation This study highlights a relatively high rate of severe critical events during the anaesthesia management of children for surgical or diagnostic procedures in Europe, and a large variability in the practice of paediatric anaesthesia. These findings are substantial enough to warrant attention from national, regional, and specialist societies to target education of anaesthesiologists and their teams and implement strategies for quality improvement in paediatric anaesthesia
Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
- Author
- Abad Jorge
- Abad Sebastien
- Abassi Radhiya
- Abdelhadi Nour Mekki
- Abdellaoui Abdelrafie
- Abdelmalek Abdelkrim
- Abdoul Hendy
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abergel Helene
- Abeud Fariza
- Abgrall Sophie
- Abisror Noemie
- Abolhassani Hassan
- Accordino Giulia
- Achille Cristian
- Adechian Marylise
- Aderdour Nordine
- Admane Hakeem Farid
- Adnet Frederic
- Afritt Sara
- Agostini Helene
- Agra Juan José Cáceres
- Aguilar Claire
- Aguilera-Albesa Sergio
- AguilĂł-Cucurull Aina
- Agut Sophie
- Aiello Tommaso Francesco
- Aiuti Alessandro
- Ajeenthiravasan Gokula
- Akcan Ozge Metin
- Akcan Ă–zge Metin
- Al-Muhsen Saleh
- Al-Muhsen Saleh Zaid
- Al-Mulla Fahd
- Alauzy Virginie
- Alavoine Loubna
- Alba Camille
- Albisures Jonathan Antonio Roblero
- Alby-Laurent Fanny
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Allard Lucie
- Allardet-Servent Jerome
- Allende Luis
- Alonso-Arias Rebeca
- Alosaimi Mohammed Faraj
- Alshahrani Mohammed
- Alsina Laia
- Alsohime Fahad
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Alyanakian Marie-Alexandra
- Amam Sabrina
- Amara Yasmina Ould
- Amat Karine
- Amoura Zahir
- Amrouche Lucile
- Anderson Mark
- Andreakos Evangelos
- Andrejak Claire
- Andronikof Marc
- Anglicheau Dany
- Angoulvant François
- Anguel Nadia
- Annane Djillali
- AntolĂ Arnau
- Aounzou Mohammed
- Aparicio Caroline
- Appelman Brent
- Aratus Gladys
- Arias Andrés
- Arias Andrés Augusto
- Arlet Jean-Benoit
- Arquero Miguel Fernandez
- Arranz MarĂa JesĂşs
- Arrestier Romain
- Arzoine Jeremy
- Asano Takaki
- Aslangul Elisabeth
- Assefi Mona
- Aubart MĂ©lodie
- Aubry Adeline
- Audiffred Laetitia
- Audureau Etienne
- Auger Christelle Nathalie
- Auguet Teresa
- Auregan Jean-Charles
- Avramenko Iryna
- Awotar Celine
- Aytekin Gokhan
- Aytekin Gökhan
- Aytekin Selma Erol
- Azan Delphine
- Azemar Laurene
- Azot Axelle
- Azzouguen Billal
- Bachelet Delphine
- Badsi AĂŻda
- Baghdadi Jamila El
- Bahram Seiamak
- Bajolle Fanny
- Bakouboula Prissile
- Balcerowiak Coline
- Baldanti Fausto
- Balde Fanta
- Baldivia Elodie
- Baldolli Aurélie
- Ballester Maite
- Bangamingo Eliane-Flore
- Baptiste Amandine
- Baran-Marszak Fanny
- Barau Caroline
- Barget Nathalie
- Baris-Feldman Hagit
- Baronnet Flore
- Barrou Benoit
- Barthelemy Romain
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Baudel Jean-Luc
- Baudry Camille
- Baudry Elodie
- Bauters Fré
- Bax Diane
- Bayhan Gulsum Iclal
- Beaugerie Laurent
- Behilill Sylvie
- Behillil Sylvie
- Belamri Adel
- Belaube Nicolas
- Belilita Rhida
- Bellani Giacomo
- Bellassen Pierre
- Belmokhtar Rawan
- Belot Alexandre
- Belot Alexandre
- Beltran Isabel
- Beluze Marine
- Benainous Ruben
- Benallaoua Mourad
- Benamouzig Robert
- Benbara Amélie
- Benhida Jaouad
- Benkerrou Dehbia
- Benkhelouf Anis
- Benlagha Jihene
- Benmostafa Chahinez
- Benothmane Skander
- Bentifraouine Miassa
- Berard Laurence
- Beretta Ilaria
- Bergman Peter
- Berkell Matilda
- Bernier Quentin
- Bertholon Frédérique
- Berti Enora
- Bertier Astrid
- Berton Laure
- Bessis Simon
- Bettini Laura Rachele
- Beudel Martijn
- Beurton Alexandra
- Bezrodnik Liliana
- Bhavsar Krishna
- Bianco Celine
- Bianquis Clara
- Bidar Frank
- Biggs Catherine
- Bilbao Agurtzane
- Biondi Andrea
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanche Philippe
- Blanco Ignacio
- Blandinières Adeline
- Blayau Clarisse
- Bleibtreu Alexandre
- Bleibtreu Alexandre
- Blin Emmanuelle
- Bloch-Queyrat Coralie
- Bloomfield Marketa
- Blázquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boissier Marie-Christophe
- Boisson Bertrand
- Boisson-Dupuis Stephanie
- Boland Anne
- Bolivar-Prados Mireia
- Bollens Diane
- Bolze Alexandre
- Bolzoni Marion
- Bomers Marije
- Bompard Rudy Pierre
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bondesan Simone
- Bonnet Nicolas
- Bonnouvrier Justine
- Bonta Peter
- Borghesi Alessandro
- Borie Raphael
- Borrero Blanca Amador
- Borrero Blanca Amador
- Bos Lieuwe
- Bosteels CĂ©dric
- Botdhlo-Nevers Elisabeth
- Botelho-Nevers Elisabeth
- Botha Shirmonecrystal
- Botta Michela
- Bouadma Lila
- Boucenna Wissam
- Bouchama Fatiha
- Bouchaud Olivier
- Bouchez Sabelline
- Bouchghoul Hanane
- Boudjebla Taoueslylia
- Boudjema Noel
- Bouffard Catherine
- Bougle Adrien
- Bouguerra Meriem
- Bouiller KĂ©vin
- Boulanger CĂ©cile
- Bouras Leila
- Bourcier Agnes
- Bourgeon Marilou
- Bourrier Anne
- Bouscambert Maude
- Bouscarat Fabrice
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousquet Aurore
- Boutolleau David
- Bouvattier Claire
- Bouvry Diane
- Bouziri Nesrine
- Bouzrara Ons
- Boyarchuk Oksana
- Bozdemir Ĺžefika Elmas
- Bravais Juliette
- Bribier Sarah
- Briones M. Luisa
- Brodin Petter
- Brouwer Matthijs
- Brugier Delphine
- Bruneau LĂ©a
- Brunel Melanie
- Brunner Marie-Eve
- Bruno Raffaele
- Bryceson Yenan
- Bryceson Yenan
- Bueno Maria Rita P.
- Bugiani Marianna
- Bui Eida
- Buis David
- Buisson Anne
- Bukhari Huda
- Bukreyeva Iryna
- Bulle Esther
- Burdet Charles
- Bureau CĂ´me
- Bureau Serge
- Bustamante Carlos
- Bustamante Jacinta
- Bustos Ingrid
- Butte Manish
- Cabrera-Marante Oscar
- Cadranel Jacques
- Cailhol Johann
- Calin Ruxandra
- Canavaggio Pauline
- Cancella Marta
- Cantin Delphine
- Cao Albert
- Capra Ruggero
- Carapito Raphael
- Carbillon Lionel
- Carcel Sheila
- Carelli Valerio
- Carlier Nicolas
- Carrabba Maria
- Carrera Paola
- Casanova Jean-Laurent
- Casanova Jean-Laurent
- Casari Giorgio
- Casasnovas Carlos
- Caseris Marion
- Cassaniti Irene
- Cassard Clementine
- Castelle Martin
- Castelli Francesco
- Castor Guylaine
- Castro Mateus
- Catherinot Emilie
- Cauchy Marion
- Cazzaniga Marina
- Celik Jale Bengi
- Cervantes-Gonzalez Minerva
- Ceschi Alessandro
- Cha Olivier
- Chachoua Abla
- Chahine Abir
- Chaigne Benjamin
- Chair Anissa
- Chakravorty Samya
- Chaldebas Matthieu
- Challal Salima
- Chalumeau Martin
- Chalumeau Nathalie Costedoat
- Champion Karine
- Charbit Bruno
- Chariot Patrick
- Charpentier Charlotte
- Chas Julie
- Chauveau Simon
- Chauvin Anthony
- Chauvin Clement
- Chavarot Nathalie
- ChaĂŻbi Khalil
- Chebbout Kamélia
- Cheng Matthew
- Cherai Mustapha
- Cherubini Ilaria
- Chevalier Amelie
- Chiarabini Thibault
- Chinet Thierry
- Chirouze Catherine
- Chirouze Catherine
- Chocron Richard
- Choinier Pascaline
- Chommeloux Juliette
- Choquet Christophe
- Choupeaux Laure
- Chousterman Benjamin
- Christelle Kouakam
- Christodoulou John
- Ciocan Dragosmarius
- Citerio Giuseppe
- Clarke Ada
- Clavere Gaëlle
- Clavier Florian
- Clavé Père
- Clement Karine
- Clerc Sebastien
- Cloherty Osoul Chouchane Alex
- Clotet Bonaventura
- Cobat Aurélie
- Codina Anna
- Coelho Alexandra
- Cohen Adrien
- Cohen Fleur
- Cohen Yves
- Cohen Yves
- Coilly Audrey
- Colboc Hester
- Colin Pauline
- Collet Magalie
- Colobran Roger
- Comarmond Chloé
- Comarmond Cloé
- Combacon Emeline
- Combe Caroline Lascoux
- Combes Alain
- Combes Alain
- Comoli Patrizia
- Comparon Celine
- Condino-Neto Antonio
- Constantin Jean-Michel
- Constantinescu Stefan
- Contro Ernesto
- Cooper Megan
- Cordel Hugues
- Cordier Anne-Gael
- Corsico Angelo
- Costantini Adrien
- Couffignal Camille
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Couffin-Cadiergues Sandrine
- Coupeau Doriane
- Covill Laura
- CoĹźkuner Taner
- Creange Alain
- Cuadros Esmeralda Nuñez
- Cvetkovski Aleksandar
- Cyrus Cyril
- da Silveira Charlène
- Dalgard Clifton
- Dalmau David
- Danielson Jeffrey
- Danion François
- Darazam Ilad Alavi
- Darley David Ross
- Das Vincent
- Dauby Nicolas
- Dauger Stéphane
- de Bouille Jeanne Goupil
- de Brabander Justin
- de Bree Godelieve
- de Bruin Sanne
- de Castro Nathalie
- de Chambrun Marc Pineton
- de Chambrun Marc Pineton
- de Clercq Jozefien
- de Diego Rebeca PĂ©rez
- de Farcy Pauline Mary
- de Jong Menno
- de Munter Paul
- de Pontual Loic
- de Rotte Maurits
- De Rycke Yann
- de Vera MartĂn Castillo
- de Vries Heder
- Debray Marie-Pierre
- Dechanet Aline
- Deconinck Lauren
- Dehban Amin
- del Pozo Lucie
- del Prado Maria Yolanda Ruiz
- Delannoy Quentin
- Delay Mathieu
- Deleris Robin
- Deleuze Jean-François
- Delforge Juliette
- Delmonte Ottavia
- Delphine Laëtitia
- Delplancq Geoffroy
- Demar Magalie
- Demare Noemie
- Demeret Sophie
- Demerville Lauren
- Demirkol Yasemin Kendir
- Demoule Alexandre
- Demoule Alexandre
- Deniau Aurore
- Deplanque Dominique
- Deplanque Dominique
- Depret François
- Derolez Sophie
- Derradji Ouda
- Derridj Nawal
- Desai Murkesh
- Descamps Diane
- Descamps Diane
- Descamps Vincent
- Deschamps Lydia
- Desconclois Celine
- Desguerre Isabelle
- Desille-Dugast Mireille
- Desmarets Maxime
- Desnos Cyrielle
- Desongins Karine
- Desvallée Mathilde
- Devouge Eglantine Ferrand
- Dhote Robin
- Di Sabatino Antonio
- Diallo Alpha
- Diallo Benjamin
- Didier Morgane
- Diehl Jean-Luc
- Diemer Myriam
- Diez Stephane
- Dijkstra Mirjam
- Diouf Alphonsine
- Djadi-Prat Juliette
- Djebara Siham
- Djebra Naoual
- Djietcheu Minette
- Djillali Hadjer
- Djossou FĂ©lix
- Djouadi Nouara
- Dobbelaere Stephanie
- Dobbs Kerry
- DomĂnguez-Garrido Elena
- Dongelmans Dave
- Donneger Severine
- Dorival CĂ©line
- dos Santos Catarina
- Dournon Nathalie
- Dres Martin
- Droctove Laura
- Drogrey Marie
- Drolet Beth
- Dropy Margot
- Drouet Elodie
- Dubos François
- Dubosq Valérie
- Dubost Clément
- Dubreucq Evelyne
- Dubus Estelle
- Duchemann Boris
- Duchenoy Thibault
- Dudoignon Emmanuel
- Dufau Romain
- Dujardin Romein
- Dumas Florence
- Duran Clara
- Durand Anne Bourgarit
- Duron Emmanuelle
- Durrbach Antoine
- Duval Xavier
- Duval Xavier
- Duvivier Claudine
- D’angio’ Mariella
- D’ortenzio Eric
- Ebstein Nathan
- Ecobichon Jean-Luc
- Ekwall Olov
- Elabbadi Alexandre
- Elbers Paul
- Elharrar Brigitte
- Elie Caroline
- Elnagdy Marwa
- Eloy Philippine
- Elrufaai Marwa Bachir
- Emiroglu Melike
- Endo Akifumi
- Enouf Vincent
- Enouf Vincent
- Erdeniz Emine Hafize
- Ernotte Gabriel
- Esling Anne
- Esperou Hélène
- Espinosa-Padilla Sara
- Esposito-Farese Marina
- Espérou Hélène
- Etienne Manuel
- Etienne Martin
- Euvrard Romain
- Eyer Xavier
- Fabio Giovanna
- Faivre Laurence
- Falck Antonin
- Fartoukh Muriel
- Fartoukh Muriel Sarah
- Faure Morgane
- Fayali Takoua
- Feldman Hagit Baris
- Feldman Hagit Baris
- Fellay Jacques
- Fermaut Marion
- Ferrer Ricard
- Ferreres Jose
- Fiorentino Alessia
- Fiorentino Arianna
- Fleuren Lucas
- Fliss Souha
- Flores Carlos
- Florkin Benoit
- Foti Giuseppe
- Fouchard Julie
- Fournier Benjamin
- Fournier Marie-CĂ©line
- Franco Jose Luis
- Franco José Luis
- Francois Bruno
- Francois Hélène
- Freynet Olivia
- Frezouls Wahiba
- Frigout Yvann
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- Fuentes Axelle
- FumadĂł Victoria
- Fung Kitty
- Furet Thomas
- Fusco Francesca
- Gagneux-Brunon Amandine
- Gagro Alenka
- Galand Joris
- Garnier Marc
- Garçon Pierre
- Gatineau Audrey Giraud
- Gaubert Agnes
- Gaudry Stéphane
- Gaugain Samuel
- Gault Nathalie
- Gaussem Pascale
- Gauthier Damien
- Gautier Maxime
- Gaymard Alexandre
- Gayretli Zeynep
- Geijtenbeek Suzanne Geerlings Theo
- Georgin-Lavialle Sophie
- Geromin Daniela
- Gervais Adrian
- Ghalayini Mohamed
- Ghaleh Bijan
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- Goas Carole
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- Gomes Doryan
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- Gonzalez-Granado Luis
- González-Montelongo Rafaela
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- Greffe Segolene
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- Gumucio Victor Daniel
- Gunst Jan
- Gut Marta
- Gysembergh-Houal Anne
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- Hagens Laura
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- Hamann Jorg
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- Hammarström Lennart
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- Hanitsch Leif Gunnar
- Hanon Olivier
- Hariyan Tetyana
- Harris Vanessa
- Harrois Anarole
- Hatipoglu Nevin
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- Hautem Coraline
- Heath James
- Heijmans Catherine
- Hekimian Guillaume
- Heming Nicholas
- Hemke Robert
- Hendou Samia
- Henrickson Sarah
- Heppekcan Deniz
- Hermine Olivier
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- Heunks Sabine
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- Hollmann Markus
- Horcajada Juan
- Horn Janneke
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- Hoste Levi
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- Hovius Joppe
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- Huscenot Tessa
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- Iglesias Alejandro
- Ikherbane Ghilas
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- Jean-Marc Jean-Francois
- Jeulin Hélène
- Jeyarajasingham Deleena
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- Jordan Iolanda
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- Khalifa Jihane El
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- Lafont Emmanuel
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- Laine Fabrice
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- Landman Cecilia
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- Lanternier Fanny
- Laouénan Cédric
- Larcheveque Cecile
- Laribi Samira
- Larmurier Isabelle Nion
- Lasa Maria Pilar Etxart
- Lassel Ludovic
- Lau Yu-Lung
- Laverdant Benjamin
- Lavergne Christophe
- Lavillegrand Jean-RĂ©mi
- Laviolle Bruno
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- Lefebvre Marylou
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- Leporrier-Ext Jeremie
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- Tresoldi Cristina
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- Uzunhan Yurdagul
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- Valent Arnaud
- Valentian Maelle
- Valin Nadia
- Vallet Hélène
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt Michèle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vaz Marina
- Vazquezibarra Miguel-Alejandro
- Vedie Benoit
- Veelo Denise
- Vega Clara Campos
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Velly Laetitia
- Verstuyft Celine
- Viallette Cedric
- Vicaut Eric
- Vidaud Michel
- Vidigal Mateus
- Viel SĂ©bastien
- Vignali Valérie
- Vignes Dorothee
- Vilaire-Meunier Marie
- Villain CĂ©dric
- Villar-GarcĂa Judit
- Vimpere Damien
- Vincent Audrey
- Vinh Donald
- Virlouvet Myriam
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Voiriot Guillaume
- Voiriot Guillaume
- Voisot Lena
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- Vught Lonneke
- Vuotto Fanny
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Weiss Emmanuel
- Weiss Nicolas
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wilkerson Matthew
- Winchenne AnaĂŻs
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- YahĹźi Aysun
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yesilbas Osman
- Yildiz Mehmet
- Yordanov Youri
- Youkou Christy Gaëlla Kotokpo
- Young Barnaby
- YĂĽkselmiĹź Ufuk
- Zafrani Lara
- Zaidan Mohamad
- Zaidi Wissem
- Zak Cathia
- Zarhrate-Ghoul Aida
- Zatout Ouassila
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zecca Marco
- Zein Loubna El
- Zeino Suzanne
- Zeitouni Michel
- Zemirli NaĂŻma
- Zerah Lorene
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Xijun
- Zhang Yu
- Zia Ounsa
- Ziol Marianne
- Zolario Oceane
- Zuber Julien
- Zuccaro Valentina
- Zwinderman A.
- Íñigo-Campos Antonio
- Ă–z Ĺžadiye KĂĽbra TĂĽter
- Ă–zkan Esra AkyĂĽz
- Özçelik Tayfun
- Publication venue
- BioMed Central
- Publication date
- 06/01/2024
- Field of study
International audienc
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
- Author
- Abad Jorge
- Abad Sebastien
- Abassi Radhiya
- Abdelhadi Nour Mekki
- Abdellaoui Abdelrafie
- Abdelmalek Abdelkrim
- Abdoul Hendy
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abergel Helene
- Abeud Fariza
- Abgrall Sophie
- Abisror Noemie
- Abolhassani Hassan
- Abou Tayoun Ahmad
- Accordino Giulia
- Achille Cristian
- Adechian Marylise
- Aderdour Nordine
- Admane Hakeem Farid
- Adnet Frederic
- Afritt Sara
- Agostini Helene
- Agra Juan José Cáceres
- Aguilar Claire
- Aguilera-Albesa Sergio
- AguilĂł-Cucurull Aina
- Agut Sophie
- Aiello Tommaso Francesco
- Aiuti Alessandro
- Ajeenthiravasan Gokula
- Akcan Ă–zge Metin
- Al-Muhsen Saleh
- Al-Muhsen Saleh Zaid
- Al-Mulla Fahd
- Alauzy Virginie
- Alavi Darazam Ilad
- Alavoine Loubna
- Alba Camille
- Albisures Jonathan Antonio Roblero
- Alby-Laurent Fanny
- Aldave Juan C.
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- AlKhater Suzan A.
- Allard Lucie
- Allardet-Servent Jerome
- Allende Luis M.
- Alonso-Arias Rebeca
- Alosaimi Mohammed Faraj
- Alshahrani Mohammed S.
- Alsina Laia
- Alsohime Fahad M.
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Alyanakian Marie-Alexandra
- Amam Sabrina
- Amara Yasmina Ould
- Amat Karine
- Amoura Zahir
- Amrouche Lucile
- Amsterdam UMC Covid-19 Biobank [missing]
- Anderson Mark S.
- Andreakos Evangelos
- Andrejak Claire
- Andronikof Marc
- Anglicheau Dany
- Angoulvant François
- Anguel Nadia
- Annane Djillali
- AntolĂ Arnau
- Aounzou Mohammed
- Aparicio Caroline
- Appelman Brent
- Aratus Gladys
- Arias Andrés A.
- Arias Andrés Augusto
- Arlet Jean-Benoit
- Arquero Miguel Fernandez
- Arranz MarĂa JesĂşs
- Arrestier Romain
- Arzoine Jeremy
- Asano Takaki
- Aslangul Elisabeth
- Assefi Mona
- Aubart MĂ©lodie
- Aubry Adeline
- Audiffred Laetitia
- Audureau Etienne
- Auger Christelle Nathalie
- Auguet Teresa
- Auregan Jean-Charles
- Avramenko Iryna
- Awotar Celine
- Aytekin Gokhan
- Aytekin Gökhan
- Aytekin Selma Erol
- Azan Delphine
- Azemar Laurene
- Azot Axelle
- Azzouguen Billal
- Bachelet Delphine
- Badsi AĂŻda
- Baghdadi Jamila El
- Bahram Seiamak
- Bajolle Fanny
- Bakouboula Prissile
- Balcerowiak Coline
- Baldanti Fausto
- Balde Fanta
- Baldivia Elodie
- Baldolli Aurélie
- Ballester Maite
- Bangamingo Eliane-Flore
- Baptiste Amandine
- Baran-Marszak Fanny
- Barau Caroline
- Barget Nathalie
- Baris-Feldman Hagit
- Baronnet Flore
- Barrou Benoit
- Barthelemy Romain
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Baudel Jean-Luc
- Baudry Camille
- Baudry Elodie
- Bauters Fre
- Bax Diane
- Bayhan Gulsum Iclal
- Beaugerie Laurent
- Behilill Sylvie
- Behillil Sylvie
- Belamri Adel
- Belaube Nicolas
- Belilita Rhida
- Bellani Giacomo
- Bellassen Pierre
- Belmokhtar Rawan
- Belot Alexandre
- Belot Alexandre
- Beltran Isabel
- Beluze Marine
- Benainous Ruben
- Benallaoua Mourad
- Benamouzig Robert
- Benbara Amélie
- Benhida Jaouad
- Benkerrou Dehbia
- Benkhelouf Anis
- Benlagha Jihene
- Benmostafa Chahinez
- Benothmane Skander
- Bentifraouine Miassa
- Berard Laurence
- Beretta Ilaria
- Bergman Peter
- Berkell Matilda
- Bernier Quentin
- Bertholon Frédérique
- Berti Enora
- Bertier Astrid
- Berton Laure
- Bessis Simon
- Bettini Laura Rachele
- Beudel Martijn
- Beurton Alexandra
- Bezrodnik Liliana
- Bhavsar Krishna
- Bianco Celine
- Bianquis Clara
- Bidar Frank
- Biggs Catherine M.
- Bilbao Agurtzane
- Biondi Andrea
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanche Philippe
- Blanco Ignacio
- Blandinières Adeline
- Blayau Clarisse
- Bleibtreu Alexandre
- Bleibtreu Alexandre
- Blin Emmanuelle
- Bloch-Queyrat Coralie
- Bloomfield Marketa
- Blázquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boissier Marie-Christophe
- Boisson Bertrand
- Boisson-Dupuis Stephanie
- Boland Anne
- Bolivar-Prados Mireia
- Bollens Diane
- Bolze Alexandre
- Bolzoni Marion
- Bomers Marije
- Bompard Rudy pierre
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bondesan Simone
- Bonnet Nicolas
- Bonnouvrier Justine
- Bonta Peter
- Borghesi Alessandro
- Borie Raphael
- Borrero Blanca Amador
- Borrero Blanca Amador
- Bos Lieuwe
- Bosteels Cedric
- Botdhlo-Nevers Elisabeth
- Botelho-Nevers Elisabeth
- Botha Shirmonecrystal
- Botta Michela
- Bouadma Lila
- Boucenna Wissam
- Bouchama Fatiha
- Bouchaud Olivier
- Bouchez Sabelline
- Bouchghoul Hanane
- Boudjebla Taoueslylia
- Boudjema Noel
- Bouffard Catherine
- Bougle Adrien
- Bouguerra Meriem
- Bouiller KĂ©vin
- Boulanger CĂ©cile
- Bouras Leila
- Bourcier Agnes
- Bourgeon Marilou
- Bourrier Anne
- Bouscambert Maude
- Bouscarat Fabrice
- Bousfiha Ahmed A.
- Bousfiha Ahmed A.
- Bousquet Aurore
- Boutolleau David
- Bouvattier Claire
- Bouvry Diane
- Bouziri Nesrine
- Bouzrara Ons
- Boyarchuk Oksana
- Bozdemir Ĺžefika Elmas
- Bravais Juliette
- Bribier Sarah
- Briones M. Luisa
- Brodin Petter
- Brouwer Matthijs C.
- Brugier Delphine
- Bruneau LĂ©a
- Brunel Melanie
- Brunner Marie-Eve
- Bruno Raffaele
- Bryceson Yenan
- Bryceson Yenan T.
- Bueno Maria Rita P.
- Bugiani Marianna
- Bui Eida
- Buis David T. P.
- Buisson Anne
- Bukhari Huda
- Bukreyeva Iryna
- Bulle Esther
- Burdet Charles
- Bureau CĂ´me
- Bureau Serge
- Bustamante Carlos D.
- Bustamante Jacinta
- Bustos Ingrid G.
- Butte Manish J.
- Cabrera-Marante Oscar
- Cadranel Jacques
- Cailhol Johann
- Calin Ruxandra
- Canavaggio Pauline
- Cancella Marta
- Cantin Delphine
- Cao Albert
- Capra Ruggero
- Carapito Raphael
- Carbillon Lionel
- Carcel Sheila
- Carelli Valerio
- Carlier Nicolas
- Carrabba Maria
- Carrera Paola
- Casanova Jean-Laurent
- Casanova Jean-Laurent
- Casari Giorgio
- Casasnovas Carlos
- Caseris Marion
- Cassaniti Irene
- Cassard Clementine
- Castelle Martin
- Castelli Francesco
- Castor Guylaine
- Castro Mateus V.
- Catherinot Emilie
- Cauchy Marion
- Cazzaniga Marina
- Celik Jale Bengi
- Cervantes-Gonzalez Minerva
- Ceschi Alessandro
- Cha Olivier
- Chachoua Abla
- Chahine Abir
- Chaigne Benjamin
- Chair Anissa
- Chakravorty Samya
- Chaldebas Matthieu
- Challal Salima
- Chalumeau Martin
- Chalumeau Nathalie Costedoat
- Champion Karine
- Charbit Bruno
- Chariot Patrick
- Charpentier Charlotte
- Chas Julie
- Chauveau Simon
- Chauvin Anthony
- Chauvin Clement
- Chavarot Nathalie
- ChaĂŻbi Khalil
- Chebbout Kamélia
- Cheng Matthew P.
- Cherai Mustapha
- Cherubini Ilaria
- Chevalier Amelie
- Chiarabini Thibault
- Chinet Thierry
- Chirouze Catherine
- Chirouze Catherine
- Chocron Richard
- Choinier Pascaline
- Chommeloux Juliette
- Choquet Christophe
- Choupeaux Laure
- Chousterman Benjamin
- Christelle Kouakam
- Christodoulou John
- Ciocan Dragosmarius
- Citerio Giuseppe
- Clarke Ada
- Clavere Gaëlle
- Clavier Florian
- Clavé Père
- Clement Karine
- Clerc Sebastien
- Cloherty Osoul Chouchane Alex
- Clotet Bonaventura
- Cobat Aurélie
- Codina Anna
- Coelho Alexandra
- Cohen Adrien
- Cohen Fleur
- Cohen Yves
- Cohen Yves
- Coilly Audrey
- Colboc Hester
- Colin Pauline
- Collet Magalie
- Colobran Roger
- Comarmond Chloé
- Comarmond Cloé
- Combacon Emeline
- Combe Caroline Lascoux
- Combes Alain
- Combes Alain
- Comoli Patrizia
- Comparon Celine
- Condino-Neto Antonio
- Constantin Jean-Michel
- Constantinescu Stefan N.
- Contro Ernesto
- Cooper Megan A.
- Cordel Hugues
- Cordier Anne-Gael
- Corsico Angelo G.
- Costantini Adrien
- Couffignal Camille
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Couffin-Cadiergues Sandrine
- Coupeau Doriane
- CoV-Contact Cohort [missing]
- COVID Clinicians [missing]
- COVID Human Genetic Effort [missing]
- COVID-STORM Clinicians [missing]
- COVIDeF Study Group [missing]
- Covill Laura E.
- CoĹźkuner Taner
- Creange Alain
- Cuadros Esmeralda Nuñez
- Cvetkovski Aleksandar
- Cyrus Cyril
- Da Silveira Charlène
- Dalgard Clifton L.
- Dalmau David
- Danielson Jeffrey J.
- Danion François
- Darley David Ross
- Das Vincent
- Dauby Nicolas
- Dauger Stéphane
- De Bouille Jeanne Goupil
- de Brabander Justin
- de Bree Godelieve
- de Bruin Sanne
- De Castro Nathalie
- De Chambrun Marc Pineton
- de Chambrun Marc Pineton
- de Diego Rebeca PĂ©rez
- De Farcy Pauline Mary
- de Jong Menno D.
- De Munter Paul
- de Pontual Loic
- de Rotte Maurits C. F. J.
- De Rycke Yann
- de Vera MartĂn Castillo
- de Vries Heder
- Debray Marie-Pierre
- Dechanet Aline
- Declercq Jozefien
- Deconinck Lauren
- Dehban Amin
- Del Pozo Lucie
- del Prado Maria Yolanda Ruiz
- Delannoy Quentin
- Delay Mathieu
- Deleris Robin
- Deleuze Jean-François
- Delforge Juliette
- Delmonte Ottavia M.
- Delphine Laëtitia
- Delplancq Geoffroy
- Demar Magalie
- Demare Noemie
- Demeret Sophie
- Demerville Lauren
- Demirkol Yasemin Kendir
- Demoule Alexandre
- Demoule Alexandre
- Deniau Aurore
- Deplanque Dominique
- Deplanque Dominique
- Depret François
- Derolez Sophie
- Derradji Ouda
- Derridj Nawal
- Desai Murkesh
- Descamps Diane
- Descamps Diane
- Descamps Vincent
- Deschamps Lydia
- Desconclois Celine
- Desguerre Isabelle
- Desille-Dugast Mireille
- Desmarets Maxime
- Desnos Cyrielle
- Desongins Karine
- Desvallée Mathilde
- Devouge Eglantine Ferrand
- Dhote Robin
- Di Sabatino Antonio
- Diallo Alpha
- Diallo Benjamin
- Didier Morgane
- Diehl Jean-Luc
- Diemer Myriam
- Diez Stephane
- Dijkstra Mirjam
- Diouf Alphonsine
- Djadi-Prat Juliette
- Djebara Siham
- Djebra Naoual
- Djietcheu Minette
- Djillali Hadjer
- Djossou FĂ©lix
- Djouadi Nouara
- Dobbelaere Stephanie
- Dobbs Kerry
- DomĂnguez-Garrido Elena
- Dongelmans Dave A.
- Donneger Severine
- Dorival CĂ©line
- Dos Santos Catarina
- Dournon Nathalie
- Dres Martin
- Droctove Laura
- Drogrey Marie
- Drolet Beth A.
- Dropy Margot
- Drouet Elodie
- Dubos François
- Dubosq Valérie
- Dubost Clément
- Dubreucq Evelyne
- Dubus Estelle
- Duchemann Boris
- Duchenoy Thibault
- Dudoignon Emmanuel
- Dufau Romain
- Dujardin Romein W. G.
- Dumas Florence
- Duran Clara
- Durand Anne Bourgarit
- Duron Emmanuelle
- Durrbach Antoine
- Duval Xavier
- Duval Xavier
- Duvivier Claudine
- D’Angio’ Mariella
- d’Ortenzio Eric
- Ebstein Nathan
- Ecobichon Jean-Luc
- Ekwall Olov
- El Zein Loubna
- Elabbadi Alexandre
- Elbers Paul
- Elharrar Brigitte
- Elie Caroline
- Elnagdy Marwa H.
- Eloy Philippine
- Elrufaai Marwa Bachir
- Emiroglu Melike
- Endo Akifumi
- Enouf Vincent
- Enouf Vincent
- Erdeniz Emine Hafize
- Ernotte Gabriel
- Esling Anne
- Esperou Hélène
- Espinosa-Padilla Sara
- Esposito-Farese Marina
- Espérou Hélène
- Etienne Manuel
- Etienne Martin
- Euvrard Romain
- Eyer Xavier
- Fabio Giovanna
- Faivre Laurence
- Falck Antonin
- Fartoukh Muriel
- Fartoukh Muriel sarah
- Faure Morgane
- Fayali Takoua
- Feldman Hagit Baris
- Feldman Hagit Baris
- Fellay Jacques
- Fermaut Marion
- Ferrer Ricard
- Ferreres Jose
- Fiorentino Alessio
- Fiorentino Arianna
- Fleuren Lucas
- Fliss Souha
- Flores Carlos
- Florkin Benoit
- Foti Giuseppe
- Fouchard Julie
- Fournier Benjamin
- Fournier Marie-CĂ©line
- Franco Jose Luis
- Franco José Luis
- Francois Bruno
- Francois Hélène
- French COVID Cohort Study Group [missing]
- Freynet Olivia
- Frezouls Wahiba
- Frigout Yvann
- Froidure Antoine
- Fromont Isaure
- Fuentes Axelle
- FumadĂł Victoria
- Fung Kitty S. C.
- Furet Thomas
- Fusco Francesca
- Gagneux-Brunon Amandine
- Gagro Alenka
- Galand Joris
- Garnier Marc
- Garçon Pierre
- Gatineau Audrey Giraud
- Gaubert Agnes
- Gaudry Stéphane
- Gaugain Samuel
- Gault Nathalie
- Gaussem Pascale
- Gauthier Damien
- Gautier Maxime
- Gaymard Alexandre
- Gayretli Zeynep
- Geijtenbeek Suzanne Geerlings Theo
- Georgin-Lavialle Sophie
- Geromin Daniela
- Gervais Adrian
- Ghalayini Mohamed
- Ghaleh Bijan
- Ghezal Myriam
- Ghosn Jade
- Gibelin Aude
- Gigante Tristan
- Gil-Herrera Juana
- Gilardin Laurent
- Gilg Morgane
- Gimeno Linda
- Girard Benoit
- Girbes Armand
- Girona-Alarcón Mònica
- Gissot Valérie
- Goas Carole L. E.
- GodĂnez Karen Alejandra Cifuentes
- Goffard Jean-Christophe
- Gomes Doryan
- Gomes-Pires Elisabete
- Gonzales Nacho
- Gonzalez-Granado Luis I.
- González-Montelongo Rafaela
- Goorhuis Bram
- Gorochov Guy
- Gouge Anne
- Gouja Amel
- Goulet Helene
- Goupil Sylvain
- Gras Julien
- Greffe Segolene
- Gregersen Peter K.
- Grimaldi Lamiae
- Grobusch Martin P.
- Guedeney Paul
- Guedj Jérémie
- Guerder Antoine
- Guidet Bertrand
- Guillo Matthias
- Gulczynski Mariechristelle
- Gumucio Victor Daniel
- Gunst Jan
- Gut Marta
- Gysembergh-Houal Anne
- GĂ©rardin Patrick
- GĂĽlhan Belgin
- Hadjadj JĂ©rĂ´me
- Hadjam Tassadit
- Haerynck Filomeen
- Hafkamp Florianne
- Hagens Laura
- Hagin David
- Haguenauer Didier
- Halwani Rabih
- Hamann Jorg
- Hammal Soumeya
- Hammarström Lennart
- Hammoudi Nadjib
- Hancerli Selda
- Hanitsch Leif Gunnar
- Hanon Olivier
- Hariyan Tetyana
- Harris Vanessa
- Harrois Anarole
- Hatipoglu Nevin
- HatipoÄźlu Nevin
- Hausfater Pierre
- Hautem Coraline
- Heath James R.
- Heijmans Catherine
- Hekimian Guillaume
- Heming Nicholas
- Hemke Robert
- Hendou Samia
- Henrickson Sarah E.
- Heppekcan Deniz
- Hermine Olivier
- Hernandez-Brito Elisa
- Heunks Sabine M. Hermans Leo
- Ho Po-ki
- Ho Sylvie
- Hoctin Alexandre
- Hoffmann Isabelle
- Holanda-Peña MarĂa Soledad
- Hollmann Markus
- Horcajada Juan P.
- Horn Janneke
- Hoste Eric
- Hoste Levi
- Houas Ikram
- Houhou Nadhira
- Houllier Marie
- Hovius Joppe W.
- Hraiech Sami
- Hsieh Elena W. Y.
- Hulot Jean-SĂ©bastien
- Humbert Linda
- Hung Ivan F. N.
- Huot Benjamin
- Hupalo Daniel N.
- Huscenot Tessa
- Husebye Eystein
- Iglesias Alejandro D.
- Ikherbane Ghilas
- Imai Kohsuke
- Imarazene Meriem
- Imberti Luisa
- Ingiliz Patrick
- Iratni Lina
- Itan Yuval
- Jaafoura Salma
- Jamme Matthieu
- Jarvis Erich D.
- Jaureguiberry Stephane
- Jean-Marc Jean-Francois
- Jeulin Hélène
- Jeyarajasingham Deleena
- Jimeno Marie-Thérèse
- Jordan Iolanda
- Jouanguy Emmanuelle
- Jouany Pauline
- Jouis Veronique
- Jourdaine Clement
- Kaci Marc Ait
- Kafif Ouifiya
- Kafif Ouifiya
- Kafif Ouifiya
- Kaguelidou Florentia
- Kahn-Kirby Amanda
- Kali Sabrina
- Kallala Rim
- Kara Yalcin Burak
- Karahan Aydın
- Karamitros Timokratis
- Karbuz Adem
- Kasapcopur Ozgur
- Kashimada Kenichi
- Katsahian Sandrine
- Kayani Sandrine Dautheville Guibal El
- Keles Sevgi
- Kelesyan Lilit
- Keo Vixra
- Kermanach Nathalie Saidenberg
- Ketz Flora
- Khalifa Jihane El
- Khalil Antoine
- Khamis Warda
- Khan Coralie
- Khan Taj Ali
- Khelili Enfel
- Khellaf Mehdi
- Kido Yasutoshi
- Kılıç Ahmet Osman
- Kisand Kai
- Kizil Can
- Klocperk Adam
- Koning Rutger
- Kounis Ilias
- Koutsoukou Antonia
- Kpalma Gaelle
- Krause Jessica
- KrĂłl Zbigniew J.
- Ksouri Hatem
- Ku Cheng-Lung
- Kuentz Paul
- Kwan Arthur M. C.
- Kwan Yat Wah M.
- Kwok Janette S. Y.
- Kyheng Christèle
- Labbe Vincent
- Lack Justin
- Lacombe Karine
- Lacorte Jean-Marc
- Lafont Anne Gaelle
- Lafont Emmanuel
- Lagha Lynda
- Lagier Jean-Christophe
- Laine Fabrice
- Lam David S. Y.
- Lamarre Yannie Cuvillier
- Lambrecht Bart
- Lamhaut Lionel
- Lampropoulou Vicky
- Lancelot Aymeric
- Landman Cecilia
- Lanternier Fanny
- Lanternier Fanny
- Laouénan Cédric
- Larcheveque Cecile
- Laribi Samira
- Larmurier Isabelle Nion
- Lasa Maria Pilar Etxart
- Lassel Ludovic
- Lau Yu-Lung
- Laverdant Benjamin
- Lavergne Christophe
- Lavillegrand Jean-RĂ©mi
- Laviolle Bruno
- Lazureanu Pompilia
- Le Bourgeois Fleur
- Le Guennec LoĂŻc
- Le Hingrat Quentin
- Le Mestre Soizic
- Le Nagard Hervé
- Le Minh
- Leberre Lamia
- Leblanc Claire
- Leboyer Marion
- Lecomte Francois
- Lecorre Marine
- Leenhardt Romain
- Lefebvre Bénédicte
- Lefebvre Marylou
- Lefévre Benjamin
- Legendre Paul
- Leger Anne
- Legrand Karine
- Legros Laurence
- Legrosse Justyna
- Lehacaut Jonathan
- Lehuunghia SĂ©bastien
- Lemarec Julien
- Leo Yee-Sin
- Leon-Lopez Rafael
- Leporrier-Ext Jeremie
- Leprieur Bénédicte Giroux
- Lermine Alban
- Lescure François-Xavier
- Lesein Manon
- Lesur Hubert
- Letrou Sophie
- Letrou Sophie
- Leung Daniel
- Levin Michael
- Levy Albert
- Levy Michael
- Levy Vincent
- Levy Yves
- Li Zhi
- Lien Olivia Tran Dinh Thanh
- Lifton Richard P.
- Lilleri Daniele
- Lim Endry H. T.
- Lima Breno Melo
- Lima Edson Jose Adrian Bolanos
- Lina Bruno
- Lina Bruno
- Ling Yun
- Lingas Guillaume
- Linglart Agnes
- Llovich Alex Serra
- Lomazzi Sandra
- Lopes Amanda
- Lopes Edwige
- Lopez Rafael Leon
- Lopez Vanessa
- Lopinto Julien
- Lorenzo-Salazar José M.
- Lortholary Olivier
- Louadah Badr
- Louapre CĂ©line
- Loze Bénédicte
- Lubetzki Catherine
- Lucarelli Aude
- Lucas Carrie L.
- Lucas Marie-Laure
- Lucasamichi Axelle
- Lucet Jean Christophe
- Lucet Jean-Christophe
- Lung Kwok-Cheung
- Luong Liem Binh
- Luyt Charles-Edouard
- Lye David C.
- LĂ©vy Romain
- LĂłpez-Collazo Eduardo
- Magazimama-Ext Arouna
- Magnone Cinthia
- Maillot Adrien
- Maingret David
- Malhotra Surbi
- Malvy Denis
- Malvy Denis
- Mambert Marina
- Mameri Lakhdar
- Manchon Pauline
- Maniatis Tom
- Manivet Philippe
- Manry Jeremy
- Mansouri Cylia
- Mansouri Davood
- Marcault Estelle
- Marchal Astrid
- Marchioni Enrico
- Marey Jonathan
- Marin Nathalie
- Marioli Carola
- Marjani Majid
- Marois Clémence
- Marques Laura
- Martin Olivier
- Martin-Nalda Andrea
- Martineau Lou
- Martinez Antonio Morales
- Martinez-Lopez Cannelle
- Martinez-Picado Javier
- Martyniuck Pierre
- MartĂn-Nalda Andrea
- Marzana Iciar
- Marzouk Nessrine
- Maródi László
- Masmoudi Rafik
- Mata-MartĂnez Carmen
- Mathian Alexis
- Matos Larissa R. B.
- Matthews Gail V.
- Mattiaccio Alessandro
- Matuozzo Daniela
- Mayaux Julien
- McLaughlin-Garcia Raquel
- Mebazaa Alexandre
- Mechai Frédéric
- Mecozzi Fabio
- Medina Yeray Novoa
- Mediouni Chamseddine
- Meersseman Philippe
- Megarbane Bruno
- Meghadecha Mohamed
- Mejean Élodie
- Mekinian Arsene
- Mekni Rania
- Mekontso-Dessap Armand
- Meliti Thinhinan Sabrina
- Melián Abián Montesdeoca
- Melki Isabelle
- Meloni Federica
- Meng Paris
- Mentre France
- Mentré France
- Merbah Soraya
- Mergeay-Fabre Mayka
- Meritet Jean-François
- Merlani Paolo
- Messani Fadhila
- Messaoudi Yasmine
- Metin Akcan Ozge
- Meunier Alexandre
- Mewasing Baboo-Irwinsingh
- Meyts Isabelle
- Meyts Isabelle
- Meyts Isabelle
- Meziane Amina
- Meziane Lydia
- Mezidi Mehdi
- Michelot-Burger Carole
- Migaud Maria-Claire
- Migeotte Isabelle
- Mignot Françoise
- Milisavljevic Baptiste
- Milla Sonia Ayllon
- Millereux Maude
- Million Matthieu
- Milner Joshua D.
- Minka Fadi Hillary
- Mirault Tristan
- Mircher Clotilde
- Mironska Kristina
- Mirsaeidi Mehdi
- Miyara Makoto
- Mizoguchi Yoko
- Modi Bhavi P.
- Mogensen Trine H.
- Moine Pierre
- Mojoli Francesco
- Molina Jean-Michel
- Moncomble Elsa
- Monnory Fatima-Zohra Djamouri
- Montagne Samatha
- Montegnies-Boulet AnaĂŻs
- Monti Alexandra
- Montlahuc Claire
- Montout Anne-Lise
- Moores Alexandre
- Morandeira Francisco
- Morange Pierre-Emmanuel
- Morbieu Caroline
- Mordacq Cléemence
- Morelle Guillaume
- Morio Tomohiro
- Mortelette Helene
- Mouly Stéphane
- Mouly Stéphane J.
- Mouquet Hugo
- Mullaert Jimmy
- Muzaffar Rosita
- Muñoz-Barrera Adrián
- Mège Jean-Louis
- Nacerddine Cherifa Iness
- Nadal Marine
- Nadif Hajer
- Nadji Seyed Alireza
- Naesens Leslie
- Nafati Cyril
- Nagashima Shintaro
- Nakagama Yu
- Narvaez Rafael Usubillaga
- Nassarmadji Kladoum
- Natella Pierre
- Ndingamondze Sandrine
- Neant Nadège
- Nellen Jeaninne
- Neraal Stefan
- Neven Bénédicte
- Neves JoĂŁo Farela
- Ng Lisa F. P.
- Ng Lisa F. P.
- Ng Yuk-Yung
- Nguyen Caroline
- Nguyen Duc
- Nguyen Duc
- NIAID-USUHS COVID Study Group [missing]
- Nicolas Leturque
- Nielly hubert
- Nlomenyengue Luc
- Noel Nicolas
- Noret Marion
- Nossent Esther J.
- Notarangelo Luigi D.
- Notarangelo Luigi D.
- Nouroudine Mariama
- Novelli Antonio
- Novelli Giuseppe
- Nseir Saad
- Nunes Hilario
- Nussbaum Robert
- N’Guyen Bao
- Ocejo-Vinyals J. Gonzalo
- Okada Satoshi
- Okamoto Keisuke
- Oler Andrew J.
- Omar Edris
- Orchestra Working Group [missing]
- Oualha Mehdi
- Ouazene Zineb
- Ouedrani Amani
- Ouedraogo Elise
- Ouelaa Wassila
- Oufella Hafid Ait
- Oukhedouma Anissa
- Oya Herve
- Ozcelik Tayfun
- Oziel Johanna
- Ozkaya-Parlakay Aslinur
- O’Farrelly Cliona
- Padilla Thomas
- Pagani Michele
- Paillaud Elena
- Paiva Solenne
- Palabiyik Figen
- Pan-Hammarström Qiang
- Papadaki Maria
- Papadopoulos Aurélie
- Parfait Beatrice
- Paris Christophe
- Parize Perrine
- Parizot Christophe
- Parizot Christophe
- Parola Philippe
- Parrot Antoine
- Pascreau Tiffany
- Paul Christelle
- Paul Stéphane
- Paulus Frederique
- Pavot Arthur
- Payet Christine
- Paz-Artal Estela
- Peaudecerf Laetitia
- Pedraza Sigifredo
- Peiffer-Smadja Nathan
- Pellecer Nancy Carolina González
- Pellegrini Silvia
- Pene Frédéric
- Pepin Marion
- Pereira Jesus Marquez
- Pernet Julie
- Pernin Claire
- Perpoint Thomas
- Perreau Pauline
- Pesci Alberto
- Peters Edgar
- Petit Mylène
- Petrov-Sanchez Ventzislava
- Peyrony Olivier
- Peytavin Gilles
- Pham Huong
- Philippe Aurélien
- Philippot Quentin
- Picod Adrien
- Picone Olivier
- Pietri Marie-Pierre
- Pietri Olivia
- Pina-Fuentes Dan A. I.
- Pinson Michelle
- Pintado Claire
- Pippucci Tommaso
- Piquard Valentine
- Piquard Valentine
- Piquard Valentine
- Piralla Antonio
- Pires Christine
- Pistone Thierry
- Planas Anna M.
- Planas-Serra Laura
- Planquette Benjamin
- Pleguezuelo Daniel E.
- Ploin Dominique
- Poirier Sandrine
- Poissy Julien
- Pomel Anne-Laure
- Poncelet GĂ©raldine
- Pons Stéphanie
- Ponscarme Diane
- Poulakou Garyphallia
- Pouletty Marie S.
- Pourcelot Annegaelle
- Pourcher Valérie
- Pourshahnazari Persia
- Pouvaret Anne
- Prando Carolina
- Preckel Bennedikt
- Prever Florian
- Previlon Miresta
- Prevost Margot
- Prins Jan M.
- Provoost Marie-Julie
- Puel Anne
- Pueyo David MartĂnez
- Pujol Aurora
- Puéchal Oriane
- Pérez-Fernández Xosé Luis
- Qiu-Chen Jia Li
- Quaresima Virginia
- Quemeneur Cyril
- Quentric Paul
- Quintana-Murci Lluis
- Quintin Caroline
- Quiros-Roldan Eugenia
- Raasveld Jorinde
- Rabaud Christian
- Rafat CĂ©dric
- Ramaswamy Sathishkumar
- Rambaud Thomas
- Rami Agathe
- Ramos Miquel Alfonso
- Ranque Brigitte
- Raoult Didier
- Raoult Violette
- Raphael Maurice
- Raphalen Jean Herle
- Rastoin Anna
- Raux Mathieu
- Rebai Amani
- Rebillat Anne-Sophie
- Reby Michael
- Redin Claire
- Regent Alexis
- Regrag Asma
- Reijnders Tom
- Renia Laurent
- Resche-Rigon Matthieu
- Resmini LĂ©a
- Resnick Igor
- Ressaire Quentin
- Reyes Luis Felipe
- Ricart Pilar
- Richard Christian
- Richard Jean-Christophe
- Richard Lucie
- Richard Mariecaroline
- Rigo-Bonnin RaĂşl
- rivet Nadia
- Rivière Jacques G.
- Robert Maxence
- Rocamora-Blanch Gemma
- Rodero Mathieu P.
- Rodrigo Carlos
- Rodriguez Luis Antonio
- Rodriguez-Gallego Carlos
- Rodriguez-Palmero AgustĂ
- RodrĂguez-Gallego Carlos
- Rohaut Benjamin
- Rojas Julian
- Rolland-Debord Camille
- Romero Carolina Soledad
- Ropers Jacques
- Roque-Afonso Anne-Marie
- Rosa-Calatrava Manuel
- Rosenberger John
- Rossi Camillo
- Rossignol Bénédicte
- Rossignol Patrick
- Rosso Charlotte
- Rothenbuhler Anya
- Roufai Layidé
- Rousseaux MĂ©lanie
- Rousseaux Nabila
- Roux Damien
- Roux Lorène
- Roux Swasti
- Rouzaud Claire
- Rovere-Querini Patrizia
- Rovina Nikoletta
- Roy Carine
- Rozenberg Flore
- Rozes Antoine
- Rubenstein Emma
- Ruch Yvon
- Ruiz Montse
- Ruiz-Rodriguez Juan Carlos
- Sabate Jean-Marc
- Sabater-Riera Joan
- Sabet Sheila
- Sacleux Sophie-Caroline
- Saied Wafa Ibn
- Saks Kai
- Salagianni Maria
- Saliba Faouzi
- Salmon Dominique
- Sanchez Oliver
- Sancho-Shimizu Vanessa
- Savale Laurent
- Savary Guillaume
- Sberro Rebecca
- Scemla Anne
- Schidlowski Laire
- Schinkel Michiel
- Schlemmer Frederic
- Schluter Agatha
- SchlĂĽter Agatha
- Schmidt Julien
- Schmidt Matthieu
- Schneider Marion
- Schrauwen Femke A. P.
- Schuetz Catharina
- Schultz Marcus J.
- Schuurmans Alex
- Schuurmans Jaap
- Schwartz Mathieu
- Schweitzer Cyril E.
- Scolari Francesco
- Sedfi SaĂŻd
- Sediva Anna
- Sediva Anna
- Seeleuthner Yoann
- Sefir-Kribel Samia
- Seijo Luis
- Seksik Philippe
- Sellier Pierre
- Selves Agathe
- Sembach Nicole
- Semerano Luca
- Seminario Analia Gisela
- Senat Marie-Victoire
- Sene Damien
- Sene Damien
- Seng Piseth
- Senoglu Sevtap
- Seppänen Mikko
- Seppänen Mikko R. J.
- Seri Marco
- Serris Alexandra
- Sese Lucile
- Sghiouar Naima
- Shahrooei Mohammad
- Shcherbina Anna
- Shcherbina Anna
- Sigaloff Kim
- Sigaux Johanna
- Siguier Martin
- Siguret Virginie
- Silvain Johanne
- Simon Noémie
- Simon Tabassome
- Siouti Eleni
- Skandri Lina Innes
- Slabbynck Hans
- Slaby Ondrej
- Slim Marleen A.
- Slimani Miassa
- Smadja David M.
- Smeele Patrick
- Smit Marry
- Smith Nikaia
- Snauwaert Aurélie
- Snow Andrew L.
- Snow Andrew L.
- Sobh Ali
- Sokol Harry
- Solanich Xavier
- Soler Catherine
- Soler-Palacin Pere
- Soler-PalacĂn Pere
- Soler-PalacĂn Pere
- Soliman Heithem
- Solis Blanca Garcia
- Soltani Nisrine
- Solé-Violán Jordi
- Sottini Alessandra
- Soyer Benjamin
- Sozeri Betul
- Spaan András N.
- Steg Gabriel
- Stella Giulia Maria
- Stepanovskiy Yuriy
- Stijnis Cornelis S.
- Stilma Willemke
- Stoclin Annabelle
- Su Helen C.
- Su Helen C.
- Su Richa
- Suarez Lydia
- Sukumar Gauthaman
- Szwebel Tali-Anne
- Sánchez-Montalvá Adrián
- Sánchez-Ramón Silvia
- Sözeri Betül
- Taccone Fabio
- Tacconelli Evelina
- Taffame Kossi
- Talouarn Estelle
- Tancevski Ivan
- Tandjaoui-Lambiotte Yacine
- Tangye Stuart G.
- Tantet Claire
- Tardivon Coralie
- Tardy Bernard
- Tateo Mariagrazia
- Taupin Jean-Luc
- Tavernier Simon
- Tellier Marie-Capucine
- Tello Loreto Vidaur
- Terrier Benjamin
- Terrier Olivier
- Teunissen Charlotte
- Theodose Igor
- Thiebaud Pierre clement
- Thiery Guillaume
- Thomas Caroline
- Thoral Patrick
- Thorball Christian
- Thorn Karolina
- Thumerelle Caroline
- Thy Michael
- Tiercelet Kelly
- Timsit Jean-François
- Tipu Imran
- Tisserand Julie
- Tolstrup Martin
- Tomasoni Gabriele
- Tomczak Carole
- Tompkins Miranda F.
- Torelino Krystel
- Touam-Ext Fatima
- Toubiana Julie
- Toumi Lilia
- Toury Gustave
- Toy-Miou Mireille
- Trandinh Alexy
- Treluyer Jean-Marc
- Tresoldi Cristina
- Triantafyllia Vasiliki
- Trinque Baptiste
- Trouillet-Assant Sophie
- Troya Jesus
- Troya JesĂşs
- Truchot Jennifer
- Tsang Owen T. Y.
- Tserel Liina
- Tso Eugene Y. K.
- Tsonas Anissa M.
- Tual Christelle
- Tubach Florence
- Tubiana Sarah
- Tucci Alessandra
- Tuinman Pieter R.
- Tunesi Simone
- Turpin Agathe
- Turpin Matthieu
- Turvey Stuart E.
- Téoulé François
- Uddin Furkan
- Uddin Mohammed J.
- Urbina Tomas
- Ursini Matilde Valeria
- Utsumi Takanori
- Uzunhan Yurdagul
- Uzunhan Yurdagul
- Vabres Pierre
- Vacher Yannick
- Vaittinadaayar Prabakar
- Valencia-Ramos Juan
- Valent Arnaud
- Valentian Maelle
- Valin Nadia
- Vallet Hélène
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- Van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- Van Den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- Van Der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- Van Praet Jens
- van Vugt Michèle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vaz Marina
- Vazquezibarra Miguel-Alejandro
- Vedie Benoit
- Veelo Denise
- Vega Clara Campos
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Velly Laetitia
- Verstuyft Celine
- Viallette Cedric
- Vicaut Eric
- Vidaud Michel
- Vidigal Mateus C.
- Viel SĂ©bastien
- Vignali Valérie
- Vignes Dorothee
- Vilaire-Meunier Marie E.
- Villain CĂ©dric
- Villar-GarcĂa Judit
- Vimpere Damien
- Vincent Audrey
- Vinh Donald C.
- Virlouvet Myriam
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander P. J.
- Voiriot Guillaume
- Voiriot Guillaume
- Voisot Lena
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- Vught Lonneke A.
- Vuotto Fanny
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Weiss Emmanuel
- Weiss Nicolas
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wilkerson Matthew D.
- Winchenne AnaĂŻs
- Wouters Dorien
- Wu Alan K. L.
- Wu Tak-Chiu
- YahĹźi Aysun
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yesilbas Osman
- Yildiz Mehmet
- Yordanov Youri
- Youkou Christy Gaëlla Kotokpo
- Young Barnaby E.
- Yüksek Saliha Kanık
- YĂĽkselmiĹź Ufuk
- Zafrani Lara
- Zaidan Mohamad
- Zaidi Wissem
- Zak Cathia
- Zarhrate-Ghoul Aida
- Zatout Ouassila
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zecca Marco
- Zeino Suzanne
- Zeitouni Michel
- Zemirli NaĂŻma
- Zerah Lorene
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Xijun
- Zhang Yu
- Zia Ounsa
- Ziol Marianne
- Zolario Oceane
- Zuber Julien
- Zuccaro Valentina
- Zwinderman A. H.
- Íñigo-Campos Antonio
- Ă–z Ĺžadiye KĂĽbra TĂĽter
- Ă–zkan Esra AkyĂĽz
- Özçelik Tayfun
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 01/01/2023
- Field of study
BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old