Location of Violent Crime Relative to Trauma Resources in Detroit: Implications for Community Interventions

Introduction: Detroit, Michigan, is among the leading United States cities for per-capita homicide and violent crime. Hospital- and community-based intervention programs could decrease the rate of violent-crime related injury but require a detailed understanding of the locations of violence in the community to be most effective.Methods: We performed a retrospective geospatial analysis of all violent crimes reported within the city of Detroit from 2009-2015 comparing locations of crimes to locations of major hospitals. We calculated distances between violent crimes and trauma centers, and applied summary spatial statistics.Results: Approximately 1.1 million crimes occurred in Detroit during the study period, including approximately 200,000 violent crimes. The distance between the majority of violent crimes and hospitals was less than five kilometers (3.1 miles). Among violent crimes, the closest hospital was an outlying Level II trauma center 60% of the time.Conclusion: Violent crimes in Detroit occur throughout the city, often closest to a Level II trauma center. Understanding geospatial components of violence relative to trauma center resources is important for effective implementation of hospital- and community-based interventions and targeted allocation of resources.

Investigating the New Landscapes of Welfare: Housing Policy, Politics and the Emerging Research Agenda

As debates about housing form an increasingly important arena of political controversy, much has been written about the new fissures that have appeared as governments not only struggle to reduce public expenditure deficits but also attempt to address problems such as affordability and homelessness. It is widely anticipated that new conflicts will be played out in the private rental market as access to homeownership becomes unrealistic and the supply of social housing diminishes. However, what other tensions might surface; that hitherto have not been subject to the critical gaze of housing research? In this paper, we provide some thoughts on the nascent policy issues as well as the ideological schisms that are likely to develop in coming years, offering suggestions as to how the focus of housing policy research might be reoriented towards a “politics” framework to capture and better understand the conflicts that are likely to arise

Molecular basis of FIR-mediated c-myc transcriptional control

The far upstream element (FUSE) regulatory system promotes a peak in the concentration of c-Myc during cell cycle. First, the FBP transcriptional activator binds to the FUSE DNA element upstream of the c-myc promoter. Then, FBP recruits its specific repressor (FIR), which acts as an on/off transcriptional switch. Here we describe the molecular basis of FIR recruitment, showing that the tandem RNA recognition motifs of FIR provide a platform for independent FUSE DNA and FBP protein binding and explaining the structural basis of the reversibility of the FBP-FIR interaction. We also show that the physical coupling between FBP and FIR is modulated by a flexible linker positioned sequentially to the recruiting element. Our data explain how the FUSE system precisely regulates c-myc transcription and suggest that a small change in FBP-FIR affinity leads to a substantial effect on c-Myc concentration.MRC Grant-in-aid U11757455

Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers

Small molecule splicing modifiers have been previously described that target the general splicing machinery and thus have low specificity for individual genes. Several potent molecules correcting the splicing deficit of the SMN2 (survival of motor neuron 2) gene have been identified and these molecules are moving towards a potential therapy for spinal muscular atrophy (SMA). Here by using a combination of RNA splicing, transcription, and protein chemistry techniques, we show that these molecules directly bind to two distinct sites of the SMN2 pre-mRNA, thereby stabilizing a yet unidentified ribonucleoprotein (RNP) complex that is critical to the specificity of these small molecules for SMN2 over other genes. In addition to the therapeutic potential of these molecules for treatment of SMA, our work has wide-ranging implications in understanding how small molecules can interact with specific quaternary RNA structures

Bare mass effects on the reheating process after inflation

We consider the effects of a bare mass term for the inflaton, when the inflationary potential takes the form $V(\phi)= \lambda \phi^k$ about its minimum with $k \ge 4$. We concentrate on $k=4$, but discuss general cases as well. Further, we assume $\lambda \phi_{\rm end}^2 \gg m_\phi^2$, where $\phi_{\rm end}$ is the inflaton field value when the inflationary expansion ends. We show that the presence of a mass term (which may be present due to radiative corrections or supersymmetry breaking) can significantly alter the reheating process, as the equation of state of the inflaton condensate changes from $w_\phi=\frac{1}{3}$ to $w_\phi=0$ when $\lambda \phi^2$ drops below $m_\phi^2$. We show that for a mass $m_\phi \gtrsim T_{\rm RH}/250$, the mass term will dominate at reheating. We compute the effects on the reheating temperature for cases where reheating is due to inflaton decay (to fermions, scalars, or vectors) or to inflaton scattering (to scalars or vectors). For scattering to scalars and in the absence of a decay, we derive a strong upper limit to the inflaton bare mass $m_\phi < 350~{\rm MeV} (T_{\rm RH}/10^{10}~{\rm GeV})^{3/5}$, as there is always a residual inflaton background which acts as cold dark matter. We also consider the effect of the bare mass term on the fragmentation of the inflaton condensate.Comment: 16 pages, 10 figure

"There's nothing”: unemployment, attitudes to work and punitive welfare reform in post-crash Salford

This article explores attitudes and barriers to work and the impact of punitive welfare reform in the city of Salford (Greater Manchester). Contextualising our discussion in relation to the contemporary landscape of inequality and social class in the UK, we draw attention to the trends towards the expansion of low paid work, precarity and stigmatisation, and highlight the need for more qualitative, geographically sensitive, studies of how these phenomena are being played out. Describing the economic context of the City of Salford and the current state of its labour market, we then present the findings from qualitative interviews with a sample of low income, mostly working-class participants, who describe their orientations towards employment, perceptions of the labour market, barriers to employment and interactions with punitive welfare reform. Ultimately, we conclude by noting that both strategies of neoliberal statecraft aimed at the reduction of the charitable state described by Wacquant are at play in Salford and that their result is a discouragement from claiming welfare and a recommodification of labour

Co-deployment of bioenergy with carbon capture and storage in the UK: Growth or gridlock?

This study critically evaluates a BECCS-Hub within the North-West Industrial Carbon Capture cluster using advanced digital twin modelling via the Carbon Navigation System and detailed biomass mapping. It investigates five distinct BECCS supply chains at the Protos site, each reflecting novel configurations that closely align with real-life upcoming BECCS projects within the cluster. This research highlights significant carbon performance and scalability variations, crucial for aligning with evolving BECCS business models. A key finding is the essential role of biomass security and adaptability in uncertain future biomass availability and heightened intra-BECCS competition. The study reveals potential gridlock scenarios where intense competition for biomass could severely limit the scalability and efficiency of BECCS operations, especially under high competition scenarios. These gridlocks could significantly hinder strategic BECCS deployments by constraining resource availability and complicating logistics, thus impacting the pursuit of the UK's Net-Zero goals. The findings underscore the need for diverse and adaptable deployment strategies that account for biomass availability, technological feasibility, and local infrastructure—factors pivotal to achieving scalable and efficient BECCS operations. Advocating a nuanced, integrated approach to managing biomass competition and optimise resource use, the paper calls for proactive strategic planning and adaptability in BECCS deployment. By leveraging modelling innovations, the study aligns BECCS operations with the UK's stringent Net-Zero objectives and specific business models for BECCS. Such an approach will enhance the sustainable and efficient deployment of BECCS technologies in a competitive and rapidly evolving energy landscape

Measuring disadvantage in the early years in the UK: A systematic scoping review

Background: The relationship between disadvantage and child health in the early years is well established. For this evidence base to most helpfully inform services, we need to better understand how disadvantage is conceptualised and measured in the literature. We aimed to conceptualise disadvantage measured in child health literature and explore the associations between disadvantage and child health using these measures. Method: We conducted a scoping review using systematic methods to identify key concepts of disadvantage used in empirical child health literature. We searched MEDLINE, Scopus, and grey literature for studies exploring the association between disadvantage and child health outcomes for children aged 0-5 in the United Kingdom. We extracted and analysed data from 86 studies. Results: We developed a framework describing two domains, each with two attributes conceptualising disadvantage: level of disadvantage indicator (individual and area) and content of disadvantage indicator (social and economic). Individual-level measures of disadvantage tended to identify stronger associations between disadvantage and child health compared with area-level measures. Conclusion: The choice of disadvantage indicators, particularly whether individual- or area-level, can affect the inferences made about the relationship between disadvantage and child health. Better access to individual-level disadvantage indicators in administrative data could support development and implementation of interventions aimed at reducing child health inequalities in the early years

Brave new brains: sociology, family and the politics of knowledge

This article critically explores sociological arguments for greater biosocial synthesis, centring contemporary developments in public policy to demonstrate how such a reframing of humanity tends to reinforce existing political orders and socially patterned normativities. The case for further amalgamation of the social and life sciences is examined to suggest that production of somatic markers of truth from relational encounters largely relies upon an anaemic and politically contained version of the social as acquired in early childhood. More specifically, the gendered, classed and culturally specific practice of parenting children has come to occupy a new significance in accounts of social brains and environmentally reactive genomes. This is highlighted through a discussion of ‘early intervention’ as a heavily biologised policy rationale framing opportunities for biosocial collaboration. It is argued that late capitalist objectives of personal investment and optimisation are driving this assimilation of the social and life sciences, pursuing an agenda that traces and re-scores longstanding social divisions in the name of progress

Competitive and Cooperative Interactions Mediate RNA Transfer from Herpesvirus Saimiri ORF57 to the Mammalian Export Adaptor ALYREF

The essential herpesvirus adaptor protein HVS ORF57, which has homologs in all other herpesviruses, promotes viral mRNA export by utilizing the cellular mRNA export machinery. ORF57 protein specifically recognizes viral mRNA transcripts, and binds to proteins of the cellular transcription-export (TREX) complex, in particular ALYREF. This interaction introduces viral mRNA to the NXF1 pathway, subsequently directing it to the nuclear pore for export to the cytoplasm. Here we have used a range of techniques to reveal the sites for direct contact between RNA and ORF57 in the absence and presence of ALYREF. A binding site within ORF57 was characterized which recognizes specific viral mRNA motifs. When ALYREF is present, part of this ORF57 RNA binding site, composed of an a-helix, binds preferentially to ALYREF. This competitively displaces viral RNA from the a-helix, but contact with RNA is still maintained by a flanking region. At the same time, the flexible N-terminal domain of ALYREF comes into contact with the viral RNA, which becomes engaged in an extensive network of synergistic interactions with both ALYREF and ORF57. Transfer of RNA to ALYREF in the ternary complex, and involvement of individual ORF57 residues in RNA recognition, were confirmed by UV cross-linking and mutagenesis. The atomic-resolution structure of the ORF57-ALYREF interface was determined, which noticeably differed from the homologous ICP27-ALYREF structure. Together, the data provides the first site-specific description of how viral mRNA is locked by a herpes viral adaptor protein in complex with cellular ALYREF, giving herpesvirus access to the cellular mRNA export machinery. The NMR strategy used may be more generally applicable to the study of fuzzy protein-protein-RNA complexes which involve flexible polypeptide regions