E-Browsing: Serendipity and Questions of Access and Discovery

Browsing is an essential component to discovery. Understanding the foundations of browsing patterns and preferences is crucial in developing effective e-browsing environments. It’s important to understand how researchers in diverse disciplines have described their discoveries in terms of browsing, searching, and serendipitous encounters. Examining the works of scientists, social scientists, and humanists through the lens of discovery will reveal essential components to be aware of in developing e-browsing environments. In turning to a wide range of sources, often outside traditional library literature, we deepen our understanding of what it means to browse in an electronic environment. As librarians, we have an obligation to create physical and virtual spaces that cultivate wonder and curiosity and acknowledge varied paths to discovery. Electronic browsing options must become more robust if libraries are to be vital to scholarly communication. In this presentation we focus on the language and experience of browsing, with particular attention to serendipitous discovery, in order to encourage librarians, particularly those in public service, to more effectively articulate concerns and opportunities to developers

E-Browsing: Serendipity and Questions of Access and Discovery

Browsing is an essential component to discovery. Understanding the foundations of browsing patterns and preferences is crucial in developing effective e-browsing environments. It is important to understand how researchers in diverse disciplines have described their discoveries in terms of browsing, searching, and serendipitous encounters. Examining the works of scientists, social scientists, and humanists through the lens of discovery will reveal essential components to be aware of in developing e-browsing environments. In turning to a wide range of sources, often outside traditional library literature, we deepen our understanding of what it means to browse in an electronic environment. As librarians, we have an obligation to create physical and virtual spaces that cultivate wonder and curiosity and acknowledge varied paths to discovery. Electronic browsing options must become more robust if libraries are to be vital to scholarly communication. In this presentation, we focus on the language and experience of browsing, with particular attention to serendipitous discovery, in order to encourage librarians, particularly those in public service, to more effectively articulate concerns and opportunities to developers

Critical Collection Analysis: Using DH Tools to Contextualize Historical Collecting Patterns within a Political Framework

With the growth of digital humanities and a wide range of free and open source analysis tools at our fingertips, librarians have a unique opportunity to use these new tools to critically analyze library collections. Moving beyond usage and budgets, strategies such as text analysis, temporal pattern finding and data visualization offer insights into the structure and content of our collections, which in turn supports evidenced-based decision-making for future acquisitions. At the Claremont Colleges Library, librarians across divisions have been encouraged to learn tools and approaches to Digital Humanities, and apply these principles to our own work and relationships with researchers. This presentation was delivered on Friday, November 4th at the Charleston Conference. It covered: methods for gathering historic acquisitions data; strategies for using Digital Humanities tools to both analyze and communicate findings; an overview of this team\u27s findings on terrorism and collection development at Claremont; and potential future applications for the use of Digital Humanities tools to support collection assessment and development

Moyo Vol. VII N 2

Durica, Paul. Editor\u27s Letter . 4. Spears, Amy L. As If Lipstick Was A Sign of My Declining Mind (How ChickRock Happened) . 5. Frey, Randall. Portrait of the Cartoonist as a Young Man . 6. Clements, Nina. Grease Me Up: One Woman\u27s Descent into the Depths of Pittsburgh Dinner Culture . 7. Levine, Robert. Under the Needle\u27s Point (The Healing Power of Acupuncture) . 8. Durica, Paul. The Glory that was/is Greek: Denison Three Years After the Decision . 12. Lamont, Jean. Smokin\u27 Joe Lights Up . 13. Durica, Paul. Ode on a Second Grecian Turn: An Interview with President Michele T. Myers . 14. Fisher, Dan. Lenane on the Social Scene . 19. Combe, Kirk. Intellectual Bio-Diversity: A Faculty Perspective on the Greek Residential Issue . 20. Williams, Adam. Elephants on the Floor Above and Brats in the Basement: Life on the North Quad . 22. Pfleeger, Jon. New Kid on the Block (Sigma Phi Epsilon\u27s President Speaks) . 23. Werne, Kirsten. Coffee Talk at the Bandersnatch (An Interview with Kevin Clay and Adam) . 29

Moyo Vol. VIII N 1

Durica, Paul Editor\u27s Letter . 4. Thackeray, Alex. Postcard from the sXe . 5. Ward, Luc. Gods & Monsters (Hook-Up at Church) . 6. Anshuman, Karan. The India Nobody Knows (Mysticism and Misconceptions Revealed) . 8. Clements, Nina and Betsy Falconer. God as One of Us: Diverse Faiths Thrive at Denison . 10. Million, Chris. Splendor in the Fall (First Year Love Bittersweet) . 16. Grindstaff, Michelle. Beer by Night, Bed by Morning . 17. Hart, Madeline and Meredith Newman. Smoke Alarm: Reading This may Cause Lung Cancer, Heart Disease, Emphysema, and Complicate Pregnancy . 21. Almirall, Sara and Kirsten Werne. 20 Best Spots to Smoke on Campus . 22. Werne, Kirsten. An Interview with Painted Thin . 23. Burt, Kara. All in All, We\u27re Just Paper o the Wall (Dorm Art Clue to Denison Identity) . 25. Levine, Robert. Less Talk, Moore Rock (Thurston\u27 Sound Uplifts Soul) . 30. Almirall, R.R. Turtles . 31. Almirall, RR. The Warthog Feels He Has Much in Common With Paul Newman, Others Don\u27t . 20

High Seroprevalence of Rift Valley Fever and Evidence for Endemic Circulation in Mbeya Region, Tanzania, in a Cross-Sectional Study

We describe a high seropositivity rate for Rift Valley fever virus, in up to 29.3% of tested individuals from the shore of Lake Malawi in southwestern Tanzania, and much lower rates from areas distant to the lake. Rift Valley fever disease or outbreaks have not been observed there in the past, which suggests that the virus is circulating under locally favorable conditions and is either a non-pathogenic strain, or that occasional occurrence of disease is missed. We were able to identify a low socio-economic status and cattle ownership as possible socio-economic risk factors for an individual to be seropositive. Environmental risk factors associated with seropositivity include dense vegetation, and ambient land surface temperatures which may be important for breeding success of the mosquitoes which transmit Rift Valley fever, and for efficient multiplication of the virus in the mosquito. Low elevation of the home, and proximity to Lake Malawi probably lead to abundant surface water collections, which serve as breeding places for mosquitoes. These findings will inform patient care in the areas close to Lake Malawi, and may help to design models which predict low-level virus circulation

The potential role of lycopene for the prevention and therapy of prostate cancer: From molecular mechanisms to clinical evidence

Lycopene is a phytochemical that belongs to a group of pigments known as carotenoids. It is red, lipophilic and naturally occurring in many fruits and vegetables, with tomatoes and tomato-based products containing the highest concentrations of bioavailable lycopene. Several epidemiological studies have linked increased lycopene consumption with decreased prostate cancer risk. These findings are supported by in vitro and in vivo experiments showing that lycopene not only enhances the antioxidant response of prostate cells, but that it is even able to inhibit proliferation, induce apoptosis and decrease the metastatic capacity of prostate cancer cells. However, there is still no clearly proven clinical evidence supporting the use of lycopene in the prevention or treatment of prostate cancer, due to the only limited number of published randomized clinical trials and the varying quality of existing studies. The scope of this article is to discuss the potential impact of lycopene on prostate cancer by giving an overview about its molecular mechanisms and clinical effects. © 2013 by the authors; licensee MDPI, Basel, Switzerland

Helicobacter pylori versus the Host: Remodeling of the Bacterial Outer Membrane Is Required for Survival in the Gastric Mucosa

Modification of bacterial surface structures, such as the lipid A portion of lipopolysaccharide (LPS), is used by many pathogenic bacteria to help evade the host innate immune response. Helicobacter pylori, a gram-negative bacterium capable of chronic colonization of the human stomach, modifies its lipid A by removal of phosphate groups from the 1- and 4′-positions of the lipid A backbone. In this study, we identify the enzyme responsible for dephosphorylation of the lipid A 4′-phosphate group in H. pylori, Jhp1487 (LpxF). To ascertain the role these modifications play in the pathogenesis of H. pylori, we created mutants in lpxE (1-phosphatase), lpxF (4′-phosphatase) and a double lpxE/F mutant. Analysis of lipid A isolated from lpxE and lpxF mutants revealed lipid A species with a 1 or 4′-phosphate group, respectively while the double lpxE/F mutant revealed a bis-phosphorylated lipid A. Mutants lacking lpxE, lpxF, or lpxE/F show a 16, 360 and 1020 fold increase in sensitivity to the cationic antimicrobial peptide polymyxin B, respectively. Moreover, a similar loss of resistance is seen against a variety of CAMPs found in the human body including LL37, β-defensin 2, and P-113. Using a fluorescent derivative of polymyxin we demonstrate that, unlike wild type bacteria, polymyxin readily associates with the lpxE/F mutant. Presumably, the increase in the negative charge of H. pylori LPS allows for binding of the peptide to the bacterial surface. Interestingly, the action of LpxE and LpxF was shown to decrease recognition of Helicobacter LPS by the innate immune receptor, Toll-like Receptor 4. Furthermore, lpxE/F mutants were unable to colonize the gastric mucosa of C57BL/6J and C57BL/6J tlr4 -/- mice when compared to wild type H. pylori. Our results demonstrate that dephosphorylation of the lipid A domain of H. pylori LPS by LpxE and LpxF is key to its ability to colonize a mammalian host