Industrial Self-Regulation and the Public Interest

As the affluence of the American society grows, a concern about such matters as health, education, and welfare has also become more apparent. Some concern derives from technological breakthroughs which require control, such as the development of aircraft for mass transportation. In other cases, increased recognition of serious threats to public health and safety has led various groups of aroused citizens to advocate governmental control. Today, growing numbers of individuals and organizations believe that the consumer\u27s health and safety are not being adequately protected in at least two areas-cigarettes and automobiles. Thus, the following discussion is directed to the vital issue of whether these two industries can voluntarily advance consumers\u27 interests through the imposition of adequate safety and health standards, or whether widened federal intercession is essential

Unsupervised Analysis of Classical Biomedical Markers: Robustness and Medical Relevance of Patient Clustering Using Bioinformatics Tools

Motivation: It has been proposed that clustering clinical markers, such as blood test results, can be used to stratify patients. However, the robustness of clusters formed with this approach to data pre-processing and clustering algorithm choices has not been evaluated, nor has clustering reproducibility. Here, we made use of the NHANES survey to compare clusters generated with various combinations of pre-processing and clustering algorithms, and tested their reproducibility in two separate samples. Method: Values of 44 biomarkers and 19 health/life style traits were extracted from the National Health and Nutrition Examination Survey (NHANES). The 1999–2002 survey was used for training, while data from the 2003–2006 survey was tested as a validation set. Twelve combinations of pre-processing and clustering algorithms were applied to the training set. The quality of the resulting clusters was evaluated both by considering their properties and by comparative enrichment analysis. Cluster assignments were projected to the validation set (using an artificial neural network) and enrichment in health/life style traits in the resulting clusters was compared to the clusters generated from the original training set. Results: The clusters obtained with different pre-processing and clustering combinations differed both in terms of cluster quality measures and in terms of reproducibility of enrichment with health/life style properties. Z-score normalization, for example, dramatically improved cluster quality and enrichments, as compared to unprocessed data, regardless of the clustering algorithm used. Clustering diabetes patients revealed a group of patients enriched with retinopathies. This coul

Standards and Practices for Forecasting

One hundred and thirty-nine principles are used to summarize knowledge about forecasting. They cover formulating a problem, obtaining information about it, selecting and applying methods, evaluating methods, and using forecasts. Each principle is described along with its purpose, the conditions under which it is relevant, and the strength and sources of evidence. A checklist of principles is provided to assist in auditing the forecasting process. An audit can help one to find ways to improve the forecasting process and to avoid legal liability for poor forecasting

The composition of consumer savings portfolios. 3

Bibliographical footnotes

Industrial Self-Regulation and the Public Interest

As the affluence of the American society grows, a concern about such matters as health, education, and welfare has also become more apparent. Some concern derives from technological breakthroughs which require control, such as the development of aircraft for mass transportation. In other cases, increased recognition of serious threats to public health and safety has led various groups of aroused citizens to advocate governmental control. Today, growing numbers of individuals and organizations believe that the consumer\u27s health and safety are not being adequately protected in at least two areas-cigarettes and automobiles. Thus, the following discussion is directed to the vital issue of whether these two industries can voluntarily advance consumers\u27 interests through the imposition of adequate safety and health standards, or whether widened federal intercession is essential