A Decade Of Malaria During Pregnancy In Brazil: What Has Been Done Concerning Prevention And Management.

In Brazil, malaria remains a disease of major epidemiological importance because of the high number of cases in the Amazonian Region. Plasmodium spp infections during pregnancy are a significant public health problem with substantial risks for the pregnant woman, the foetus and the newborn child. In Brazil, the control of malaria during pregnancy is primarily achieved by prompt and effective treatment of the acute episodes. Thus, to assure rapid diagnosis and treatment for pregnant women with malaria, one of the recommended strategy for low transmission areas by World Health Organization and as part of a strategy by the Ministry of Health, the National Malaria Control Program has focused on integrative measures with woman and reproductive health. Here, we discuss the approach for the prevention and management of malaria during pregnancy in Brazil over the last 10 years (2003-2012) using morbidity data from Malaria Health Information System. Improving the efficiency and quality of healthcare and education and the consolidation of prevention programmes will be challenges in the control of malaria during pregnancy in the next decade.109706-

A decade of malaria during pregnancy in Brazil: what has been done concerning prevention and management

In Brazil, malaria remains a disease of major epidemiological importance because of the high number of cases in the Amazonian Region. Plasmodium spp infections during pregnancy are a significant public health problem with substantial risks for the pregnant woman, the foetus and the newborn child. In Brazil, the control of malaria during pregnancy is primarily achieved by prompt and effective treatment of the acute episodes. Thus, to assure rapid diagnosis and treatment for pregnant women with malaria, one of the recommended strategy for low transmission areas by World Health Organization and as part of a strategy by the Ministry of Health, the National Malaria Control Program has focused on integrative measures with woman and reproductive health. Here, we discuss the approach for the prevention and management of malaria during pregnancy in Brazil over the last 10 years (2003-2012) using morbidity data from Malaria Health Information System. Improving the efficiency and quality of healthcare and education and the consolidation of prevention programmes will be challenges in the control of malaria during pregnancy in the next decade1095706708CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAIS - FAPEMIGFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPSem informaçãoSem informaçãoSem informaçãoSem informaçã

The impacts of the pandemic on the health and well-being of children in Latin America and the Caribbean and its effect on child-sensitive social protection systems

The coronavirus disease (COVID-19) pandemic has had a profound impact on health, economic and social conditions in the countries of Latin America and the Caribbean, affecting different population groups in various ways. While children have not been among the main direct victims of the virus, the crisis triggered by the pandemic has placed children in a situation where they face obstacles to exercising their rights to health and education, social security, a standard of living that allows for their full development and protection from all forms of violence. These challenges are compounded by the fact that in 2020, one in two children was living in poverty. The public health measures most countries have implemented to contain the spread of the virus have also hampered children’s access to routine feeding and vaccination programmes, health check-ups and food and nutrition monitoring, timely diagnosis and medical referrals, and opportunities for free play or camaraderie with peers, all of which are fundamental to achieving their developmental potential.Executive summary .-- Introduction .-- I. The COVID-19 pandemic in the region: the prolongation of the health crisis and its multidimensional impact .-- II. The multidimensional impact of the pandemic on the overall well-being of children in Latin America and the Caribbean .-- III. Recommendations to make progress towards child-sensitive social protection policies and reverse the impact of the pandemic

Los impactos de la pandemia sobre la salud y el bienestar de niños y niñas en América Latina y el Caribe: la urgencia de avanzar hacia sistemas de protección social sensibles a los derechos de la niñez

La crisis generada por la pandemia de enfermedad por coronavirus (COVID-19) ha planteado diversos obstáculos para el ejercicio de los derechos de niños y niñas a la salud y a la educación, a la seguridad social, a un nivel de vida que permita su desarrollo integral y a la protección contra todo tipo de violencia, en un contexto en que, en 2020, uno de cada dos niños y niñas de América Latina y el Caribe se encontraba en situación de pobreza. Tras analizar los efectos de la pandemia en el bienestar integral de la niñez, sobre la base del Marco para el Cuidado Cariñoso y Sensible, en el presente documento se brinda un conjunto de recomendaciones para avanzar hacia políticas de protección social que atiendan los derechos de niños y niñas y que permitan revertir, en aquellas dimensiones en que sea posible, los efectos negativos de la pandemia en la infancia.Resumen .-- Introducción .-- I. La pandemia de COVID-19 en la región: la prolongación de la crisis sanitaria y su impacto multidimensional .-- II. Los efectos multidimensionales de la pandemia sobre el bienestar integral de niños y niñas en América Latina y el Caribe .-- III. Recomendaciones para avanzar hacia políticas de protección social que atiendan los derechos de la niñez y reviertan los impactos de la pandemia

Escravidão Contemporânea e Toyotismo

Neste artigo, estamos identificando relações entre a gestão toyotista, como formulada por seu criador, Taiichi Ohno, e praticada por várias empresas, e elementos que caracterizam o trabalho escravo contemporâneo. Nossos referenciais reúnem a psicodinâmica dejouriana, o aporte que descreve o trabalho escravo contemporâneo e formulações de Ohno, em seu O sistema Toyota de produção. Confrontando os dois primeiros elementos com as concepções e a prática toyotistas, podemos associar esse discurso corrente entre as organizações e nas próprias escolas de gestão com a incidência da escravidão contemporânea. A conclusão a que chegamos é de que há um recuo histórico a padrões primitivos do capitalismo, com ilimitada disposição para cortar custos e, nesse contexto, crescente desapreço pelos custos sociais. Isto está levando ao aparente paradoxo de constatar-se, muito além de reminiscências feudais ou escravagistas, a difusão e naturalização das condições pré-capitalistas de trabalho no modo de produção capitalista

Potential cross-contamination of similar Giardia duodenalis assemblage in children and pet dogs in southern Brazil, as determined by PCR-RFLP

Giardia duodenalis is an enteric parasite that has distinct genetic groups. Human infections are mainly caused by assemblages A and B, although sporadic infections by assemblages C and D have also been reported. Animals can be infected by a wide range of assemblages (A to H). The aim of this study is to identify the assemblages and sub-assemblages of G. duodenalis with zoonotic features in fecal samples of school-aged children, and in dogs that coexist in the same households in Lages, Santa Catarina, Brazil. Fecal samples of 91 children and 108 dogs were obtained and G. duodenalis cysts were detected in samples from 11 (12.08%) children and 10 (9.25%) dogs. DNA extracted from the 21 positive samples was analyzed by PCR-RFLP, using the gdh gene. Results showed the presence of sub-assemblages AI (2/11), AII (4/11), BIII (2/11), and BIV(3/11) among children and AI (5/10) and BIV(3/10) in dogs, with zoonotic characteristics, and the carnivore specific assemblage C (2/10). G. duodenalis was found to infect both children and dogs living in the same household, with the same sub-assemblage (BIV) indicating that pet dogs are a potential risk of transmission of G. duodenalis to humans

OCCURRENCE OF Calodium hepaticum (BANCROFT, 1893) MORAVEC, 1982 EGGS IN FECES OF DOGS AND CATS IN LAGES, SANTA CATARINA, BRAZIL

This study aims to report the incidence of Calodium hepaticum among dogs and cats, pets or stray animals, captured by the Zoonosis Control Center (CCZ) in Lages, Santa Catarina, Brazil. Fecal samples from 108 pet dogs and eight pet cats, and from 357 stray dogs and 97 stray cats, captured by CCZ, were analyzed within the period from July 2010 to November 2012. Coproparasitological exams were performed by techniques of sedimentation, centrifuge-flotation, and simple flotation. Among 465 fecal samples from dogs and 105 from cats, the overall spurious infections for C. hepaticum eggs were 1.05%. For dogs, this positivity was 0.43% and for cats it was 3.81%. The two positive dogs were stray and out of the four cats, three were stray and one was a pet. Although the occurrence of C. hepaticum eggs was low, these data reveal the existence of infected rodents, especially in public places, since, out of the six infected animals, five (83.33%) were stray. These results are discussed and analyzed with an emphasis on the risk to public health

Recrudescent Plasmodium berghei from Pregnant Mice Displays Enhanced Binding to the Placenta and Induces Protection in Multigravida

Pregnancy-associated malaria (PAM) is associated with placenta pathology and poor pregnancy outcome but the mechanisms that control the malaria parasite expansion in pregnancy are still poorly understood and not amenable for study in human subjects. Here, we used a set of new tools to re-visit an experimental mouse model of pregnancy-induced malaria recrudescence, BALB/c with chronic Plasmodium berghei infection. During pregnancy 60% of the pre-exposed primiparous females showed pregnancy-induced malaria recrudescence and we demonstrated that the recrudescent P. berghei show an unexpected enhancement of the adherence to placenta tissue sections with a marked specificity for CSA. Furthermore, we showed that the intensity of parasitemia in primigravida was quantitatively correlated with the degree of thickening of the placental tissue and up-regulation of inflammation-related genes such as IL10. We also confirmed that the incidence of pregnancy-induced recrudescence, the intensity of the parasitemia peak and the impact on the pregnancy outcome decreased gradually from the first to the third pregnancy. Interestingly, placenta pathology and fetal impairment were also observed at low frequency among non-recrudescent females. Together, the data raise the hypothesis that recrudescent P. berghei displays selected specificity for the placenta tissue enabling on one hand, the triggering of the pathological process underlying PAM and on the other hand, the induction of PAM protection mechanisms that are revealed in subsequent pregnancies. Thus, by exploiting P. berghei pregnancy-induced recrudescence, this experimental system offers a mouse model to study the susceptibility to PAM and the mechanisms of disease protection in multigravida

Effective cloud resource utilisation in cloud ERP decision-making process for industry 4.0 in the United States

Cloud enterprise resource planning (C-ERP) represents an evolution of traditional ERP, which also offers the advantages of cloud computing (CC) such as ease of use and resource elasticity. This article presents the opportunities and challenges of the C-ERP adoption for industry 4.0 in the United States as well as the factors that boost or hinder such a decision. The quantitative research method is used to gather the predictor factors and correlation amongst them. An online survey questionnaire received 109 responses, mainly decision-makers and professionals from the US consumer goods industry. Statistical analysis has been carried out to rank the different levels of influence in the C-ERP adoption decision. The predictor’s complexity and regulatory compliance positively influence C-ERP private service deployment, whereas technology readiness is a good predictor of community service deployment. This paper also proposes a decision support system (DSS), tailored to industry 4.0, and aimed at assisting decision-makers in adopting C-ERP as an effective resource for decision-making. The DSS is built upon the predictors using the analytic hierarchy process (AHP) and it supports decision-makers in the selection of services and deployment models for C-ERP as a resource.peer-reviewe

Ultrastructure of the lung in a murine model of malaria-associated acute lung injury/acute respiratory distress syndrome

Background: the mechanisms through which infection with Plasmodium spp. result in lung disease are largely unknown. Recently a number of mouse models have been developed to research malaria-associated lung injury but no detailed ultrastructure studies of the disease in its terminal stages in a murine model have yet been published. the goal was to perform an ultrastructural analysis of the lungs of mice that died with malaria-associated acute lung injury/acute respiratory distress syndrome to better determine the relevancy of the murine models and investigate the mechanism of disease.Methods: DBA/2 mice were infected with Plasmodium berghei strain ANKA. Mice had their lungs removed immediately after death, processed using standard methods and viewed by transmission electron microscopy (TEM).Results: Infected red blood cell: endothelium contact, swollen endothelium with distended cytoplasmic extensions and thickening of endothelium basement membrane were observed. Septa were thick and filled with congested capillaries and leukocytes and the alveolar spaces contained blood cells, oedema and cell debris.Conclusion: Results show that the lung ultrastructure of P. berghei ANKA-infected mice has similar features to what has been described in post-mortem TEM studies of lungs from individuals infected with Plasmodium falciparum. These data support the use of murine models to study malaria-associated acute lung injury.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ São Paulo, Dept Immunol, São Paulo, BrazilUniv São Paulo, Fac Med, Lab Med Invest 59, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Phys & Earth Sci, Diadema, BrazilUniv São Paulo, Dept Parasitol, São Paulo, BrazilUniv São Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Phys & Earth Sci, Diadema, BrazilFAPESP: 2009/53256-7FAPESP: 2009/53889-0CNPq: 306668/2012-2FAPESP: 2011/195252-0Web of Scienc