Determinazione delle potenzialita di utilizzo dell'energia solare nel centro urbano di Pisa. Modellazione in 3D mediante software LiDAR Analyst

Questo lavoro ha come scopo quello di determinare le potenzialità di utilizzo dell’energia solare nel centro urbano di Pisa nell’ottica di installazioni solari termiche, non venendo meno a vincoli normativi e ambientali. Il lavoro parte da una modellazione in 3D dell’edificato per poi passare ad analisi di soleggiamento e di visibilità, all’incrocio domanda e offerta e capire quali sino le strutture idonee per installazioni solari. Per la modellazione dell’edificato sono stati utilizzati principalmente i dati LiDAR, Carte Tecniche Regionali e foto aeree. Una volta ottenuta una modellistica accettabile dei tetti degli edifici si può passare alla verifica sul soleggiamento che investe tali coperture nell’arco dell’intero anno, e capire quindi quali sono le potenzialità sfruttabili per coprire i fabbisogni. Un’ulteriore indagine è lo studio di visibilità. Infatti, per poter capire quali siano effettivamente le superfici sfruttabili per un’applicazione energetica, è necessario prendere in considerazione i vincoli sulle installazioni di impianti solari volti a preservare l’aspetto della città; questo significa stabilire quali siano i tetti invisibili da punti o percorsi turistici. A questo punto è possibile sovrapporre l’analisi di soleggiamento a quella di visibilità in modo da avere superfici soleggiate e invisibili e capire quale sia la potenzialità di ogni singolo tetto. This work aims to determine the potential use of solar energy in the urban center of Pisa in view of solar thermal installations, not failing to regulatory and environmental constraints. The work starts from a 3D modeling of the building and then switch to daylight and visibility analysis, at the demand and supply up and see what the appropriate structures for solar installations. For modeling of the building were mainly used LiDAR data, regional technical maps and aerial photographs. Once an acceptable modeling of the roofs of the buildings you can go to check on those hedges that invests sunshine throughout the year, and then figure out what are the exploitable potential to cover the needs. Further investigation is the study of vision. In fact, in order to understand which areas are actually usable energy for an application, you must take into account the constraints on installations of solar systems aimed at preserving the city's appearance, which means we determine which are invisible from the rooftops points or locations tourism. Now you can overlay analysis of vision to that of daylight so that you have invisible and sunny areas and understand what the potential of every single roof

MODELO DE MADUREZ COMO BASE PARA EL DIAGNÓSTICO DE LA GESTIÓN DE PROCESOS PYME

La gestión de procesos de negocio y sus modelos de madurez están recibiendo especial interés académico como herramienta para evaluar procesos, reconocer dónde y cómo avanzar y mejorar el uso de recursos. En un ambiente complejo como el actual, las PYME Argentinas pueden recurrir a elevar la madurez de sus sistemas de gestión de procesos como medio para apoyar su desarrollo empresarial y confrontar la inestabilidad del contexto. El modelo de madurez de procesos de negocios propuesto por Fisher proporciona un balance entre una representación simple y un suficiente grado de detalle para ser usado en PYME. En la presente investigación se utiliza dicho modelo para obtener un diagnóstico en tres casos de estudio PYME y confirmar la hipótesis planteada donde se afirma que las organizaciones certificadas bajo Norma ISO 9001:2015 obtienen mayores niveles de madurez en su sistema de gestión de proceso de negocios. La prueba estadística de comparación de medias comprobó que existe diferencia significativa entre las organizaciones, confirmando la hipótesis. Se concluye que los factores de éxito de la gestión por procesos establecida y el uso de modelos de madurez de procesos de negocios integrados a sistemas de gestión bajo normas de calidad son beneficiosos.Business process management and maturity models are receiving special academic interest as a key tool for evaluating, recognizing where and how to move forward, improving resource use, and achieving distinctive capabilities. In the actual complex and dynamic environment, SMEs can resort to raising the maturity of their process management systems as a means to support their business development and confront context instability with internal strengthening. The business process maturity model proposed by Fisher provides a balance between a simple representation and a sufficient degree of detail for use in SME. This research uses this model to obtain a diagnosis in three case studies and confirm the hypotheses raised where it is stated that organizations certified under ISO 9001:2015 obtain higher levels of maturity in their process management system. A statistical test of comparison of means found significant differences between companies, confirming the hypothesis. It is concluded that the success factors of process management established and the use of business process maturity models integrated into management systems under quality standards are useful

Targeted next-generation sequencing identification of mutations in disease resistance gene analogs (RGAs) in wild and cultivated beets

Resistance gene analogs (RGAs) were searched bioinformatically in the sugar beet (Beta vulgaris L.) genome as potential candidates for improving resistance against different diseases. In the present study, Ion Torrent sequencing technology was used to identify mutations in 21 RGAs. The DNA samples of ninety-six individuals from six sea beets (Beta vulgaris L. subsp. maritima) and six sugar beet pollinators (eight individuals each) were used for the discovery of single-nucleotide polymorphisms (SNPs). Target amplicons of about 200 bp in length were designed with the Ion AmpliSeq Designer system in order to cover the DNA sequences of the RGAs. The number of SNPs ranged from 0 in four individuals to 278 in the pollinator R740 (which is resistant to rhizomania infection). Among different groups of beets, cytoplasmic male sterile lines had the highest number of SNPs (132) whereas the lowest number of SNPs belonged to O-types (95). The principal coordinates analysis (PCoA) showed that the polymorphisms inside the gene Bv8_184910_pkon (including the CCCTCC sequence) can effectively differentiate wild from cultivated beets, pointing at a possible mutation associated to rhizomania resistance that originated directly from cultivated beets. This is unlike other resistance sources that are introgressed from wild beets. This gene belongs to the receptor-like kinase (RLK) class of RGAs, and is associated to a hypothetical protein. In conclusion, this first report of using Ion Torrent sequencing technology in beet germplasm suggests that the identified sequence CCCTCC can be used in marker-assisted programs to differentiate wild from domestic beets and to identify other unknown disease resistance genes in beet

First report of Bufo bufo (Linnaeus, 1758) from Sardinia (Italy)

The Common toad Bufo bufo (Linneaus, 1758) was found for the first time in Sardinia in 2016 during herpetological surveys. The species appears to be well established in the finding area. Many adults and juveniles, tadpoles at different developmental stages, and eggs have been found during repeated monitoring. In order to infer the geographic origin of the Sardinian population, we amplified two mitochondrial markers (16S, cytb) and compared sequences with those available for the species across its natural range. We also screened samples for the presence of Bd pathogen to assess the risk of infection mediated by the species in the area. Results suggest that Sardinian individuals are genetically close to the Central Italian populations, although they show a unique distinct haplotype. Though the species should be considered allochthonous to the Island, further molecular and ecological data are urgently needed to assess the genetic structure and the possible impact on the local fauna, which is largely composed by endemic taxa. Particularly, possible interactions with other native amphibians like the green toad Bufo balearicus (Boettger, 1880), also present in the area, should be investigated, both in terms of competition for breeding sites and genetic pollution, as these species are already known to hybridize in the wild

Transcription of Satellite III non-coding RNAs is a general stress response in human cells

In heat-shocked human cells, heat shock factor 1 activates transcription of tandem arrays of repetitive Satellite III (SatIII) DNA in pericentromeric heterochromatin. Satellite III RNAs remain associated with sites of transcription in nuclear stress bodies (nSBs). Here we use real-time RT-PCR to study the expression of these genomic regions. Transcription is highly asymmetrical and most of the transcripts contain the G-rich strand of the repeat. A low level of G-rich RNAs is detectable in unstressed cells and a 104-fold induction occurs after heat shock. G-rich RNAs are induced by a wide range of stress treatments including heavy metals, UV-C, oxidative and hyper-osmotic stress. Differences exist among stressing agents both for the kinetics and the extent of induction (>100- to 80.000-fold). In all cases, G-rich transcripts are associated with nSBs. On the contrary, C-rich transcripts are almost undetectable in unstressed cells and modestly increase after stress. Production of SatIII RNAs after hyper-osmotic stress depends on the Tonicity Element Binding Protein indicating that activation of the arrays is triggered by different transcription factors. This is the first example of a non-coding RNA whose transcription is controlled by different transcription factors under different growth conditions

A LYSO Calorimeter for the SuperB Factory

The SuperB project is an asymmetric e+e? accelerator of 1036cm?2s?1 luminosity, capable of collecting a data sample of 50?75 ab?1 in five years of running. The SuperB electromagnetic calorimeter (EMC), that will be described in this paper, provides energy and direction measurement of photons and electrons, and is used for identification of electrons versus other charged particles. In particular we will present its design, geometry study and related simulations, as well as R&D on LYSO crystals, a project for the mechanical structure and development on readout and electronics. A matrix of 6 crystals has been tested this year June 2010 at the Beam Test Facility of Frascati (BTF) at energies between 200 MeV and 500 MeV, and a beam test with the complete prototype of 25 crystals is foreseen at CERN in October 2010 to cover the energy range between 500 MeV and 7 GeV

Lack of SARS-CoV-2 RNA environmental contamination in a tertiary referral hospital for infectious diseases in Northern Italy

none140noNAnoneColaneri M.; Seminari E.; Piralla A.; Zuccaro V.; Di Filippo A.; Baldanti F.; Bruno R.; Mondelli M.U.; Brunetti E.; Di Matteo A.; Maiocchi L.; Pagnucco L.; Mariani B.; Ludovisi S.; Lissandrin R.; Parisi A.; Sacchi P.; Patruno S.F.A.; Michelone G.; Gulminetti R.; Zanaboni D.; Novati S.; Maserati R.; Orsolini P.; Vecchia M.; Sciarra M.; Asperges E.; Sambo M.; Biscarini S.; Lupi M.; Roda S.; Chiara Pieri T.; Gallazzi I.; Sachs M.; Valsecchi P.; Perlini S.; Alfano C.; Bonzano M.; Briganti F.; Crescenzi G.; Giulia Falchi A.; Guarnone R.; Guglielmana B.; Maggi E.; Martino I.; Pettenazza P.; Pioli di Marco S.; Quaglia F.; Sabena A.; Salinaro F.; Speciale F.; Zunino I.; De Lorenzo M.; Secco G.; Dimitry L.; Cappa G.; Maisak I.; Chiodi B.; Sciarrini M.; Barcella B.; Resta F.; Moroni L.; Vezzoni G.; Scattaglia L.; Boscolo E.; Zattera C.; Michele Fidel T.; Vincenzo C.; Vignaroli D.; Bazzini M.; Iotti G.; Mojoli F.; Belliato M.; Perotti L.; Mongodi S.; Tavazzi G.; Marseglia G.; Licari A.; Brambilla I.; Daniela B.; Antonella B.; Patrizia C.; Giulia C.; Giuditta C.; Marta C.; Rossana D.; Milena F.; Bianca M.; Roberta M.; Enza M.; Stefania P.; Maurizio P.; Elena P.; Antonio P.; Francesca R.; Antonella S.; Maurizio Z.; Guy A.; Laura B.; Ermanna C.; Giuliana C.; Luca D.; Gabriella F.; Gabriella G.; Alessia G.; Viviana L.; Claudia L.; Valentina M.; Simona P.; Marta P.; Alice B.; Giacomo C.; Irene C.; Alfonso C.; Di Martino R.; Di Napoli A.; Alessandro F.; Guglielmo F.; Loretta F.; Federica G.; Alessandra M.; Federica N.; Giacomo R.; Beatrice R.; Maria S.I.; Monica T.; Nepita Edoardo V.; Calvi M.; Tizzoni M.; Nicora C.; Triarico A.; Petronella V.; Marena C.; Muzzi A.; Lago P.; Comandatore F.; Bissignandi G.; Gaiarsa S.; Rettani M.; Bandi C.Colaneri, M.; Seminari, E.; Piralla, A.; Zuccaro, V.; Di Filippo, A.; Baldanti, F.; Bruno, R.; Mondelli, M. U.; Brunetti, E.; Di Matteo, A.; Maiocchi, L.; Pagnucco, L.; Mariani, B.; Ludovisi, S.; Lissandrin, R.; Parisi, A.; Sacchi, P.; Patruno, S. F. A.; Michelone, G.; Gulminetti, R.; Zanaboni, D.; Novati, S.; Maserati, R.; Orsolini, P.; Vecchia, M.; Sciarra, M.; Asperges, E.; Sambo, M.; Biscarini, S.; Lupi, M.; Roda, S.; Chiara Pieri, T.; Gallazzi, I.; Sachs, M.; Valsecchi, P.; Perlini, S.; Alfano, C.; Bonzano, M.; Briganti, F.; Crescenzi, G.; Giulia Falchi, A.; Guarnone, R.; Guglielmana, B.; Maggi, E.; Martino, I.; Pettenazza, P.; Pioli di Marco, S.; Quaglia, F.; Sabena, A.; Salinaro, F.; Speciale, F.; Zunino, I.; De Lorenzo, M.; Secco, G.; Dimitry, L.; Cappa, G.; Maisak, I.; Chiodi, B.; Sciarrini, M.; Barcella, B.; Resta, F.; Moroni, L.; Vezzoni, G.; Scattaglia, L.; Boscolo, E.; Zattera, C.; Michele Fidel, T.; Vincenzo, C.; Vignaroli, D.; Bazzini, M.; Iotti, G.; Mojoli, F.; Belliato, M.; Perotti, L.; Mongodi, S.; Tavazzi, G.; Marseglia, G.; Licari, A.; Brambilla, I.; Daniela, B.; Antonella, B.; Patrizia, C.; Giulia, C.; Giuditta, C.; Marta, C.; D'Alterio, Rossana; Milena, F.; Bianca, M.; Roberta, M.; Enza, M.; Stefania, P.; Maurizio, P.; Elena, P.; Antonio, P.; Francesca, R.; Antonella, S.; Maurizio, Z.; Guy, A.; Laura, B.; Ermanna, C.; Giuliana, C.; Luca, D.; Gabriella, F.; Gabriella, G.; Alessia, G.; Viviana, L.; Meisina, Claudia; Valentina, M.; Simona, P.; Marta, P.; Alice, B.; Giacomo, C.; Irene, C.; Alfonso, C.; Di Martino, R.; Di Napoli, A.; Alessandro, F.; Guglielmo, F.; Loretta, F.; Federica, G.; Albertini, Alessandra; Federica, N.; Giacomo, R.; Beatrice, R.; Maria, S. I.; Monica, T.; Nepita Edoardo, V.; Calvi, M.; Tizzoni, M.; Nicora, C.; Triarico, A.; Petronella, V.; Marena, C.; Muzzi, A.; Lago, P.; Comandatore, F.; Bissignandi, G.; Gaiarsa, S.; Rettani, M.; Bandi, C

Clinical characteristics of coronavirus disease (COVID-19) early findings from a teaching hospital in Pavia, North Italy, 21 to 28 February 2020

We describe clinical characteristics, treatments and outcomes of 44 Caucasian patients with coronavirus disease (COVID-19) at a single hospital in Pavia, Italy, from 21\u201328 February 2020, at the beginning of the outbreak in Europe. Seventeen patients developed severe disease, two died. After a median of 6 days, 14 patients were discharged from hospital. Predictors of lower odds of discharge were age>65 years, antiviral treatment and for severe disease, lactate dehydrogenase >300 mg/dL

First report of bufo bufo (Linnaeus, 1758) from sardinia (Italy)

The Common toad Bufo bufo (Linneaus, 1758) was found for the first time in Sardinia in 2016 during her-petological surveys. The species appears to be well established in the finding area. Many adults and juveniles, tadpoles at different developmental stages, and eggs have been found during repeated monitoring. In order to infer the geographic origin of the Sardinian population, we amplified two mitochondrial markers (16S, cytb) and compared sequences with those available for the species across its natural range. We also screened samples for the presence of Bd pathogen to assess the risk of infection mediated by the species in the area. Results suggest that Sardinian individuals are genetically close to the Central Italian populations, although they show a unique distinct haplotype. Though the species should be considered allochthonous to the Island, further molecular and ecological data are urgently needed to assess the genetic structure and the possible impact on the local fauna, which is largely composed by endemic taxa. Particularly, possible interactions with other native amphibians like the green toad Bufo balearicus (Boettger, 1880), also present in the area, should be investigated, both in terms of competition for breeding sites and genetic pollution, as these species are already known to hybridize in the wild