Flow of foam through a convergent channel

International audienceWe study experimentally the flow of a foam confined as a bubble monolayer between two plates through a convergent channel. We quantify the velocity, the distribution and orientation of plastic events, and the elastic stress, using image analysis. We use two different soap solutions: a sodium dodecyl sulfate (SDS) solution, with a negligible wall friction between the bubbles and the confining plates, and a mixture containing a fatty acid, giving a large wall friction. We show that for SDS solutions, the velocity profile obeys a self-similar form which results from the superposition of plastic events, and the elastic deformation is uniform. For the other solution, the velocity field differs and the elastic deformation increases towards the exit of the channel. We discuss and quantify the role of wall friction on the velocity profile, the elastic deformation, and the rate of plastic events

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

L’hydrologie en géographie, in , dynamique et gestion de l'hydrosystème, L'Harmattan.

International audienceLa problématique de l'eau a envahi les sphères médiatiques et sociologiques, qu'il s'agisse du manque d'eau, des différentes formes de vulnérabilité liées aux inondations, à l'épuisement ou à l'altération qualitative de la ressource en eau, ou encore de la protection et de la mise en valeur des hydrosystèmes. Cet ouvrage invite le lecteur à parcourir les lieux qui unissent la société à l'eau et à découvrir les géographies de l'eau à travers les avancées les plus récentes

Réseaux et pouvoir. Logiques de l'informel

International audienc

Drawing everyday sexism in academia: Observations and analysis of a community-based initiative

Sexist behaviour in the workplace contributes to create a hostile environment, hindering the chance of women and gender non-conforming individuals to pursue an academic career, but also reinforcing gender stereotypes that are harmful to their progress and recognition. The Did this really happen?! project aims at publishing real-life, everyday sexism in the form of comic strips. Its major goal is to raise awareness about unconscious biases that transpire in everyday interactions in academia and increase the visibility of sexist situations that arise within the scientific community, especially to those who might not notice it. Through the website didthisreallyhappen.net, we collect testimonies about everyday sexism occurring in the professional academic environment (universities, research institutes, scientific conferences…). We translate these stories into comics and publish them anonymously without any judgement or comments on the website. By now, we have collected over 100 testimonies. From this collection, we identified six recurrent patterns: (1) behaviours that aim at maintaining women in stereotypical feminine roles, (2) behaviours that aim at maintaining men in stereotypical masculine roles, (3) the questioning of the scientific skills of female researchers, (4) situations where women have the position of an outsider, especially in informal networking contexts, (5) the objectification of women, and (6) the expression of neosexist views. We first present a detailed analysis of these categories, then we report on the different ways we interact and engage with the Earth science community, the scientific community at large and the public in this project.ISSN:1680-7340ISSN:1680-735

Drawing everyday sexism in academia: observations and analysis of a community-based initiative

International audienceAbstract. Sexist behaviour in the workplace contributes to create a hostile environment, hindering the chance of women and gender non-conforming individuals to pursue an academic career, but also reinforcing gender stereotypes that are harmful to their progress and recognition. The Did this really happen?! project aims at publishing real-life, everyday sexism in the form of comic strips. Its major goal is to raise awareness about unconscious biases that transpire in everyday interactions in academia and increase the visibility of sexist situations that arise within the scientific community, especially to those who might not notice it. Through the website didthisreallyhappen.net, we collect testimonies about everyday sexism occurring in the professional academic environment (universities, research institutes, scientific conferences…). We translate these stories into comics and publish them anonymously without any judgement or comments on the website. By now, we have collected over 100 testimonies. From this collection, we identified six recurrent patterns: (1) behaviours that aim at maintaining women in stereotypical feminine roles, (2) behaviours that aim at maintaining men in stereotypical masculine roles, (3) the questioning of the scientific skills of female researchers, (4) situations where women have the position of an outsider, especially in informal networking contexts, (5) the objectification of women, and (6) the expression of neosexist views. We first present a detailed analysis of these categories, then we report on the different ways we interact and engage with the Earth science community, the scientific community at large and the public in this project

Genetic population structure across Brittany and the downstream Loire basin provides new insights on the demographic history of Western Europe

European genetic ancestry originates from three main ancestral populations - Western hunter-gatherers, early European farmers and Yamnaya Eurasian herders - whose edges geographically met in present-day France. Despite its central role to our understanding of how the ancestral populations interacted and gave rise to modern population structure, the population history of France has remained largely understudied. Here, we analysed 856 high-coverage whole-genome sequences along with genome-wide genotyping data of 3,234 present-day individuals from the northern half of France and merged them with publicly available present-day and ancient Europe-wide genotype datasets. We also analysed, for the first time, the whole-genome sequences of six medieval individuals (300-1100 CE) from Western France to gain insights into the genetic impact of what is commonly known as the Migration Period in Europe. We found extensive fine-scale population structure across Brittany and the downstream Loire basin, emphasizing the need for investigating local populations to better understand the distribution of rare and putatively deleterious variants across space. Overall, we observed an increased population differentiation between the northern and southern sides of the river Loire, which are characterised by different proportions of steppe vs. Neolithic-related ancestry. Samples from Western Brittany carry the largest levels of steppe ancestry and show high levels of allele sharing with individuals associated with the Bell Beaker complex, levels that are only comparable with those found in populations lying on the northwestern edges of Europe. Together, our results imply that present-day individuals from Western Brittany retain substantial legacy of the genetic changes that occurred in Northwestern Europe following the arrival of the Bell Beaker people c. 2500 BCE. Such genetic legacy may explain the sharing of disease-related alleles with other present-day populations from Western Britain and Ireland

Towards carbon neutrality by 2040 in La Rochelle metropolitan area (France): quantifying the role of wetlands and littoral zone in the capture and sequestration of blue carbon

International audienceRising greenhouse gas emissions are causing increasing worldwide impacts and changes on climate patterns, sea level, food production, human lives and livelihoods. Maintaining or improving the ability of coastal aquatic ecosystems and oceans to remove CO2 from the atmosphere is a crucial aspect for climate mitigation. The vegetated coastal ecosystems are able to catch and to sequestrate carbon, the so-called Blue Carbon. These ecosystems are key exchange zones that mediate the biogeochemical cycles across the continent, the ocean and the atmosphere. Given the importance of these ecosystems in biogeochemical cycles and their sensitivity to natural and anthropogenic pressures, the carbon cycle within and between compartments (e.g. pelagos, benthos…) and across the interfaces (e.g. atmosphere, ocean…) need to be addressed. On a regional scale, in the extended urban area of La Rochelle located on the French Atlantic coast (La Rochelle metropolitan area), lack in situ measurements within the wetlands and littoral zone make very uncertain their role as a sink or a source of CO2 to the atmosphere. We will first present a vast research project “La Rochelle Territoire Zéro Carbone” project (https://www.agglo-larochelle.fr/projet-de-territoire/territoire-zero-carbone), that target the ambition of carbon neutrality in La Rochelle metropolitan area by 2040 through a holistic approach (from measuring CO2 to raising people's awareness and assessing the impact of exogenous natural factors). Second, we will present some first results on the Blue Carbon dynamics within the freshwater and salt marshes, and seagrasses

Towards carbon neutrality by 2040 in La Rochelle metropolitan area (France): quantifying the role of wetlands and littoral zone in the capture and sequestration of blue carbon

International audienceRising greenhouse gas emissions are causing increasing worldwide impacts and changes on climate patterns, sea level, food production, human lives and livelihoods. Maintaining or improving the ability of coastal aquatic ecosystems and oceans to remove CO2 from the atmosphere is a crucial aspect for climate mitigation. The vegetated coastal ecosystems are able to catch and to sequestrate carbon, the so-called Blue Carbon. These ecosystems are key exchange zones that mediate the biogeochemical cycles across the continent, the ocean and the atmosphere. Given the importance of these ecosystems in biogeochemical cycles and their sensitivity to natural and anthropogenic pressures, the carbon cycle within and between compartments (e.g. pelagos, benthos…) and across the interfaces (e.g. atmosphere, ocean…) need to be addressed. On a regional scale, in the extended urban area of La Rochelle located on the French Atlantic coast (La Rochelle metropolitan area), lack in situ measurements within the wetlands and littoral zone make very uncertain their role as a sink or a source of CO2 to the atmosphere. We will first present a vast research project “La Rochelle Territoire Zéro Carbone” project (https://www.agglo-larochelle.fr/projet-de-territoire/territoire-zero-carbone), that target the ambition of carbon neutrality in La Rochelle metropolitan area by 2040 through a holistic approach (from measuring CO2 to raising people's awareness and assessing the impact of exogenous natural factors). Second, we will present some first results on the Blue Carbon dynamics within the freshwater and salt marshes, and seagrasses