The Whispering Voices Behind the Poetry of Robert Browning and Matthew Arnold: Three Theoretical Approaches to Selected Works: Formalist, Psychoanalytic, and Marxist

Throughout the literary world, many critics have attempted to pinpoint the root cause for the sudden changes in style and attitude about writing the poetry that ultimately chased Robert Browning and Matthew Arnold into developing their own style in which to convey their innermost compassion for humanity. They hid their injured poetic souls; they hid their innermost thoughts, but they expressed themselves through their characters. By expressing themselves as the voice behind the speaker, they were able to create an artificial mask and utilize the mask as a method of capitalizing on the very essence of what the dramatic monologue tried to express and establish: a poetic play. But by creating this avenue, Browning and Arnold were able to create a niche for themselves in the closing years of the Victorian Age. Of course one can understand that there are limitless factors that can contribute to the direction of a person’s development from childhood to adulthood, and also the time that elapses between each event and how their points of view change along the way. In studying Robert Browning and Matthew Arnold, a few choice factors should be considered as foremost when analyzing these two poets. In the cases of Robert Browning and Matthew Arnold, the key factors one should focus on are their family upbringing, their cultural values, and the literary pressures they were experiencing. I will demonstrate that formalist, psychoanalysis, and Marxist materialism theories are the keys for unraveling the personas of these two Victorian poets. The formalist critic focuses on the lasting impact a work forms on the readers’ mental imagery of the poem and how the readers react to the poem’s flexibility, while also allowing the readers to find whatever they may wish to find in it. The formalist critic also applies to the appropriateness of the poem’s structure. This method allows the readers to form a pattern, to evoke an idea of where the poet is going with the theme or the plot of the poem. On the other hand, the psychoanalytic critic probes the theory of the development of the human psyche. The psychoanalytic critic focuses on what and how certain personal experiences and events affected these two poets and what compelled them to alter their lives and to alter their writing styles so abruptly. In the case of the Marxist materialist theory, I will show that the status of both of these poets contributed to the transformation of their attitudes, and how their class status enhanced the shaping of their views about their surroundings. This study will focus on their experiences growing up, their experiences concerning their relationship with other family members, and their encounters with their contemporaries. In this study, I will present the argument that both these authors were strongly influenced by parochial expectations, by social upheavals, and by literary pressures from other contemporary poets. The emphasis is to demonstrate how in each poem these influences surface to reveal how these factors played a major role in molding their true personas. This study will take into consideration the historical and personal events that were taking place at the time, such as the after effects of the long lasting change of the transference between ideologies from Hellenist to Hebraic, and the Industrial Revolution, which obscured anything that stood in its way. It was a golden age for innovation, but a trying time for literary works; however, ironically, it was during this time that Browning and Arnold were producing their finest works . Furthermore, in this argument I will show that the poems of Browning, such as “My Last Duchess,” “Porphyria’s Lover,” and “Fra Lippo Lippi,” and Arnold’s “Dover Beach,” “The Buried Life,” and his literary criticism on various poets reveal how each influence surfaces in their poems. This study will shed light on how each historical event was relevant in forming the poet’s resilience and state of mind, in developing his particular views about the world he lived in. This study further explores the possible and probable consequences that peer pressure had on both these writers. The focus of each analysis will be upon revealing clues to their character, to their attitude, and, with the emphasis on the direction each poet took in order to overcome the stigma of exclusion. This overview reveals how each poet earned the right to be included into the company of elite writers and into the realm of great poets whose works are read worldwid

Aquatic mammal fossils in Latin America – a review of records, advances and challenges in research in the last 30 years

Records of aquatic mammal fossils (e.g. cetaceans, pinnipeds, sirenians, mustelids, and desmostylians) from Latin America (Mexico to Tierra del Fuego, including Antartica) span since the mid-1800s. Aquatic mammal fossils received little attention from the scientific community, with most of the first studies conducted by Northern Hemisphere researchers. Over the last 30 years, paleontological research in Latin America has increased considerably, with descriptions of several new species and revisions of published original records. The Latin American fossil record of marine mammals spans from the Eocene to the Pleistocene, with formations and specimens of global significance. All three main groups of cetaceans are represented in the continent (Archaeoceti, Mysticeti, and Odontoceti). Pinnipedia are represented by the families Otariidae and Phocidae, with records starting in the Middle Miocene. Both living families of Sirenia (Trichechidae and Dugongidae) are recorded. While less common, but still relevant, records of desmostylians and mustelids are known from Oligocene and Miocene deposits. This review provides a summary of the aquatic mammals known to date, with a special focus on the advances and developments of the last 30 years, since Cozzuol’s (1996) review of the South American fossil record. An up-to-date complete list of species based on the literature and unpublished data is also provided. The study also provides future directions for paleontological research in Latin America, and discusses the challenges and opportunities in the field, including the emergence of a strong new generation of Latin American researchers, many of whom are women. Keywords: Cetacea, Pinnipedia, Sirenia, Southern Hemispher

Prior COVID-19 infection may increase risk for developing endothelial dysfunction following hematopoietic cell transplantation

Endothelial dysfunction underlies many of the major complications following hematopoietic cell transplantation (HCT), including transplant-associated thrombotic microangiopathy (TA-TMA), veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS), and engraftment syndrome (ES). Emerging evidence similarly implicates endothelitis and microangiopathy in severe COVID-19-related multi-system organ dysfunction. Given the overlap in these two illness states, we hypothesize that prior COVID-19 infection may increase risk for HCT-related endotheliopathies. This retrospective, multicenter study included patients aged 0-25 years who underwent autologous or allogeneic HCT for any indication between January 1, 2020 and September 21, 2021, with close attention to those infected with COVID-19 in either the six months prior to transplant or twelve months following transplant. Incidences of TA-TMA, VOD/SOS, and ES were compared among patients with COVID-19 infection pre-HCT and post-HCT, as well as with historical controls who were never infected with SARS-CoV-2. Those who underwent HCT following COVID-19 infection displayed significantly increased rates of TA-TMA compared to those who were never infected. Additionally, our data suggests a similar trend for increased VOD/SOS and ES rates, although this did not reach statistical significance. Therefore, a history of COVID-19 infection prior to undergoing HCT may be a nonmodifiable risk factor for endothelial-related complications following HCT. Further studies are warranted to better clarify this relationship among larger cohorts and in the era of the Omicron SARS-CoV-2 variants

Host factor PLAC8 is required for pancreas infection by SARS-CoV-2

Although mounting evidence demonstrated that pancreas is infected by SARS-CoV-2 the severity and pathophysiology of pancreatic COVID-19 disease are still unclear. Here we investigated the consequences of SARS-CoV-2 infection of the pancreas and the role of Placenta-associated protein-8 (PLAC8). Our data showed pancreatic damage in patients who died from COVID-19. Notably, circulating pancreatic enzymes stratified patients according to COVID-19 severity and outcome. PLAC8 expression was associated with SARS-CoV-2 infection in postmortem analysis of COVID-19 patients and functional assays demonstrated the requirement of PLAC8 in SARS-CoV-2 pancreatic infection. Full SARS-CoV-2 infectious virus revealed a requirement of PLAC8 for efficient viral infection of pancreatic cell lines. Finally, we observed colocalization of PLAC8 and SARS-CoV-2 in the pancreas of deceased patients. In conclusion, our data confirm the human pancreas as a SARS-CoV-2 target and demonstrate the requirement of PLAC8 for SARS-CoV-2 pancreatic infection thereby opening new target opportunities for COVID-19-associated pancreatic pathogenesis.N

Novel Methods for Analysing Bacterial Tracks Reveal Persistence in Rhodobacter sphaeroides

Tracking bacteria using video microscopy is a powerful experimental approach to probe their motile behaviour. The trajectories obtained contain much information relating to the complex patterns of bacterial motility. However, methods for the quantitative analysis of such data are limited. Most swimming bacteria move in approximately straight lines, interspersed with random reorientation phases. It is therefore necessary to segment observed tracks into swimming and reorientation phases to extract useful statistics. We present novel robust analysis tools to discern these two phases in tracks. Our methods comprise a simple and effective protocol for removing spurious tracks from tracking datasets, followed by analysis based on a two-state hidden Markov model, taking advantage of the availability of mutant strains that exhibit swimming-only or reorientating-only motion to generate an empirical prior distribution. Using simulated tracks with varying levels of added noise, we validate our methods and compare them with an existing heuristic method. To our knowledge this is the first example of a systematic assessment of analysis methods in this field. The new methods are substantially more robust to noise and introduce less systematic bias than the heuristic method. We apply our methods to tracks obtained from the bacterial species Rhodobacter sphaeroides and Escherichia coli. Our results demonstrate that R. sphaeroides exhibits persistence over the course of a tumbling event, which is a novel result with important implications in the study of this and similar species

Global urban environmental change drives adaptation in white clover.

Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. Sequencing 2074 genomes from 26 cities revealed that the evolution of urban-rural clines was best explained by adaptive evolution, but the degree of parallel adaptation varied among cities. Our results demonstrate that urbanization leads to adaptation at a global scale

Global urban environmental change drives adaptation in white clover

Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. Sequencing 2074 genomes from 26 cities revealed that the evolution of urban-rural clines was best explained by adaptive evolution, but the degree of parallel adaptation varied among cities. Our results demonstrate that urbanization leads to adaptation at a global scale