jsFLAP: A JavaScript Formal Languages and Automata Package for Computer Science Education

Visualization and simulation software serves an important role in education, especially in the education of abstract topics. The field of computational theory, and specifically the topics of formal languages and finite automata are well suited to visualization. When done properly, this improves the learning experience for both students and educators. The JavaScript Formal Languages and Automata Package (jsFLAP) was created to facilitate the construction and simulation of different types of finite state automata. Following best practices for visualization design, jsFLAP was designed to be accessible and easy to use. It aims to reduce frustration for students, allowing them to focus on engaging directly with the underlying concepts, and to require as little technological overhead as possible for instructors wishing to integrate it into their curriculum. In doing this, jsFLAP can serve an important role in the education of computing theory, replacing existing automata construction tools or reaching audiences that those tools could not.Keywords: computer science, education, visualization, formal languages, automat

Lecturas

Se reseñan las siguientes publicaciones: Comunicación política, diplomática y sociocultural entre Corea y el mundo Min, Wonjung (ed.) Del Atlántico al Pacifico reconstruyendo el orden global Arturo Oropeza García Contribuciones al estudio del Derecho Internacional Silvia González Napolitano y Leopoldo Godio (compiladores) Curso de Organismos Internacionales Julio Barboza Derecho Internacional Público José Antonio Musso (coordinador) Temas jurisdiccionales en materia de Derecho internacional Hortensia D.T. Gutiérrez Posse et al. ISIS: A history Fawas Gerges Política Internacional Argentina. Desde la formación nacional hasta nuestros días Mario Rapoport. The international politics of Human Trafficking Gillian Wylie.Instituto de Relaciones Internacionales (IRI

Lecturas

Se reseñan las siguientes publicaciones: Comunicación política, diplomática y sociocultural entre Corea y el mundo Min, Wonjung (ed.) Del Atlántico al Pacifico reconstruyendo el orden global Arturo Oropeza García Contribuciones al estudio del Derecho Internacional Silvia González Napolitano y Leopoldo Godio (compiladores) Curso de Organismos Internacionales Julio Barboza Derecho Internacional Público José Antonio Musso (coordinador) Temas jurisdiccionales en materia de Derecho internacional Hortensia D.T. Gutiérrez Posse et al. ISIS: A history Fawas Gerges Política Internacional Argentina. Desde la formación nacional hasta nuestros días Mario Rapoport. The international politics of Human Trafficking Gillian Wylie.Instituto de Relaciones Internacionales (IRI

Comparison of the modified Rodnan skin score and durometer in patients with diffuse systemic sclerosis

A esclerose sistêmica é uma enfermidade autoimune, causadora de danos vasculares e fibroses. É dentre as doenças de sistema conjuntivo, bem conhecida, devido à alta mortalidade, principalmente pelas causas pulmonares e cardíacas. Para a avaliação do tecido cutâneo de portadores de esclerose sistêmica é utilizado o Escore de Rodnan Modificado, que consiste no pregueamento da pele, porém esta avaliação pode ser subjetiva, devido às limitações na mensuração do escore, tanto pela variabilidade do profissional, quanto pela percepção na aferição do procedimento. Na busca de uma forma de avaliação embasada em evidências científicas, propôs-se este estudo para subsidiar a aferição objetiva do tecido cutâneo. O objetivo do estudo foi correlacionar os Escores de Rodnan Modificados e as medidas do aparelho durômetro, obtidos por dois pesquisadores distintos, em pacientes com esclerose sistêmica difusa. Trata-se de um estudo analítico e transversal, realizado com pacientes maiores de 16 anos, de ambos os sexos. A amostra desta pesquisa foi constituída por 58 pacientes, com maior predominância entre pacientes com cor da pele branca. Houve correlação discretamente moderada e moderada entre as avaliações das medidas obtidas com o Escore de Rodnan Modificado e também com o aparelho durômetro realizadas pelos pesquisadores 1 e 2. A concordância entre os pesquisadores foi avaliada com Coeficiente de Kappa para Escore de Rodnan Modificado e Coeficiente de Correlação Interclasse para o aparelho durômetro, com melhores resultados para as medidas obtidas com este aparelho. Houve também forte correlação positiva entre o escore de Rodnan modificado, média durômetro total e espessura da derme. Portanto, concluí-se que o aparelho durômetro poderá ser utilizado como método de avaliação do tecido cutâneo em pacientes com esclerose sistêmica difusa. Além disso, é um aparelho de fácil manuseio, o que possibilita os demais integrantes da equipe de saúde realizarem as medidas.Systemic sclerosis is an autoimmune disease that causes vascular damage and fibrosis. It belongs to the group of connective tissue diseases and is well known because of the high mortality associated with it, especially as a consequence of lung and heart problems. The modified Rodnan skin score is used to evaluate the skin tissue of people with systemic sclerosis. It consists of assessing skin wrinkling, but it can be subjective because of the limitations in the process of obtaining the score, both because of the variability of the professionals who perform the procedure and the perception during the measurement. The present study was proposed to provide resources to objectively measure skin tissue, as an attempt to design an evaluation form based on scientific evidence. Its objective was to correlate modified Rodnan skin scores and measures obtained with durometers collected by two different researchers in patients with diffuse systemic sclerosis. It is an analytical and cross-sectional study, carried out with patients at least 16 years old, of both genders. The sample was made up of 58 patients, with a predominance of people with white skin. There were discreetly moderate and moderate correlations between the evaluations of the measurements obtained with the modified Rodnan score and the durometer equipment carried out by researchers 1 and 2. Agreement between the researchers was assessed by using the kappa coefficient for the modified Rodnan skin score and the interclass correlation coefficient for the durometer equipment, with better results for the measurements collected with the latter method. There was a strong positive correlation between the modified Rodnan skin score, the total average obtained with the durometer, and dermis thickness. It was concluded that durometers can be used as a method to evaluate the skin tissue in patients with diffuse systemic sclerosis. The equipment is easy to handle, which allows other members of the health team to carry out the measurements

Alteration of the erythrocyte glutathione redox balance by N-acetylcysteine, captopril and exogenous glutathione

The effect of the thiol containing compounds N-acetylcysteine and captopril on glutathione metabolism in human erythrocytes has been investigated non-invasively using 1H spin echo NMR. N-Acetylcysteine was found to increase the reduced form of glutathione while captopril increased the oxidized form, but no changes in the total glutathione concentration were observed. Incubation of the cells with buthionine sulphoximine to inhibit de novo glutathione synthesis did not affect the response. The results show that these compounds act by altering the redox balance of glutathione rather than by stimulating its synthesis, and that their mechanisms of action are different, and not simply due to the presence of the thiol group