In the Shadows of Dominion: Anthropocentrism and the Continuance of a Culture of Oppression

The oppression of nonhuman animals in Western culture observed in societal institutions and practices such as the factory farm, hunting, and vivisection, exhibits alarming linkages and parallels to some episodes of the oppression of human animals. This work traces the foundations of anthropocentrism in Western philosophy and connects them to the oppressions of racism, sexism, and ethnocentrism. In outlining a uniform theory of oppression detailed through the marginalization, isolation, and exploitation of human and nonhuman animals alike, parallels among the groups emerge as the fused oppression of each exhibits a commonality among them. The analysis conducted within this work highlights the development and sustainment of oppression in the West and illuminates the socio-historical tendencies apparent in the oppression of human and nonhuman animals alike

A Laser-Guided Spinal Cord Displacement Injury in Adult Mice

Mouse models are unique for studying molecular mechanisms of neurotrauma because of the availability of various genetic modified mouse lines. For spinal cord injury (SCI) research, producing an accurate injury is essential, but it is challenging because of the small size of the mouse cord and the inconsistency of injury production. The Louisville Injury System Apparatus (LISA) impactor has been shown to produce precise contusive SCI in adult rats. Here, we examined whether the LISA impactor could be used to create accurate and graded contusive SCIs in mice. Adult C57BL/6 mice received a T10 laminectomy followed by 0.2, 0.5, and 0.8 mm displacement injuries, guided by a laser, from the dorsal surface of the spinal cord using the LISA impactor. Basso Mouse Scale (BMS), grid-walking, TreadScan, and Hargreaves analyses were performed for up to 6 weeks post-injury. All mice were euthanized at the 7th week, and the spinal cords were collected for histological analysis. Our results showed that the LISA impactor produced accurate and consistent contusive SCIs corresponding to mild, moderate, and severe injuries to the cord. The degree of injury severities could be readily determined by the BMS locomotor, grid-walking, and TreadScan gait assessments. The cutaneous hyperalgesia threshold was also significantly increased as the injury severity increased. The terminal lesion area and the spared white matter of the injury epicenter were strongly correlated with the injury severities. We conclude that the LISA device, guided by a laser, can produce reliable graded contusive SCIs in mice, resulting in severity-dependent behavioral and histopathological deficits

Dissecting the Power Sources of Low-Luminosity Emission-Line Galaxy Nuclei via Comparison of HST-STIS and Ground-Based Spectra

Using a sample of ~100 nearby line-emitting galaxy nuclei, we have built the currently definitive atlas of spectroscopic measurements of H_alpha and neighboring emission lines at subarcsecond scales. We employ these data in a quantitative comparison of the nebular emission in Hubble Space Telescope (HST) and ground-based apertures, which offer an order-of-magnitude difference in contrast, and provide new statistical constraints on the degree to which Transition Objects and low-ionization nuclear emission-line regions (LINERs) are powered by an accreting black hole at <10 pc. We show that while the small-aperture observations clearly resolve the nebular emission, the aperture dependence in the line ratios is generally weak, and this can be explained by gradients in the density of the line-emitting gas: the higher densities in the more nuclear regions potentially flatten the excitation gradients, suppressing the forbidden emission. The Transition Objects show a threefold increase in the incidence of broad H_alpha emission in the high-resolution data, as well as the strongest density gradients, supporting the composite model for these systems as accreting sources surrounded by star-forming activity. The narrow-line LINERs appear to be the weaker counterparts of the Type 1 LINERs, where the low accretion rates cause the disappearance of the broad-line component. The enhanced sensitivity of the HST observations reveals a 30% increase in the incidence of accretion-powered systems at z~0. A comparison of the strength of the broad-line emission detected at different epochs implies potential broad-line variability on a decade-long timescale, with at least a factor of three in amplitude.Comment: 27 pages, 13 figures, 4 tables, accepted for publication in Ap

Concept development of a Mach 4 high-speed civil transport

A study was conducted to configure and analyze a 250 passenger, Mach 4 High Speed Civil Transport with a design range of 6500 n.mi. The design mission assumed an all-supersonic cruise segment and no community noise or sonic boom constraints. The study airplane was developed in order to examine the technology requirements for such a vehicle and to provide an unconstrained baseline from which to assess changes in technology levels, sonic boom limits, or community noise constraints in future studies. The propulsion, structure, and materials technologies utilized in the sizing of the study aircraft were assumed to represent a technology availability date of 2015. The study airplane was a derivative of a previously developed Mach 3 concept and utilized advanced afterburning turbojet engines and passive airframe thermal protection. Details of the configuration development, aerodynamic design, propulsion system, mass properties, and mission performance are presented. The study airplane was estimated to weigh approx. 866,000 lbs. Although an aircraft of this size is a marginally acceptable candidate to fit into the world airport infrastructure, it was concluded that the inclusion of community noise or sonic boom constraints would quickly cause the aircraft to grow beyond acceptable limits using the assumed technology levels

Using Group Model Building to Understand Factors That Influence Childhood Obesity in an Urban Environment

Background: Despite increased attention, conventional views of obesity are based upon individual behaviors, and children and parents living with obesity are assumed to be the primary problem solvers. Instead of focusing exclusively on individual reduction behaviors for childhood obesity, greater focus should be placed on better understanding existing community systems and their effects on obesity. The Milwaukee Childhood Obesity Prevention Project is a community-based coalition established to develop policy and environmental change strategies to impact childhood obesity in Milwaukee, Wisconsin. The coalition conducted a Group Model Building exercise to better understand root causes of childhood obesity in its community. Methods: Group Model Building is a process by which a group systematically engages in model construction to better understand the systems that are in place. It helps participants make their mental models explicit through a careful and consistent process to test assumptions. This process has 3 main components: (1) assembling a team of participants; (2) conducting a behavior-over-time graphs exercise; and (3) drawing the causal loop diagram exercise. Results: The behavior-over-time graph portion produced 61 graphs in 10 categories. The causal loop diagram yielded 5 major themes and 7 subthemes. Conclusions: Factors that influence childhood obesity are varied, and it is important to recognize that no single solution exists. The perspectives from this exercise provided a means to create a process for dialogue and commitment by stakeholders and partnerships to build capacity for change within the community

Formation of a Quasar Host Galaxy through a Wet Merger 1.4 Billion Years after the Big Bang

We present high-resolution Very Large Array imaging of the molecular gas in the host galaxy of the high redshift quasar BRI 1335-0417 (z=4.41). Our CO(2-1) observations have a linear resolution of 0.15" (1.0 kpc) and resolve the molecular gas emission both spatially and in velocity. The molecular gas in BRI 1335-0417 is extended on scales of 5 kpc, and shows a complex structure. At least three distinct components encompassing about two thirds of the total molecular mass of 9.2 x 10^10 M_sun are identified in velocity space, which are embedded in a structure that harbors about one third of the total molecular mass in the system. The brightest CO(2-1) line emission region has a peak brightness temperature of 61+/-9 K within 1 kpc diameter, which is comparable to the kinetic gas temperature as predicted from the CO line excitation. This is also comparable to the gas temperatures found in the central regions of nearby ultra-luminous infrared galaxies, which are however much more compact than 1 kpc. The spatial and velocity structure of the molecular reservoir in BRI 1335-0417 is inconsistent with a simple gravitationally bound disk, but resembles a merging system. Our observations are consistent with a major, gas-rich (`wet') merger that both feeds an accreting supermassive black hole (causing the bright quasar activity), and fuels a massive starburst that builds up the stellar bulge in this galaxy. Our study of this z>4 quasar host galaxy may thus be the most direct observational evidence that `wet' mergers at high redshift are related to AGN activity.Comment: 5 pages, 4 figures, to appear in ApJL (accepted August 27, 2008

Effects of capecitabine treatment on the uptake of thymidine analogs using exploratory PET imaging agents: 18F-FAU, 18F-FMAU, and 18F-FLT

Patient Image Data. (XLSX 19 kb

Shielding noises from spins

Electrons in InAs/GaAs quantum dots are strong candidates for qubits due to quantum confinement of the spin ½ system. However, electrons couple with nearby nuclear spins and the fluctuating electrostatic environment, these impose an undesired bottleneck on the performance of a quantum spin device. We show that the fluctuating charge and spin environment may be circumvented to an extent. Compared to InAs/GaAs quantum dots, two-dimensional materials may be used to minimise nuclear spin noise; combined with careful sample design a low-decoherence platform is envisioned

Time-efficient physical activity intervention for older adolescents with disability : rationale and study protocol for the Burn 2 Learn adapted (B2La) cluster randomised controlled trial

Introduction Physical activity declines during adolescence, with the lowest levels of activity observed among those with disability. Schools are ideal settings to address this issue; however, few school-based interventions have been specifically designed for older adolescents with disability. Our aim is to investigate the effects of a school-based physical activity programme, involving high-intensity interval training (HIIT), on physical, mental and cognitive health in older adolescents with disability. Methods and analysis We will evaluate the Burn 2 Learn adapted (B2La) intervention using a two-arm, parallel group, cluster randomised controlled trial with allocation occurring at the school level (treatment or waitlist control). Secondary schools will be recruited in two cohorts from New South Wales, Australia. We will aim to recruit 300 older adolescents (aged 15–19 years) with disability from 30 secondary schools (10 in cohort 1 and 20 in cohort 2). Schools allocated to the intervention group will deliver two HIIT sessions per week during scheduled specialist support classes. The sessions will include foundational aerobic and muscle strengthening exercises tailored to meet student needs. We will provide teachers with training, resources, and support to facilitate the delivery of the B2La programme. Study outcomes will be assessed at baseline, 6 months (primary endpoint), and 9 months. Our primary outcome is functional capacity assessed using the 6 min walk/push test. Secondary outcomes include physical activity, muscular fitness, body composition, cognitive function, quality of life, physical literacy, and on-task behaviour in the classroom. We will also conduct economic and process evaluations to determine cost-effectiveness, programme acceptability, implementation, adaptability, and sustainability in schools. Ethics and dissemination This study has received approval from the University of Newcastle (H-2021–0262) and the New South Wales Department of Education (SERAP: 2021257) human research ethics committees. Findings will be published in peer-reviewed journals, and key stakeholders will be provided with a detailed report following the study. Trial registration number Australian New Zealand Clinical Trials Registry Number: ACTRN12621000884808