Outcomes of elective liver surgery worldwide: a global, prospective, multicenter, cross-sectional study

Background: The outcomes of liver surgery worldwide remain unknown. The true population-based outcomes are likely different to those vastly reported that reflect the activity of highly specialized academic centers. The aim of this study was to measure the true worldwide practice of liver surgery and associated outcomes by recruiting from centers across the globe. The geographic distribution of liver surgery activity and complexity was also evaluated to further understand variations in outcomes. Methods: LiverGroup.org was an international, prospective, multicenter, cross-sectional study following the Global Surgery Collaborative Snapshot Research approach with a 3-month prospective, consecutive patient enrollment within January–December 2019. Each patient was followed up for 90 days postoperatively. All patients undergoing liver surgery at their respective centers were eligible for study inclusion. Basic demographics, patient and operation characteristics were collected. Morbidity was recorded according to the Clavien–Dindo Classification of Surgical Complications. Country-based and hospital-based data were collected, including the Human Development Index (HDI). (NCT03768141). Results: A total of 2159 patients were included from six continents. Surgery was performed for cancer in 1785 (83%) patients. Of all patients, 912 (42%) experienced a postoperative complication of any severity, while the major complication rate was 16% (341/2159). The overall 90-day mortality rate after liver surgery was 3.8% (82/2,159). The overall failure to rescue rate was 11% (82/ 722) ranging from 5 to 35% among the higher and lower HDI groups, respectively. Conclusions: This is the first to our knowledge global surgery study specifically designed and conducted for specialized liver surgery. The authors identified failure to rescue as a significant potentially modifiable factor for mortality after liver surgery, mostly related to lower Human Development Index countries. Members of the LiverGroup.org network could now work together to develop quality improvement collaboratives

High-temperature quantum Hall effect in finite gapped HgTe quantum wells

\u3cp\u3eWe report on the observation of the quantum Hall effect at high temperatures in HgTe quantum wells with a finite band gap and a thickness below and above the critical thickness dc that separates a conventional semiconductor from a two-dimensional topological insulator. At high carrier concentrations, we observe a quantized Hall conductivity up to 60 K with energy gaps between Landau levels of the order of 25 meV, in good agreement with the Landau level spectrum obtained from k·p calculations. Using the scaling approach for the plateau-plateau transition at ν=2→1, we find the scaling coefficient κ=0.45±0.04 to be consistent with the universality of scaling theory, and we do not find signs of increased electron-phonon interaction to alter the scaling even at these elevated temperatures. Comparing the high-temperature limit of the quantized Hall resistance in HgTe quantum wells with a finite band gap with room-temperature experiment in graphene, we find that the energy gaps at the breakdown of the quantization exceed the thermal energy by the same order of magnitude.\u3c/p\u3

Reply: Induction of Adipogenesis by External Volume Expansion

Računovodstvene informacije predstavljaju jedan od najvažnijih faktora kada je u pitanju donošenje poslovnih odluka, te postoji više različitih načina za njihovo prezentiranja. Financijski izvještaji su svakako najvažniji put kojim se prezentiraju računovodstvene informacije, a najznačajniji su sljedeći izvještaji. Bilanca, račun dobiti i gubitka te izvještaj o novčanim tijekovima. Na temelju navedenih izvještaja, u ovom radu analizirana je poslovna uspješnost poduzeća Dukat d.d. u vremenskom razdoblju od 2013. do 2016. godine. Analizom je utvrđeno kako poduzeće uspješno posluje, što se potvrđuje solidnom likvidnosti i zadovoljavajućom razinom zaduženosti. Osim toga, neto dobit poduzeća konstantno raste u odnosu na 2013. godinu.Financial information represents one of the most important factors of business decisions making, and there are a number of ways of their presentation.Financial reports are the most important ways of presenting financial information. The most significant financial reports are: balance sheet, profit and loss account and the cash flow reports. On the basis of these reports, this thesis represents an analysis of business success of Dukat d.d. company from the period of 2013. to 2016. The analysis confirmed that the company has a successful business. Confirmed by solid liquidity and an adequate level of debit furthermore, net profit of the company continues to grow from 2013

Anchored phylogenomics unravels the evolution of spider flies (Acroceridae) and reveals discordance between nucleotides and amino acids

<p>Supplementary Material accompanying the manuscript titled "Anchored phylogenomics unravels the evolution of spider flies (Acroceridae) and reveals discordance between nucleotides and amino acids", including Supplementary Figures, Tables and Datasets.</p

Bias in big-data phylogenetics: anchored phylogenomics unravels the evolution of spider flies (Acroceridae) and reveals discordance between nucleotides and amino acids

<p>Supplementary Material accompanying the manuscript titled "Bias in big-data phylogenetics: anchored phylogenomics unravels the evolution of spider flies (Acroceridae) and reveals discordance between nucleotides and amino acids", including Supplementary Figures, Tables and Datasets.</p

Relapse risk in patients with malignant diseases given allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning

Allogeneic hematopoietic cell transplantation (HCT) after nonmyeloablative conditioning for hematologic malignancies depends on graft-versus-tumor effects for eradication of cancer. Here, we estimated relapse risks according to disease characteristics. Between 1997 and 2006, 834 consecutive patients (median age, 55 years; range, 5-74 years) received related (n = 498) or unrelated (n = 336) HCT after 2 Gy total body irradiation alone (n = 171) or combined with fludarabine (90 mg/m2; n = 663). Relapse rates per patient year (PY) at risk, corrected for follow-up and competing nonrelapse mortality, were calculated for 29 different diseases and stages. The overall relapse rate per PY was 0.36. Patients with chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) in remission (CR), low-grade or mantle cell non-Hodgkin lymphoma (NHL) (CR + partial remission [PR]), and high-grade NHL-CR had the lowest rates (0.00-0.24; low risk). In contrast, patients with advanced myeloid and lymphoid malignancies had rates of more than 0.52 (high risk). Patients with lymphoproliferative diseases not in CR (except Hodgkin lymphoma and high-grade NHL) and myeloid malignancies in CR had rates of 0.26-0.37 (standard risk). In conclusion, patients with low-grade lymphoproliferative disorders experienced the lowest relapse rates, whereas patients with advanced myeloid and lymphoid malignancies had high relapse rates after nonmyeloablative HCT. The latter might benefit from cytoreductive treatment before HCT