Distinct subdivisions of the cingulum bundle revealed by diffusion MRI fibre tracking: Implications for neuropsychological investigations

The cingulum is a prominent white matter tract that supports prefrontal, parietal, and temporal lobe interactions. Despite being composed of both short and long association fibres, many MRI-based reconstructions ( tractography ) of the cingulum depict an essentially uniform tract that almost encircles the corpus callosum. The present study tested the validity of dividing this tract into subdivisions corresponding to the ‘parahippocampal’, ‘retrosplenial’, and ‘subgenual’ portions of the cingulum. These three cingulum subdivisions occupied different medial–lateral locations, producing a topographic arrangement of cingulum fibres. Other comparisons based on these different reconstructions indicate that only a small proportion of the total white matter in the cingulum traverses the length of the tract. In addition, both the radial diffusivity and fractional anisotropy of the subgenual subdivision differed from that of the retrosplenial subdivision which, in turn, differed from that of the parahippocampal subdivision. The extent to which the radial diffusivity scores and the fractional anisotropy scores correlated between the various cingulum subdivisions proved variable, illustrating how one subdivision may not act as a proxy for other cingulum subdivisions. Attempts to relate the status of the cingulum, as measured by MRI-based fibre tracking, with cognitive or affective measures will, therefore, depend greatly on how and where the cingulum is reconstructed. The present study provides a new framework for subdividing the cingulum, based both on its known connectivity and MRI-based properties

Search for the standard model Higgs boson produced in association with W and Z bosons in pp collisions at √s=7 TeV

This is the pre-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2012 Springer Verlag.A search for the Higgs boson produced in association with a W or Z boson in proton-proton collisions at a center-of-mass energy of 7 TeV is performed with the CMS detector at the LHC using the full 2011 data sample, from an integrated luminosity of 5 fb−1. Higgs boson decay modes to ττ and WW are explored by selecting events with three or four leptons in the final state. No excess above background expectations is observed, resulting in exclusion limits on the product of Higgs associated production cross section and decay branching fraction for Higgs boson masses between 110 and 200 GeV in these channels. Combining these results with other CMS associated production searches using the same dataset in the H→ γγ and H→ bb− decay modes, the cross section for associated Higgs boson production 3.3 times the standard model expectation or larger is ruled out at the 95% confidence level for a Higgs boson mass of 125 GeV.This study is funded by the BMWF and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS (Colombia); MSES (Croatia); RPF (Cyprus); MoER, SF0690030s09 and ERDF (Estonia); Academy of Finland, MEC, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NKTH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF and WCU (Korea); LAS (Lithuania); CINVESTAV, CONACYT, SEP, and UASLP-FAI (Mexico); MSI (New Zealand); PAEC (Pakistan); MSHE and NSC (Poland); FCT (Portugal); JINR (Armenia, Belarus, Georgia, Ukraine, Uzbekistan); MON, RosAtom, RAS and RFBR (Russia); MSTD (Serbia); SEIDI and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); ThEP, IPST and NECTEC (Thailand); TUBITAK and TAEK (Turkey); NASU (Ukraine); STFC (United Kingdom); DOE and NSF (USA)

Search for the standard model Higgs boson produced in association with W and Z bosons in pp collisions at root s=7 TeV

A search for the Higgs boson produced in association with a W or Z boson in proton-proton collisions at a center-of-mass energy of 7 TeV is performed with the CMS detector at the LHC using the full 2011 data sample, from an integrated luminosity of 5 fb−1. Higgs boson decay modes to ττ and WW are explored by selecting events with three or four leptons in the final state. No excess above background expectations is observed, resulting in exclusion limits on the product of Higgs associated production cross section and decay branching fraction for Higgs boson masses between 110 and 200 GeV in these channels. Combining these results with other CMS associated production searches using the same dataset in the H→ γγ and H→ b b¯ decay modes, the cross section for associated Higgs boson production 3.3 times the standard model expectation or larger is ruled out at the 95% confidence level for a Higgs boson mass of 125 GeV