166 research outputs found
Integrating children\u27s literature and mathematics in the early childhood classroom
Historically there have been three reasons for groups to formally adopt a set of standards: (1) to ensure quality, (2) to indicate goals, and (3) to promote change. For NCTM, all three reasons are of equal importance (The National Council of Teachers of Mathematics, 1989, p. 2).
Now, more than any other time in history, mathematical reform is essential in our school systems. The traditional mathematics curriculum was designed to prepare shopkeepers, farmers, and factory workers for occupations in the early 1900s. Some of those skills are still useful in today\u27s society. However, as the new millennium approaches, our future citizens require an education in mathematics that goes far beyond basic computational skills. Research has revealed that although students can perform arithmetic computations adequately, they are not able to use their skills to solve problems (Burns, 1992). All students must deepen their understanding of mathematical concepts and processes, and develop their problem solving, reasoning, and communication abilities while using mathematics to make sense of, and to solve, compelling problems (NCTM, 1996a)
Who\u27s accessing emergency food services?
Introduction:
Last year, Chittenden Emergency Food Shelf provided 1,260,517 pounds of food to over 11,000 people each month via groceries, hot meals and home delivery, supplying an average of almost 40% of food for families.
CEFS seeks to improve their services and offerings by better understanding the demographics, food preference, and needs of the clients they serve.
Our goal was to collect demographic and utilization data to identify areas where CEFS could enhance services and improve client access to healthful food.https://scholarworks.uvm.edu/comphp_gallery/1208/thumbnail.jp
Recombinant canine single chain insulin analogues: Insulin receptor binding capacity and ability to stimulate glucose uptake
Virtually all diabetic dogs require exogenous insulin therapy to control their hyperglycaemia. In the UK, the only licensed insulin product currently available is a purified porcine insulin preparation. Recombinant insulin is somewhat problematic in terms of its manufacture, since the gene product (preproinsulin) undergoes substantial post-translational modification in pancreatic β cells before it becomes biologically active. The aim of the present study was to develop recombinant canine single chain insulin (SCI) analogues that could be produced in a prokaryotic expression system and which would require minimal processing. Three recombinant SCI constructs were developed in a prokaryotic expression vector, by replacing the insulin C-peptide sequence with one encoding a synthetic peptide (GGGPGKR), or with one of two insulin-like growth factor (IGF)-2 C-peptide coding sequences (human: SRVSRRSR; canine: SRVTRRSSR). Recombinant proteins were expressed in the periplasmic fraction of Escherichia coli and assessed for their ability to bind to the insulin and IGF-1 receptors, and to stimulate glucose uptake in 3T3-L1 adipocytes.
All three recombinant SCI analogues demonstrated preferential binding to the insulin receptor compared to the IGF-1 receptor, with increased binding compared to recombinant canine proinsulin. The recombinant SCI analogues stimulated glucose uptake in 3T3-L1 adipocytes compared to negligible uptake using recombinant canine proinsulin, with the canine insulin/cIGF-2 chimaeric SCI analogue demonstrating the greatest effect. Thus, biologically-active recombinant canine SCI analogues can be produced relatively easily in bacteria, which could potentially be used for treatment of diabetic dogs
MosquitoMap and the Mal-area calculator: new web tools to relate mosquito species distribution with vector borne disease
<p>Abstract</p> <p>Background</p> <p>Mosquitoes are important vectors of diseases but, in spite of various mosquito faunistic surveys globally, there is a need for a spatial online database of mosquito collection data and distribution summaries. Such a resource could provide entomologists with the results of previous mosquito surveys, and vector disease control workers, preventative medicine practitioners, and health planners with information relating mosquito distribution to vector-borne disease risk.</p> <p>Results</p> <p>A web application called MosquitoMap was constructed comprising mosquito collection point data stored in an ArcGIS 9.3 Server/SQL geodatabase that includes administrative area and vector species x country lookup tables. In addition to the layer containing mosquito collection points, other map layers were made available including environmental, and vector and pathogen/disease distribution layers. An application within MosquitoMap called the Mal-area calculator (MAC) was constructed to quantify the area of overlap, for any area of interest, of vector, human, and disease distribution models. Data standards for mosquito records were developed for MosquitoMap.</p> <p>Conclusion</p> <p>MosquitoMap is a public domain web resource that maps and compares georeferenced mosquito collection points to other spatial information, in a geographical information system setting. The MAC quantifies the Mal-area, i.e. the area where it is theoretically possible for vector-borne disease transmission to occur, thus providing a useful decision tool where other disease information is limited. The Mal-area approach emphasizes the independent but cumulative contribution to disease risk of the vector species predicted present. MosquitoMap adds value to, and makes accessible, the results of past collecting efforts, as well as providing a template for other arthropod spatial databases.</p
Lot Splitting and Development Regulation: The Information Asymmetries and Free Rider Issues Associated with Arizona's Wildcat Development
Abstract Arizona is currently facing a land use problem commonly referred to as "wildcat" development. This type of development occurs when parcels of land are split into five or fewer lots and developed without following the state's typical subdivision regulations. This behavior results in a myriad of market failure issues such as the free rider phenomenon, when the general public is taxed to provide basic services such as waste disposal for wildcat property owners, as well as information asymmetry, when wildcat properties are sold to unsuspecting buyers. There are also a number of public health, safety and welfare concerns involved
NuSTAR and Swift observations of the black hole candidate XTE J1908+094 during its 2013 outburst
The black hole candidate XTE J1908+094 went into outburst for the first time
since 2003 in October 2013. We report on an observation with the Nuclear
Spectroscopic Telescope Array (NuSTAR) and monitoring observations with Swift
during the outburst. NuSTAR caught the source in the soft state: the spectra
show a broad relativistic iron line, and the light curves reveal a ~40 ks flare
with the count rate peaking about 40% above the non-flare level and with
significant spectral variation. A model combining a multi-temperature thermal
component, a power-law, and a reflection component with an iron line provides a
good description of the NuSTAR spectrum. Although relativistic broadening of
the iron line is observed, it is not possible to constrain the black hole spin
with these data. The variability of the power-law component, which can also be
modeled as a Comptonization component, is responsible for the flux and spectral
change during the flare, suggesting that changes in the corona (or possibly
continued jet activity) are the likely cause of the flare.Comment: 9 pages, 6 figures, 3 tables, accepted for publication in Ap
NuSTAR Observations of the Magnetar 1E 2259+586
We report on new broad band spectral and temporal observations of the
magnetar 1E 2259+586, which is located in the supernova remnant CTB 109. Our
data were obtained simultaneously with the Nuclear Spectroscopic Telescope
Array (NuSTAR) and Swift, and cover the energy range from 0.5-79 keV. We
present pulse profiles in various energy bands and compare them to previous
RXTE results. The NuSTAR data show pulsations above 20 keV for the first time
and we report evidence that one of the pulses in the double-peaked pulse
profile shifts position with energy. The pulsed fraction of the magnetar is
shown to increase strongly with energy. Our spectral analysis reveals that the
soft X-ray spectrum is well characterized by an absorbed double-blackbody or
blackbody plus power-law model in agreement with previous reports. Our new hard
X-ray data, however, suggests that an additional component, such as a
power-law, is needed to describe the NuSTAR and Swift spectrum. We also fit the
data with the recently developed coronal outflow model by Beloborodov for hard
X-ray emission from magnetars. The outflow from a ring on the magnetar surface
is statistically preferred over outflow from a polar cap.Comment: 37 pages, 9 figures, corresponding author, [email protected]
Challenging Social Cognition Models of Adherence:Cycles of Discourse, Historical Bodies, and Interactional Order
Attempts to model individual beliefs as a means of predicting how people follow clinical advice have dominated adherence research, but with limited success. In this article, we challenge assumptions underlying this individualistic philosophy and propose an alternative formulation of context and its relationship with individual actions related to illness. Borrowing from Scollon and Scollonâs three elements of social action â âhistorical body,â âinteraction order,â and âdiscourses in placeâ â we construct an alternative set of research methods and demonstrate their application with an example of a person talking about asthma management. We argue that talk- or illness-related behavior, both viewed as forms of social action, manifest themselves as an intersection of cycles of discourse, shifting as individuals move through these cycles across time and space. We finish by discussing how these dynamics of social action can be studied and how clinicians might use this understanding when negotiating treatment with patients
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