Positive youth development in swimming: clarification and consensus of key psychosocial assets

The purpose of this study was to gain a more cohesive understanding of the assets considered necessary to develop in young swimmers to ensure both individual and sport specific development. This two stage study involved (a) a content analysis of key papers to develop a list of both psychosocial skills for performance enhancement and assets associated with positive youth development, and (b) in-depth interviews involving ten expert swim coaches, practitioners and youth sport scholars. Five higher order categories containing seventeen individual assets emerged. These results are discussed in relation to both existing models of positive youth development and implications for coaches, practitioners and parents when considering the psychosocial development of young British swimmers

Engineering tyrosine-based electron flow pathways in proteins: The case of aplysia myoglobin

Tyrosine residues can act as redox cofactors that provide an electron transfer ("hole-hopping") route that enhances the rate of ferryl heme iron reduction by externally added reductants, for example, ascorbate. Aplysia fasciata myoglobin, having no naturally occurring tyrosines but 15 phenylalanines that can be selectively mutated to tyrosine residues, provides an ideal protein with which to study such through-protein electron transfer pathways and ways to manipulate them. Two surface exposed phenylalanines that are close to the heme have been mutated to tyrosines (F42Y, F98Y). In both of these, the rate of ferryl heme reduction increased by up to 3 orders of magnitude. This result cannot be explained in terms of distance or redox potential change between donor and acceptor but indicates that tyrosines, by virtue of their ability to form radicals, act as redox cofactors in a new pathway. The mechanism is discussed in terms of the Marcus theory and the specific protonation/deprotonation states of the oxoferryl iron and tyrosine. Tyrosine radicals have been observed and quantified by EPR spectroscopy in both mutants, consistent with the proposed mechanism. The location of each radical is unambiguous and allows us to validate theoretical methods that assign radical location on the basis of EPR hyperfine structure. Mutation to tyrosine decreases the lipid peroxidase activity of this myoglobin in the presence of low concentrations of reductant, and the possibility of decreasing the intrinsic toxicity of hemoglobin by introduction of these pathways is discussed. © 2012 American Chemical Society

Coastally Trapped Wind Reversals: Progress toward Understanding

Coastally trapped wind reversals along the U.S. west coast, which are often accompanied by a northward surge of fog or stratus, are an important warm-season forecast problem due to their impact on coastal maritime activities and airport operations. Previous studies identified several possible dynamic mechanisms that could be responsible for producing these events, yet observational and modeling limitations at the time left these competing interpretations open for debate. In an effort to improve our physical understanding, and ultimately the prediction, of these events, the Office of Naval Research sponsored an Accelerated Research Initiative in Coastal Meteorology during the years 1993â 98 to study these and other related coastal meteorological phenomena. This effort included two field programs to study coastally trapped disturbances as well as numerous modeling studies to explore key dynamic mechanisms. This paper describes the various efforts that occurred under this program to provide an advancement in our understanding of these disturbances. While not all issues have been solved, the synoptic and mesoscale aspects of these events are considerably better understood.Most of the authors were supported through the Office of Naval Research Coastal Meteorology Accelerated Research Initiative, one of the authors (WTT) was supported by Program Element 0601153N, Naval Research Laboratory

Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer:a nested case-control study

Vitamin D pathway single nucleotide polymorphisms (SNPs) are potentially useful proxies for investigating whether circulating vitamin D metabolites [total 25-hydroxyvitamin-D, 25(OH)D; 1,25-dihydroxyvitamin, 1,25(OH)2D] are causally related to prostate cancer. We investigated associations of sixteen SNPs across seven genes with prostate-specific antigen-detected prostate cancer

Coastally Trapped Wind Reversals: Progress toward Understanding

Coastally trapped wind reversals along the U.S. west coast, which are often accompanied by a northward surge of fog or stratus, are an important warm-season forecast problem due to their impact on coastal maritime activities and airport operations. Previous studies identified several possible dynamic mechanisms that could be responsible for producing these events, yet observational and modeling limitations at the time left these competing interpretations open for debate. In an effort to improve our physical understanding, and ultimately the prediction, of these events, the Office of Naval Research sponsored an Accelerated Research Initiative in Coastal Meteorology during the years 1993-98 to study these and other related coastal meteorological phenomena. This effort included two field programs to study coastally trapped disturbances as well as numerous modeling studies to explore key dynamic mechanisms. This paper describes the various efforts that occurred under this program to provide an advancement in our understanding of these disturbances. While not all issues have been solved, the synoptic and mesoscale aspects of these events are considerably better understood

Coastally trapped wind reversals : progress toward understanding

Coastally trapped wind reversals along the U.S. west coast, which are often accompanied by a northward surge of fog or stratus, are an important warm—season forecast problem due to their impact on coastal maritime activities and airport operations. Previous studies identified several possible dynamic mechanisms that could be responsible for producing these events, yet observational and modeling limitations at the time left these competing interpretations open for debate. In an effort to improve our physical understanding, and ultimately the prediction, of these events, the Office of Naval Research sponsored an Accelerated Research Initiative in Coastal Meteorology during the years 1993—98 to study these and other related coastal meteorological phenomena. This effort included two field programs to study coastally trapped disturbances as well as numerous modeling studies to explore key dynamic mechanisms. This paper describes the various efforts that occurred under this program to provide an advancement in our understanding of these disturbances. While not all issues have been solved, the synoptic and mesoscale aspects of these events are considerably better understood

Confronting Uncertainty in Wildlife Management: Performance of Grizzly Bear Management

Scientific management of wildlife requires confronting the complexities of natural and social systems. Uncertainty poses a central problem. Whereas the importance of considering uncertainty has been widely discussed, studies of the effects of unaddressed uncertainty on real management systems have been rare. We examined the effects of outcome uncertainty and components of biological uncertainty on hunt management performance, illustrated with grizzly bears (Ursus arctos horribilis) in British Columbia, Canada. We found that both forms of uncertainty can have serious impacts on management performance. Outcome uncertainty alone – discrepancy between expected and realized mortality levels – led to excess mortality in 19% of cases (population-years) examined. Accounting for uncertainty around estimated biological parameters (i.e., biological uncertainty) revealed that excess mortality might have occurred in up to 70% of cases. We offer a general method for identifying targets for exploited species that incorporates uncertainty and maintains the probability of exceeding mortality limits below specified thresholds. Setting targets in our focal system using this method at thresholds of 25% and 5% probability of overmortality would require average target mortality reductions of 47% and 81%, respectively. Application of our transparent and generalizable framework to this or other systems could improve management performance in the presence of uncertainty. &nbsp

Emergence of a Novel Avian Pox Disease in British Tit Species

Avian pox is a viral disease with a wide host range. In Great Britain, avian pox in birds of the Paridae family was first diagnosed in a great tit (Parus major) from south-east England in 2006. An increasing number of avian pox incidents in Paridae have been reported each year since, indicative of an emergent infection. Here, we utilise a database of opportunistic reports of garden bird mortality and morbidity to analyse spatial and temporal patterns of suspected avian pox throughout Great Britain, 2006–2010. Reports of affected Paridae (211 incidents) outnumbered reports in non-Paridae (91 incidents). The majority (90%) of Paridae incidents involved great tits. Paridae pox incidents were more likely to involve multiple individuals (77.3%) than were incidents in non-Paridae hosts (31.9%). Unlike the small wart-like lesions usually seen in non-Paridae with avian pox in Great Britain, lesions in Paridae were frequently large, often with an ulcerated surface and caseous core. Spatial analyses revealed strong clustering of suspected avian pox incidents involving Paridae hosts, but only weak, inconsistent clustering of incidents involving non-Paridae hosts. There was no spatial association between Paridae and non-Paridae incidents. We documented significant spatial spread of Paridae pox from an origin in south-east England; no spatial spread was evident for non-Paridae pox. For both host clades, there was an annual peak of reports in August/September. Sequencing of the avian poxvirus 4b core protein produced an identical viral sequence from each of 20 great tits tested from Great Britain. This sequence was identical to that from great tits from central Europe and Scandinavia. In contrast, sequence variation was evident amongst virus tested from 17 non-Paridae hosts of 5 species. Our findings show Paridae pox to be an emerging infectious disease in wild birds in Great Britain, apparently originating from viral incursion from central Europe or Scandinavia