Efficacy and Tolerability of Peginterferon Alpha Plus Ribavirin in the Routine Daily Treatment of Chronic Hepatitis C Patients in Korea: A Multi-Center, Retrospective Observational Study

Background/Aims: We aimed to evaluate the efficacy and safety of peginterferon plus ribavirin for chronic hepatitis C (CHC) patients under real life setting in Korea. Methods: We retrospectively analyzed the medical records of 758 CHC patients treated with peginterferon plus ribavirin between 2000 and 2008 from 14 university hospitals in the Gyeonggi-Incheon area in Korea. Results: Hepatitis C virus (HCV) genotype 1 was detected in 61.2% of patients, while genotype 2 was detected in 35.5%. Baseline HCV RNA level was >= 6x10(5) IU/mL in 51.6% of patients. The sustained virological response (SVR) rate was 59.6% regardless of genotype; 53.6% in genotype 1 and 71.4% in genotype 2/3. On multivariate analysis, male gender (p=0.011), early virological response (p<0.001), genotype 2/3 (p<0.001), HCV RNA <6x10(5) IU/mL (p=0.005) and adherence to the drug >80% of the planned dose (p<0.001) were associated with SVR. The rate of premature discontinuation was 35.7%. The main reason for withdrawal was intolerance to the drug due to common adverse events or cytopenia (48.2%). Conclusions: Our data suggest that the efficacy of peginterferon and ribavirin therapy in Koreans is better in Koreans than in Caucasians for the treatment of CHC, corroborating previous studies that have shown the superior therapeutic efficacy of this regimen in Asians.This study was supported by the Korean Association for the Study of the Liver in 2009

The impact of environmental barriers on attendance of outdoor and indoor professional sports: the case of the South Korean soccer, baseball and basketball leagues

© 2021, Emerald Publishing Limited.Purpose: This study sought to determine if environmental barriers (i.e. air pollution, temperature and precipitation) affect outdoor (i.e. soccer and baseball) and indoor (i.e. basketball) professional sport attendance in South Korea. Design/methodology/approach: By including actual air quality, temperature and precipitation data collected from each place where the sporting events take place, this study conducted a regression analysis to examine factors that influenced outdoor and indoor sport attendance. Findings: In outdoor sports, the estimated results suggested that soccer and baseball attendance were not affected by air pollution. Indoor sport consumers did not change their consumption behaviors in attending sports despite the presence of air pollution. In addition, there was mixed evidence on the effect of weather-related variables on attendance. Average temperature had a positive effect on baseball (outdoor) and basketball (indoor) sport attendance, indicating that the warmer the temperature, the more likely those fans were to attend the games. Average precipitation was negatively associated with outdoor (soccer) sport spectators. Originality/value: The present study contributes to the sport environment literature by examining the impact of environmental barriers on spectators' behaviors in the context of outdoor and indoor professional sports.N

Examining Television Consumers of Mixed Martial Arts: The Relationship Among Risk Taking, Emotion, Attitude, and Actual Sport-Media-Consumption Behavior

The current study employs the hedonic paradigm model (Hirschman & Holbrook, 1982) to investigate the interceding function of emotions on the relationship between personality (i.e., risk taking) and attitude toward mixed martial arts. This study also examines sport-media (e.g., television) consumption of a nontraditional sport. Structural equation modeling was used to examine the proposed model incorporating risk taking, pleasure, arousal, attitude, and actual consumption behavior. The study found a significant mediation effect of emotion (pleasure and arousal) in the relationship between risk taking and attitude. In addition, attitude showed a direct and significant influence on actual media-consumption behavior. Theoretical and practical implications of the results are discussed, along with future directions for research

Examining Television Consumers of Mixed Martial Arts: The Relationship Among Risk Taking, Emotion, Attitude, and Actual Sport-Media-Consumption Behavior

The current study employs the hedonic paradigm model (Hirschman & Holbrook, 1982) to investigate the interceding function of emotions on the relationship between personality (i.e., risk taking) and attitude toward mixed martial arts. This study also examines sport-media (e.g., television) consumption of a nontraditional sport. Structural equation modeling was used to examine the proposed model incorporating risk taking, pleasure, arousal, attitude, and actual consumption behavior. The study found a significant mediation effect of emotion (pleasure and arousal) in the relationship between risk taking and attitude. In addition, attitude showed a direct and significant influence on actual media-consumption behavior. Theoretical and practical implications of the results are discussed, along with future directions for research

Quality of a mobile sport website: development and psychometric evaluation of a scale

With the prevalence of mobile Internet usage among sport fans, providing quality service in a mobile setting has become an essential part of sport management. Given some unique characteristics of the mobile-accessed Internet over traditional PC-accessed Internet, the current research aimed to develop a psychometrically sound measurement of the Quality for Mobile Sport Website Scale (QMSWS). In Study 1, the content validity of the scale was established through a comprehensive review of literature and expert review, initial psychometric properties of the scale with college students (n=257). In Study 2, the factor structure of the scale was cross-validated from a general population (n=242) and its predictive validity was established. Overall, the results indicated that the QMSWS would be a valid and reliable scale to assess mobile website quality as perceived by sport fans.Keywords: Mobile sport consumption; Mobile sport website quality; Sport fans; Psychometric Scale developmen

Why we follow: An examination of parasocial interaction and fan motivations for following athlete archetypes on Twitter

An Internet-based survey was posted on the Twitter feeds and Facebook pages of 1 predominantly social and 1 predominantly parasocial athlete to ascertain the similarities and differences between their follower sets in terms of parasocial interaction development and follower motivations. Analysis of the data revealed a sense of heightened interpersonal closeness based on the interaction style of the athlete. While followers of the social athlete were driven by interpersonal constructs, followers of the parasocial athlete relied more on media conventions in their interaction patterns. To understand follower motivations, exploratory factor analyses were conducted for both follower sets. For followers of the social athlete, most of the interactivity, information-gathering, personality, and entertainment items loaded together. Unlike followers of the social athlete, fanship and community items loaded alongside information-gathering items for followers of the parasocial athlete. The implications of these and other findings are discussed further

Reduced immunoreactivities of a vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide receptor (VPAC1 receptor) in the cerebral cortex, hippocampal region, and amygdala of aged rats

In this study, we examined expressional changes of VPAC1 receptor in aged rat brains using an immunohistochemical approach and found that its immunoreactivities are significantly reduced in the cerebral cortex, hippocampal region, and amygdala of aged rats. These results suggest that this reduction could underlie aging-associated memory/learning deficits and several other age-induced functional changes in these areas. However, the functional consequences of these down-regulations require further elucidation