The Mole & The Snake

This article starts from the Foucaultanian notions of biopower and discipline, deal- ing with the strategies of the modern and contemporary capitalism. Introducing the term biopower into his research, Foucault is alluding to a series of transformations re- lated to the capitalist system: life enters into the scope of power in terms of \u201ccontrolled insertion of bodies\u201d in the social apparatus of production, as well as in terms of an \u201cadaptation of population phenomena to economic processes\u201d. It involves the exchange of services on which the Fordist social pact was founded in the twentieth century. The life that is claimed in and against the relationship of capital concerns \u201cneeds\u201d that refer to a \u201cconcrete essence of man\u201d. In the undeniable awareness of a \u201ctriangulation\u201d between sovereignty, discipline and biopower, the author, as a criterion for reading the dynamics of contemporary power, analyzes the theme of control referring to Deleuze. This is de- lineated in the double form of \u201cbiopolitical algorithms\u201d and of the normalization that by means of the selection and targeted processing of big data and information packages, incessantly produced by social activity in and on the network, capture forms of life at the service of capitalism

Bridging the gap between the micro- and the macro-world of tumors

At present it is still quite difficult to match the vast knowledge on the behavior of individual tumor cells with macroscopic measurements on clinical tumors. On the modeling side, we already know how to deal with many molecular pathways and cellular events, using systems of differential equations and other modeling tools, and ideally, we should be able to extend such a mathematical description up to the level of large tumor masses. An extended model should thus help us forecast the behavior of large tumors from our basic knowledge of microscopic processes. Unfortunately, the complexity of these processes makes it very difficult -- probably impossible -- to develop comprehensive analytical models. We try to bridge the gap with a simulation program which is based on basic biochemical and biophysical processes -- thereby building an effective computational model -- and in this paper we describe its structure, endeavoring to make the description sufficiently detailed and yet understandable.Comment: 24 pages, 10 figures. Accepted for publication in AIP Advances, in the special issue on the physics of cance

Sulla critica delle fonti della storia costituzionale. Ancora su Otto Brunner, Reinhart Koselleck, la Begriffsgeschichte

The essay explores the exchange between Otto Brunner and Reinhart Koselleck about the use of historical sources in Begriffsgeschichte. Criticizing historicism in Brunner, who asserts the difference between ancient Europe and mo- dernity starting from the idea of a strong epochalization of modern politics as linked to the short time of the State, Koselleck assumes the idea of transformation of political and juridical concepts insisting on their continuity between ancient and modern time. The comparison between the two historians questions the very limits of Western modern political experienc

Diferencia y repetici\uf3n. Brunner, Koselleck, la hist\uf3ria conceptual

The article deals with the critic that Reinhart Koselleck makes to Otto Brunner\u2019s use of historical sources, which is regarded as a crucial point to understand the methodological reflection of both German speakers authors. This reflection is related, on one hand to the history of political and social concepts; on the other to constitutional history. In addition, it will be argued that methodological discussion had an important role in the very concept of history and the meaning acquired by historio- graphical practic

HISTORIA DE LOS CONCEPTOS E HISTORIOGRAFÍA DEL DISCURSO POLÍTICO

The essay deals with the relations between political concepts and history, which are preliminary in the historiography of political discourse, after the linguistic turn of the social sciences. The thread is the last contribution of Melvin Richter to the controversy between the History of Concepts (Begriffsgeschichte) and the History of Ideas of anglosaxon tradition, between the german academic lexicography and the analytic current of thought, and its importance in political philosophy.Este ensayo versa sobre las relaciones entre los conceptos políticos y la historia, que poseen un carácter preliminar en la historiografía del discurso político, desués del giro lingüístico experimentado por las ciencias sociales. El hilo conductor lo constituye la última contribución de Melvin Richter al contraste entre la Historia de los Conceptos (Begriffsgeschichte) y la Historia de las Ideas, propia de la tradición anglosajona, entre la lexicografía académica alemana y la corriente analítica de pensamiento, y su repercusión en la filosofía política

The Lord and the Land. Vladimir Putin, Russian History, and the Concept of the State

Review of Claudio Ingerflom. El dominio del amo. El estado ruso, la guerra con Ucrania y el nuevo orden mundial. Buenos Aires, Fondo de Cultura Económica, 2022, 216 pp.Review of Claudio Ingerflom. El dominio del amo. El estado ruso, la guerra con Ucrania y el nuevo orden mundial. Buenos Aires, Fondo de Cultura Económica, 2022, 216 pp

Interplay between distribution of live cells and growth dynamics of solid tumours

Experiments show that simple diffusion of nutrients and waste molecules is not sufficient to explain the typical multilayered structure of solid tumours, where an outer rim of proliferating cells surrounds a layer of quiescent but viable cells and a central necrotic region. These experiments challenge models of tumour growth based exclusively on diffusion. Here we propose a model of tumour growth that incorporates the volume dynamics and the distribution of cells within the viable cell rim. The model is suggested by in silico experiments and is validated using in vitro data. The results correlate with in vivo data as well, and the model can be used to support experimental and clinical oncology