A digital archive of human activity in the McMurdo Dry Valleys, Antarctica

Over the last half century, the McMurdo Dry Valleys (MDV) of East Antarctica have become a globally important site for scientific research and environmental monitoring. Historical data can make important contributions to current research activities and environmental management in Antarctica but tend to be widely scattered and difficult to access. We address this need in the MDV by compiling over 5000 historical photographs, sketches, maps, oral interviews, publications, and other archival resources into an online digital archive. The data have been digitized and georeferenced using a standardized metadata structure, which enables intuitive searches and data discovery via an online interface. The ultimate aim of the archive is to create as comprehensive as possible a record of human activity in the MDV to support ongoing research, management, and conservation efforts. This is a valuable tool for scientists seeking to understand the dynamics of change in lakes, glaciers, and other physical systems, as well as humanistic inquiry into the history of the Southern Continent. In addition to providing benchmarks for understanding change over time, the data can help target field sampling for studies working under the assumption of a pristine landscape by enabling researchers to identify the date and extent of past human activities

Ethiopian socio-hydrology: geographies of development and change in the water tower of Africa

2017 Fall.Includes bibliographical references.Water access, sanitation, and security remain key foci of international aid and development initiatives. However, the increasing interconnectedness of hydrologic and social systems can cause such initiatives to have unexpected and cascading effects across geographic scales. This presents new challenges for meeting ever-growing demand, as distant and complex socioeconomic and environmental relationships, or "telecouplings," may significantly influence the outcomes and sustainability of development projects. Predicting future water scenarios thus requires both integrative and basic research into the structure and function of socio-hydrological systems. I explored these emerging concepts in Ethiopia, which is the source of water for much of the Horn of Africa and receives over half of its annual budget from foreign development aid. I analyzed the geography of water in Ethiopia from two perspectives. First, I used examples from the literature to identify water development initiatives in rural and urban settings and at local and national scales. I then situated these initiatives within the telecoupling framework to reveal underlying socio-hydrological relationships. My results indicate that water development is linking Ethiopia's hydrology with geographically distant communities and markets and creating new and often unexpected flows of people, material, and capital. This is resulting in cross-scale feedbacks among urbanization, geopolitics, and the food-energy-water nexus in Ethiopia. Second, I conducted basic research into alpine wetland dynamics in the Bale Mountains, which provide the only perennial source of water to highland communities and 12 million downstream water users in East Africa. I found that wetlands more than double in extent between dry and wet seasons, and that just 4% of the alpine zone is saturated year-round. I found evidence of a hydrological continuum based on geologic and glacial legacies, which suggests that geology is a principal control on alpine wetland hydrology in Bale. I used this to develop a typology of wetland function, which provides a baseline for future research into climate change impacts and surface-groundwater connectivity

Research Sites Get Closer to Field Camps over Time: Informing Environmental Management Through a Geospatial Analysis of Science in the Mcmurdo Dry Valleys, Antarctica

As in many parts of the world, the management of environmental science research in Antarctica relies on cost-benefit analysis of negative environmental impact versus positive scientific gain. Several studies have examined the environmental impact of Antarctic field camps, but very little work looks at how the placement of these camps influences scientific research. In this study, we integrate bibliometrics, geospatial analysis, and historical research to understand the relationship between field camp placement and scientific production in the McMurdo Dry Valleys of East Antarctica. Our analysis of the scientific corpus from 1907–2016 shows that, on average, research sites have become less dispersed and closer to field camps over time. Scientific output does not necessarily correspond to the number of field camps, and constructing a field camp does not always lead to a subsequent increase in research in the local area. Our results underscore the need to consider the complex historical and spatial relationships between field camps and research sites in environmental management decision-making in Antarctica and other protected areas

The demise of caterpillar fungus in the Himalayan region due to climate change and overharvesting

Demand for traditional medicine ingredients is causing species declines globally. Due to this trade, Himalayan caterpillar fungus (Ophiocordyceps sinensis) has become one of the world’s most valuable biological commodities, providing a crucial source of income for hundreds of thousands of collectors. However, the resulting harvesting boom has generated widespread concern over the sustainability of its collection. We investigate whether caterpillar fungus production is decreasing—and if so, why—across its entire range. To overcome the limitations of sparse quantitative data, we use a multiple evidence base approach that makes use of complementarities between local knowledge and ecological modeling. We find that,according to collectors across four countries, caterpillar fungus production has decreased due to habitat degradation, climate change,and especially overexploitation. Our statistical models corroborate that climate change is contributing to this decline. They indicate that caterpillar fungus is more productive under colder conditions, growing in close proximity to areas likely to have permafrost. With significant warming already underway throughout much of its range, we conclude that caterpillar fungus populations have been negatively affected by a combination of overexploitation and climate change. Our results underscore that harvesting is not the sole threat to economically valuable species, and that a collapse of the caterpillar fungus system under ongoing warming and high collection pressurewould have serious implications throughout the Himalayan region

Patterns of interdisciplinary collaboration resemble biogeochemical relationships in the McMurdo Dry Valleys, Antarctica: a historical social network analysis of science, 1907–2016

Co-authorship networks can provide key insights into the production of scientific knowledge. This is particularly interesting in Antarctica, where most human activity relates to scientific research. Bibliometric studies of Antarctic science have provided a useful understanding of international and interdisciplinary collaboration, yet most research has focused on broad-scale analyses over recent time periods. Here, we take advantage of a ‘Goldilocks’ opportunity in the McMurdo Dry Valleys, an internationally important region of Antarctica and the largest ice-free region on the continent. The McMurdo Dry Valleys have attracted continuous and diverse scientific activity since 1958. It is a geographically confined region with limited access, making it possible to evaluate the influence of specific events and individuals. We trace the history of environmental science in this region using bibliometrics and social network analysis. Our results show a marked shift in focus from the geosciences to the biosciences, which mirrors wider trends in the history of science. Collaboration among individuals and academic disciplines increased through time, and the most productive scientists in the network are also the most interdisciplinary. Patterns of collaboration among disciplines resemble the biogeochemical relationships among respective landscape features, raising interesting questions about the role of the material environment in the development of scientific networks in the region, and the dynamic interaction with socio-cultural and political factors. Our focused, historical approach adds nuance to broad-scale bibliometric studies and could be applied to understanding the dynamics of scientific research in other regions of Antarctica and elsewhere

Patterns of Interdisciplinary Collaboration Resemble Biogeochemical Relationships in the McMurdo Dry Valleys, Antarctica: a Historical Social Network Analysis of Science, 1907–2016

Co-authorship networks can provide key insights into the production of scientific knowledge. This is particularly interesting in Antarctica, where most human activity relates to scientific research. Bibliometric studies of Antarctic science have provided a useful understanding of international and interdisciplinary collaboration, yet most research has focused on broad-scale analyses over recent time periods. Here, we take advantage of a ‘Goldilocks’ opportunity in the McMurdo Dry Valleys, an internationally important region of Antarctica and the largest ice-free region on the continent. The McMurdo Dry Valleys have attracted continuous and diverse scientific activity since 1958. It is a geographically confined region with limited access, making it possible to evaluate the influence of specific events and individuals. We trace the history of environmental science in this region using bibliometrics and social network analysis. Our results show a marked shift in focus from the geosciences to the biosciences, which mirrors wider trends in the history of science. Collaboration among individuals and academic disciplines increased through time, and the most productive scientists in the network are also the most interdisciplinary. Patterns of collaboration among disciplines resemble the biogeochemical relationships among respective landscape features, raising interesting questions about the role of the material environment in the development of scientific networks in the region, and the dynamic interaction with socio-cultural and political factors. Our focused, historical approach adds nuance to broad-scale bibliometric studies and could be applied to understanding the dynamics of scientific research in other regions of Antarctica and elsewhere

Reduction of Copper(II) to Copper(I) in the Copper-Curcumin Complex Induces Decomposition of Curcumin

We report the decomposition of curcumin due to reduction of Cu(ii) to Cu(i). Cu(ii) binds tightly with curcumin to form a complex which exhibits a high stability in methanol, but it decomposes readily in acetonitrile and in SDS micelles in the presence of ascorbic acid, coincident with reduction of Cu(ii) to Cu(i). In this study, the UV-Vis absorption of the Cu-curcumin complex shows a monotonic decrease as a function of time, consistent with the decomposition of curcumin. At a high copper : curcumin molar ratio of 10 : 1, the UV-Vis absorption spectrum of the Cu(ii)-curcumin complex in acetonitrile exhibits a substantial blue shift of the absorption maximum from 420 nm to 350 nm, which is indicative of a significant decrease in conjugation length of curcumin in the presence of Cu(ii). Time-dependent mass spectrometry and high performance liquid chromatography (HPLC) data are also consistent with the decomposition of curcumin as a consequence of reduction of Cu(ii) to Cu(i).Mandy H. M. Leung, Pravena Mohan, Tara L. Pukala, Denis B. Scanlon, Stephen F. Lincoln, and Tak W. Ke

Diamide linked gamma-cyclodextrin dimers as molecular-scale delivery systems for the medicinal pigment curcumin to prostate cancer cells

Diamide linked γ-cyclodextrin (γ-CD) dimers are proposed as molecular-scale delivery agents for the anticancer agent curcumin. N,N'-Bis(6(A)-deoxy-γ-cyclodextrin-6(A)-yl)succinamide (66γCD2su) and N,N'-bis(6(A)-deoxy-γ-cyclodextrin-6(A)-yl)urea (66γCD2ur) markedly suppress the degradation of curcumin by forming a strong 1:1 cooperative binding complexes. The results presented in this study describe the potential efficacy of 66γCD2su and 66γCD2ur for intracellular curcumin delivery to cancer cells. Cellular viability assays demonstrated a dose-dependent antiproliferative effect of curcumin in human prostate cancer (PC-3) cells that was preserved by the curcumin-66γCD2su complex. In contrast, delivery of curcumin by 66γCD2ur significantly delayed the antiproliferative effect. We observed similar patterns of gene regulation in PC-3 cells for curcumin complexed with either 66γCD2su or 66γCD2ur in comparison to curcumin alone, although curcumin delivered by either 66γCD2su or 66γCD2ur induces a slightly higher up-regulation of heme oxygenase-1. Highlighting their nontoxic nature, neither 66γCD2su nor 66γCD2ur carriers alone had any measurable effect on cell proliferation or candidate gene expression in PC-3 cells. Finally, confocal fluorescence imaging and uptake studies were used to demonstrate the intracellular delivery of curcumin by 66γCD2su and 66γCD2ur. Overall, these results demonstrate effective intracellular delivery and action of curcumin when complexed with 66γCD2su and 66γCD2ur, providing further evidence of their potential applications to deliver curcumin effectively in cancer and other treatment settings.Takaaki Harada, Lauren Giorgio, Tiffany J. Harris, Pham Duc-Truc, Huy Tien Ngo, Eleanor F. Need, Brendon J. Coventry, Stephen F. Lincoln, Christopher J. Easton, Grant Buchanan, and Tak W. Ke