ДOCBIДЛIКУBAHHЯ BУЛЬBOBAГIHITIB ПОЄДНАНИХ З ДИСПЛАЗІЯМИ ШИЙКИ МАТКИ.

To study the ciinicai and iaboratory efficacy and safety of vaginai use of the Lomeksin for the treatment of vuivovaginitis caused by Candida and microbiaiassociations in conjunction with squamous cervicai dyspiasia there were examined and treated 5O patients aged 18 to З? years, mean age was 2З,9±5,4 years. Vuivoginitis, caused by fungi, vegetating in the form of yeast, budding fungi and in the form of myceiium, diagnosed in 1З.8 % microscopy of vaginai smears . However, oniy in 5O.O %of patients we diagnosed opportunistic fiora in the form of Gram-positive coccus, and the compiete absence of Doderiein baciiiusat54.O % and their faiiure in44.O % of patients. In our opinion, suchmicrobiocenosis of vagina preciudes therapeutic purposes preparations containing antibiotics. Ciinicai and iaboratory efficacy of the Lomeksin for vuivoginitis treatment caused by yeast fungi in vegetative forms, in conjunction with opportunistic coccai fiora was 94.O %. High efficacy, toierabiiity, ease of use, avaiiabiiity of dosage forms for simuitaneous treatment of sexuai partners and the absence of side effects can be recommended for wide use in ciinicai practice.С целью изучения клинической и лабораторной эффективности и безопасности вагинального применения препарата Ломексин для лечения вульвовагинитов, обусловленных кандидами и микробными ассоциациями в сочетании с плоскоклеточной дисплазией шейки матки обследовано и пролечено 5O больных в возрасте от 18 до З? лет, средний возраст составил 2З,9±5,4 лет. Byльвoгиниты, обусловленные грибами, вегетирующими в форме дрожжей , грибами почкующимися и в форме мицелия, диагностируются в 1З,8 % микроскопий влагалищных мазков. При этом лишьу 5O,O % больных диагностируется условно-патогенная флора ввиде грамположительных кокков, а полное отсутствие палочек Додерлейна у 54,O % и их недостаточность у 44,O % больных. По нашему мнению, подобный микробиоценоз влагалища исключает возможность применения с лечебной целью препаратов, содержащих антибиотики. Клиническая и лабораторная эффективность применения препарата Ломексин для лечениявульвогинитив, обусловленных дрожжевыми грибами в вегетирующих формах, в комплексе с условно-патогенной кокковой флорой составляла 94,O %. Bыcoкaя эффективность препарата, хорошая переносимость, удобство применения, наличие лекарственных форм для одновременного лечения половых партнеров и отсутствие побочных эффектов позволяют рекомендовать его для широкого использования в клинической практике. З метою вивчення клінічної та лабораторної ефективності і безпечності вагінального застосування препарату Ломексин для лікування вульвовагінітів, обумовлених кандидами і мікробними асоціаціями в сполученні з плоскоклітинними дісплазіями шийки матки обстежено іпроліковано 5O хворих віком від 18 до З? років, середній вік склав 2З,9±5,4 років. Byльвoгiнiти, які обумовлені грибами, що вегетуютьу формі дріжджів, грибами, що брунькуються, й у формі міцелію, діагностуються у 1З,8 % мікроскопій вагінальних мазків. При цьому тільки у 5O,O % хворих діагностується умовно-патогенна флора у вигляді грампозитивних коків, а повна відсутність паличок Додерлейна у 54,O % і їхня недостатність у 44,O % хворих. На нашу думку, подібний мікробіоценоз піхви виключає можливість застосування з лікувальною метою препаратів, які містять антибіотики. Клінічна і лабораторна ефективність застосування препарату Ломексин для лікування вульвогінітів, обумовлених дріжджовими грибами у формах, що вегетують, в комплексі з умовно-патогенною коковою флорою становила 94,O %. Bиcoкa ефективність препарату, добра переносність,зручність застосування, наявність лікарських форм для одночасного лікування статевих партнерів та відсутність побічних ефектів дозволяють рекомендувати його для широкого використання у клінічній практиці

Media justice: Madeleine McCann, intermediatization and "trial by media" in the British press

Three-year-old Madeleine McCann disappeared on 3 May 2007 from a holiday apartment in Portugal. Over five years and multiple investigations that failed to solve this abducted child case, Madeleine and her parents were subject to a process of relentless ‘intermediatization’. Across 24–7 news coverage, websites, documentaries, films, YouTube videos, books, magazines, music and artworks, Madeleine was a mediagenic image of innocence and a lucrative story. In contrast to Madeleine’s media sacralization, the representation of her parents, Kate and Gerry McCann, fluctuated between periods of vociferous support and prolonged and libellous ‘trial by media’. This article analyses how the global intermediatization of the ‘Maddie Mystery’ fed into and fuelled the ‘trial by media’ of Kate and Gerry McCann in the UK press. Our theorization of ‘trial by media’ is developed and refined through considering its legal limitations in an era of ‘attack journalism’ and unprecedented official UK inquiries into press misconduct and criminality

Efficacy of once daily darunavir/ritonavir 800/100 mg in PI/r-experienced HIV-1 infected patients with suppressed HIV-1 replication: the RADAR study

International audiencen.

Estimating the Cost of No-Shows and Evaluating the Effects of Mitigation Strategies

To measure the cost of non-attendance (“no-shows”) and benefit of overbooking and interventions to reduce no-shows for an outpatient endoscopy suite

Real-time smart and standalone vision/IMU navigation sensor

In this paper, we present a smart, standalone, multi-platform stereo vision/IMU-based navigation system, providing ego-motion estimation. The real-time visual odometry algorithm is run on a nano ITX single-board computer (SBC) of 1.9 GHz CPU and 16-core GPU. High-resolution stereo images of 1.2 megapixel provide high-quality data. Tracking of up to 750 features is made possible at 5 fps thanks to a minimal, but efficient, features detection–stereo matching–feature tracking scheme runs on the GPU. Furthermore, the feature tracking algorithm benefits from assistance of a 100 Hz IMU whose accelerometer and gyroscope data provide inertial features prediction enhancing execution speed and tracking efficiency. In a space mission context, we demonstrate robustness and accuracy of the real-time generated 6-degrees-of-freedom trajectories from our visual odometry algorithm. Performance evaluations are comparable to ground truth measurements from an external motion capture system

Local and global interactions in an evolutionary resource game

Conditions for the emergence of cooperation in a spatial common-pool resource game are studied. This combines in a unique way local and global interactions. A fixed number of harvesters are located on a spatial grid. Harvesters choose among three strategies: defection, cooperation, and enforcement. Individual payoffs are affected by both global factors, namely, aggregate harvest and resource stock level, and local factors, such as the imposition of sanctions on neighbors by enforcers. The evolution of strategies in the population is driven by social learning through imitation, based on local interaction or locally available information. Numerous types of equilibria exist in these settings. An important new finding is that clusters of cooperators and enforcers can survive among large groups of defectors. We discuss how the results contrast with the non-spatial, but otherwise similar, game of Sethi and Somanathan (American Economic Review 86(4):766–789, 1996)

Scale of Auditory Behaviors e testes auditivos comportamentais para avaliação do processamento auditivo em crianças falantes do português europeu

PURPOSE: The objective of this research was to assess the auditory abilities of Portuguese children and compare such abilities to the score of the Scale of Auditory Behaviors (SAB). METHODS: Fifty-one children were evaluated with audiometry, speech audiometry, acoustic immittance measures, and eight behavioral tests involving dichotic listening, monotic listening, temporal processing, and sound localization. Their parents filled in the SAB questionnaire adapted to European A. SAB scores and auditory tests scores were submitted to Pearson's correlation coefficient. RESULTS: There is significant correlation between the score on SAB questionnaire and the auditory processing tests. The greatest coefficient was observed in temporal processing test (p=0.000). CONCLUSION: There was correlation between the score of SAB and the performance in auditory processing tests, suggesting that the SAB may be used for auditory processing screening.OBJETIVO: Investigar as habilidades auditivas de crianças portuguesas e verificar se há correlação entre aquelas e o escore do Scale of Auditory Behaviors (SAB). MÉTODOS: Todas as crianças foram submetidas a audiometria tonal, logoaudiometria, medidas de imitância acústica e oito testes comportamentais do processamento auditivo, envolvendo tarefas de escuta dicótica, escuta monótica, processamento temporal e localização sonora. Os pais das 51 crianças portuguesas avaliadas preencheram o questionário SAB adaptado ao português europeu. Foram calculados os valores do coeficiente de correlação de Pearson entre os escores obtidos no questionário e os dos testes do processamento auditivo. RESULTADOS: Observou-se correlação significativa entre o escore do questionário e o dos testes comportamentais, tendo a maior sido observada nos testes relacionados ao processamento temporal (p=0,000). CONCLUSÃO: Houve correlação entre o escore da SAB e os resultados obtidos nos testes auditivos comportamentais em crianças portuguesas, sugerindo que este questionário pode ser utilizado em triagem do processamento auditivo.CIEC – Research Centre on Child Studies, UM (FCT R&D 317

Evolution of noninvasive tests of liver fibrosis is associated with prognosis in patients with chronic hepatitis C

UNLABELLED: No data are available about the prediction of long-term survival using repeated noninvasive tests of liver fibrosis in chronic hepatitis C (CHC). We aimed to assess the prognostic value of 3-year liver stiffness measurement (LSM), aspartate aminotransferase to platelet ratio index (APRI), and fibrosis 4 (FIB-4) evolution in CHC. CHC patients with two LSM (1,000-1,500 days interval) were prospectively included. Blood fibrosis tests APRI and FIB-4 were calculated the day of baseline (bLSM) and follow-up (fLSM) LSM. Evolution of fibrosis tests was expressed as delta: (follow-up-baseline results)/duration. Date and cause of death were recorded during follow-up that started the day of fLSM. In all, 1,025 patients were included. Median follow-up after fLSM was 38.0 months (interquartile range [IQR]: 27.7-46.1) during which 35 patients died (14 liver-related death) and seven had liver transplantation. Prognostic accuracy (Harrell C-index) of multivariate models including baseline and delta results was not significantly different between LSM and FIB-4 (P ≥ 0.24), whereas FIB-4 provided more accurate prognostic models than APRI (P = 0.03). By multivariate analysis including LSM variables, overall survival was independently predicted by bLSM, delta (dLSM), and sustained virological response (SVR). Prognosis was excellent in patients having bLSM <7 kPa, SVR, or no increase (<1 kPa/year) in 7-14 kPa bLSM. Prognosis was significantly impaired in patients with an increase (≥ 1 kPa/year) in 7-14 kPa bLSM, or decrease (≤ 0 kPa/year) in ≥ 14 kPa bLSM (P = 0.949 between these two groups). Patients with an increase (>0 kPa/year) in ≥ 14 kPa bLSM had the worst prognosis. Baseline and delta FIB-4 also identified patient subgroups with significantly different prognosis. CONCLUSION: Three-year evolution of noninvasive tests of liver fibrosis has a strong prognostic value in CHC patients. These tests should be repeated to monitor patients and predict their outcome

Punishing Terrorists: A Re-Examination of U.S. Federal Sentencing in the Postguidelines Era

The empirical literature on the theory and practice of sentencing politically motivated offenders such as terrorists in U.S. federal courts is limited. Thus, we know relatively little about the dealings between terrorist offenders and the criminal justice system or how these interactions may be influenced by changes in American legal or political context. This study summarizes previous findings relative to sentencing disparity among terrorists and nonterrorists in U.S. federal courts prior to the imposition of the U.S. Sentencing Guidelines. We then identify events occurring after the advent of the guidelines, including the early acts of terrorism on American soil. We evaluate the sentencing of terrorists versus nonterrorists following the confluence imposition of the guidelines and these events. We determine whether and how the sentencing disparity between terrorist and nonterrorist has changed since the implementation of the U.S. Sentencing Guidelines and the terrorist events of the early 1990s. Based on our findings, we put forth suggestions as to the possible ways these conditions may have affected sentencing outcomes.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline