Achieving Good Angular Resolution in 3D Arc Diagrams

We study a three-dimensional analogue to the well-known graph visualization approach known as arc diagrams. We provide several algorithms that achieve good angular resolution for 3D arc diagrams, even for cases when the arcs must project to a given 2D straight-line drawing of the input graph. Our methods make use of various graph coloring algorithms, including an algorithm for a new coloring problem, which we call localized edge coloring.Comment: 12 pages, 5 figures; to appear at the 21st International Symposium on Graph Drawing (GD 2013

Microwave characteristics of liquid-crystal tunable capacitors

[[abstract]]This letter investigates the microwave characteristics of the liquid crystal tunable capacitors for the first time. With the dielectric anisotropy properties, the liquid crystal capacitors present very different characteristics compared to the semiconductor or MEMS tunable capacitors. A quality factor of 310 with a control voltage of 5 V was achieved at 4 GHz. A tuning range of 25.3% for the control voltages from 0 to 5 V was obtained at 5 GHz. The results demonstrate the potential applications of liquid crystals as dielectric materials for capacitors with high quality factors and wide tuning ranges at high frequencies, particularly suitable for the future flexible electronics with transparent substrates.[[fileno]]2030121010007[[department]]電機工程學

Pattern Registration Between Spherical Block-Copolymer Domains and Topographical Templates

Pattern registration is achieved in thin films of self-assembling block copolymers by using a topographical template to guide the positions of the polymer domains. The placement accuracy of the polymer domains is related to the edge roughness of the topographical template, and the ultimate placement accuracy is assessed (see Figure). For a block copolymer with spherical morphology, a registered polymer array is achieved by using a two-dimensional template

Circulating human leucine-rich a-2-glycoprotein 1 mRNA and protein levels to detect acute appendicitis in patients with acute abdominal pain

Background Elevated levels of circulating plasma and urine leucine-rich-2-glycoprotein-1 (LRG1) protein has been found in patients with acute appendicitis (AA) and may be useful for diagnosis. This study aimed to investigate whether combined tests including circulating LRG1 mRNA levels improve the early diagnosis of AA. Methods Between December 2011 and October 2012, a prospective study was conducted on patients aged 18 years or older presenting to the ED with acute abdominal pain (< 7 days of symptom onset). Levels of whole blood LRG1 mRNA and plasma LRG1 protein taken from these patients within 24 h of arrival (mean 12.4 h) were analyzed. The primary outcome was AA. Results Eighty-four patients (40 (47.6%) with AA and 44 (52.4%) without AA; mean age 35 years; 41.6% males) were recruited. Median whole blood LRG1 mRNA and plasma LRG1 levels were higher in AA patients than in non-AA. Of 40 AA patients, 13 (32.5%) were diagnosed as complicated AA. In ROC analysis of LRG1 mRNA (normalized to GAPDH), LRG1 protein and Alvarado score for discriminating AA and non-AA, the areas under the curve (AUC) were 0.723, 0.742 and 0.805 respectively. The AUC of combination of normalized LRG1 mRNA, LRG1 protein and Alvarado score was 0.845. Conclusion A combination of modified whole blood LRG1 mRNA levels, plasma LRG1 protein and Alvarado score at the ED may be useful to diagnose simple and complicated AA from other causes of abdominal pain

High-throughput avian molecular sexing by SYBR green-based real-time PCR combined with melting curve analysis

<p>Abstract</p> <p>Background</p> <p>Combination of <it>CHD </it>(chromo-helicase-DNA binding protein)-specific polymerase chain reaction (PCR) with electrophoresis (PCR/electrophoresis) is the most common avian molecular sexing technique but it is lab-intensive and gel-required. Gender determination often fails when the difference in length between the PCR products of <it>CHD-Z </it>and <it>CHD-W </it>genes is too short to be resolved.</p> <p>Results</p> <p>Here, we are the first to introduce a PCR-melting curve analysis (PCR/MCA) to identify the gender of birds by genomic DNA, which is gel-free, quick, and inexpensive. <it>Spilornis cheela hoya </it>(<it>S. c. hoya</it>) and <it>Pycnonotus sinensis </it>(<it>P. sinensis</it>) were used to illustrate this novel molecular sexing technique. The difference in the length of <it>CHD </it>genes in <it>S. c. hoya </it>and <it>P. sinensis </it>is 13-, and 52-bp, respectively. Using Griffiths' P2/P8 primers, molecular sexing failed both in PCR/electrophoresis of <it>S. c. hoya </it>and in PCR/MCA of <it>S. c. hoya </it>and <it>P. sinensis</it>. In contrast, we redesigned sex-specific primers to yield 185- and 112-bp PCR products for the <it>CHD-Z </it>and <it>CHD-W </it>genes of <it>S. c. hoya</it>, respectively, using PCR/MCA. Using this specific primer set, at least 13 samples of <it>S. c. hoya </it>were examined simultaneously and the Tm peaks of <it>CHD-Z </it>and <it>CHD-W </it>PCR products were distinguished.</p> <p>Conclusion</p> <p>In this study, we introduced a high-throughput avian molecular sexing technique and successfully applied it to two species. This new method holds a great potential for use in high throughput sexing of other avian species, as well.</p

Chiral Compactification on a Square

We study quantum field theory in six dimensions with two of them compactified on a square. A simple boundary condition is the identification of two pairs of adjacent sides of the square such that the values of a field at two identified points differ by an arbitrary phase. This allows a chiral fermion content for the four-dimensional theory obtained after integrating over the square. We find that nontrivial solutions for the field equations exist only when the phase is a multiple of \pi/2, so that this compactification turns out to be equivalent to a T^2/Z_4 orbifold associated with toroidal boundary conditions that are either periodic or anti-periodic. The equality of the Lagrangian densities at the identified points in conjunction with six-dimensional Lorentz invariance leads to an exact Z_8\times Z_2 symmetry, where the Z_2 parity ensures the stability of the lightest Kaluza-Klein particle.Comment: 28 pages, latex. References added. Clarifying remarks included in section 2. Minor corrections made in section

Local influence of boundary conditions on a confined supercooled colloidal liquid

We study confined colloidal suspensions as a model system which approximates the behavior of confined small molecule glass-formers. Dense colloidal suspensions become glassier when confined between parallel glass plates. We use confocal microscopy to study the motion of confined colloidal particles. In particular, we examine the influence particles stuck to the glass plates have on nearby free particles. Confinement appears to be the primary influence slowing free particle motion, and proximity to stuck particles causes a secondary reduction in the mobility of free particles. Overall, particle mobility is fairly constant across the width of the sample chamber, but a strong asymmetry in boundary conditions results in a slight gradient of particle mobility.Comment: For conference proceedings, "Dynamics in Confinement", Grenoble, March 201

Flavor Changing Effects in Family Nonuniversal Z' Models

Flavor-changing and CP-violating interactions of Z' to fermions are generally present in models with extra U(1) gauge symmetry that are string-inspired or related to broken gauged family symmetry. We study the consequences of such couplings in fermion electric dipole moments, muon g-2, and K and B meson mixings. From experimental limits or measured values, we constrain the off-diagonal Z' couplings to fermions. Some of these constraints are comparable or stronger than the existing constraints obtained from other observables.Comment: 17 pages, 2 figure

Poisson Statistics for the Largest Eigenvalues in Random Matrix Ensemble

The paper studies the spectral properties of large Wigner, band and sample covariance random matrices with heavy tails of the marginal distributions of matrix entries.Comment: This is an extended version of my talk at the QMath 9 conference at Giens, France on September 13-17, 200

Identifying cell-type-specific metabolic signatures using transcriptome and proteome analyses

Studies in various tissues have revealed a central role of metabolic pathways in regulating adult stem cell function in tissue regeneration and tumor initiation. The unique metabolic dependences or preferences of adult stem cells, therefore, are emerging as a new category of therapeutic target. Recently, advanced methods including high-resolution metabolomics, proteomics, and transcriptomics have been developed to address the growing interest in stem cell metabolism. A practical framework integrating the omics analyses is needed to systematically perform metabolic characterization in a cell-type-specific manner. Here, we leverage recent advances in transcriptomics and proteomics research to identify cell-type-specific metabolic features by reconstructing cell identity using genes and the encoded enzymes involved in major metabolic pathways. We provide protocols for cell isolation, transcriptome and proteome analyses, and metabolite profiling and measurement. The workflow for mapping cell-type-specific metabolic signatures presented here, although initially developed for intestinal crypt cells, can be easily implemented for cell populations in other tissues, and is highly compatible with most public dataset