NUCLEAR TRANSLOCATION OF MET VIA INTERNET MECHANISM

MET is one of the receptor tyrosine kinases (RTKs) that are overexpressed in malignant cancer types, including breast cancer. While RTKs are traditionally known for their roles in signaling transduction from the cell surface, recent studies have provided evidence demonstrating that most of RTKs can translocate into nucleus to regulate cellular processes in response to both ligand and stress stimulation. Oxidative stress is a common stress in cancer cells due to alteration of metabolism, and constitutive oxidative stress related to reactive oxygen species (ROS) has been observed in breast cancer cells. Here, we show that hepatocyte growth factor (HGF) as well as hydrogen peroxide (H2O2) can induce nuclear translocation of full-length MET holoreceptor via a membrane-bound vesicle transport mechanism in breast cancer cells. Our findings provide a putative mechanism by which breast cancer cells adapt to oxidative stress

Value-added Teacher Estimates as Part of Teacher Evaluations: Exploring the Effects of Data and Model Specifications on the Stability of Teacher Value-added Scores

In this study we explored the effects of statistical controls, single versus multiple cohort models, and student sample size on the stability of teacher value-added estimates (VAEs). We estimated VAEs for all 5th grade mathematics teachers in a large urban district by fitting two level mixed models using four cohorts of student data. We found that student sample size had the largest effect on changes in teachers’ relative standing and designation into performance groups, while control variables affected VAEs only minimally. However, we also found that teacher VAEs showed a fair degree of stability; year-to-year correlations ranged between .62 and .66, and changes in teacher effectiveness systematically varied by teacher experience, with beginning teachers showing the largest improvements over the four years under study.  Our results suggest that some model specifications are likely to produce teacher value-added scores that can reflect meaningful differences in teachers while we also found that other models might produce VAEs that might be unreliable.   

Diagnosing quantum phase transition via holographic entanglement entropy at finite temperature

We investigate the behavior of the holographic entanglement entropy (HEE) in proximity to the quantum critical points (QCPs) of the metal-insulator transition (MIT) in the Einstein-Maxwell-dilaton-axions (EMDA) model. Due to the fact that the ground state entropy density of the EMDA model is vanishing for insulating phase, but non-vanishing for the metallic phase, we used to expect that it is the HEE itself that characterizes the QCPs. This expectation is validated for certain case, however, we make a noteworthy observation: for a specific scenario, it is not the HEE itself but rather the second-order derivative of HEE with respect to the lattice wave number that effectively characterizes the quantum phase transition (QPT). This distinction arises due to the influence of thermal effects. These findings present novel insights into the interplay between HEE and QPTs in the context of the MIT, and have significant implications for studying QPT at finite temperatures.Comment: 15 pages, 5 figure

FY2014 Annual Report

Abstract Background This population-based study was designed to investigate whether consumption of sugar-sweetened beverages (SSB) is associated with lower serum total testosterone concentration in men 20–39 years old. Methods All data for this study were retrieved from the National Health and Nutrition Examination Survey (NHANES) 2011–2012. The primary outcome was serum testosterone concentration, and main independent variable was SSB intake. Other variables included age, race/ethnicity, poverty/income ratio, body mass index (BMI), serum cotinine, heavy drinking, and physical activity. Results Among all subjects (N = 545), 486 (90.4%) had normal testosterone levels (defined as ≥231 ng/dL) and 59 (9.6%) had low testosterone levels (defined as < 231 ng/dL). Multivariate logistic regression revealed the odds of low testosterone was significantly greater with increasing SSB consumption (Q4 [≥442 kcal/day] vs. Q1 [≤137 kcal/day]), adjusted odds ratio [aOR] = 2.29, p = 0.041]. After adjusting for possible confounding variables, BMI was an independent risk factor for low testosterone level; subjects with BMI ≥ 25 kg/m2 had a higher risk of having a low testosterone level than those with BMI < 25 kg/m2 (aOR = 3.68, p = 0.044). Conclusion SSB consumption is significantly associated with low serum testosterone in men 20–39 years old in the United States

A Fuzzy MCDM Approach for Green Supplier Selection from the Economic and Environmental Aspects

Due to the challenge of rising public awareness of environmental issues and governmental regulations, green supply chain management (SCM) has become an important issue for companies to gain environmental sustainability. Supplier selection is one of the key operational tasks necessary to construct a green SCM. To select the most suitable suppliers, many economic and environmental criteria must be considered in the decision process. Although numerous studies have used economic criteria such as cost, quality, and lead time in the supplier selection process, only some studies have taken into account the environmental issues. This study proposes a comprehensive fuzzy multicriteria decision making (MCDM) approach for green supplier selection and evaluation, using both economic and environmental criteria. In the proposed approach, a fuzzy analytic hierarchy process (AHP) is employed to determine the important weights of criteria under vague environment. In addition, a fuzzy technique for order performance by similarity to ideal solution (TOPSIS) is used to evaluate and rank the potential suppliers. Finally, a case study in Luminance Enhancement Film (LEF) industry is presented to illustrate the applicability and efficiency of the proposed method

Thermal fluctuations in viscous cosmology

In this paper we investigate the power spectrum of thermal fluctuations in very early stage of viscous cosmology. When the state parameter as well as the viscous coefficient of a barotropic fluid is properly chosen, a scale invariant spectrum with large non-Gaussianity can be obtained. In contrast to the results previously obtained in string gas cosmology and holographic cosmology, we find the non-Gaussianity in this context can be k-independent such that it is not suppressed at large scale, which is expected to be testified in future observation.Comment: 13 pages, no figure, typos corrected, references adde

Association between estradiol levels in early pregnancy and risk of preeclampsia after frozen embryo transfer

IntroductionThe failure of remodeling the spiral arteries is associated with the pathogenesis of preeclampsia. Estradiol (E2) plays a crucial role in placentation and may be involved in the development of preeclampsia. However, there is a lack of data in this area. This study aims to assess the association between serum estradiol levels in early pregnancy and the risk of preeclampsia.MethodsWe conducted a retrospective cohort study on patients who conceived after frozen embryo transfer (FET) using data from a database at a university-affiliated in vitro fertilization center. The study period spanned from January 1, 2010, to December 31, 2020. Multivariable logistic regression analyses were performed to determine the adjusted effect of E2 levels on the risk of preeclampsia. We compared the odds ratios of preeclampsia across quartiles of E2 levels and assessed their significance.ResultsSerum E2 levels at the fifth gestational week were significantly different between women with and without preeclampsia after FET programmed cycles (607.5 ± 245.4 vs. 545.6 ± 294.4 pg/ml, p=0.009). A multivariable logistic regression model demonstrated that E2 levels in early pregnancy were independent risk factors for preeclampsia. We observed an increased odds ratio of preeclampsia with increasing quartiles of estradiol levels after adjusting for potential confounders in FET programmed cycles. When comparing quartiles 3 and 4 (E2 &gt; 493 pg/ml at the fifth gestational week) to quartiles 1 and 2, the odds ratios of preeclampsia were significantly higher.ConclusionWe found that serum E2 levels in early pregnancy may impact the risk of preeclampsia, particularly following FET programmed cycles. The association between E2 levels in early pregnancy and preeclampsia deserves further investigation

Sustainabilitas Arsitektur Masjid: Evaluasi Konsep “Simple Architecture” sebagai Implementasi Desain Arsitektur Berkelanjutan suatu Kawasan

Makalah ini membahas aspek-aspek “kesederhanaan” (simplicity) sebagai konsep desain bangunan masjid secara berkelanjutan (sustainable) sesuai konteks dengan mengambil studi kasus masjid kawasan Al-Irsyad Satya Kota Baru Parahyangan, Bandung. Masjid sebagai subyek arsitektur dan pusat ibadah menjadi ruang publik yang didesain dari elemen-elemen yang secara ideal mengandung nilai-nilai Islam dan bertujuan mendukung fungsinya. Desain masjid berkonsep simple atau “sederhana” digunakan sebagai alternatif kontemporer untuk mengoptimalisasi fungsi tersebut, meliputi struktur bangunan hingga biaya pemeliharaan (maintenance) sesuai prinsip keberlanjutan. Keterkaitan erat bangunan masjid dengan aktivitas masyarakat berpotensi melibatkan partisipasi masyarakat dan pengelola dalam menerapkan program sustainabilitas sesuai konteks lingkungannya. Metode yang digunakan dalam penelitian ini berbasis pendekatan Grounded Theory secara kualitatif melalui pengumpulan data dari kegiatan observasi, interview dan analisis program keberlanjutan kawasan. Penelitian menemukan keterkaitan konsep “sederhana” yang mendukung sustainabilitas desain sekaligus menggarisbawahi evaluasi konsep desain “sederhana” yang hadir serta faktor pemeliharaan/pengembangan masjid dan kawasan

Preliminary study of neuroimaging and psychophysiology in adults with ADHD

Attention Deficit Hyperactivity Disorder  (ADHD) affects in both children and adults leading to poor executive functioning and quality of life. However, very little study focuses on neuroimaging and psychophysiology in the adults with ADHD. This preliminary study aimed to report neuroimaging and psychophysiology outcomes in the adults with ADHD. Participants in this study consisted of three groups: unaffected fathers of offspring with ADHD, adults with ADHD, and matched controls, were enrolled. A psychological battery was used in order to assess the participants’ cool cognitive function. Levels of dopaminergic activity were assessed by using the single positron emission computed tomography (SPECT) with [99mTc] TRODAT-1. In a pilot test for further study, the Iowa gambling test in a mock functional MRI was conducted. Molecular neuroimaging indicated the pivotal role of dopaminergicactivity altered a swellas functional brain imaging demonstrated difference between cool and hot executive functions. Using the Event-Related Potentials (ERP), the P300 amplitude of adults with ADHD was found to be lower than healthy group. In conclusions, Neuroimaging and psychophysiology outcome were effectively identified in adult with ADHD. Further study of neuroendocrinological factors might be related