Formulation and Evaluation of Teneligliptin and Telmisartan Bilayer Tablets for the Treatment of Coexistent Type II Diabetes Mellitus and Hypertension

In the current scenario type two diabetes mellitus and hypertension have become prevalent in large number of population. But there are many patients which are suffering from Type II Diabetes Mellitus as well as hypertension. Such condition is called co-existent Type II Diabetes Mellitus and Hypertension. In the present work an attempt is made to treat co-existent type II Diabetes Mellitus and hypertension by formulating a Bilayer tablet of Teneligliptin and Telmisartan. Both drugs are sustained released to give a day long relief to the patients and to also reduce the dose frequency. Both the layers of the tablets were formulated by wet granulation method. The granules were tested for angle of repose, bulk density, tapped density, compressibility and Hausner’s ratio to check their efficacy. Eleven different types of formulations were made using various polymers and excipients with the drugs such as PVP K30, HPMC K4M, Starch, Crospovidone, Lactose, Mannitol, Talc and Magnesium Stearate. From these 11 formulations F6 showed better tablet characteristics and drug release rate than other formulations. Thus F6 is the best formulation in this study. Biological screening of the drugs combination of Teneligliptin and Telmisartan was also done to check the presence of antidiabetic activity of the combination which showed positive results. Keywords: - Teneligliptin, Telmisartan, Sustained, Bilayer.&nbsp

Feasibility Of Tensile Membrane Structure In Ahmednagar City

Membrane structures are hugely popular in the rapidly developing world of civil engineering and there use is increasing in different aspects of buildings. There is an increasing trend concerning the use of membrane structures within architectural design for better aesthetical view and better alternative for traditional roofing materials. It is important to recognize the reasoning behind the growth in popularity. The implementation of these new technique needs to be boosted in Ahmednagar city as there are very few practical applications at present. This paper contains the survey of the city for the locations where these structures can be assembled. Market survey is also mentioned to ultimately check that is a tensile membrane structure really feasible in current scenario of Ahmednagar district

Feasibility of Tensile Membrane Structure in Ahmednagar City

Membrane structures are hugely popular in the rapidly developing world of civil engineering and there use is increasing in different aspects of buildings. There is an increasing trend concerning the use of membrane structures within architectural design for better aesthetical view and better alternative for traditional roofing materials. It is important to recognize the reasoning behind the growth in popularity. The implementation of these new technique needs to be boosted in Ahmednagar city as there are very few practical applications at present. This paper contains the survey of the city for the locations where these structures can be assembled. Market survey is also mentioned to ultimately check that is a tensile membrane structure really feasible in current scenario of Ahmednagar district