Versatility, Cost Analysis, and Scale-up in Fluoride and Arsenic Removal Using Metal-organic Framework-based Adsorbents

Fluoride and arsenic are hazardous inorganic contaminants due to associated health risks and relatively higher levels of occurrence in groundwater. Metal-organic frameworks, (MOFs) with their high surface area, versatile building blocks and numerous active sites, are a novel approach to fluoride and arsenic uptake. This review presents the different types of MOFs for fluoride and arsenic removal along with a study of dynamic breakthrough times and cost analysis. MOF performances are based on a variety of synthesis methods, notable among which solvothermal one is more described. However, all research works concluded that MOFs have poor yield compared to conventional adsorbents. But, their high adsorption capacity, tailored chemical structure and ionic uptake of fluoride and arsenic make them a more favorable option than many other adsorbents. The cost of different MOFs usually varies between 0.1 and 5 US$/g depending on the synthesis routes

Exploring diffuse radio emission in galaxy clusters and groups with the uGMRT and the SKA

Diffuse radio emission has been detected in a considerable number of galaxy clusters and groups, revealing the presence of pervasive cosmic magnetic fields, and of relativistic particles in the large-scale structure (LSS) of the Universe. Since cluster radio emission is faint and steep spectrum, its observations are largely limited by the instrument sensitivity and frequency of observation, leading to a dearth of information, more so for lower-mass systems. The unprecedented sensitivity of recently commissioned low-frequency radio telescope arrays, aided by the development of advanced calibration and imaging techniques, have helped in achieving unparalleled image quality. At the same time, the development of sophisticated numerical simulations and the availability of supercomputing facilities have paved the way for high-resolution numerical modeling of radio emission, and the structure of the cosmic magnetic fields in LSS, leading to predictions matching the capabilities of observational facilities. In view of these rapidly-evolving scenerio in modeling and observations, in this review, we summarise the role of the new telescope arrays and the development of advanced imaging techniques and discuss the detections of various kinds of cluster radio sources. In particular, we discuss observations of the cosmic web in the form of supercluster filaments, studies of emission in poor clusters and groups of galaxies, and of ultra-steep spectrum sources. We also review the current theoretical understanding of various diffuse cluster radio sources and the associated magnetic field and polarization. As the statistics of detections improve along with our theoretical understanding, we update the source classification schemes based on their intrinsic properties. We conclude by summarising the role of the upgraded GMRT and our expectations from the upcoming Square Kilometre Array (SKA) observatories.Comment: 32 pages, 10 figures, accepted for publication in the Journal of Astrophysics and Astronomy (JoAA) (to appear in the special issue on "Indian participation in the SKA"

Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis

Macrophages contribute to host immunity and tissue homeostasis via alternative activation programs. M1-like macrophages control intracellular bacterial pathogens and tumor progression. In contrast, M2-like macrophages shape reparative microenvironments that can be conducive for pathogen survival or tumor growth. An imbalance of these macrophages phenotypes may perpetuate sites of chronic unresolved inflammation, such as infectious granulomas and solid tumors. We have found that plant-derived and synthetic rocaglates sensitize macrophages to low concentrations of the M1-inducing cytokine IFN-gamma and inhibit their responsiveness to IL-4, a prototypical activator of the M2-like phenotype. Treatment of primary macrophages with rocaglates enhanced phagosome-lysosome fusion and control of intracellular mycobacteria. Thus, rocaglates represent a novel class of immunomodulators that can direct macrophage polarization toward the M1-like phenotype in complex microenvironments associated with hypofunction of type 1 and/or hyperactivation of type 2 immunity, e.g., chronic bacterial infections, allergies, and, possibly, certain tumors.R35 GM118173 - NIGMS NIH HHS; R01 HL126066 - NHLBI NIH HHS; R01 GM120272 - NIGMS NIH HHS; R01 CA218500 - NCI NIH HHS; R01 HL133190 - NHLBI NIH HHS; R33 AI105944 - NIAID NIH HHSPublished versio

Patient satisfaction at a primary level health-care facility in a district of West Bengal: Are our patients really satisfied?

Introduction: Many recent studies have shown an increased association between patient's satisfaction levels, patient's compliance, and success of treatment. Aim: The aim of this study is to assess the level of satisfaction among patients who have utilized the outpatient department services provided in the primary care level health institution. Materials and Methods: A health center-based observational cross-sectional study was conducted from July 2011 to October 2011 at Guskara Primary health center, Burdwan among 422 patients using a pre-designed pre-tested structured schedule. Results: Overall, mean satisfaction score was 2.97 ± 0.37. Highest satisfaction scores were observed among 18–20 years, males were more satisfied regarding technical quality of care, whereas females reported higher satisfaction regarding interpersonal manner, unmarried/single group reported the highest satisfaction with most of the services, literate group reported higher satisfaction than the illiterate group, affluent patients reported higher satisfaction regarding technical quality of care, financial aspect. Conclusions: Causes of dissatisfaction were long waiting time, the inadequacy of seating arrangement in the waiting area, inadequate cleanliness of surroundings, inadequate toilet facilities, nonavailability of medicines, and behavior of doctor

Exploring diffuse radio emission in galaxy clusters and groups with the uGMRT and the SKA

Diffuse radio emission has been detected in a considerable number of galaxy clusters and groups, revealing the presence of pervasive cosmic magnetic fields, and of relativistic particles in the large-scale structure (LSS) of the Universe. Since cluster radio emission is faint and steep spectrum, its observations are largely limited by the instrument sensitivity and frequency of observation, leading to a dearth of information, more so for lower-mass systems. The unprecedented sensitivity of recently commissioned low-frequency radio telescope arrays, aided by the development of advanced calibration and imaging techniques, have helped in achieving unparalleled image quality. At the same time, the development of sophisticated numerical simulations and the availability of supercomputing facilities have paved the way for high-resolution numerical modeling of radio emission, and the structure of the cosmic magnetic fields in LSS, leading to predictions matching the capabilities of observational facilities. In view of these rapidly-evolving scenerio in modeling and observations, in this review, we summarise the role of the new telescope arrays and the development of advanced imaging techniques and discuss the detections of various kinds of cluster radio sources. In particular, we discuss observations of the cosmic web in the form of supercluster filaments, studies of emission in poor clusters and groups of galaxies, and of ultra-steep spectrum sources. We also review the current theoretical understanding of various diffuse cluster radio sources and the associated magnetic field and polarization. As the statistics of detections improve along with our theoretical understanding, we update the source classification schemes based on their intrinsic properties. We conclude by summarising the role of the upgraded GMRT and our expectations from the upcoming Square Kilometre Array (SKA) observatories

Exploring diffuse radio emission in galaxy clusters and groups with the uGMRT and the SKA

Diffuse radio emission has been detected in a considerable number of galaxy clusters and groups, revealing the presence of pervasive cosmic magnetic fields, and of relativistic particles in the large-scale structure (LSS) of the Universe. Since cluster radio emission is faint and steep spectrum, its observations are largely limited by the instrument sensitivity and frequency of observation, leading to a dearth of information, more so for lower-mass systems. The unprecedented sensitivity of recently commissioned low-frequency radio telescope arrays, aided by the development of advanced calibration and imaging techniques, have helped in achieving unparalleled image quality. At the same time, the development of sophisticated numerical simulations and the availability of supercomputing facilities have paved the way for high-resolution numerical modeling of radio emission, and the structure of the cosmic magnetic fields in LSS, leading to predictions matching the capabilities of observational facilities. In view of these rapidly-evolving scenerio in modeling and observations, in this review, we summarise the role of the new telescope arrays and the development of advanced imaging techniques and discuss the detections of various kinds of cluster radio sources. In particular, we discuss observations of the cosmic web in the form of supercluster filaments, studies of emission in poor clusters and groups of galaxies, and of ultra-steep spectrum sources. We also review the current theoretical understanding of various diffuse cluster radio sources and the associated magnetic field and polarization. As the statistics of detections improve along with our theoretical understanding, we update the source classification schemes based on their intrinsic properties. We conclude by summarising the role of the upgraded GMRT and our expectations from the upcoming Square Kilometre Array (SKA) observatories

Exploring diffuse radio emission in galaxy clusters and groups with the uGMRT and the SKA

Diffuse radio emission has been detected in a considerable number of galaxy clusters and groups, revealing the presence of pervasive cosmic magnetic fields, and of relativistic particles in the large-scale structure (LSS) of the Universe. Since cluster radio emission is faint and steep spectrum, its observations are largely limited by the instrument sensitivity and frequency of observation, leading to a dearth of information, more so for lower-mass systems. The unprecedented sensitivity of recently commissioned low-frequency radio telescope arrays, aided by the development of advanced calibration and imaging techniques, have helped in achieving unparalleled image quality. At the same time, the development of sophisticated numerical simulations and the availability of supercomputing facilities have paved the way for high-resolution numerical modeling of radio emission, and the structure of the cosmic magnetic fields in LSS, leading to predictions matching the capabilities of observational facilities. In view of these rapidly-evolving scenerio in modeling and observations, in this review, we summarise the role of the new telescope arrays and the development of advanced imaging techniques and discuss the detections of various kinds of cluster radio sources. In particular, we discuss observations of the cosmic web in the form of supercluster filaments, studies of emission in poor clusters and groups of galaxies, and of ultra-steep spectrum sources. We also review the current theoretical understanding of various diffuse cluster radio sources and the associated magnetic field and polarization. As the statistics of detections improve along with our theoretical understanding, we update the source classification schemes based on their intrinsic properties. We conclude by summarising the role of the upgraded GMRT and our expectations from the upcoming Square Kilometre Array (SKA) observatories