Current and Future of “Turn‐On” Based Small‐Molecule Copper Probes for Cuproptosis

Abstract Increasing evidence shows that abnormal copper (Cu) metabolism is highly related to many diseases, such as Alzheimer's disease, Wilson's disease, hematological malignancies and Menkes disease. Very recently, cuproptosis, a Cu‐dependent, programmed cell death was firstly described by Tsvetkov et al. in 2022. Their findings may provide a new perspective for the treatment of related diseases. However, the concrete mechanisms of these diseases, especially cuproptosis, remain completely unclear, the reason of which may be a lack of reliable tools to conduct highly selective, sensitive and high‐resolution imaging of Cu in complex life systems. So far, numerous small‐molecular fluorescent probes have been designed and utilized to explore the Cu signal pathway. Among them, fluorescence turn‐on probes greatly enhance the resolution and accuracy of imaging and may be a promising tool for research of investigation into cuproptosis. This review summarizes the probes developed in the past decade which have the potential to study cuproptosis, focusing on the design strategies, luminescence mechanism and biological‐imaging applications. Besides, we put forward some ideas concerning the design of next‐generation probes for cuproptosis, aiming to tackle the main problems in this new field. Furthermore, the prospect of cuproptosis in the treatment of corresponding diseases is also highlighted

Utilizing borehole electrical images to interpret lithofacies of fan-delta: A case study of Lower Triassic Baikouquan Formation in Mahu Depression, Junggar Basin, China

Large-scale conglomerate fan-delta aprons were typical deposits on the slope of Mahu Depression during the Early Triassic. Without outcrops, it is difficult to study the lithofacies only by examining the limited cores from the main oil-bearing interval of the Baikouquan Formation. Borehole electrical imaging log provides abundant high-resolution geologic information that is obtainable only from real rocks previously. Referring to the lithology and sedimentary structure of cores, a case study of fan-deltas in the Lower Triassic Baikouquan Formation of the Mahu Depression presents a methodology for interpreting the complicated lithofacies utilizing borehole electrical images. Eleven types of lithologies and five types of sedimentary structures are summarized in borehole electrical images. The sediments are fining upward from gravel to silt and clay in the Baikouquan Formation. Fine-pebbles and granules are the main deposits in T1b1 and T1b2, but sandstones, siltstones and mudstones are more developed in T1b3. The main sedimentary textures are massive beddings, cross beddings and scour-and-fill structures. Parallel and horizontal beddings are more developed in T1b3 relatively. On integrated analysis of the lithology and sedimentary structure, eight lithofacies from electrical images, referred to as image lithofacies, is established for the fan-deltas. Granules to coarse-pebbles within massive beddings, granules to coarse-pebbles within cross and parallel beddings, siltstones within horizontal and massive beddings are the most developed lithofacies respectively in T1b1, T1b2 and T1b3. It indicates a gradual rise of the lake level of Mahu depression during the Early Triassic, with the fan-delta aprons retrograding towards to the margin of the basin. Therefore, the borehole electrical imaging log compensate for the limitation of cores of the Baikouquan Formation, providing an effective new approach to interpret the lithofacies of fan-delta