On the Dark Side of Therapies with Immunoglobulin Concentrates: The Adverse Events

Therapy by human immunoglobulin G (IgG) concentrates is a success story ongoing for decades with an ever increasing demand for this plasma product. The success of IgG concentrates on a clinical level is documented by the slowly increasing number of registered indication and the more rapid increase of the off-label uses, a topic dealt with in another contribution to this special issue of Frontiers in Immunology. A part of the success is the adverse event (AE) profile of IgG concentrates which is, even at life-long need for therapy, excellent. Transmission of pathogens in the last decade could be entirely controlled through the antecedent introduction by authorities of a regulatory network and installing quality standards by the plasma fractionation industry. The cornerstone of the regulatory network is current good manufacturing practice. Non-infectious AEs occur rarely and mainly are mild to moderate. However, in recent times, the increase in frequency of hemolytic and thrombotic AEs raised worrying questions on the possible background for these AEs. Below, we review elements of non-infectious AEs, and particularly focus on hemolysis and thrombosis. We discuss how the introduction of plasma fractionation by ion-exchange chromatography and polishing by immunoaffinity chromatographic steps might alter repertoire of specificities and influence AE profiles and efficacy of IgG concentrates

L’actualité scientifique de ce début 2022 vue par les étudiants de l’AMPS

L’AMPS rassemble les étudiants en santé qui, en plus de suivre une formation clinique, se forment à la recherche scientifique dans le but de devenir soignant-chercheurs. Elle promeut les interactions multidisciplinaires entre la santé et les sciences, et permet une émulation scientifique entre les étudiants des différentes facultés, aux profils, compétences et idées variés

Management of patients with inherited bleeding disorders in oral surgery: A 13-year experience

International audienc

Integrating machine learning and artificial intelligence in life-course epidemiology: pathways to innovative public health solutions.

The integration of machine learning (ML) and artificial intelligence (AI) techniques in life-course epidemiology offers remarkable opportunities to advance our understanding of the complex interplay between biological, social, and environmental factors that shape health trajectories across the lifespan. This perspective summarizes the current applications, discusses future potential and challenges, and provides recommendations for harnessing ML and AI technologies to develop innovative public health solutions. ML and AI have been increasingly applied in epidemiological studies, demonstrating their ability to handle large, complex datasets, identify intricate patterns and associations, integrate multiple and multimodal data types, improve predictive accuracy, and enhance causal inference methods. In life-course epidemiology, these techniques can help identify sensitive periods and critical windows for intervention, model complex interactions between risk factors, predict individual and population-level disease risk trajectories, and strengthen causal inference in observational studies. By leveraging the five principles of life-course research proposed by Elder and Shanahan-lifespan development, agency, time and place, timing, and linked lives-we discuss a framework for applying ML and AI to uncover novel insights and inform targeted interventions. However, the successful integration of these technologies faces challenges related to data quality, model interpretability, bias, privacy, and equity. To fully realize the potential of ML and AI in life-course epidemiology, fostering interdisciplinary collaborations, developing standardized guidelines, advocating for their integration in public health decision-making, prioritizing fairness, and investing in training and capacity building are essential. By responsibly harnessing the power of ML and AI, we can take significant steps towards creating healthier and more equitable futures across the life course

Laserterapia transcongiuntivale nella correzione della eversione esclusiva del puntino lacrimale inferiore sintomatico (E.e.P.i.S.). Nostra esperienza

Gli autori descrivono una tecnica di correzione parachirurgica dell'eversione sintomatica ed esclusiva del puntino lacrimale inferior

CONSIDERAZIONI CLINICO STATISTICHE SULLE VARIAZIONI DELLA PRESSIONE INTRAOCULARE IN RAPPORTO AL SESSO E ALL'ETA'

Gli Autori si sono proposti in questo studio di valutare statisticamente l'andamento della pressione oculare in relazione al sesso ed all'età. La popolazione in esame (modalità di raccolta dei dati e metodi statistici usati sono già stati riferiti), è stata divisa in 3 gruppi di età per ogni sesso, 25-35 anni, 35-45 anni età fertile - oltre 50 anni - menopausa. Il confronto dei valori medi del tono oculare dei vari gruppi ha messo in evidenza una notevole variazione pressoria nel sesso femminile all'età della menopausa. I risultati statistici suggeriscono una correlazione tra l'influenza ormonale sessuale e la pressione oculare.This study analyzes with statistical criteria, the behaviour of ocular pressure in relation to sex and age. The tested population has been divided into three groups according to age and sex as follows: 25-35 years, 35-45 years - fertile age, above 50 years - menopause (Modality of collecting data and statistical methodology have been already presented). The comparison of the average values of the ocular pressure among the various groups shows a noticeable variation in pressure in the menopause age group. The results of the statistical study suggests relationship between the influence of sex hormones and ocular pressure