391 research outputs found

    Anti-Imperialism in the Buffy-verse: Challenging the Mythos of Bush as Vampire Slayer

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    The Sky and the Mud. The Art and Politics of Television

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    The “return effect” of critical television studies has proved difficult if not impossible to discern in the discipline of politics. This essay suggests this failure may have much to do with the pervasive and insidious dichotomy art/non-art, which undergirds the refusal to see television as capable of doing politics. I argue for the fundamental politics of television by way of a critique of David Foster Wallace’s 1993 effort to keep television in its place. Wallace’s polemic pivots on a cheap allusion to Stendhal’s novel of 1830, The Red and the Black, because Wallace defines television as a mirror – “not the Stendhalian mirror” but a mere “bathroom mirror” that reflects our own image back to us. I turn this allusion against Wallace by showing that a careful reading of Stendhal unravels the entire thread of Wallace’s own critique. Drawing from Jacques Rancière’s account of “art” as that which sustains itself by including “non-art,” I show that Wallace has television exactly inside-out, because he gets both Stendhal and art completely wrong. Contra Wallace’s typology, there are never two kinds of mirrors (simple mirrors and Stendhalian mirrors), but only ever just mirrors. Stendhal’s mirror is a powerful mirror in motion, but we all have access to such mirrors. The rich and vibrant history of television studies repeatedly explores television as precisely a Stendhalian mirror, capable of not just reflecting but also refracting the world. Television is a moving, blurring, zooming, and focusing mirror capable of showing us the sky or revealing the mud in a way that may alter the very partition of the sensible.Aux États-Unis, l'effet « retour » des études télévisuelles sur la science politique comme discipline universitaire semble difficile, voire impossible, à discerner. Cet échec a sans doute beaucoup à voir avec la dichotomie art /non-art, cette dichotomie sous-tendant le refus de considérer la télévision comme de « faire » œuvre politique ; le présent article passe donc par la critique de l’essai de David Foster Wallace (« E Unibus Pluram : Television and U.S. Fiction », 1993) dont le but était de « maintenir » la télévision à sa place. L’essai polémique de Wallace s'articule en effet autour d'une allusion un peu facile au roman de Stendhal Le Rouge et le Noir, Wallace définissant la télévision – « non pas [comme] le miroir stendhalien » mais comme un simple « miroir de salle de bains » fixe et narcissique. S’appuyant sur Jacques Rancière, Samuel Chambers argumente que Wallace fait un contresens sur la télévision (et sur les séries télévisées), parce qu'il se trompe complètement à la fois sur Stendhal et sur l'art. Contrairement à ce que Wallace avance, il n'y a pas deux sortes de miroirs (les miroirs ordinaires et les miroirs stendhaliens), mais seulement des miroirs. L'histoire (riche et dynamique) des études sur la télévision et les séries télévisées explore précisément ce médium en tant que miroir stendhalien, capable non seulement de refléter mais aussi de réfracter le monde. La télévision est un miroir en mouvement, qui à travers ses effets de flou, de zoom et de focalisation se révèle capable de nous faire voir le ciel ou de nous révéler la boue d'une manière qui modifie le partage même du sensible

    Operationalizing Ecological Resilience Concepts for Managing Species and Ecosystems at Risk

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    This review provides an overview and integration of the use of resilience concepts to guide natural resources management actions. We emphasize ecosystems and landscapes and provide examples of the use of these concepts from empirical research in applied ecology. We begin with a discussion of definitions and concepts of ecological resilience and related terms that are applicable to management. We suggest that a resilience-based framework for management facilitates regional planning by providing the ability to locate management actions where they will have the greatest benefits and determine effective management strategies. We review the six key components of a resilience-based framework, beginning with managing for adaptive capacity and selecting an appropriate spatial extent and grain. Critical elements include developing an understanding of the factors influencing the general and ecological resilience of ecosystems and landscapes, the landscape context and spatial resilience, pattern and process interactions and their variability, and relationships among ecological and spatial resilience and the capacity to support habitats and species. We suggest that a spatially explicit approach, which couples geospatial information on general and spatial resilience to disturbance with information on resources, habitats, or species, provides the foundation for resilience-based management. We provide a case study from the sagebrush biome that illustrates the use of geospatial information on ecological and spatial resilience for prioritizing management actions and determine effective strategies

    Editorial: Operationalizing the Concepts of Resilience and Resistance for Managing Ecosystems and Species at Risk

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    Ecological resilience is essential for maintaining ecosystem services in an era of rapid global change, but successful attempts to operationalize it for managing ecosystems at risk have been limited. Clear formulation and application of ecological resilience concepts can guide ecosystem management so that it enhances the capacity of ecosystems to resist and recover from disturbances and provides adaptive space for periods of ecological reorganization. As originally defined, ecological resilience measures the amount of perturbation required to change an ecosystem from one set of processes and structures to a different set of processes and structures, or the amount of disturbance that a system can withstand before it shifts into a new regime or alternative stable state (Holling, 1973). In applied ecology, ecological resilience is increasingly used to evaluate the capacity of ecosystems to absorb, persist, and adapt to inevitable and often unpredictable change, and to use that information to determine the most effective management strategies (e.g., Chambers et al., 2014; Curtin and Parker, 2014; Pope et al., 2014; Seidl et al., 2016). As the scale and magnitude of ecological change increases, operationalizing ecological resilience for ecosystem management becomes ever more important. To date, much of the literature on ecological resilience has focused on theory, definitions, and broad conceptualizations (e.g., Gunderson, 2000; Folke et al., 2004, 2010; Walker et al., 2004; Folke, 2006; Gunderson et al., 2010). Much of the more applied research has focused on the importance of species diversity and species functional attributes in affecting responses to stress and disturbance (e.g., Pope et al., 2014; Angeler and Allen, 2016; Baho et al., 2017; Roberts et al., 2018). Recent, interdisciplinary research demonstrates that information on the relationships between an ecosystem’s environmental characteristics (climate, topography, soils, and potential biota) and its response to stress and disturbance provides a viable mechanism for assessing ecosystem resilience and relative risks (Chambers et al., 2014; Hessburg et al., 2016; Cushman et al., 2017; Kaszta et al., 2019). Approaches have been developed that enable application of resilience concepts at the scales needed for effective management of ecosystems experiencing progressive and deleterious change. For example, in the sagebrush biome of the western U.S. the concepts of resilience to fire and resistance to non-native invasive annual grasses have recently been used in an interagency framework to enhance conservation and restoration and help prevent listing of greater sage-grouse (Centrocercus urophasianus) under the Endangered Species Act (Chambers et al., 2017). In ecosystems around the globe, levels of ecological stress and disturbance are increasing while resources for natural resources management remain limited. Fully developing the capacity to operationalize the concept of ecological resilience can enable managers to prioritize the types and locations of management activities needed to optimize ecosystem conservation and restoration

    Remotely identifying potential vector habitat in areas of refugee and displaced person populations due to the Syrian civil war

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    Historically leishmaniasis is most prevalent in established urban centres but this research shows that refugees and, most significantly, internally displaced persons are now commonly in areas characterized by the presence of fly habitats potentially leading to higher prominence of Leishmania infection. Areas engulfed by the Syrian civil war has thus caused the dispersal of humans into previously unpopulated areas amid habitats of the sand fly Phlebotomus papatasi that hosts the parasite Leishmania. The addition of new places of exposure to this disease add to difficulties with respect to diagnosis as well as provision of care and treatment. We used geospatial methodology adapting it to remotely identifying and analyzing sand fly habitats with the aim of measuring how common it is. Our methodology helps avoid the issue of resolution in satellite imagery by measuring likelihood rather than strictly known locations. We followed up this information with spatial analysis identifying which civilian populations are most prone to sand fly exposure, and therefore leishmaniasis, due to their geographical situation. Our results suggest that those most likely to be exposed to Leishmania are internally displaced persons, those camps less likely to receive medical relief and typically having temporary residents migrating elsewhere

    Exploring High Aspect Ratio Gold Nanotubes as Cytosolic Agents: Structural Engineering and Uptake into Mesothelioma Cells.

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    The generation of effective and safe nanoagents for biological applications requires their physicochemical characteristics to be tunable, and their cellular interactions to be well characterized. Here, the controlled synthesis is developed for preparing high-aspect ratio gold nanotubes (AuNTs) with tailorable wall thickness, microstructure, composition, and optical characteristics. The modulation of optical properties generates AuNTs with strong near infrared absorption. Surface modification enhances dispersibility of AuNTs in aqueous media and results in low cytotoxicity. The uptake and trafficking of these AuNTs by primary mesothelioma cells demonstrate their accumulation in a perinuclear distribution where they are confined initially in membrane-bound vesicles from which they ultimately escape to the cytosol. This represents the first study of the cellular interactions of high-aspect ratio 1D metal nanomaterials and will facilitate the rational design of plasmonic nanoconstructs as cytosolic nanoagents for potential diagnosis and therapeutic applications.BLF-Papworth Fellowship from the British Lung Foundation and the Victor Dahdaleh Foundation

    A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease

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    Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association studies (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of 185 thousand CAD cases and controls, interrogating 6.7 million common (MAF>0.05) as well as 2.7 million low frequency (0.005<MAF<0.05) variants. In addition to confirmation of most known CAD loci, we identified 10 novel loci, eight additive and two recessive, that contain candidate genes that newly implicate biological processes in vessel walls. We observed intra-locus allelic heterogeneity but little evidence of low frequency variants with larger effects and no evidence of synthetic association. Our analysis provides a comprehensive survey of the fine genetic architecture of CAD showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect siz
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