115 research outputs found
Scoping study of the changing landscape of opportunities for patient and public involvement in NHS healthcare commissioning decision-making
Close encounters in young stellar clusters: implications for planetary systems in the solar neighbourhood
The stars that populate the solar neighbourhood were formed in stellar
clusters. Through N-body simulations of these clusters, we measure the rate of
close encounters between stars. By monitoring the interaction histories of each
star, we investigate the singleton fraction in the solar neighbourhood. A
singleton is a star which formed as a single star, has never experienced any
close encounters with other stars or binaries, or undergone an exchange
encounter with a binary. We find that, of the stars which formed as single
stars, a significant fraction are not singletons once the clusters have
dispersed. If some of these stars had planetary systems, with properties
similar to those of the solar system, the planets orbits may have been
perturbed by the effects of close encounters with other stars or the effects of
a companion star within a binary. Such perturbations can lead to strong
planet-planet interactions which eject several planets, leaving the remaining
planets on eccentric orbits. Some of the single stars exchange into binaries.
Most of these binaries are broken up via subsequent interactions within the
cluster, but some remain intact beyond the lifetime of the cluster. The
properties of these binaries are similar to those of the observed binary
systems containing extra-solar planets. Thus, dynamical processes in young
stellar clusters will alter significantly any population of solar-system-like
planetary systems. In addition, beginning with a population of planetary
systems exactly resembling the solar system around single stars, dynamical
encounters in young stellar clusters may produce at least some of the
extra-solar planetary systems observed in the solar neighbourhood.Comment: 11 pages, 9 figures, 1 table. Accepted for publication in MNRA
Greater exercise tolerance in COPD during acute intermittent compared to continuous shuttle walking protocols: a proof-of-concept study
Accretion of Planetary Material onto Host Stars
Accretion of planetary material onto host stars may occur throughout a star's
life. Especially prone to accretion, extrasolar planets in short-period orbits,
while relatively rare, constitute a significant fraction of the known
population, and these planets are subject to dynamical and atmospheric
influences that can drive significant mass loss. Theoretical models frame
expectations regarding the rates and extent of this planetary accretion. For
instance, tidal interactions between planets and stars may drive complete
orbital decay during the main sequence. Many planets that survive their stars'
main sequence lifetime will still be engulfed when the host stars become red
giant stars. There is some observational evidence supporting these predictions,
such as a dearth of close-in planets around fast stellar rotators, which is
consistent with tidal spin-up and planet accretion. There remains no clear
chemical evidence for pollution of the atmospheres of main sequence or red
giant stars by planetary materials, but a wealth of evidence points to active
accretion by white dwarfs. In this article, we review the current understanding
of accretion of planetary material, from the pre- to the post-main sequence and
beyond. The review begins with the astrophysical framework for that process and
then considers accretion during various phases of a host star's life, during
which the details of accretion vary, and the observational evidence for
accretion during these phases.Comment: 18 pages, 5 figures (with some redacted), invited revie
Landscape genetics structure of European sweet chestnut (Castanea sativa Mill): indications for conservation priorities
Sweet chestnut is a tree of great economic (fruit and wood production), ecological and
cultural importance in Europe. A large-scale landscape genetic analysis of natural
populations of sweet chestnut across Europe is applied to 1) evaluate the geographic
patterns of genetic diversity 2) identify spatial coincidences between genetic
discontinuities and geographic barriers 3) propose certain chestnut populations as
reservoirs of genetic diversity for conservation and breeding programmes. Six
polymorphic microsatellite markers were used for genotyping 1608 wild trees sampled
in 73 European sites. The Geostatistical IDW technique (ArcGIS 9.3) was used to
produce maps of genetic diversity parameters (He, Ar, PAr) and a synthetic map of the
population membership (Q value) to the different gene pools. Genetic barriers were
investigated using BARRIER 2.2 software and their locations were overlaid on a Digital
Elevation Model (GTOPO30). The DIVA-GIS software was used to propose priority
areas for conservation. High values of genetic diversity (He) and allelic richness (Ar)
were observed in the central area of C. sativa's European distribution range. The
highest values of private allelic richness (PAr) were found in the eastern area. Three
main gene pools and a significant genetic barrier separating the eastern from the
central and western populations were identified. Areas with high priority for genetic
conservation were indicated in Georgia, eastern Turkey and Italy. Our results increase
knowledge of the biogeographic history of C. sativa in Europe, indicate the geographic
location of different gene pools and identify potential priority reservoirs of genetic
diversity
Mapping the evidence of the effects of environmental factors on the prevalence of antibiotic resistance in the non-built environment: Protocol for a systematic evidence map
Background: Human, animal, and environmental health are increasingly threatened by the emergence and spread of antibiotic resistance. Inappropriate use of antibiotic treatments commonly contributes to this threat, but it is also becoming apparent that multiple, interconnected environmental factors can play a significant role. Thus, a One Health approach is required for a comprehensive understanding of the environmental dimensions of antibiotic resistance and inform science-based decisions and actions. The broad and multidisciplinary nature of the problem poses several open questions drawing upon a wide heterogeneous range of studies.
Objective: This study seeks to collect and catalogue the evidence of the potential effects of environmental factors on the abundance or detection of antibiotic resistance determinants in the outdoor environment, i.e., antibiotic resistant bacteria and mobile genetic elements carrying antibiotic resistance genes, and the effect on those caused by local environmental conditions of either natural or anthropogenic origin.
Methods: Here, we describe the protocol for a systematic evidence map to address this, which will be performed in adherence to best practice guidelines. We will search the literature from 1990 to present, using the following electronic databases: MEDLINE, Embase, and the Web of Science Core Collection as well as the grey literature. We shall include full-text, scientific articles published in English. Reviewers will work in pairs to screen title, abstract and keywords first and then full-text documents. Data extraction will adhere to a code book purposely designed. Risk of bias assessment will not be conducted as part of this SEM. We will combine tables, graphs, and other suitable visualisation techniques to compile a database i) of studies investigating the factors associated with the prevalence of antibiotic resistance in the environment and ii) map the distribution, network, cross-disciplinarity, impact and trends in the literature.This work was supported by funding from the European Unionâs Horizon 2020 Research and Innovation programme under grant agreement No 773830: One Health European Joint Programme. The funder had no role in the development of this protocol.info:eu-repo/semantics/publishedVersio
The effect of COVID rehabilitation for ongoing symptoms Post HOSPitalisation with COVID-19 (PHOSP-R):protocol for a randomised parallel group controlled trial on behalf of the PHOSP consortium
Introduction
Many adults hospitalised with COVID-19 have persistent symptoms such as fatigue, breathlessness and brain fog that limit day-to-day activities. These symptoms can last over 2 years. Whilst there is limited controlled studies on interventions that can support those with ongoing symptoms, there has been some promise in rehabilitation interventions in improving function and symptoms either using face-to-face or digital methods, but evidence remains limited and these studies often lack a control group.
Methods and analysis
This is a nested single-blind, parallel group, randomised control trial with embedded qualitative evaluation comparing rehabilitation (face-to-face or digital) to usual care and conducted within the PHOSP-COVID study. The aim of this study is to determine the effectiveness of rehabilitation interventions on exercise capacity, quality of life and symptoms such as breathlessness and fatigue. The primary outcome is the Incremental Shuttle Walking Test following the eight week intervention phase. Secondary outcomes include measures of function, strength and subjective assessment of symptoms. Blood inflammatory markers and muscle biopsies are an exploratory outcome. The interventions last eight weeks and combine symptom-titrated exercise therapy, symptom management and education delivered either in a face-to-face setting or through a digital platform (www.yourcovidrecovery.nhs.uk). The proposed sample size is 159 participants, and data will be intention-to-treat analyses comparing rehabilitation (face-to-face or digital) to usual care.
Ethics and dissemination
Ethical approval was gained as part of the PHOSP-COVID study by Yorkshire and the Humber Leeds West Research NHS Ethics Committee, and the study was prospectively registered on the ISRCTN trial registry (ISRCTN13293865). Results will be disseminated to stakeholders, including patients and members of the public, and published in appropriate journals.
Article summary
Strengths and limitations of this study
âą This protocol utilises two interventions to support those with ongoing symptoms of COVID-19
âą This is a two-centre parallel-group randomised controlled trial
âą The protocol has been supported by patient and public involvement groups who identified treatments of symptoms and activity limitation as a top priorit
Characterizing Atmospheric Transport Pathways to Antarctica and the Remote Southern Ocean Using Radon-222
We discuss remote terrestrial influences on boundary layer air over the Southern Ocean and Antarctica, and the mechanisms by which they arise, using atmospheric radon observations as a proxy. Our primary motivation was to enhance the scientific communityâs ability to understand and quantify the potential effects of pollution, nutrient or pollen transport from distant land masses to these remote, sparsely instrumented regions. Seasonal radon characteristics are discussed at 6 stations (Macquarie Island, King Sejong, Neumayer, Dumont dâUrville, Jang Bogo and Dome Concordia) using 1â4 years of continuous observations. Context is provided for differences observed between these sites by Southern Ocean radon transects between 45 and 67°S made by the Research Vessel Investigator. Synoptic transport of continental air within the marine boundary layer (MBL) dominated radon seasonal cycles in the mid-Southern Ocean site (Macquarie Island). MBL synoptic transport, tropospheric injection, and Antarctic outflow all contributed to the seasonal cycle at the sub-Antarctic site (King Sejong). Tropospheric subsidence and injection events delivered terrestrially influenced air to the Southern Ocean MBL in the vicinity of the circumpolar trough (or âPolar Frontâ). Katabatic outflow events from Antarctica were observed to modify trace gas and aerosol characteristics of the MBL 100â200 km off the coast. Radon seasonal cycles at coastal Antarctic sites were dominated by a combination of local radon sources in summer and subsidence of terrestrially influenced tropospheric air, whereas those on the Antarctic Plateau were primarily controlled by tropospheric subsidence. Separate characterization of long-term marine and katabatic flow air masses at Dumont dâUrville revealed monthly mean differences in summer of up to 5 ppbv in ozone and 0.3 ng m-3 in gaseous elemental mercury. These differences were largely attributed to chemical processes on the Antarctic Plateau. A comparison of our observations with some Antarctic radon simulations by global climate models over the past two decades indicated that: (i) some models overestimate synoptic transport to Antarctica in the MBL, (ii) the seasonality of the Antarctic ice sheet needs to be better represented in models, (iii) coastal Antarctic radon sources need to be taken into account, and (iv) the underestimation of radon in subsiding tropospheric air needs to be investigated
Description of the Method for Evaluating Digital Endpoints in Alzheimer Disease Study : Protocol for an Exploratory, Cross-sectional Study
©Jelena Curcic, Vanessa Vallejo, Jennifer Sorinas, Oleksandr Sverdlov, Jens Praestgaard, Mateusz Piksa, Mark Deurinck, Gul Erdemli, Maximilian BĂŒgler, Ioannis Tarnanas, Nick Taptiklis, Francesca Cormack, Rebekka Anker, Fabien MassĂ©, William Souillard-Mandar, Nathan Intrator, Lior Molcho, Erica Madero, Nicholas Bott, Mieko Chambers, Josef Tamory, Matias Shulz, Gerardo Fernandez, William Simpson, Jessica Robin, JĂłn G SnĂŠdal, Jang-Ho Cha, Kristin Hannesdottir. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 10.08.2022.BACKGROUND: More sensitive and less burdensome efficacy end points are urgently needed to improve the effectiveness of clinical drug development for Alzheimer disease (AD). Although conventional end points lack sensitivity, digital technologies hold promise for amplifying the detection of treatment signals and capturing cognitive anomalies at earlier disease stages. Using digital technologies and combining several test modalities allow for the collection of richer information about cognitive and functional status, which is not ascertainable via conventional paper-and-pencil tests. OBJECTIVE: This study aimed to assess the psychometric properties, operational feasibility, and patient acceptance of 10 promising technologies that are to be used as efficacy end points to measure cognition in future clinical drug trials. METHODS: The Method for Evaluating Digital Endpoints in Alzheimer Disease study is an exploratory, cross-sectional, noninterventional study that will evaluate 10 digital technologies' ability to accurately classify participants into 4 cohorts according to the severity of cognitive impairment and dementia. Moreover, this study will assess the psychometric properties of each of the tested digital technologies, including the acceptable range to assess ceiling and floor effects, concurrent validity to correlate digital outcome measures to traditional paper-and-pencil tests in AD, reliability to compare test and retest, and responsiveness to evaluate the sensitivity to change in a mild cognitive challenge model. This study included 50 eligible male and female participants (aged between 60 and 80 years), of whom 13 (26%) were amyloid-negative, cognitively healthy participants (controls); 12 (24%) were amyloid-positive, cognitively healthy participants (presymptomatic); 13 (26%) had mild cognitive impairment (predementia); and 12 (24%) had mild AD (mild dementia). This study involved 4 in-clinic visits. During the initial visit, all participants completed all conventional paper-and-pencil assessments. During the following 3 visits, the participants underwent a series of novel digital assessments. RESULTS: Participant recruitment and data collection began in June 2020 and continued until June 2021. Hence, the data collection occurred during the COVID-19 pandemic (SARS-CoV-2 virus pandemic). Data were successfully collected from all digital technologies to evaluate statistical and operational performance and patient acceptance. This paper reports the baseline demographics and characteristics of the population studied as well as the study's progress during the pandemic. CONCLUSIONS: This study was designed to generate feasibility insights and validation data to help advance novel digital technologies in clinical drug development. The learnings from this study will help guide future methods for assessing novel digital technologies and inform clinical drug trials in early AD, aiming to enhance clinical end point strategies with digital technologies. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/35442.Peer reviewe
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
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