Identification of Novel Genetic Loci Associated with Thyroid Peroxidase Antibodies and Clinical Thyroid Disease

Peer reviewe

Réaction p, 2p sur le carbone 12 à 155 MeV

For the reaction 12C(p, 2p)11B the summed-energy spectra have been measured with two scintillation telescopes, for coplanar scattering between 28° and 70°, when the two protons are emitted at two equal angles relative to the incident beam and with almost the same energy. The spectra show two well-defined peaks which can be interpreted as those in which a proton is knocked out respectively from the p-shell and from the s-shell in the carbon. From the angular distributions we can deduce the momentum distribution of the p and s protons. These distributions are in agreement with the distributions which can be calculated from the harmonic oscillator model, but with different parameters for the two states.On a mesuré par deux télescopes à scintillations les spectres de la somme des énergies des»deux protons de la réaction 12C(p, 2p)11 B lorsque ceux-ci sont émis symétriquement par rapport aux protons incidents, coplanairement et avec des énergies voisines, ceci pour des angles de diffusion compris entre 28° et 70°. Les spectres font apparaître deux pics bien déterminés qui s'interprètent par la diffusion des protons incidents sur les protons du noyau 12C dans des états p et s respectivement. Les distributions angulaires permettent d'évaluer les distributions en impulsion des protons p et s. Ces distributions sont compatibles avec celles que l'on déduit du modèle de l'oscillateur harmonique, mais en faisant intervenir des paramètres différents pour les deux états

Diffusion inélastique de protons de 155 MeV sur 28Si, 32S et 40Ca

The angular distributions of inelastic scattering of protons have been studied for the low lying excited states of 28Si, 32S and 40Ca. Comparison has been made with results obtained by inelastic scattering of electrons.Étude des distributions angulaires des protons de diffusion inélastique pour les premiers niveaux excités de 28Si, 32S et 40Ca. Comparaison avec les résultats obtenus par diffusion inélastique d'électrons

Diffusion élastique et inélastique des protons de 155 MeV sur le carbone

Elastic and inelastic scattering differential cross-sections of 155 MeV protons by carbon have been studied by a scintillation telescope between 5° and 60°. Excitation levels of 4.4-9.6-15 and 20 MeV have been investigated.Nous avons déterminé par télescope à scintillateurs et en fonction de l'angle de diffusion, entre 5° et 60°, les sections efficaces différentielles de diffusion élastique et inélastique avec excitation du noyau de carbone aux niveaux de 4,4-9,6-15 et 20 MeV

ÉTUDE DES RÉACTIONS (p, 2p) A 155 MeV SUR 7Li , 9Be ET 23Na AVEC UN ORDINATEUR EN LIGNE

L'étude des réactions (p, 2 p) à 155 MeV a été reprise avec un nouvel ensemble comprenant deux spectromètres magnétiques, deux chambres à étincelles à localisation et une calculatrice en ligne. Les premiers résultats ont été obtenus avec une résolution de 1,6 MeV sur 7Li, 9Be et 23Na.(p, 2 p) reactions at 155 MeV have been restudied with a new experimental set-up combining two magnetic spectrometers, two spark chambers and an on-line computer. We obtained preliminary spectra on 7Li, 9Be and 23Na with an overall energy resolution of 1.6 MeV

Increased waist circumference is independently associated with hypothyroidism in Mexican Americans: replicative evidence from two large, population-based studies

BACKGROUND: Mexican Americans are at an increased risk of both thyroid dysfunction and metabolic syndrome (MS). Thus it is conceivable that some components of the MS may be associated with the risk of thyroid dysfunction in these individuals. Our objective was to investigate and replicate the potential association of MS traits with thyroid dysfunction in Mexican Americans. METHODS: We conducted association testing for 18 MS traits in two large studies on Mexican Americans – the San Antonio Family Heart Study (SAFHS) and the National Health and Nutrition Examination Survey (NHANES) 2007–10. A total of 907 participants from 42 families in SAFHS and 1633 unrelated participants from NHANES 2007–10 were included in this study. The outcome measures were prevalence of clinical and subclinical hypothyroidism and thyroid function index (TFI) – a measure of thyroid function. For the SAFHS, we used polygenic regression analyses with multiple covariates to test associations in setting of family studies. For the NHANES 2007–10, we corrected for the survey design variables as needed for association analyses in survey data. In both datasets, we corrected for age, sex and their linear and quadratic interactions. RESULTS: TFI was an accurate indicator of clinical thyroid status (area under the receiver-operating-characteristic curve to detect clinical hypothyroidism, 0.98) in both SAFHS and NHANES 2007–10. Of the 18 MS traits, waist circumference (WC) showed the most consistent association with TFI in both studies independently of age, sex and body mass index (BMI). In the SAFHS and NHANES 2007–10 datasets, each standard deviation increase in WC was associated with 0.13 (p < 0.001) and 0.11 (p < 0.001) unit increase in the TFI, respectively. In a series of polygenic and linear regression models, central obesity (defined as WC ≥ 102 cm in men and ≥88 cm in women) was associated with clinical and subclinical hypothyroidism independent of age, sex, BMI and type 2 diabetes in both datasets. Estimated prevalence of hypothyroidism was consistently high in those with central obesity, especially below 45y of age. CONCLUSIONS: WC independently associates with increased risk of thyroid dysfunction. Use of WC to identify Mexican American subjects at high risk of thyroid dysfunction should be investigated in future studies