Estudio técnico económico para reemplazar una maquina Hepro y su contribución en la rentabilidad de la empresa Danper Trujillo SAC 2020

El objetivo principal del presente trabajo de investigación fue proponer un estudio técnico económico de remplazo de activos en la empresa Danper Trujillo SAC que permita determinar su viabilidad económica y financiera con generación de valor. El estudio se inició con un diagnóstico económico y financiero utilizando los estados financieros de la empresa y aplicando metodologías de análisis horizontal y vertical de estados financieros. Los resultados fueron la determinación de un 78% de incremento de los gastos de mantenimiento de la maquina HEPRO del año 2019-2020. En la fase del desarrollo del estudio se realizó un análisis de costos y gastos operativos y financieros que demandaría la adquisición de la maquina HEPRO peladora de espárragos, para ello se utilizó el análisis de los costos relevantes del proyecto es decir tomando como base los estados financieros de la fase del diagnóstico se elaboró los estados financieros propuestos haciendo variar solamente las partidas que son afectadas por la ejecución del proyecto. Los resultados fueron positivos en términos económicos y financieros con valores del VANE y VANF de S/14´765,069.37 y S/ 13´117,497.91 respectivamente lo que indica que la ejecución del proyecto genera valor económico y financiero a la empresa. Asimismo, se determinó que el costo de financiamiento del proyecto fue menor a la tasa mínima de rentabilidad económica del proyecto (TIRE=26.77%), asimismo el costo de oportunidad del dinero en el mercado resulto menor que la tasa mínima de rentabilidad del proyecto (TIRF=27.12%) lo que demostró que el proyecto es viable económica y financieramente.The main objective of this research work was to propose a technical economic study of asset replacement in the company Danper Trujillo SAC that allows to determine its economic and financial viability with value generation. The study began with an economic and financial diagnosis using the company's financial statements and applying horizontal and vertical analysis methodologies of financial statements. The results were the determination of a 78% increase in the maintenance costs of the HEPRO machine for the year 2019-2020. In the phase of the development of the study, an analysis of costs and operating and financial expenses that would require the acquisition of the HEPRO asparagus peeling machine was carried out, for this the analysis of the relevant costs of the project was used, that is, based on the financial statements of the diagnosis phase, the financial statements proposed with the project were elaborated, varying only the items that are affected by the execution of the project. The results were positive in economic and financial terms with VALUES of the VANE and VANF of S/14 ́765,069.37 and S/ 13 ́117,497.91 respectively which indicates that the execution of the project generates economic and financial value to the company. Likewise, it was determined that the financing cost of the project was lower than the minimum rate of economic return of the project (TIRE=26.77%), likewise the opportunity cost of money in the market was lower than the minimum rate of return of the project (TIRF=27.12%) which demonstrates that the project is economically and financially viable.Tesi

Marketing emocional y su incidencia en el lovemarks de los jugos Liber, Trujillo, 2019

El presente trabajo de investigación tiene la finalidad de determinar el marketing emocional y su incidencia en el lovemarks de los jugos Liber, Trujillo, 2019. El nivel de la presente investigación tendrá un tipo correlacional de diseño no experimental de corte transversal, la población estuvo conformada por 381 clientes de jugos Liber, el instrumento utilizado en la investigación fue un cuestionario lo cual se usó 24 ítems entre las dos variables, la validez de los instrumentos estuvieron a cargo de expertos y la confiabilidad del cuestionario se realizó con base a la aplicación del análisis estadístico del coeficiente de Alfa de Cronbach, para conocer si el instrumento es fiable. Por ello, se ejecutó una prueba piloto a 30 jóvenes en la ciudad de Trujillo. Se concluye que existe relación significativa entre las variables el marketing emocional y los lovemarks de los jugos Liber, Trujillo, 2019. Dado que al haber aplicado la prueba estadística de Rho de Spearman, se obtuvo un coeficiente de correlación “valor r” de 0.664 y un valor de significancia “valor p” de 0.00 siendo menor al grado de error de 0.05; por lo que hay alta evidencia de una relación directa y fuerte entre ambas variable

Motavizumab, A Neutralizing Anti-Respiratory Syncytial Virus (Rsv) Monoclonal Antibody Significantly Modifies The Local And Systemic Cytokine Responses Induced By Rsv In The Mouse Model

Motavizumab (MEDI-524) is a monoclonal antibody with enhanced neutralizing activity against RSV. In mice, motavizumab suppressed RSV replication which resulted in significant reduction of clinical parameters of disease severity. We evaluated the effect of motavizumab on the local and systemic immune response induced by RSV in the mouse model. Balb/c mice were intranasally inoculated with 106.5 PFU RSV A2 or medium. Motavizumab was given once intraperitoneally (1.25 mg/mouse) as prophylaxis, 24 h before virus inoculation. Bronchoalveolar lavage (BAL) and serum samples were obtained at days 1, 5 (acute) and 28 (long-term) post inoculation and analyzed with a multiplex assay (Beadlyte Upstate, NY) for simultaneous quantitation of 18 cytokines: IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, KC (similar to human IL-8), IL-10, IL-12p40, IL-12p70, IL-13, IL-17, TNF-α, MCP-1, RANTES, IFN-γ and GM-CSF. Overall, cytokine concentrations were lower in serum than in BAL samples. By day 28, only KC was detected in BAL specimens at low concentrations in all groups. Administration of motavizumab significantly reduced (p < 0.05) BAL concentrations of IL-1α, IL-12p70 and TNF-α on day 1, and concentrations of IFN-γ on days 1 and 5 compared with RSV-infected untreated controls. In the systemic compartment, the concentrations of IL-10, IFN-γ and KC were significantly reduced in the motavizumab-treated mice compared with the untreated controls. In summary, prophylactic administration of motavizumab was associated with significant reductions on RSV replication and concentrations of cytokine and chemokines, which are likely related to the improvement observed in clinical markers of disease severity

How Does Vaccination against SARS-CoV-2 Affect Hospitalized Patients with COVID-19?

Background: The development of effective COVID-19 vaccines has reduced the impact of COVID-19 on the general population. Our study aims to analyze how vaccination modifies the likelihood of death and length of stay in hospitalized patients with COVID-19; (2) Methods: A retrospective cohort study of 1927 hospitalized patients infected with COVID-19 was conducted. Information was gathered on vaccination status, hospitalization episode, and clinical profile of the patients. The effect of vaccination on mortality was analyzed using a multiple logistic regression model, and length of stay was analyzed using linear regression. The performance and fit of the models were evaluated; (3) Results: In hospitalized patients with COVID-19, the risk of dying during admission in vaccinated patients was half that of non-vaccinated (OR: 0.45; CI 95%: 0.25 to 0.84). In patients who were discharged due to improvement, the reduction in hospital stay in vaccinated patients was 3.17 days (CI 95%: 5.88 to 0.47); (4) Conclusions: Patients who, despite having been vaccinated, acquire the infection by SARS-CoV-2, have a significant reduction of the risk of death during admission and a reduction of hospital stay compared with unvaccinated patients

Materiotecas: el puente entre arte y ciencia para generar experiencias con materiales a través del trabajo multidisciplinar

Hoy en día existen alrededor de 160000 materiales de los cuales 15000 son sólo plásticos. ¿Cuántos diseñadorestienen conocimiento de este número maravilloso de posibilidades? Aquí es donde las bibliotecas de materiales juegan un papel sumamente importante al reunir, clasificar, almacenar y exhibir muestras de materiales que se han desarrollado en la industria a través de los años, para ponerlos a disposición de quien esté interesado en experimentar sensorialmente con ellos para su aplicación en el diseño de productos. También llamadas materiotecas, Tiene como propósito brindarle al creativo una experiencia sensorial con el material, así como toda la información técnica y mecánica que él o ella puedan necesitar para desarrollar correctamente un diseño. Así mismo, las muestras de los materiales están acompañados por los datos del proveedor y la información necesaria para poder adquirir mayores cantidades de este

High expression of prolactin receptor is associated with cell survival in cervical cancer cells

Background: The altered expression of prolactin (PRL) and its receptor (PRLR) has been implicated in breast and other types of cancer. There are few studies that have focused on the analysis of PRL/PRLR in cervical cancer where the development of neoplastic lesions is influenced by the variation of the hormonal status. The aim of this study was to evaluate the expression of PRL/PRLR and the effect of PRL treatment on cell proliferation and apoptosis in cervical cancer cell lines. Results:High expression of multiple PRLR forms and PRLvariants of 60-80 kDa were observed in cervical cancer cell lines compared with non-tumorigenic keratinocytes evaluated by Western blot, immunofluorecence and real time PCR. Treatment with PRL (200 ng/ml) increased cell proliferation in HeLa cells determined by the MTT assay at day 3 and after 1 day a protective effect against etoposide induced apoptosis in HeLa, SiHa and C-33A cervical cancer cell lines analyzed by the TUNEL assay. Conclusions: Our data suggests that PRL/PRLR signaling could act as an important survival factor for cervical cancer. The use of an effective PRL antagonist may provide a better therapeutic intervention in cervical cancer. � 2013 Lopez-Pulido et al.; licensee BioMed Central Ltd

Materiales utilizados en la policromía de la fachada de Pedro I (Real Alcázar de Sevilla, España)

This research has been conducted on the architectural decoration of the façade of the Palace of King Pedro I (The Royal Alcazar of Seville, Spain). The stratigraphic study of pictorial layers has revealed numerous interventions made on the polychrome decorations that have been related to those referenced in historical documents. Mineralogical and compositional studies of the natural and synthetic pigments and their alteration have provided an independent chronology for the polychrome decorations. Finally, this study has revealed the importance of colour of the decorative elements over the history of the palace.El estudio de la fachada del palacio de Pedro I ha puesto de manifiesto la existencia de un gran número de policromías realizadas con una amplia variedad de pigmentos de diferentes cronologías. Mediante diversas técnicas analíticas han sido diferenciadas y caracterizadas química y mineralógicamente. El estudio estratigráfico detallado de las diferentes policromías ha permitido relacionarlas con las sucesivas intervenciones documentadas, comprobando así la gran importancia que el color ha tenido en todas las épocas o momentos históricos del Palacio

The Causative Organisms of Bacterial Meningitis in Korean Children in 1996-2005

Bacterial meningitis remains a serious cause of morbidity and mortality in childhood, despite the availability of effective vaccines against Haemophilus influenzae type b (Hib) or Streptococcus pneumoniae. The purpose of this study was to analyze data on bacterial meningitis cases in Korea from 1996 through 2005. The information of all hospitalized bacteria-proven meningitis cases was obtained from 17 university hospitals nationwide. A total of 402 cases were identified. Of these, 125 (29.9%) cases were neonates. Streptococcus agalactiae was the most common bacteria responsible for 99 (24.6%) of all cases regardless of age, followed by S. pneumoniae for 91 (22.6%) and H. influenzae for 67 (16.7%) patients. The common etiology beyond the neonatal period was S. pneumoniae for 91 (33.0%) followed by H. influenzae for 63 (22.8%) patients. The overall case fatality rate was 9.4%, which was similar with that in 1986-1995. In conclusion, S. agalactiae, S. pneumoniae and H. influenzae were important etiologic agents of bacterial meningitis in children in the last 10 yrs. It is required to establish the preventive strategy of the three bacteria. The nationwide epidemiologic study should be continued to evaluate immunization strategy and efficacy

Ecological Niche Modeling of Three Species of Stenella Dolphins in the Caribbean Basin, With Application to the Seaflower Biosphere Reserve

Dolphins of the genus Stenella occur in pelagic waters of both tropical and warm-temperate oceans. Three species, the Atlantic spotted dolphin (Stenella frontalis), the pantropical spotted dolphin (S. attenuata), and the spinner dolphin (S. longirostris) are abundant worldwide, but in the Caribbean Basin they have been poorly studied and information on their distribution patterns is scarce. Specifically, in Colombia’s remote Seaflower Biosphere Reserve (SFBR) S. attenuata has been reported occasionally, but S. frontalis and S. longirostris have never been recorded before. To address this information gap, an ecological niche modeling approach was used to determine the potential distribution patterns of these three dolphin species in the region. Records of these species for the Caribbean Basin were compiled, including both published and unpublished data. Environmental information, including bathymetry, bathymetric slope, distance to shore, sea surface temperature, sea surface salinity, and chlorophyll-a concentration was gathered from public databases (MARSPEC and Bio-ORACLE) in raster format. The maximum entropy algorithm (Maxent) for modeling species’ geographic distributions with presence-only data was used. After filtering the data, 210 records of S. attenuata, 204 of S. frontalis, and 80 of S. longirostris were used to run models. The best configuration for each model was chosen based on the ΔAICc criterion. For all three species, the final ecological niche models returned AUC test values higher than 0.8, indicating satisfactory model performance. The resulting potential distribution maps suggested that areas closest to continental shorelines of the Caribbean Basin and surrounding islands had the highest environmental suitability for all species (&gt;70%). All models reported high environmental suitability for S. attenuata and S. longirostris in the SFBR, mainly in the southernmost part surrounding San Andrés and Providence Archipelago. Assessment of niche overlap from the predictions of species distributions using the similarity statistic and pairwise map overlap indicated that S. frontalis and S. longirostris had niches slightly more similar in comparison to S. attenuata. As this was a first effort to fill a gap in our understanding of the distribution of species in the genus Stenella in the Caribbean Basin, further studies are necessary using both niche modeling and biological/ecological approaches