Mejora del proceso de abastecimiento de inventarios mediante la aplicación de los métodos EOQ y ABC en la empresa DCP Ingeniería S.R.L. de la ciudad de Arequipa

En el presente trabajo se buscó mejorar el proceso de abastecimiento de repuestos en la empresa “Desarrollo y Control de Proyectos de Ingeniería S.R.L “, ubicada en la ciudad de Arequipa, esto mediante la reducción de costos, clasificación de suministros e información cuantitativa. Para realizar esto fue necesario conocer y analizar la problemática que afronta la empresa, es decir, el deficiente abastecimiento, lo que produce un desabastecimiento continuo de repuestos que son necesarios para brindar los servicios de mantenimiento, lo que se traduce en pérdidas de ingresos de la empresa ascendentes a S/. 162,000 anuales y un aumento de los costos del área logística. Una vez identificados los problemas se planteó la aplicación del método ABC – Inventarios, para reconocer aquellos repuestos necesarios y el modelo EOQ – Cantidad Optima de Pedido, para encontrar el punto de equilibrio entre el stock adecuado y los costos. Con la aplicación de estos métodos se logró la reducción de stock de 28 repuestos que están dentro de la clasificación “C” y por consiguiente hubo una reducción de costos logísticos de S/. 18,986.01 anules. Teniendo como respaldo un modelo cuantitativo, como es el modelo EOQ – Cantidad Optima de Pedido, se garantizaría el abastecimiento continuo de todos los repuestos, esto es esencial para ya no perder más servicios de mantenimiento de bombas de agua tanto domiciliarias como industriales, traduciendo en cifras se obtendrá un ingreso adicional por servicios de mantenimiento de S/. 162,000 anuales, de esta manera se logra tener una mejora en el proceso abastecimiento de la empresa.In this work we sought to improve the spare parts supply process in the company "Desarrollo y Control de Proyectos de Ingeniería S.R.L.", located in the city of Arequipa, by reducing costs, classifying supplies and quantitative information. To do this it was necessary to know and analyze the problems faced by the company, that is, the deficient supply, which produces a continuous shortage of spare parts that are necessary to provide maintenance services, which results in losses of income for the company amounting to S/. 162,000 per year and increased costs in the logistics office. Once the problems were identified, the ABC - Inventories method was applied to identify the necessary spare parts and the EOQ - Optimal Order Quantity model was used to find the balance point between adequate stock and costs. With the application of these methods, it was possible to reduce the stock of 28 spare parts that are in the "C" clasificación and consequently there was a reduction in logistics costs of S/. 18,986.01 per year. Having as support a quantitative model, such as the EOQ model - Optimal Order Quantity, would guarantee the continuous supply of all spare parts, this is essential to no longer lose more maintenance services for both domestic and industrial water pumps, translating into figures will result in an additional income for maintenance services of S/. 162,000 per year, thus achieving an improvement in the supply process of the company.Campus Arequip

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Immune Milieu and Genomic Alterations Set the Triple-Negative Breast Cancer Immunomodulatory Subtype Tumor Behavior

Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous disease. Seven subtypes have been described based on gene expression patterns. Herein, we characterized the tumor biology and clinical behavior of the immunomodulatory (IM) subtype. Methods: Formalin-fixed paraffin-embedded tumor samples from 68 high-risk (stage III-IV) TNBC patients were analyzed through microarrays, immunohistochemistry, and DNA sequencing. Results: The IM subtype was identified in 24% of TNBC tumor samples and characterized by a higher intratumoral (intT) and stromal (strml) infiltration of FOXP3+ TILs (Treg) compared with non-IM subtypes. Further, PD-L1+ (>1%) expression was significantly higher, as well as CTLA-4+ intT and strml expression in the IM subtype. Differential expression and gene set enrichment analysis identified biological processes associated with the immune system. Pathway analysis revealed enrichment of the β-catenin signaling pathway. The non-coding analysis led to seven Long Intergenic Non-Protein Coding RNAs (lincRNAs) (6 up-regulated and 1 down-regulated) that were associated with a favorable prognosis in the TNBC-IM subtype. The DNA sequencing highlighted two genes relevant to immune system responses: CTNNB1 (Catenin β-1) and IDH1. Conclusion: the IM subtype showed a distinct immune microenvironment, as well as subtype-specific genomic alterations. Characterizing TNBC at a molecular and transcriptomic level might guide immune-based therapy in this subgroup of patients

Gestión integrada de la cuenca alta del río Magdalena: instrumentos para su evaluación y planificación

Watersheds are fundamental units of analysis for the development of planning and management processes. Understanding their dynamics, structure, and functioning is the basis for territory planning and decision-making. However, their functionality and sustainable use depend on the information and knowledge of these ecosystems, as well as their regimes and responsiveness against anthropogenic interventions, variability, and climate change. This book provides tools and methodologies for the planning and evaluation of water resources, as well as for the formulation and implementation of mechanisms for adaptation to climate change and integrated watershed management. The publication “Integral management of the upper basin of the Magdalena River: tools for its evaluation and planning” is the result of research carried out by students, professors, and graduates from the School of Agricultural, Livestock and Environmental Sciences (ECAPMA, for its Spanish acronym) of UNAD (Spanish acronym for Universidad Nacional Abierta y a Distancia), and the research group Inyumacizo, classified in an A Category group according to the Colombian Ministry of Sciences—MinCiencias.Las cuencas hidrográficas se constituyen en unidades fundamentales de análisis para el desarrollo de procesos de planificación y gestión. La comprensión de su dinámica, estructura y funcionamiento constituyen el soporte para la planificación del territorio y la toma de decisiones. Sin embargo, la funcionalidad y aprovechamiento sostenible son dependientes de la información y el conocimiento de estos ecosistemas, así como de sus regímenes y capacidades de respuesta frente a las intervenciones antrópicas, variabilidad y cambio climático. Este libro brinda instrumentos y metodologías para la planificación y evaluación del recurso hídrico, así como en la formulación e implementación de mecanismos de adaptación al cambio climático y la gestión integrada de cuencas hidrográficas. La publicación denominada: “Gestión integrada de la cuenca alta del río Magdalena: instrumentos para su evaluación y planificación” es producto de investigaciones realizadas por estudiantes, docentes y egresados de la Escuela de Ciencias Agrícolas, Pecuarias y del Medio Ambiente (ECAPMA) de la UNAD y el grupo de investigación Inyumacizo, categorizado en A por MinCiencias.As bacias hidrográficas são unidades fundamentais de análise para o desenvolvimento de processos de planejamento e gestão. A compreensão de sua dinâmica, estrutura e funcionamento é a base para o planejamento territorial e a tomada de decisões. Entretanto, a funcionalidade e o uso sustentável dependem da informação e do conhecimento desses ecossistemas, bem como de seus regimes e capacidades para responder a intervenções antrópicas, variabilidade e mudanças climáticas. Este livro fornece instrumentos e metodologias para o planejamento e avaliação do recurso hídrico, bem como na formulação e implementação de mecanismos de adaptação à mudança climática e gestão integrada de bacias hidrográficas. A publicação intitulada: “Gestão integrada da bacia alta do rio Magdalena: instrumentos de avaliação e planejamento” é o produto de pesquisas realizadas por estudantes, professores e graduados da Escola de Ciências Agrárias, Pecuárias e Ambientais (ECAPMA) da UNAD e do grupo de pesquisa Inyumacizo, categorizado em A pela Min-Ciencias

Compilación de Proyectos de Investigación desde el año 2003 al 2012

Listado de Proyectos de investigación de UPIICSA desde 2003 a 201

Compilación de Proyectos de Investigacion de 1984-2002

Instituto Politecnico Nacional. UPIICS